Wophunzitsa

Zamkati

• Musanatenge cobicistat,
• Cobicistat ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati chizindikiro ichi ndi choopsa kapena sichitha:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

Cobicistat imagwiritsidwa ntchito kuonjezera kuchuluka kwa atazanavir (Reyataz, ku Evotaz) mwa akulu ndi ana omwe amalemera pafupifupi 35 kg (35 kg) kapena darunavir (Prezista, ku Prezcobix) mwa akulu ndi ana omwe amalemera pafupifupi mapaundi 88 (40 kg) mu magazi pamene mankhwalawa amagwiritsidwa ntchito pochizira kachilombo ka HIV. Cobicistat ali mgulu la mankhwala otchedwa cytochrome P450 3A (CYP3A) inhibitors. Imagwira ntchito pakukulitsa kuchuluka kwa atazanavir kapena darunavir mthupi kuti athe kukhala ndi gawo lalikulu.

Cobicistat imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa ndi chakudya kamodzi patsiku limodzi ndi atazanavir kapena darunavir. Tengani cobicistat ndi atazanavir kapena darunavir mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani cobicistat ndendende monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ndikofunika nthawi zonse kutenga cobicistat nthawi yomweyo ndi atazanavir kapena darunavir.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge cobicistat,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la cobicistat, mankhwala ena aliwonse, kapena zosakaniza zilizonse pamapiritsi a cobicistat. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala ngati mukumwa mankhwala aliwonse awa: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid) (sikupezeka ku U.S.); colchicine (Colcrys, Mitigare, mu Col-Probenecid); dronearone (Multaq); mankhwala a ergot monga dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, ku Cafergot, ku Migergot), ndi methylergonovine (Methergine); lomitapide (Wowonjezera); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Ndime) pakamwa; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, ku Rifamate, ku Rifater); sildenafil (mtundu wa Revatio wokha womwe umagwiritsidwa ntchito matenda am'mapapo); simvastatin (Flolipid, Zocor); Chingwe cha St. kapena triazolam (Halcion). Ngati mukumwa atazanavir pamodzi ndi cobicistat, uzani dokotala ngati mukumwa drospirenone ndi ethinyl estradiol (njira zina zakumwa monga Beyaz, Safyral, Yasmin, Yaz, ndi ena); indinavir (Crixivan), irinotecan (Camptosar), kapena nevirapine (Viramune). Dokotala wanu angakuuzeni kuti musamwe cobicistat ngati mukumwa mankhwala aliwonse.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: anticoagulants ('magazi ochepetsa magazi') monga apixaban (Eliquis), mafutaxaban (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban powder (Xarelto), ndi warfarin (Coumadin, Jantoven) ; mankhwala antiplatelet monga clopidogrel (Plavix) ndi ticagrelor (Brilinta); atorvastatin (Lipitor, mu Caduet); benzodiazepines monga diazepam (Valium), estazolam, midazolam amapatsidwa kudzera m'mitsempha (mumtsempha), ndi zolpidem (Ambien, Edluar, Intermezzo); zotchinga beta monga carvedilol (Coreg), metoprolol (Lopressor), ndi timolol; boceprevir (Victrelis) (sikupezeka ku U.S.); chifuwa (Tracleer); buprenorphine (Belbuca, Butrans, Probuphine); buprenorphine ndi naloxone (Suboxone, Zubsolv); busipulo; calcium blockers monga amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, ena), felodipine, nifedipine (Adalat, Afeditab, Procardia), ndi verapamil (Calan, Verelan, ena); clarithromycin (Biaxin, mu PrevPac); corticosteroids monga beclomethasone (Beconase AQ), budesonide (Rhinocort Aqua), ciclesonide (Omnaris), dexamethasone (Decadron), fluticasone (Flonase, Flovent), methylprednisolone (Medrol), momentasone (Flonase), ndi triamcinolone (Nasacort) dasatinib (Sprycel); efavirenz (Sustiva, ku Atripla); erythromycin (E.E.S, Erytab, ena); etravirine (Kutengeka); fentanyl (Abstral, Actiq, Fentora, ena); itraconazole (Onmel, Sporanox); ketoconazole; mankhwala a kukhumudwa monga amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), ndi trazodone; mankhwala a kugunda kwamtima mosasinthasintha monga amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), ndi quinidine (ku Nuedexta); mankhwala ogwidwa monga clonazepam (Klonopin), eslicarbazepine (Aptiom), ndi oxcarbazepine (Trileptal); mankhwala omwe amaletsa chitetezo cha mthupi monga cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), ndi tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (ku Kaletra); nthawi (Selzentry); methadone (Dolophine, Methadose); nilotinib (Tasigna); njira zakulera zam'kamwa (mapiritsi olera); perphenazine; ena a phosphodiesterase (PDE5) inhibitors monga avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), ndi vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); ritonavir (Norvir, ku Kaletra); mankhwala a Rivaroxaban (Xarelto); rosuvastatin; salmeterol (Serevent, ku Advair); simeprevir (Olysio); telaprevir (Incivek) (sikupezeka ku U.S.); telithromycin (Ketek); tenofovir (Viread, ku Atripla, Complera, Truvada, ena), thioridazine; tramadol (Conzip, Ultram, mu Ultracet); vinblastine; vincristine (Marqibo Kit); ndi voriconazole (Vfend). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi a cobicistat kotero onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa cobicistat ndi atazanavir komanso mukumwa maantacid (Maalox, Mylanta, Tums, ena), tengani maola awiri musanadutse kapena maola awiri kuchokera pa cobicistat ndi atazanavir.
• ngati mukumwa cobicistat ndi atazanavir ndipo mukumwanso mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda (H₂ blockers) monga cimetidine, famotidine (Pepcid, in Duexis), nizatidine (Axid), kapena ranitidine (Zantac), awatenge nthawi yomweyo kapena osachepera maola 10 mutatenga H₂ choyimitsa.
• ngati mukumwa cobicistat ndi atazanavir ndipo mukumwanso mankhwala a kudzimbidwa, kutentha pa chifuwa, kapena zilonda (proton pump inhibitors) monga esomeprazole (Nexium, ku Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, ku Zegerid), pantoprazole (Protonix), kapena rabeprazole (AcipHex) imawatenga osachepera maola 12 mutatenga proton pump inhibitor.
• uzani dokotala wanu ngati mwakhalapo ndi matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga cobicistat, itanani dokotala wanu. Simuyenera kuyamwa ngati muli ndi kachilombo ka HIV kapena ngati mukumwa cobicistat.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mulingo wanu wotsatira ukukwana maola 12 kapena kupitilira apo, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mlingo wotsatira udzatengeke pasanathe maola 12, tulukani mlingo womwe mwaphonyawo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Cobicistat ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati chizindikiro ichi ndi choopsa kapena sichitha:

• nseru

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala nthawi yomweyo:

• chikasu cha khungu kapena maso
• zidzolo
• kuchepa pokodza

Cobicistat imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira kwa cobicistat.

Sungani mankhwala pafupi. Musayembekezere mpaka mutatsala pang'ono kumwa mankhwala kuti mudzaze mankhwala anu.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®

• Evotaz^® (yokhala ndi Atazanavir, Cobicistat)
• Prezcobix^® (yokhala ndi Cobicistat, Darunavir)