Dabrafenib

Zamkati

• Musanatenge dabrafenib,
• Dabrafenib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo:

Dabrafenib imagwiritsidwa ntchito yokha kapena kuphatikiza trametinib (Mekinist) kuchiza mitundu ina ya khansa ya khansa (mtundu wa khansa yapakhungu) yomwe singathe kuchiritsidwa ndi opaleshoni kapena yomwe yafalikira mbali zina za thupi. Amagwiritsidwanso ntchito limodzi ndi trametinib pochiza ndikupewa kubwerera kwa mtundu wina wa khansa yapakhungu pambuyo pochitidwa opaleshoni kuti muchotse ndi ma lymph node. Dabrafenib imagwiritsidwanso ntchito limodzi ndi trametinib kuchiza mtundu wina wa khansa yaying'ono yamapapo yam'mapapo (NSCLC) yomwe yafalikira kumatenda oyandikira kapena mbali zina za thupi. Amagwiritsidwanso ntchito pochiza mtundu wina wa khansa ya chithokomiro yomwe yafalikira kumatenda oyandikira kapena mbali zina za thupi zomwe sizinayankhe kuchipatala cham'mbuyomu. Dabrafenib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

Dabrafenib amabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kawiri patsiku osadya kanthu, ola limodzi musanadye kapena maola awiri mutadya. Tengani dabrafenib pafupifupi maola 12 padera nthawi zofanana tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani dabrafenib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala. Osasiya kumwa dabrafenib osalankhula ndi dokotala.

Kumeza makapisozi lonse; musatsegule, kapena kuphwanya.

Dokotala wanu akhoza kusintha mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha malinga ndi yankho lanu kuchipatala ndi zotsatirapo zilizonse zomwe mungakumane nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi dabrafenib ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge dabrafenib,

• auzeni dokotala ndi wazamankhwala ngati muli ndi vuto la dabrafenib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a dabrafenib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: clarithromycin (Biaxin, mu PrevPac); dexamethasone; gemfibrozil (Lopid); ketoconazole; masewera; nefazodone; rifampin (Rifadin, ku Rifamate, ku Rifater, Rimactane); ndi warfarin (Coumadin, Jantoven). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi dabrafenib, chifukwa chake onetsetsani kuti mumauza dokotala za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda ashuga; shuga-6-phosphate dehydrogenase (G6PD) kusowa (chibadwa); kutaya magazi; mavuto amaso; kulephera kwa mtima kapena mavuto ena amtima; chiwindi kapena matenda a impso; kapena matenda aliwonse.
• uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira mankhwala, ndipo muyenera kugwiritsa ntchito njira yolerera yoletsa kutenga mimba mukamalandira chithandizo komanso kwa milungu iwiri mutalandira mankhwala. Ngati ndinu wamwamuna ndipo mnzanu atha kutenga pakati, muyenera kugwiritsa ntchito kondomu mukamamwa mankhwalawa, komanso kwa masabata awiri mutalandira chithandizo, ngakhale mutakhala ndi vasectomy (opareshoni yoletsa umuna kuti usatuluke mthupi lanu ndikupangitsa kutenga pakati) . Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa abambo ndi amai; komabe, simuyenera kuganiza kuti simungatenge mimba kapena kuti simungapatse wina mimba. Ngati inu kapena mnzanu mukhala ndi pakati mukatenga dabrafenib, itanani dokotala wanu. Dabrafenib atha kuvulaza mwana wosabadwayo.
• muyenera kudziwa kuti dabrafenib imatha kuchepetsa mphamvu yolera yakumapiritsi (mapiritsi oletsa kubala, zigamba, mphete, zopangira, ndi jakisoni). Muyenera kugwiritsa ntchito njira yina yolerera kuti mupewe kutenga pakati kapena mnzanu mukamamwa mankhwala ndi dabrafenib komanso masabata awiri mutatha kumwa. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukamamwa dabrafenib komanso masabata awiri mutatha kumwa.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa dabrafenib.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ndi ochepera maola 6 mpaka mulingo womwe mudzakonzekere, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Dabrafenib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kulumikizana, minofu, kapena msana
• nseru
• kutsegula m'mimba
• kudzimbidwa
• kusowa chilakolako
• chifuwa, mphuno, kapena pakhosi
• kutayika tsitsi
• kutopa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo:

• kusintha pakhungu (khungu latsopano, chilonda pakhungu, kapena bampu yofiira yomwe imatuluka kapena siyichiritsa)
• kusintha kukula kapena mtundu wa mole
• zidzolo, khungu lofiira, kapena ziphuphu
• malungo
• kukomoka
• chizungulire, mutu wopepuka, kapena kufooka
• kuzizira
• kuchepa pokodza
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
• kukodza pafupipafupi
• ludzu lowonjezeka
• kupweteka kwa diso
• zofiira zofiira kapena zotupa
• kutengeka ndi kuwala
• kusawona bwino kapena masomphenya amasintha, kuphatikiza kuwona ma halos (mawonekedwe osalongosoka mozungulira zinthu) kapena madontho achikuda
• kutupa, kupweteka, kufiira, kapena khungu la zikhatho ndi mapazi
• kupweteka komwe kumayambira m'mimba koma kumafalikira kumbuyo
• kutuluka mwachilendo kapena kuphwanya
• wamagazi kapena wakuda, malo obisalira
• kutsokomola kapena kusanza magazi kapena zinthu zomwe zimawoneka ngati malo a khofi
• kupweteka pachifuwa
• kupuma movutikira
• kutupa kwa manja, mapazi, akakolo kapena miyendo yakumunsi
• kuthamanga, kusasinthasintha, kapena kugunda kwamtima
• chikasu cha khungu ndi maso

Dabrafenib akhoza kuonjezera chiopsezo kuti mudzayamba khansa yatsopano yapakhungu kapena khansa zina. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Dabrafenib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi dabrafenib. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira dabrafenib. Dokotala wanu amayang'ana khungu lanu ngati lingasinthe, miyezi iwiri iliyonse mukamalandira chithandizo, komanso kwa miyezi 6 mutalandira chithandizo.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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