Panobinostat

Zamkati

• Musanatenge panobinostat,
• Panobinostat imatha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo izi:

Panobinostat imatha kuyambitsa kutsekula m'mimba ndi zina zoyipa m'mimba (GI; zomwe zimakhudza m'mimba kapena m'matumbo) zoyipa. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kukokana m'mimba; mipando yotayirira; kutsegula m'mimba; kusanza; kapena pakamwa pouma, mkodzo wakuda, kuchepa thukuta, khungu louma, ndi zizindikilo zina zakusowa madzi m'thupi. Lankhulani ndi dokotala wanu zomwe muyenera kuchita ngati mukudwala m'mimba mukamalandira panobinostat. Komanso lankhulani ndi dokotala musanamwe mankhwala ofewetsa mankhwala ofewetsa tuvi tolimba kapena chopondapo mukamamwa mankhwalawa.

Panobinostat imatha kubweretsa mavuto owopsa kapena owopsa pamoyo wanu mukamalandira chithandizo. Uzani dokotala wanu ngati mwangoyamba kumene kudwala matenda a mtima kapena ngati muli ndi matenda a QT (zomwe zimawonjezera chiopsezo chokhala ndi kugunda kwamtima kosafunikira komwe kumatha kukomoka kapena kufa mwadzidzidzi), angina (kupweteka pachifuwa), kapena mavuto ena amtima. Dokotala wanu adzaitanitsa mayesero monga electrocardiogram (ECG; mayeso omwe amalemba zamagetsi mumtima) musanachitike komanso mukamalandira chithandizo kuti muwone ngati zili bwino kuti mutenge panobinostat. Ngati mukukumana ndi izi, uzani dokotala nthawi yomweyo: kupweteka pachifuwa, kuthamanga, kuthamanga, kapena kugunda kwa mtima, mutu wopepuka, kukomoka, chizungulire, milomo yofiirira, kupuma pang'ono, kapena kutupa kwa manja, mikono, mapazi, akakolo, kapena miyendo yakumunsi.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti aone momwe thupi lanu likuyankhira panobinostat.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba chithandizo ndi panobinostat ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kotenga panobinostat.

Panobinostat imagwiritsidwa ntchito limodzi ndi bortezomib (Velcade) ndi dexamethasone pochiza anthu omwe ali ndi myeloma angapo (mtundu wa khansa ya m'mafupa) omwe adalandira kale mankhwala ena awiri, kuphatikiza bortezomib (Velcade). Panobinostat ali mgulu la mankhwala otchedwa histone deacetylase (HDAC) inhibitors. Zimagwira ntchito popha ma cell a khansa.

Panobinostat imabwera ngati kapisozi wotenga pakamwa. Nthawi zambiri amatengedwa wopanda chakudya kamodzi tsiku lililonse m'masiku ena azaka 21. Kuzungulira kumatha kubwerezedwa mpaka mpaka 16. Tengani panobinostat mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani panobinostat ndendende monga mwadongosolo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; osaphwanya, kutafuna, kapena kutsegula. Gwiritsani makapisozi pang'ono momwe zingathere. Ngati mutagwira kapisozi wosweka wa panobinostat kapena mankhwala omwe ali mu kapisozi, sambani m'dera lanu ndi sopo. Ngati mankhwala omwe ali mu kapisozi akulowa mkamwa, mphuno, kapena maso, tsukeni ndi madzi ambiri.

Ngati musanza mutatenga panobinostat, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo. Dokotala wanu akhoza kuchepetsa kuchuluka kwanu kwa panobinostat kapena kuyimitsa chithandizo chanu kwakanthawi kapena kwamuyaya, ngati mukukumana ndi zovuta zamankhwala.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge panobinostat,

• uzani dokotala wanu komanso wamankhwala ngati mukugwirizana ndi panobinostat, mankhwala ena aliwonse, kapena zosakaniza zilizonse za makapisozi a panobinostat. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: amiodarone (Cordarone, Nexterone, Pacerone); antifungals monga itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ndi voriconazole (Vfend); atomoxetine (Strattera); bepridil (Vascor; sakupezeka ku U.S.); boceprevir (Wopambana); carbamazepine (Carbatrol, Tegretol, Teril, ena); chloroquine (Aralen); clarithromycin (Biaxin, mu PrevPac); conivaptan (Vaprisol); desipramine (Norpramin); dextromethorphan; disopyramide (Norpace); dolasetron (Anzemet); mankhwala ena a HIV monga indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra, ku Viekira Pak), saquinavir (Invirase); methadone (Dolophine, Methadose); metoprolol (Lopressor, Toprol-XL); moxifloxacin (Avelox); nebivolol (Bystolic); nefazodone; ondansetron (Zofran, Zuplenz); perphenazine; pimozide (Orap); phenobarbital; phenytoin (Dilantin, Phenytek); kupeza; quinidine (mu Nuedexta); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); sotalol (Betapace, Sorine, Sotylize); telaprevir (Incivek; sichikupezeka ku U.S.); telithromycin (Ketek); thioridazine; mavitamini (Detrol); ndi venlafaxine (Effexor). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St John's wort.
• Uzani dokotala wanu ngati muli ndi kachilombo kapena muli ndi matenda a magazi kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Panobinostat itha kuvulaza mwana wosabadwayo. Gwiritsani ntchito njira zakulera kuti muchepetse kutenga mimba mukamamwa mankhwalawa ndi panobinostat komanso kwa mwezi umodzi mutalandira mankhwala omaliza. Ngati ndinu bambo ndipo mnzanu atha kukhala ndi pakati, muyenera kugwiritsa ntchito kondomu mukamamwa mankhwalawa komanso masiku 90 mutamaliza mankhwala anu. Funsani dokotala wanu ngati muli ndi mafunso okhudza njira zakulera zomwe zingakuthandizeni. Mukakhala ndi pakati mukatenga panobinostat, itanani dokotala wanu mwachangu.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa panobinostat.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa panobinostat.

Musadye makangaza, mphesa kapena zipatso za nyenyezi kapena kumwa zipatso zamtengo wapatali kapena makangaza mukamamwa mankhwalawa.

Ngati kwatha maola 12 kapena kuchepera pomwe mudayenera kumwa mlingowo, tengani mlingo womwe mwaphonya mukangokumbukira. Ngati kwadutsa maola oposa 12 kuchokera pomwe mwalandira mlingo wanu, tulukani mlingowo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange zomwe mwaphonya.

Panobinostat imatha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kuonda
• mutu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• wakuda, wodikira, kapena chimbudzi chamagazi
• masanzi amagazi kapena zinthu zosanza zomwe zimawoneka ngati malo a khofi
• kuvulaza kapena kutuluka mwachilendo
• mkodzo wapinki kapena wabulauni
• magazi mu phlegm
• chisokonezo
• amasintha kalankhulidwe kanu
• malungo, chifuwa, kuzizira, thukuta kapena zizindikiro zina za matenda
• khungu lotumbululuka
• nseru, kusanza, kusowa kwa njala, mkodzo wakuda, kupweteka m'mimba, kutopa kwambiri, kusowa mphamvu, kapena khungu lachikaso kapena maso oyera

Panobinostat imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa).

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• kutsegula m'mimba
• nseru
• kusanza
• kuchepa kudya

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Farydak^®