Acalabrutinib

Zamkati

• Musanatenge acalabrutinib,
• Acalabrutinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi siyani kumwa acalabrutinib ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

Acalabrutinib imagwiritsidwa ntchito pochizira anthu omwe ali ndi mantle cell lymphoma (MCL; khansa yomwe ikukula mwachangu yomwe imayamba m'maselo amthupi) omwe amathandizidwa kale ndi mankhwala amodzi amodzi. Amagwiritsidwanso ntchito payekha kapena ndi obinutuzumab (Gazyva) kuchiza khansa ya m'magazi (CLL; mtundu wa khansa womwe umayambira m'maselo oyera a magazi) ndi ma lymphocytic lymphoma (SLL: mtundu wa khansa yomwe imayamba m'maselo oyera amwazi) . Acalabrutinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

Acalabrutinib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa popanda chakudya maola 12 aliwonse (kawiri patsiku) bola dokotala akakuuzani kuti mulandire chithandizo. Tengani acalabrutinib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani acalabrutinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; osatsegula, kutafuna, kapena kuwaswa.

Dokotala wanu akhoza kuyimitsa chithandizo chanu kwakanthawi kapena kosatha kapena kuchepetsa kuchuluka kwa acalabrutinib kutengera zovuta zomwe mumakumana nazo. Onetsetsani kuti mwalankhula ndi dokotala za momwe mukumvera mukamalandira chithandizo. Osasiya kumwa acalabrutinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge acalabrutinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la acalabrutinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a acalabrutinib. Funsani wamankhwala wanu kapena onani Zambiri Za Odwala kuti muwone mndandanda wazopangira.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kutchula mankhwala a anticoagulant ('magazi ochepetsa magazi') monga warfarin (Coumadin); mankhwala a antiplatelet ('magazi oonda magazi') monga aspirin, cilostazol, clopidogrel (Plavix), dipyridamole (Persantine, mu Aggrenox), prasugrel (Effient), ticagrelor (Brilinta), ndi ticlodipine; diltiazem (Cardizem, Cartia, Diltzac, ena); erythromycin (EES, Eryc, Erythrocin, ena); fluconazole (Diflucan); itraconazole (Onmel, Sporanox); proton pump inhibitors monga dexlansoprazole (Dexilant), esomeprazole (Nexium, ku Vimovo), lansoprazole (Prevacid, ku Prevpac), omeprazole (Prilosec, ku Yosprala, Zegerid), pantoprazole (Protonix), ndi rabeprazole (Aciphex) ndi rifampin (Rifadin, Rimactane, ku Rifater, Rifamate). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi acalabrutinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• ngati mukumwa cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), kapena ranitidine (Zantac) tengani acalabrutinib osachepera maola 2 musanamwe mankhwalawa.
• ngati mukumwa maantacids (Maalox, Mylanta, Tums, ena) tengani acalabrutinib osachepera maola 2 musanamwe kapena mutamwa mankhwalawa.
• Uzani dokotala wanu ngati muli ndi kachilombo kapena mwachitidwa opaleshoni posachedwapa, kapena ngati mwakhalapo kapena mwakhalapo ndi matenda a chiwindi kuphatikizapo hepatitis B, mavuto ndi mtima wanu, kapena mavuto a magazi.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Simuyenera kutenga pakati mukamamwa acalabrutinib. Simuyenera kuyamba kumwa acalabrutinib mpaka kuyezetsa kwapakati kukuwonetsa kuti mulibe pakati ndipo muyenera kugwiritsa ntchito njira yoletsa kuteteza mimba mukamalandira chithandizo komanso kwa sabata limodzi mutatha kumwa. Acalabrutinib itha kuvulaza mwana wanu wosabadwa. Mukakhala ndi pakati mukatenga acalabrutinib, itanani dokotala wanu mwachangu.
• Uzani dokotala wanu ngati mukuyamwitsa. Dokotala wanu angakuuzeni kuti musamamwe mkaka mukamamwa mankhwala komanso kwa milungu iwiri mutatha kumwa.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa acalabrutinib. Dokotala wanu angakuuzeni kuti musiye kumwa acalabrutinib kwa nthawi yayitali musanachite opaleshoni kapena pambuyo pake.
• konzekerani kupeŵa kuwunika kwa dzuwa kosafunikira kapena kwanthawi yayitali komanso kuvala zovala zoteteza, magalasi a dzuwa, ndi zoteteza ku dzuwa. Acalabrutinib itha kupangitsa khungu lanu kukhala lowopsa pazowopsa za kuwala kwa dzuwa, ndipo kungakulitse chiopsezo chanu chokhala ndi khansa yapakhungu.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati kupitilira maola atatu kwadutsa kale mlingo womwe mwaphonya, tulukani mlingo womwe mwaphonyawo ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Acalabrutinib itha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• nseru
• kusanza
• kudzimbidwa
• kutsegula m'mimba
• kupweteka m'mimba
• zidzolo
• kuvulaza pang'ono kapena mawanga ofiira ofiira kapena ofiirira pakhungu
• kulumikizana kapena kupweteka kwa minofu
• kutopa kwambiri

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi chimodzi mwazizindikirozi siyani kumwa acalabrutinib ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• chifuwa, kupuma movutikira, kupweteka pachifuwa mukamapuma kapena kutsokomola, malungo
• Kuthamanga kapena kusakhazikika kwamtima, kugundana, kumva kukhala opepuka kapena ozunguza mutu, kukomoka, kupuma movutikira, kupweteka pachifuwa
• kutuluka mwachilendo kapena kwakukulu kapena kuvulala
• magazi m'mipando yanu kapena yakuda, malo odikira; pinki kapena bulauni mkodzo; kusanza magazi kapena khofi pansi amasanza; kutsokomola magazi
• kumva chizungulire, kufooka, kapena kusokonezeka; kusintha kwa malankhulidwe; kupweteka mutu komwe kumatenga nthawi yayitali

Acalabrutinib ingawonjezere chiopsezo chanu chokhala ndi khansa zina. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Acalabrutinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone kuyankha kwa thupi lanu ku acalabrutinib.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Malangizo^®