Mlembi: Clyde Lopez
Tsiku La Chilengedwe: 23 Kulayi 2021
Sinthani Tsiku: 15 Novembala 2024
Anonim
SOBI Overview at ASH: Data from Phase 2/3 Clinical Study of Emapalumab-lzsg in Primary HLH
Kanema: SOBI Overview at ASH: Data from Phase 2/3 Clinical Study of Emapalumab-lzsg in Primary HLH

Zamkati

Jekeseni ya Emapalumab-lzsg imagwiritsidwa ntchito pochiza akuluakulu ndi ana (akhanda ndi achikulire) omwe ali ndi hemophagocytic lymphohistiocytosis (HLH; cholowa chomwe chitetezo cha mthupi sichigwira ntchito bwino ndipo chimayambitsa kutupa ndi kuwonongeka kwa chiwindi, ubongo, ndi mafupa) yemwe matenda ake sanasinthe, ayamba kukulirakulira, kapena abweranso atalandira chithandizo cham'mbuyomu kapena omwe sangathe kumwa mankhwala ena. Jekeseni ya Emapalumab-lzsg ili mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito poletsa mapuloteni ena m'thupi omwe amayambitsa kutupa.

Emapalumab-lzsg amabwera ngati madzi oti alowetsedwe mumtsempha kwa ola limodzi ndi dokotala kapena namwino kuchipatala kapena kuchipatala. Nthawi zambiri amapatsidwa kawiri pa sabata, masiku atatu kapena anayi aliwonse, malinga ngati dokotala akuuzani kuti mulandire chithandizo.

Dokotala wanu akhoza kukuyambitsani pamlingo wochepa wa jekeseni ya mapalumab-lzsg ndipo pang'onopang'ono muwonjezere mlingo wanu, osaposa kamodzi masiku atatu alionse.


Jekeseni ya Emapalumab-lzsg imatha kuyambitsa matendawa nthawi yayitali kapena patangopita nthawi yochepa kuchokera ku mankhwalawo. Dokotala kapena namwino adzakuyang'anirani mosamala mukalandira mankhwala. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kufiira khungu, kuyabwa, malungo, zidzolo, thukuta kwambiri, kuzizira, nseru, kusanza, mutu wopepuka, chizungulire, kupweteka pachifuwa, kapena kupuma pang'ono.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jekeseni ya mapalumab-lzsg ndipo nthawi iliyonse yomwe mumalandira mankhwalawo. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.


Musanalandire jekeseni wa emapalumab-lzsg,

  • uzani dokotala wanu komanso wamankhwala ngati simukugwirizana ndi mapalumab-lzsg, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu jekeseni la mapalumab-lzsg. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
  • uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda aliwonse.
  • auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
  • uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukalandira jekeseni ya mapalumab-lzsg, itanani dokotala wanu.
  • Muyenera kudziwa kuti jekeseni ya epalumab-lzsg imatha kuchepetsa kuthekera kwanu kothana ndi matenda kuchokera ku mabakiteriya, mavairasi, ndi bowa ndikuwonjezera chiopsezo choti mutenga matenda owopsa kapena owopsa. Uzani dokotala wanu ngati nthawi zambiri mumakhala ndi matenda aliwonse kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Izi zimaphatikizapo matenda ang'onoang'ono (monga mabala otseguka kapena zilonda), matenda omwe amabwera (monga herpes kapena zilonda zozizira), ndi matenda opatsirana omwe samatha. Ngati mukumane ndi izi pazomwe mungachite mukamalandira jekeseni ya epalumab-lzsg kapena mutangomaliza kumene kulandira chithandizo, itanani dokotala wanu mwachangu: malungo, thukuta, kapena kuzizira; kupweteka kwa minofu; chifuwa; ntchofu zamagazi; kupuma movutikira; zilonda zapakhosi kapena zovuta kumeza; khungu lofunda, lofiira, kapena lopweteka kapena zilonda m'thupi lanu; kutsegula m'mimba; kupweteka m'mimba; kukodza pafupipafupi, mwachangu, kapena kupweteka; kapena zizindikiro zina za matenda.
  • muyenera kudziwa kuti kulandira jekeseni wa amapalumab-lzsg kumawonjezera chiopsezo kuti mudzadwala chifuwa chachikulu (TB; matenda opatsirana m'mapapo), makamaka ngati muli ndi kachilombo ka TB koma mulibe zizindikiro zilizonse za matendawa. Uzani dokotala wanu ngati mwakhalapo ndi TB kapena mudakhalapo ndi TB, ngati mudakhala m'dziko lomwe TB imafala, kapena ngati mudakhalapo ndi munthu amene ali ndi TB. Dokotala wanu adzakuyang'anirani TB musanayambe kumwa mankhwala ndi jekeseni la mapalumab-lzsg ndipo atha kukuthandizani ngati muli ndi mbiri ya TB kapena muli ndi TB yogwira ntchito. Ngati muli ndi zizindikiro zotsatirazi za TB kapena ngati muli ndi zina mwazizindikiro mukamalandira chithandizo, itanani dokotala wanu mwachangu: kutsokomola, kutsokomola magazi kapena ntchofu, kufooka kapena kutopa, kuchepa thupi, kusowa chilakolako, kuzizira, malungo, kapena thukuta usiku.
  • mulibe katemera musanalankhule ndi dokotala mukamalandira chithandizo cha jekeseni wa mapalumab-lzsg komanso kwa masabata osachepera 4 mutatha kumwa.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.


Jekeseni wa Emapalumab-lzsg ingayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • kudzimbidwa
  • mphuno kutuluka magazi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mgawo la HOW and Special PRECAUTIONS, lekani kumwa jekeseni wa mapalumab-lzsg ndipo itanani dokotala nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

  • mofulumira, wosakwiya, kapena kugunda kwa mtima osasinthasintha
  • kupuma mofulumira
  • kukokana kwa minofu
  • dzanzi ndi kumva kulasalasa
  • wamagazi kapena wakuda, malo obisalira
  • kusanza magazi kapena zinthu zofiirira zomwe zimafanana ndi malo a khofi
  • kuchepa pokodza
  • kutupa m'manja, mapazi, akakolo, kapena miyendo yakumunsi

Jekeseni wa Emapalumab-lzsg ingayambitse mavuto ena. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amayang'ana kuthamanga kwa magazi kwanu pafupipafupi ndipo adzaitanitsa mayeso ena a labu musanachitike komanso mukamamwa mankhwala a mapalumab-lzsg kuti muwone momwe thupi lanu lingayankhire mankhwala.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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