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• Musanatenge crizotinib,
• Crizotinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Crizotinib imagwiritsidwa ntchito pochiza mitundu ina ya khansa ya m'mapapo yaing'ono (NSCLC) yomwe yafalikira kumatenda oyandikira kapena mbali zina za thupi. Amagwiritsidwanso ntchito kuthana ndi mtundu wina wa anaplastic large cell lymphoma (ALCL) womwe wabwerera kapena wosagwiritsa ntchito mankhwala ena achikulire ndi ana azaka chimodzi kapena kupitilira apo. Crizotinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa kuchitapo kanthu mwachilengedwe komwe kumafunikira kuti maselo a khansa achulukane.

Crizotinib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kawiri patsiku. Tengani crizotinib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani crizotinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osagawana, kutafuna, kapena kuwaphwanya. Musakhudze makapisozi omwe athyoka kapena kuphwanyidwa.

Dokotala wanu akhoza kuyimitsa chithandizo chanu kwakanthawi kwakanthawi kapena kosatha, kuchepetsa mlingo, kapena kukuwuzani kuti muzimwa mankhwala anu kangapo mukakumana ndi zovuta za crizotinib. Uzani dokotala wanu momwe mukumvera mukamalandira chithandizo.

Pitirizani kutenga crizotinib ngakhale mutakhala bwino. Osasiya kumwa crizotinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge crizotinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la crizotinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a crizotinib. Funsani wamankhwala wanu kapena onani zomwe wodwala akupanga kuti muwone mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchulapo izi: amiodarone (Cordarone, Pacerone); maantibayotiki ena monga clarithromycin (Biaxin); mankhwala ena oletsa mafungal monga itraconaozole (Sporanox), ketoconazole (Nizoral), ndi voriconazole (Vfend); mankhwala ena a kuthamanga kwa magazi; chloroquine (Aralen); mankhwala a chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (DHH 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); mankhwala osokoneza bongo (Inapsine); ergotamine (Ergomar, ku Cafergot, ku Migergot); erythromycin (EES, Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); zachilengedwe (Tambocor); mankhwala ena a kachirombo ka HIV (monga HIV) monga atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, ndi phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Kutchulidwa); quinidine (mu Nuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, mu Rifater); mankhwala (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); ndi vandetanib (Caprelsa). Mankhwala ena ambiri amathanso kulumikizana ndi crizotinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni adotolo ngati mwakhala mukukhala ndi matenda a QT (matenda osowa mtima omwe angayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi), kugunda kwamtima pang'ono, kulephera kwa mtima, mavuto owonera, mavuto am'mapapo kupatula khansa ya m'mapapo, kapena chiwindi kapena matenda a impso.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kuyezetsa mimba musanayambe mankhwala ndi crizotinib. Ngati ndinu wamkazi, muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso masiku 45 mutapatsidwa mankhwala omaliza. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso masiku 90 mutatha kumwa. Lankhulani ndi dokotala wanu za njira yolerera yomwe muyenera kugwiritsa ntchito. Mukakhala ndi pakati mukatenga crizotinib, itanani dokotala wanu mwachangu. Crizotinib itha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Musamwe mkaka mukamamwa mankhwala komanso kwa masiku 45 mutapatsidwa mankhwala omaliza.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka kwa abambo ndi amai. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito crizotinib.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa crizotinib.
• muyenera kudziwa kuti crizotinib imatha kuyambitsa mavuto a masomphenya, chizungulire, komanso kutopa kwambiri. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati pasanathe maola 6 musanakonzekere kumwa mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Crizotinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• kupweteka m'mimba
• zilonda mkamwa
• kusintha kwa kulawa chakudya
• kutentha pa chifuwa
• mutu
• dzanzi, kutentha, kapena kumva kulasalasa m'manja kapena m'mapazi
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kupuma movutikira
• chifuwa
• malungo
• kutupa kwa mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• kupweteka pachifuwa
• kugunda kochedwa mtima
• zidzolo
• kufooka
• kutopa kwambiri
• kupweteka kumtunda chakumanja kwam'mimba
• nseru
• kusanza
• zovuta kumeza
• chikasu cha khungu kapena maso
• mkodzo wakuda
• kuyabwa
• malungo
• kutuluka mwachilendo kapena kuphwanya
• kuwona kawiri kapena kusawona bwino
• kusintha kwa masomphenya
• kutengeka ndi kuwala
• powona kuwala kwadzidzidzi
• kuwona ma float atsopano kapena owonjezera (mawanga m'masomphenya anu)

Crizotinib itha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi crizotinib komanso adzaitanitsa mayeso ena a labu mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira crizotinib. Dokotala wanu amayang'ananso kuchuluka kwa mtima wanu ndi kuthamanga kwa magazi nthawi zonse mukamalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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