Osimertinib

Zamkati

• Musanatenge osimertinib,
• Osimertinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Osimertinib amagwiritsidwa ntchito kuthandiza kuteteza mtundu wina wa khansa ya m'mapapo yaing'ono (NSCLC) kuti isabwerere pambuyo poti chotupacho chachotsedwa ndi opaleshoni kwa akulu. Amagwiritsidwanso ntchito ngati chithandizo choyamba cha mtundu wina wa NSCLC womwe wafalikira mbali zina za thupi mwa akulu. Osimertinib imagwiritsidwanso ntchito pochiza mitundu ina ya NSCLC yomwe yafalikira mbali zina za thupi mwa akulu omwe sangachiritsidwe bwino ndi mankhwala ena ofanana ndi chemotherapy. Osimertinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa ndipo zitha kuthandiza kuchepa kwa zotupa.

Osimertinib amabwera ngati piritsi kuti atenge pakamwa. Nthawi zambiri amatengedwa kapena wopanda chakudya kamodzi patsiku. Kutalika kwa chithandizo chanu kumadalira momwe mankhwalawa amakugwiritsirani ntchito, komanso zotsatirapo zomwe mumakumana nazo. Tengani osimertinib mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani osimertinib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati simungathe kumeza mapiritsiwo, ikani piritsiyo m'masupuni 4 a madzi (60 mL) ndi kusonkhezera mpaka phale likhale tating'onoting'ono. Imwani chisakanizo nthawi yomweyo. Thirani theka la chikho china (4 oz [120 mL]) ku kapu yamadzi (8 oz [240 mL]) pachidebe chomwe mudagwiritsa ntchito, kutsuka, ndi kumwa kuti muwonetsetse kuti mukumwa osimertinib. Musagwiritse ntchito madzi a kaboni kapena madzi ena aliwonse kuti asungunule piritsi la osimertinib. Osaphwanya piritsi kapena kutentha chisakanizocho. Ngati muli ndi chubu cha nasogastric (NG), dokotala wanu kapena wamankhwala akufotokozerani momwe mungaperekere chisakanizochi kudzera mu chubu cha NG.

Dokotala wanu akhoza kuyimitsa chithandizo chanu kwakanthawi kapena kosatha kapena kuchepetsa kuchuluka kwa osimertinib kutengera zovuta zomwe mumakumana nazo. Onetsetsani kuti mwalankhula ndi dokotala za momwe mukumvera mukamalandira chithandizo. Osasiya kumwa osimertinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge osimertinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la osimertinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu piritsi la osimertinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, zowonjezera zakudya zomwe mumamwa kapena mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: anagrelide (Agrylin); arsenic trioxide (Trisenox); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); chloroquine (Aralen); mankhwala enaake; cilostazol (Pletal); citalopram (Celexa); donepezil (Aricept); escitalopram (Lexapro); haloperidol (Haldol); mankhwala a mtima kapena kuthamanga kwa magazi; methadone (Dolophine, Methadose); oxaliplatin (Eloxatin); phenytoin (Dilantin, Phenytek); pimozide (Orap); quinidine (mu Nuedexta); rifampin (Rifadin, Rimactane, ku Rifamate, Rifater); rosuvastatin (Crestor); sulfasalazine (Azulfidine); thioridazine; topotecan (Hycamtin); ndi vandetanib (Caprelsa). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi osimertinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.Dokotala wanu mwina angakuuzeni kuti musatenge wort ya St. John mukamamwa osimertinib.
• auzeni adotolo ngati mwakhala mukukumana ndi matenda a QT (zomwe zimapangitsa kuti mukhale ndi vuto lokhala ndi mtima wosagunda bwino womwe ungayambitse kukomoka kapena kufa mwadzidzidzi); kugunda kwamtima kosasintha; kulephera kwa mtima (momwe mtima sungathe kupopera magazi okwanira mbali zina za thupi); apamwamba kapena otsika poyerekeza ndi mulingo wambiri wa sodium, potaziyamu, calcium, kapena magnesium m'magazi anu; mavuto amaso; kapena matenda ena am'mapapo.
• Muyenera kudziwa kuti osimertinib imachepetsa kubereka mwa abambo ndi amai. Komabe, musaganize kuti inu kapena mnzanuyo simungakhale ndi pakati. Uzani dokotala wanu ngati muli ndi pakati, kapena konzekerani kutenga pakati. Muyenera kuyezetsa mimba musanayambe mankhwala ndipo musakhale ndi pakati mukamamwa osimertinib. Gwiritsani ntchito njira yoletsa kubereka mukamalandira chithandizo cha osimertinib, komanso kwa masabata asanu ndi limodzi mutatha kumwa. Ngati ndinu wamwamuna ndipo mnzanu atha kukhala ndi pakati, muyenera kugwiritsa ntchito njira yolerera yoyenerera mukamalandira chithandizo komanso kwa miyezi inayi mutalandira mankhwala. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga osimertinib, itanani dokotala wanu mwachangu. Osimertinib atha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Dokotala wanu angakuuzeni kuti musamamwe mkaka mukamamwa mankhwala komanso kwa milungu iwiri mutatha kumwa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musamamwe mankhwala mochedwa kapena kumwa kawiri kuti mupange amene mwaphonya.

Osimertinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• zidzolo
• kuyabwa
• khungu lowuma kapena losweka
• chikanga
• nseru
• kusanza
• kusowa chilakolako
• kutupa kapena zilonda mkamwa
• kupweteka kwa msana
• kusintha kwa misomali kuphatikiza kutupa, kufiira, kupweteka, kugawanika, kuphwanya, ndi kulekana kapena kutayika kuchokera ku msomali

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kusala, kapena kugunda kwa mtima; kupuma movutikira; kutupa kwa akakolo kapena mapazi, kapena kumverera opanda mutu
• malungo; kupuma kwatsopano kapena kukulira; kuvuta kupuma, kapena kutsokomola
• kuphulika kwa khungu kapena khungu
• wofiirira mawanga, redness, kapena ming'oma pa mikono, m'munsi miyendo, kapena matako
• kupweteka pachifuwa
• kutopa kwambiri
• kutupa, kufiira, misozi kapena maso opweteka; kutengeka ndi kuwala; kapena masomphenya amasintha

Osimertinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena am'mimba musanafike komanso mukamalandira chithandizo kuti muwone ngati zili bwino kuti mutenge osimertinib, ndikuwunika momwe thupi lanu lingayankhire mankhwala. Dokotala wanu amathanso kuyitanitsa mayeso a labu musanayambe mankhwala anu kuti mudziwe ngati khansa yanu imatha kuthandizidwa ndi osimertinib.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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