Pomalidomide

Zamkati

• Musanatenge pomalidomide,
• Pomalidomide imatha kubweretsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi kapena zomwe zalembedwa mgawo la CHENJEZO LAPANSI kapena CHENJEZO LAPadera, siyani kumwa pomalidomide ndipo itanani dokotala nthawi yomweyo:

Kuopsa kwa zilema zakubadwa, zoopsa zomwe zimayambitsa pomalidomide.

Kwa odwala onse omwe amatenga pomalidomide:

Pomalidomide sayenera kutengedwa ndi odwala omwe ali ndi pakati kapena omwe angakhale ndi pakati. Pali chiopsezo chachikulu kuti pomalidomide imayambitsa kuchepa kwa mimba kapena imapangitsa kuti mwanayo abadwe wopunduka (mavuto omwe amapezeka pakubadwa).

Pulogalamu yotchedwa Pomalyst REMS^® yakhazikitsidwa kuti iwonetsetse kuti amayi apakati samamwa pomalidomide komanso kuti amayi satenga mimba akamamwa pomalidomide. Odwala onse, kuphatikiza azimayi omwe sangatenge mimba ndi abambo, atha kupeza pomalidomide pokhapokha akalembetsedwa ndi Pomalyst REMS^®, khalani ndi mankhwala ochokera kwa dokotala yemwe adalembetsa ku Pomalyst REMS^®, ndipo lembani mankhwala ku pharmacy yomwe imalembetsedwa ndi Pomalyst REMS^®.

Mukalandira zambiri za kuopsa kwakumwa pomalidomide ndipo muyenera kusaina chikalata chololeza kuti mumvetsetsa izi musanalandire mankhwala. Muyenera kukaonana ndi dokotala mukamalandira chithandizo kuti mukambirane za momwe mulili komanso mavuto omwe mukukumana nawo kapena kukayezetsa mimba monga momwe pulogalamuyi idanenera.

Uzani dokotala wanu ngati simukumvetsa zonse zomwe munauzidwa za pomalidomide ndi Pomalyst REMS^® pulogalamu ndi momwe mungagwiritsire ntchito njira zolerera zokambirana ndi dokotala wanu, kapena ngati simukuganiza kuti mudzatha kusunga nthawi yokumana.

Osapereka magazi mukamamwa pomalidomide komanso kwa milungu 4 mutalandira chithandizo.

Osagawana pomalidomide ndi wina aliyense, ngakhale munthu yemwe ali ndi zisonyezo zomwezo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba mankhwala ndi pomalidomide ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena http://www.celgeneriskmanagement.com kuti mupeze Chithandizo cha Mankhwala.

Lankhulani ndi dokotala wanu za kuopsa kwakumwa pomalidomide.

Kwa odwala azimayi omwe amatenga pomalidomide:

Ngati mutha kutenga pakati, muyenera kukwaniritsa zofunikira mukamalandira pomalidomide. Muyenera kukwaniritsa zofunikira izi ngakhale mutakhala ndi tubal ligation ('machubu omangirizidwa,' opareshoni yopewera kutenga pakati). Mutha kukhululukidwa kukwaniritsa zofunikira izi pokhapokha ngati simunasambe kwa miyezi 24 motsatizana ndipo dokotala wanu akuti mwadutsa kusamba ('kusintha kwa moyo') kapena mwachitidwa opareshoni kuti muchotse chiberekero chanu ndi / kapena mazira onse awiri. Ngati palibe izi zomwe zili zowona kwa inu, ndiye muyenera kukwaniritsa zofunikira pansipa.

Muyenera kugwiritsa ntchito njira ziwiri zovomerezeka zolerera kwa milungu inayi musanayambe kumwa pomalidomide, mukamamwa mankhwala, kuphatikiza nthawi zomwe dokotala akukuuzani kuti musiye pomalidomide, komanso milungu 4 mutalandira chithandizo. Dokotala wanu angakuwuzeni mitundu yoletsa kubereka yomwe ili yovomerezeka ndipo adzakupatsani zambiri zolembedwa za zolera. Muyenera kugwiritsa ntchito njira ziwirizi zoletsa nthawi zonse pokhapokha mutalonjeza kuti simudzagonana ndi amuna kwamasabata anayi musanalandire chithandizo, mukamalandira chithandizo, mukasokonezedwa ndi chithandizo chanu, komanso kwa milungu 4 chithandizo chanu.

Ngati mwasankha kumwa pomalidomide, ndiudindo wanu kupewa kutenga mimba kwa milungu inayi isanakwane, mkati, komanso masabata anayi mutalandira chithandizo. Muyenera kumvetsetsa kuti njira iliyonse yolerera ikhoza kulephera. Chifukwa chake, ndikofunikira kuti muchepetse chiopsezo chotenga mimba mwangozi pogwiritsa ntchito njira ziwiri zakulera. Uzani dokotala wanu ngati simukumvetsa zonse zomwe munauzidwa zakulera kapena simukuganiza kuti mutha kugwiritsa ntchito njira ziwiri zakulera nthawi zonse.

Muyenera kukhala ndi mayeso awiri olakwika okhudzana ndi pakati musanayambe kumwa pomalidomide. Muyeneranso kukayezetsa kuti muli ndi pakati mu labotale nthawi zina mukamalandira chithandizo. Dokotala wanu angakuuzeni nthawi ndi malo omwe mungayesere.

Lekani kumwa pomalidomide ndipo itanani dokotala nthawi yomweyo ngati mukuganiza kuti muli ndi pakati, mumasowa msambo, kapena mumagonana osagwiritsa ntchito njira ziwiri zakulera. Mukakhala ndi pakati mukamalandira chithandizo kapena musanathe masiku 30 mutalandira chithandizo, dokotala wanu alumikizana ndi Pomalyst REMS^® pulogalamu, wopanga pomalidomide, ndi Food and Drug Administration (FDA).

Kwa odwala amuna omwe amatenga pomalidomide:

Pomalidomide imapezeka mu umuna (madzimadzi okhala ndi umuna womwe umatulutsidwa kudzera mu mbolo nthawi yamankhwala). Muyenera kugwiritsa ntchito kondomu ya latex kapena yokumba, ngakhale mutakhala ndi vasectomy (opareshoni yomwe imalepheretsa abambo kuyambitsa mimba), nthawi iliyonse mukamagonana ndi mayi yemwe ali ndi pakati kapena wokhoza kutenga pakati mukamamwa pomalidomide ndipo kwa masiku 28 mutalandira chithandizo. Uzani dokotala wanu ngati mukugonana ndi mkazi osagwiritsa ntchito kondomu kapena ngati mnzanu akuganiza kuti akhoza kukhala ndi pakati mukamamwa pomalidomide.

Osapereka umuna mukamamwa pomalidomide komanso kwa milungu 4 mutalandira chithandizo.

Kuopsa kwa magazi kuundana:

Ngati mukumwa pomalidomide kuti muchiritse myeloma yambiri (mtundu wa khansa ya m'mafupa), pali chiopsezo kuti mutha kudwala matenda a mtima, sitiroko, kapena magazi m'magazi mwanu (deep vein thrombosis; DVT) that imatha kupyola m'magazi kupita m'mapapu anu (embolism embolism, PE). Uzani dokotala wanu ngati mwadwala matenda a mtima kapena sitiroko. Dokotala wanu angakuuzeni kuti musamwe pomalidomide. Komanso muuzeni dokotala ngati mumasuta kapena mumasuta fodya, ngati mwadwala matenda a mtima kapena sitiroko, ndipo ngati mwakhala mukudwala kapena kuthamanga kwa magazi, kapena kuchuluka kwama cholesterol kapena mafuta, Dokotala wanu akhoza kukupatsani mankhwala ena kumwedwa ndi pomalidomide kuti muchepetse chiopsezo ichi. Ngati mukumane ndi izi pazomwe mukumwa pomalidomide, uzani dokotala nthawi yomweyo: kupweteka mutu; kusanza; mavuto a kulankhula; chizungulire kapena kukomoka; kutaya mwadzidzidzi kwathunthu kapena pang'ono masomphenya; kufooka kapena kufooka kwa mkono kapena mwendo; kupweteka pachifuwa komwe kumatha kufalikira ku mikono, khosi, nsagwada, kumbuyo, kapena mmimba; kupuma movutikira; chisokonezo; kapena kupweteka, kutupa, kapena kufiira mwendo umodzi.

Lankhulani ndi dokotala wanu za kuopsa kwakumwa pomalidomide.

Pomalidomide imagwiritsidwa ntchito limodzi ndi dexamethasone pochiza ma myeloma angapo (mtundu wa khansa ya m'mafupa) omwe sanasinthe mkati kapena mkati mwa masiku 60 achipatala ndi mankhwala osachepera awiri, kuphatikiza lenalidomide (Revlimid) ndi proteasome inhibitor monga bortezomib (Velcade) kapena carfilzomib (Kyprolis). Amagwiritsidwanso ntchito pochizira Kaposi's sarcoma (mtundu wa khansa womwe umayambitsa minofu yosazolowereka kumera m'malo osiyanasiyana amthupi) wokhudzana ndi matenda a immunodeficiency (AIDS) atatha kuchiza mankhwala ena kapena kwa anthu omwe ali ndi Kaposi's sarcoma omwe alibe ali ndi kachilombo ka HIV. Pomalidomide ali mgulu la mankhwala otchedwa ma immunomodulatory agents. Zimagwira ntchito pothandiza mafupa kupanga maselo abwinobwino amwazi komanso kupha maselo osadziwika m'mafupa.

Pomalidomide amabwera ngati kapisozi woti amwe pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku kapena wopanda chakudya masiku 1 mpaka 21 atadutsa masiku 28. Ndondomeko yamasiku 28 iyi imatha kubwerezedwa monga momwe dokotala akuwalimbikitsira. Tengani pomalidomide mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani pomalidomide ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; osanyema kapena kuzitafuna. Osatsegula makapisozi kapena kuwagwiritsa ntchito mopitilira muyeso. Ngati khungu lanu limakhudzana ndi makapisozi kapena ufa wosweka, tsukani malo owonekerawo ndi sopo. Ngati zilizonse zamakapisozi zikufika m'maso mwanu, sambani maso anu nthawi yomweyo ndi madzi.

Dokotala wanu angafunikire kuyimitsa chithandizo chanu kwakanthawi kapena kwakanthawi kapena kuchepetsa mlingo wanu ngati mukukumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira pomalidomide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge pomalidomide,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la pomalidomide, mankhwala ena aliwonse, kapena zosakaniza zilizonse za pomalidomide capsules. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: carbamazepine (Carbatrol, Tegretol, Teril, ena); ciprofloxacin (Cipro); fluvoxamine (Luvox); ndi ketoconazole (Nizoral). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi pomalidomide, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu ngati mukumalandira dialysis (chithandizo chamankhwala kuti muyeretse magazi impso zikugwira ntchito bwino) kapena mwakhalapo ndi matenda a chiwindi.
• osayamwitsa pamene mukumwa pomalidomide.
• uzani dokotala ngati mumagwiritsa ntchito fodya. Kusuta ndudu kumatha kuchepetsa mphamvu ya mankhwalawa.
• muyenera kudziwa kuti pomalidomide imatha kukupangitsani kukhala ozunguzika kapena kusokonezeka. Osayendetsa galimoto, kugwiritsa ntchito makina, kapena kuchita zina zomwe zikufuna kuti mukhale atcheru mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ndi ochepera maola 12 mpaka muyeso wanu wotsatira, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Pomalidomide imatha kubweretsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kutsegula m'mimba
• nseru
• kusanza
• kusowa chilakolako
• kulemera kumasintha
• kugwedezeka kosalamulirika kwa gawo lina la thupi
• thukuta losazolowereka kapena thukuta usiku
• nkhawa
• khungu lowuma
• kutupa kwa mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• kulumikizana, minofu, kapena msana
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi kapena zomwe zalembedwa mgawo la CHENJEZO LAPANSI kapena CHENJEZO LAPadera, siyani kumwa pomalidomide ndipo itanani dokotala nthawi yomweyo:

• zidzolo
• kuyabwa
• ming'oma
• khungu komanso khungu
• kutupa kwa maso, nkhope, lilime, mmero, manja, mikono, mapazi, akakolo, kapena miyendo yakumunsi
• kuvuta kupuma kapena kumeza
• ukali
• malungo, zilonda zapakhosi, kuzizira, chifuwa, kapena zizindikilo zina za matenda
• maso achikasu kapena khungu
• mkodzo wakuda
• kupweteka kapena kusapeza bwino kumtunda kwam'mimba
• pokodza movutikira, pafupipafupi, kapena kupweteka
• khungu lotumbululuka
• kutopa kapena kufooka kosazolowereka
• kutuluka mwachilendo kapena kuphwanya
• m'mphuno
• dzanzi, kutentha, kapena kumva kulasalasa m'manja kapena m'mapazi
• kugwidwa

Pomalidomide imatha kuonjezera chiopsezo kuti mudzadwala khansa zina. Lankhulani ndi dokotala wanu za kuopsa kwakumwa pomalidomide.

Pomalidomide imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana.Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Bweretsani mankhwala aliwonse omwe sakufunikanso ku pharmacy yanu kapena kwa wopanga. Funsani wamankhwala wanu ngati muli ndi mafunso aliwonse pakubweza mankhwala anu.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu likuyankhira pom pomomomomide.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Pomalyst^®