Fedratinib

Zamkati

• Musanatenge fedratinib,
• Fedratinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Fedratinib ingayambitse matenda encephalopathy (matenda owopsa komanso omwe amatha kupha dongosolo lamanjenje), kuphatikiza matenda a Wernicke encephalopathy (mtundu wa encephalopathy womwe umayamba chifukwa chosowa thiamine [vitamini B1]). Uzani dokotala wanu ngati mwakhalapo ndi vuto la thiamine. Ngati mukukumana ndi izi, siyani kumwa fedratinib ndikumuimbira foni msanga kapena kupeza chithandizo chamankhwala mwadzidzidzi: kuvuta kusuntha kapena kusakhazikika, kufooka kwa miyendo kapena mikono yomwe imakulirakulirabe, chisokonezo, kugona, kumvetsetsa kapena kulankhula, kutaya kukumbukira, mavuto owonera (kuphatikiza masomphenya awiri ndi kusuntha kwamaso), kapena kusintha umunthu.

Dokotala wanu akhoza kukupatsani mankhwala kuti muchepetse mavuto omwe mungakhale nawo mukamamwa fedratinib. Uzani dokotala wanu nthawi yomweyo ngati muli ndi nseru, kusanza, kutsegula m'mimba, kapena kuchepa thupi komwe sikumakhala bwino ndi chithandizo.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti aone momwe thupi lanu likuyankhira fedratinib.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi fedratinib ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso.Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Fedratinib imagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu ina ya myelofibrosis (MF; khansa ya m'mafupa momwe mafupa amalowedwa m'malo ndi zilonda zam'mimba ndipo zimayambitsa kuchepa kwama cell). Fedratinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kapena kuchepetsa kufalikira kwa maselo a khansa.

Fedratinib imabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kamodzi patsiku, kapena wopanda chakudya. Kutenga fedratinib ndi chakudya chamafuta ambiri kungathandize kuchepetsa mseru ndi kusanza. Tengani fedratinib nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani fedratinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Dokotala wanu adzaitanitsa kuyezetsa magazi musanachitike komanso mukamalandira chithandizo kuti muwone momwe zimakukhudzirani ndi mankhwalawa. Dokotala wanu akhoza kukulitsa kapena kuchepetsa kuchuluka kwa fedratinib mukamalandira chithandizo, kapena angakuuzeni kuti musiye kumwa fedratinib kwakanthawi kapena kosatha. Izi zimadalira momwe mankhwalawa amakuthandizirani, zotsatira zoyesa labu, komanso ngati mukumana ndi zovuta zina. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge fedratinib,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la fedratinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a fedratinib. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: clarithromycin (Biaxin, ku PrevPac), diltiazem (Cardizem, Dilacor, Tiazac, ena), erythromycin (EES, E-mycin, Erythrocin), idelalisib (Zydelig), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizoral), metoprolol (Lopressor, Toprol XL, ku Dutoprol, ena), midazolam (Ndime), nefazodone, nelfinavir (Viracept), omeprazole (Prilosec, ku Zegerid), ribociclib (Kisqali, Kisqali, Kisqali, Kisqali ), ritonavir (Norvir), ruxolitinib (Jakafi), ndi saquinavir (Invirase). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi fedratinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• auzeni adotolo ngati mwadwalapo chiwindi kapena impso.
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Mukakhala ndi pakati mukatenga fedratinib, itanani dokotala wanu.
• osamwa mkaka mukamamwa mankhwala ndi fedratinib komanso kwa mwezi umodzi mutangomaliza kumwa mankhwala.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa fedratinib.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Fedratinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• kutsegula m'mimba
• kudzimbidwa
• kutopa
• kutuluka kwa minofu
• mkono, mwendo, kapena mafupa
• mutu
• kunenepa
• chizungulire

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutuluka mwachilendo kapena kuphwanya
• malungo, kuzizira, kutsokomola, kupweteka kapena kukodza pafupipafupi, kapena zizindikilo zina za matenda
• kunyoza, kutopa kwambiri, kuvulaza kapena kutaya magazi, kusowa mphamvu, kusowa njala, kupweteka kumtunda kwakumimba, chikasu cha khungu kapena maso, kapena zizindikilo zonga chimfine
• kupuma pang'ono, kugunda kwamtima, mutu, chizungulire, khungu loyera, kusokonezeka, kapena kutopa

Fedratinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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