Jekeseni wa Evolocumab

Zamkati

• Musanagwiritse ntchito jakisoni wa evolocumab,
• Jekeseni wa Evolocumab itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, siyani kugwiritsa ntchito jakisoni wa evolocumab ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

Jekeseni wa Evolocumab imagwiritsidwa ntchito pochepetsa chiopsezo cha sitiroko kapena matenda amtima kapena kufunika kovulala kwamitsempha yamagazi (CABG) mwa anthu omwe ali ndi matenda amtima. Jekeseni wa Evolocumab imagwiritsidwanso ntchito limodzi ndi zakudya zokha kapena kuphatikiza ndi mankhwala ena ochepetsa mafuta m'thupi monga HMG-CoA reductase inhibitors (statins) kapena ezetimbe (Zetia) kuti achepetse kuchuluka kwa mafuta otsika kwambiri a lipoprotein (LDL) cholesterol ('cholesterol choipa' ') m'magazi, kuphatikiza anthu omwe ali ndi mabanja omwe ali ndi heterozygous hypercholesterolemia (HeFH; cholowa chomwe cholesterol sichitha kuchotsedwa mthupi mwachizolowezi). Amagwiritsidwanso ntchito limodzi ndi kusintha kwa zakudya ndi mankhwala ena kuti achepetse kuchuluka kwa mafuta otsika kwambiri a lipoprotein (LDL) cholesterol ('cholesterol yoyipa') m'magazi mwa anthu omwe ali ndi homozygous family hypercholesterolemia (HoFH; cholowa chomwe cholowa cha cholesterol sichingakhale kuchotsedwa mthupi mwachizolowezi). Jekeseni wa Evolocumab ili m'kalasi la mankhwala otchedwa proprotein convertase subtilisin kexin mtundu 9 (PCSK9) inhibitor monoclonal antibody. Zimagwira ntchito poletsa kutulutsa kwa cholesterol ya LDL m'thupi kuti ichepetse kuchuluka kwa cholesterol yomwe imatha kumangirira pamakoma a mitsempha ndikuletsa magazi kupita kumtima, ubongo, ndi ziwalo zina za thupi.

Kuwonjezeka kwa cholesterol m'mbali mwa mitsempha yanu (njira yotchedwa atherosclerosis) kumachepetsa kutuluka kwa magazi, chifukwa chake, mpweya umapereka mtima wanu, ubongo, ndi ziwalo zina za thupi lanu.

Jekeseni wa Evolocumab imabwera ngati yankho (madzi) mu jakisoni woyikapo, makina opangira mafuta, komanso pathupi pathupi lokhala ndi katiriji wodziyikira payokha (pansi pa khungu). Pamene jekeseni wa evolocumab imagwiritsidwa ntchito pochiza HeFH kapena matenda amtima kapena kuchepetsa chiopsezo cha sitiroko, matenda amtima, ndi mitsempha yodutsitsa opaleshoni, nthawi zambiri imayikidwa masabata awiri kapena kamodzi pamwezi. Mukamagwiritsa ntchito jakisoni wa evolocumab pochiza HoFH, imabayidwa kamodzi mwezi uliwonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Gwiritsani ntchito jakisoni wa evolocumab monga momwe mwalamulira. Musagwiritse ntchito mankhwala ochepa kapena ochepa kapena kuwagwiritsa ntchito nthawi zambiri kapena kwa nthawi yayitali kuposa momwe adalangizira dokotala.

Ngati mukugwiritsa ntchito jakisoni wa evolocumab kamodzi pamwezi (420 mg dose), jekeseni kamodzi pamphindi 9 ndi infusor ya thupi ndi katiriji woyikapo jekeseni iliyonse kapena jekeseni jakisoni 3 mosiyanasiyana mkati mwa mphindi 30, pogwiritsa ntchito chosankha china choyambirira syringe kapena autoinjector yoyikirira jakisoni aliyense.

Jekeseni wa Evolocumab imathandizira kuchepetsa kuchuluka kwa cholesterol ndikuchepetsa chiopsezo cha sitiroko, matenda amtima, kapena mitsempha yodutsa opaleshoni, koma sichiritsa izi kapena kuthetsa zoopsa izi. Pitirizani kugwiritsa ntchito jakisoni wa evolocumab ngakhale mukumva bwino. Osasiya kugwiritsa ntchito jakisoni wa evolocumab osalankhula ndi dokotala.

Jekeseni wa Evolocumab imadzera mu autoinjector yodzaza kale, ma syringe odzaza, komanso mu infusor yokhala ndi cartridge yomwe ili ndi mankhwala okwanira pamlingo umodzi. Nthawi zonse jekeseni evolocumab mumakina ake oyikiramo autoinjector, syringe, kapena infusor ndi cartridge yoyambira; osazisakaniza ndi mankhwala ena aliwonse. Kutaya singano zogwiritsidwa ntchito kale, ma syringe, ndi zida mu chidebe chosagundika. Lankhulani ndi dokotala wanu kapena wamankhwala za momwe mungatayire chidebe chosagwira mankhwala.

Mutha kubaya jakisoni wa evolocumab pansi pa khungu pa ntchafu kapena m'mimba, kupatula gawo lamasentimita awiri mozungulira mchombo wanu (batani lamimba). Ngati wina akukubayirani mankhwalawo, munthu ameneyo amathanso kumubaya m'manja. Gwiritsani ntchito malo osiyana jekeseni iliyonse. Osabaya jakisoni wa evolocumab pamalo ofewa, othyoka, ofiira, kapena olimba. Komanso, musabayire malo okhala ndi zipsera kapena zotambasula.

Werengani mosamala malangizo a wopanga kuti agwiritse ntchito omwe amabwera ndi mankhwala. Malangizowa amafotokoza momwe mungabayire jakisoni wa evolocumab. Onetsetsani kuti mufunse wamankhwala kapena dokotala ngati inu kapena munthu amene mukumubaya muli ndi mafunso okhudza kubayitsa mankhwalawa. Mwawona Malangizo ogwiritsira ntchito kuchokera kwa wopanga pa https://bit.ly/3jTG7cx.

Chotsani jakisoni woyikiratu kapena mafuta oyikiratu m'firiji ndikuwalola kuti azitha kutentha kwa mphindi 30 musanagwiritse ntchito. Chotsani infusor ndi cartridge yoyambira mufiriji ndikuilola kuti izitha kutentha mpaka mphindi 45 musanagwiritse ntchito. Osatenthetsa jakisoni wa evolocumab m'madzi otentha, ma microwave, kapena kuyika dzuwa.

Musanagwiritse ntchito jakisoni wa evolocumab, yang'anani yankho mosamala. Mankhwalawa ayenera kukhala owoneka achikaso otumbululuka komanso opanda tinthu tating'onoting'ono. Osamagwedeza syringe yomwe idadzaza kale, autoinjector, kapena infusor yokhala ndi cartridge yomwe ili ndi jekeseni wa evolocumab.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanagwiritse ntchito jakisoni wa evolocumab,

• uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi jakisoni wa evolocumab, mankhwala ena aliwonse, latex, labala, kapena zina zilizonse mu jakisoni wa evolocumab. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni dokotala ngati mwakhalapo kapena munakhalapo ndi matenda aliwonse.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukamagwiritsa ntchito jakisoni wa evolocumab, itanani dokotala wanu.

Idyani chakudya chochepa cha mafuta, cholesterol. Onetsetsani kuti mukutsatira zolimbitsa thupi komanso malingaliro azakudya zomwe adokotala anu kapena odyetsa. Mutha kuchezanso tsamba la National Cholesterol Education Program (NCEP) kuti mumve zambiri za zakudya pa: http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Ngati mumapereka jakisoni wa evolocumab milungu iwiri iliyonse ndipo ngati ili mkati mwa masiku 7 kuchokera pa mlingo womwe mwaphonya, jekeseni mukangokumbukira ndikupitiliza dongosolo lanu lokhazikika. Komabe, ngati pali masiku opitilira 7 kuchokera pa mlingo womwe mwaphonya, tulukani ndikupitiliza dongosolo lanu lokhazikika. Osabaya jakisoni kawiri kuti mupange mlingo womwe umasowa. Itanani dokotala wanu ngati mwaphonya mlingo ndikukhala ndi mafunso pazomwe mungachite.

Ngati mumapereka jakisoni wa evolocumab kamodzi pamwezi ndipo ngati mkati mwa masiku 7 kuchokera pa mlingo womwe mwaphonya, jekeseni mukangokumbukira ndikupitiliza dongosolo lanu lokhazikika. Komabe, ngati mumapereka jakisoni wa evolocumab kamodzi pamwezi ndipo pali masiku opitilira 7 kuchokera pa mlingo womwe mwaphonya, jekeseni nthawi yomweyo ndikuyamba ndandanda yatsopano ya dosing potengera tsikuli. Osabaya jakisoni kawiri kuti mupange mlingo womwe umasowa. Itanani dokotala wanu ngati mwaphonya mlingo ndikukhala ndi mafunso pazomwe mungachite.

Jekeseni wa Evolocumab itha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kufiira, kuyabwa, kutupa, kupweteka, kapena kukoma pamalo obayira
• zizindikiro ngati chimfine, chimfine, pakhosi, malungo, kapena kuzizira
• kupweteka kapena kuyaka pokodza
• minofu kapena kupweteka kwa msana
• chizungulire
• kupweteka m'mimba

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, siyani kugwiritsa ntchito jakisoni wa evolocumab ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

• kuyabwa
• zidzolo
• ming'oma
• kuvuta kupuma kapena kumeza
• kutupa kwa nkhope, mmero, lilime, milomo, ndi maso

Jekeseni wa Evolocumab itha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamagwiritsa ntchito mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Sungani m'firiji, koma osazizira. Osasiya jekeseni wa evolocumab kunja kwa firiji masiku opitilira 30. Jekeseni wa Evolocumab imatha kusungidwa kutentha kwa katoni woyambirira mpaka masiku 30. Sungani jekeseni wa evolocumab kutali ndi kuwala kowongoka.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu lingayankhire jekeseni wa evolocumab.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza jekeseni wa evolocumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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