Mifepristone (Korlym)

Zamkati

• Musanatenge mifepristone,
• Mifepristone ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Kwa odwala achikazi:

Musatenge mifepristone ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mifepristone itha kuyambitsa mimba. Muyenera kuyezetsa magazi musanamwe mankhwala ndi mifepristone komanso musanayambe kumwa mankhwala mukasiya kumwa kwa masiku opitilira 14. Ngati mutha kutenga pakati, muyenera kupewa kutenga mimba mukamalandira mifepristone. Muyenera kugwiritsa ntchito njira zovomerezeka zakulera mukamalandira chithandizo komanso kwa mwezi umodzi mutalandira mankhwala. Dokotala wanu angakuuzeni mitundu ya njira zolerera zovomerezeka. Ngati mukuganiza kuti muli ndi pakati, mumasowa msambo, kapena mumagonana popanda kugwiritsa ntchito njira zakulera mukamamwa mifepristone kapena patatha mwezi umodzi mutalandira chithandizo, pitani kuchipatala msanga.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena kuti aone momwe thupi lanu likuyankhira mifepristone.

Dokotala wanu kapena wamankhwala amakupatsirani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi mifepristone ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kotenga mifepristone.

Mifepristone (Korlym) amagwiritsidwa ntchito pochiza hyperglycemia (shuga wambiri wamagazi) mwa anthu omwe ali ndi mtundu wina wa Cushing's syndrome momwe thupi limapangira cortisol yochulukirapo (mahomoni) ndipo alephera kuchitidwa opaleshoni kapena sangathe kuchitidwa opaleshoni kuti athetse vutoli. Mifepristone ali mgulu la mankhwala otchedwa cortisol receptor blockers. Zimagwira ntchito poletsa zochitika za cortisol.

Mifepristone imapezekanso ngati chinthu china (Mifeprex) chomwe chimagwiritsidwa ntchito chokha kapena kuphatikiza ndi mankhwala ena kuti athetse mimba yoyambirira. Monograph iyi imangopereka zambiri za mifepristone (Korlym) yomwe imagwiritsidwa ntchito poletsa hyperglycemia mwa anthu omwe ali ndi mtundu wina wa Cushing's syndrome. Ngati mukugwiritsa ntchito mifepristone kuchotsa mimba, werengani monograph yotchedwa mifepristone (Mifeprex), yomwe yalembedwa za mankhwalawa.

Mifepristone amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku ndi chakudya. Tengani mifepristone mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani mifepristone ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya. Uzani dokotala wanu kapena wamankhwala ngati simungathe kumeza mapiritsi athunthu.

Dokotala wanu akuyambitsani pa mlingo wochepa wa mifepristone ndipo pang'onopang'ono muwonjezere mlingo wanu, osati kangapo kamodzi pamasabata awiri kapena anayi. Mukasiya kumwa mifepristone, itanani dokotala wanu. Dokotala wanu akuyenera kuti akuyambitseninso pa mlingo wotsika kwambiri wa mifepristone ndipo pang'onopang'ono muwonjezere mlingo wanu.

Mifepristone amatha kuwongolera matenda anu koma samachiritsa. Zitha kutenga milungu 6 kapena kupitilira apo kuti mumve bwino mifepristone. Pitirizani kumwa mifepristone ngakhale mukumva bwino.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge mifepristone,

• uzani dokotala wanu ngati muli ndi vuto la mifepristone, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a mifepristone. Funsani wamankhwala wanu kapena onani zomwe wodwala akupanga kuti muwone mndandanda wazosakaniza.
• uzani dokotala ngati mukumwa mankhwala aliwonse otsatirawa kapena mwawagwiritsa ntchito milungu iwiri yapitayi: corticosteroids monga betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, ena) , fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, ena), prednisolone (Prelone, ena), prednisone (Deltasone, Meticorten, Sterapred, ena), ndi triamcinolone (Aristocort, Azmacort) mankhwala omwe amaletsa chitetezo cha mthupi monga cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), ndi tacrolimus (Prograf); dihydroergotamine (DHH 45, Migranal); ergotamine (Ergomar, ku Cafergot, ku Migergot); fentanyl (Duragesic); lovastatin (Mevacor); pimozide (Orap); quinidine (Quinidex); ndi simvastatin (Zocor). Dokotala wanu angakuuzeni kuti musatenge mifepristone ngati mukumwa mankhwala amodzi kapena angapo.
• Uzani dokotala ndi wamankhwala mankhwala ena akuchipatala omwe simukulembera, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena kumwa m'masabata awiri apitawa. Onetsetsani kuti mwatchulapo izi: maanticoagulants ('ochepetsa magazi') monga warfarin (Coumadin); antifungals monga itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kapena voriconazole (Vfend); aspirin ndi mankhwala ena osagwiritsa ntchito kutupa (NSAIDs) monga ibuprofen (Advil, Motrin) ndi naproxen (Aleve, Naprosyn); bupropion (Wellbutrin); ciprofloxacin (Cipro); clarithromycin (Biaxin); conivaptan (Vaprisol); diltiazem (Cardizem); erythromycin (EES, E-Mycin, Erythrocin); fluvastatin (Lescol); njira zolerera za mahomoni monga mapiritsi oletsa kubereka, zopangira zina, zigamba, mphete, kapena jakisoni; mankhwala a hepatitis C monga boceprevir (Victrelis) ndi telaprevir (Incivek); mankhwala a HIV kapena Edzi monga amprenavir (Agenerase), atazanavir (Reyataz), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir ndi ritonavir kuphatikiza (Kaletra), nelfinavir (Viracept), ritonavir (Norvir) ndi saquinavir (Fortovase, Invirase); mankhwala a khunyu monga carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin); mankhwala a chifuwa chachikulu monga rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater) ndi rifapentine (Priftin); nefazodone (Serzone); repaglinide (Prandin); telithromycin (Ketek); ndi verapamil (Calan, Isoptin, ena). Mankhwala ena ambiri amathanso kulumikizana ndi mifepristone, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• uzani dokotala wanu ngati mudalandilidwa kapena ngati mudadwalapo matenda a chithokomiro. Ngati ndinu mayi ndipo simunachitidwe opareshoni kuti muchotse chiberekero, uzani dokotala ngati mwakhalapo ndi magazi osadziwikiratu osadziwika, endometrial hyperplasia (kukulira kwa chiberekero), kapena khansa ya endometrial (khansa ya gawo la chiberekero chako). Dokotala wanu angakuuzeni kuti musatenge mifepristone.
• Uzani dokotala ngati mwakhalapo ndi mtima kapena kulephera kwa mtima, nthawi yayitali ya QT (vuto losawerengeka la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi), potaziyamu wochepa m'magazi anu, kusakwanira kwa adrenal (momwe adrenal gland musatulutse mahomoni okwanira ofunikira kuthupi), matenda otuluka magazi, kapena chiwindi, impso, kapena matenda amtima.
• uzani dokotala wanu ngati mukuyamwitsa.

Musadye zipatso zamphesa kapena kumwa madzi amphesa pamene mukumwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Mifepristone ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kusanza
• pakamwa pouma
• kutsegula m'mimba
• kudzimbidwa
• kulumikizana kapena kupweteka kwa minofu
• kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
• zidzolo
• kuyabwa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• nseru
• kusowa chilakolako
• chizungulire kapena mutu wopepuka
• kutopa kapena kufooka kosazolowereka
• manjenje kapena kupsa mtima
• kugwedezeka
• thukuta
• kufooka kwa minofu, kupweteka, kapena kukokana
• kugunda kwamtima msanga, kosasinthasintha, kapena kwamphamvu
• kutuluka mwadzidzidzi kumaliseche kapena kuwona
• kupuma movutikira

Mifepristone ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musanayezetsedwe labotale, uzani adotolo ndi ogwira nawo ntchito kuti mukumwa mifepristone.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Khalani^®