Abemaciclib

Zamkati

• Asanatenge abemaciclib,
• Abemaciclib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zina zilizonse mgawo la ZOKHUDZITSIDWA, itanani dokotala wanu mwachangu:

[Wolemba 09/13/2019]

Omvera: Wodwala, Zaumoyo, Oncology

NKHANI: FDA ikuchenjeza kuti palbociclib (Ibrance^®), ribociclib (Kisqali^®), ndi abemaciclib (Verzenio^®) omwe amathandizira odwala ena omwe ali ndi khansa ya m'mawere amatha kuyambitsa mapapo osowa koma owopsa. A FDA avomereza machenjezo atsopano okhudzana ndi chiopsezo ichi pakufotokozera zambiri ndi Patient Package Insert kwa gulu lonse la mankhwala ozungulira kinase 4/6 (CDK 4/6) oletsa cyclin. Phindu lonse la CDK 4/6 inhibitors ndilobe kuposa zoopsa zikagwiritsidwa ntchito monga mwalamulo.

MALANGIZO: CDK 4/6 inhibitors ndi gulu la mankhwala omwe amagwiritsidwa ntchito limodzi ndi mankhwala a mahomoni kuti athandize achikulire omwe ali ndi mahomoni receptor (HR) -osintha, khansa ya m'mimba ya kukula kwa 2 (HER2) -khansa ya m'mawere yoyipa kapena yamatenda yomwe yafalikira ku ziwalo zina za thupi. Ma CDK 4/6 inhibitors amaletsa mamolekyulu ena omwe amathandizira kulimbikitsa kukula kwa maselo a khansa. FDA idavomereza palbociclib mu 2015, ndipo onse ribociclib ndi abemaciclib mu 2017. CDK 4/6 inhibitors awonetsedwa kuti apititsa patsogolo nthawi kuyambira pomwe chithandizo cha khansa sichikula kwambiri ndipo wodwalayo ali moyo, wotchedwa kupulumuka kopanda kupita patsogolo (Onani Mndandanda wa CDK 4/6 Inhibitors Wovomerezeka ndi FDA pansipa).

Malangizo:Odwala Muyenera kudziwitsa akatswiri azaumoyo nthawi yomweyo ngati muli ndi zisonyezo zatsopano kapena zoyipa zomwe zikukhudzana ndi mapapu anu, chifukwa zitha kuwonetsa zomwe zili zosowa koma zowopsa zomwe zingayambitse imfa. Zizindikiro zofunika kuziyang'ana zikuphatikizapo:

• Zovuta kapena zovuta kupuma
• Kupuma pang'ono panthawi yopuma kapena ndi ntchito zochepa

Osasiya kumwa mankhwala anu musanalankhule ndi dokotala. Mankhwala onse amakhala ndi zotsatirapo zake ngakhale atagwiritsidwa ntchito moyenera monga momwe akunenera, koma kwakukulu phindu lakumwa mankhwalawa limaposa ngozi izi.Ndikofunika kudziwa kuti anthu amayankha mosiyanasiyana mankhwala onse kutengera thanzi lawo, matenda omwe ali nawo, majini, mankhwala ena omwe akumwa, ndi zina zambiri. Zowopsa zapadera kuti mudziwe kuthekera kwake kuti munthu wina atha kutupa m'mapapo atatenga palbociclib, ribociclib, kapena abemaciclib sizikudziwika.

Ogwira ntchito zaumoyo amayenera kuwunika odwala pafupipafupi ngati ali ndi matenda am'mapapo mwanga omwe amawonetsa matenda am'mapapo (ILD) ndi / kapena pneumonitis. Zizindikiro zingaphatikizepo:

• hypoxia
• chifuwa
• ziphuphu
• kulowerera mkati mwa mayeso a radiologic mwa odwala omwe amapatsirana, zotupa m'mimba, ndi zifukwa zina sizinapezeke.

Kulepheretsa CDK 4/6 mankhwala oletsa odwala omwe ali ndi zizindikiro zatsopano kapena zowonjezereka, ndipo amasiya kuchipatala kwa odwala omwe ali ndi ILD komanso / kapena pneumonitis.

Kuti mumve zambiri pitani patsamba la FDA ku: http://www.fda.gov/Safety/MedWatch/SafetyInformation ndi http://www.fda.gov/Drugs/DrugSafety.

Abemaciclib imagwiritsidwa ntchito limodzi ndi fulvestrant (Faslodex) kuchiza mtundu wina wa khansa yolandila mahomoni, khansa ya m'mawere (khansa ya m'mawere yomwe imadalira mahomoni monga estrogen kukula) kapena khansa ya m'mawere yomwe yafalikira mbali zina za thupi mutalandira chithandizo ndi mankhwala a antiestrogen monga tamoxifen (Nolvadex). Abemaciclib imagwiritsidwanso ntchito limodzi ndi anastrozole (Arimidex), exemestane (Aromasin), kapena letrozole (Femara) ngati chithandizo choyamba cha mahomoni olandila, khansa ya m'mawere kapena khansa ya m'mawere yomwe yafalikira mbali zina za thupi. Abemaciclib imagwiritsidwanso ntchito payokha kuti ithetse mtundu wina wa khansa yam'mimba yolandila, khansa ya m'mawere kapena khansa ya m'mawere yomwe yafalikira mbali zina za thupi mwa anthu omwe adalandira kale mankhwala a antiestrogen ndi chemotherapy. Abemaciclib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Abemaciclib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa kawiri tsiku lililonse kapena wopanda chakudya. Tengani abemaciclib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani abemaciclib ndendende monga momwe akuuzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; osagawana, kutafuna, kapena kuwaphwanya. Musamamwe mapiritsi osweka, osweka, kapena owonongeka mwanjira iliyonse.

Ngati musanza mutatenga abemaciclib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kuchepetsa mlingo wanu kapena kuimitsa kanthawi kochepa kapena kosatha ngati mukukumana ndi zovuta zina. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira abemaciclib.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanatenge abemaciclib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la abemaciclib, mankhwala ena aliwonse, kapena zosakaniza zilizonse m'mapiritsi a abemaciclib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: clarithromycin (Biaxin, ku Prevpac), diltiazem (Cardizem, Tiazac, ena), itraconazole (Sporanox), ketoconazole (Nizoral), rifampin (Rifadin, Rimactane, ku Rifater), ndi verapamil (Calan , Verelan, ena). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi abemaciclib, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu ngati muli ndi malungo, kuzizira, kapena zizindikiro zilizonse za matenda kapena ngati mwakhalapo ndi matenda a chiwindi kapena impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyezetsa mimba musanayambe kumwa mankhwala ndipo muyenera kugwiritsa ntchito njira zolerera kuti muchepetse mimba mukamalandira chithandizo komanso kwa masabata atatu mutatha kumwa. Mukakhala ndi pakati mukatenga abemaciclib, itanani dokotala wanu mwachangu. Abemaciclib atha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukamamwa abemaciclib komanso kwa milungu itatu mutatha kumwa mankhwala.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito abemaciclib.
• muyenera kudziwa kuti abemaciclib nthawi zambiri imayambitsa kutsegula m'mimba, komwe kumatha kukhala koopsa. Dokotala wanu angakuuzeni kumwa zakumwa zambiri komanso kumwa mankhwala otsekula m'mimba kuti muchepetse kuchepa kwa madzi m'thupi (kutaya madzi ochulukirapo m'thupi lanu) mukayamba kutsekula m'mimba kapena zotchinga. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi zizindikiro zotsatirazi za kuchepa kwa madzi m'thupi: ludzu lokwanira, pakamwa pouma kapena pakhungu, kuchepa pokodza, kapena kugunda kwamtima msanga.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Abemaciclib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kupweteka m'mimba
• kudzimbidwa
• zilonda pamilomo, mkamwa, kapena pakhosi
• kuchepa kudya
• kuonda
• kutayika tsitsi
• kuyabwa
• zidzolo
• mutu
• kusintha kwa kukoma
• chizungulire
• kupweteka pamodzi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zina zilizonse mgawo la ZOKHUDZITSIDWA, itanani dokotala wanu mwachangu:

• kutopa
• kupweteka kumtunda chakumanja kwam'mimba
• chikasu cha khungu kapena maso
• kusowa chilakolako
• kutuluka magazi kapena kuphwanya mosavuta
• kupweteka kwa mikono kapena miyendo
• kutupa kwa manja, mapazi, miyendo kapena akakolo
• kupuma movutikira
• kupweteka pachifuwa
• kupuma mofulumira
• kuthamanga, kusasinthasintha, kapena kugunda kwamtima
• malungo, kuzizira, chifuwa kapena zizindikiro zina za matenda
• khungu lotumbululuka

Abemaciclib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira kwa abemaciclib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®