Ozanimod

Zamkati

• Musanatenge ozanimod,
• Ozanimod imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, siyani kumwa ozanimod ndipo itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

Ozanimod imagwiritsidwa ntchito pochiza achikulire omwe ali ndi mitundu yobwereranso ya multiple sclerosis (MS; matenda omwe misempha sagwira ntchito moyenera ndipo anthu amatha kufooka, kufooka, kutayika kwa kulumikizana kwa minofu, komanso mavuto a masomphenya, malankhulidwe, ndi chikhodzodzo) kuphatikizapo matenda omwe ali ndi kachipatala (CIS; zizindikiro za mitsempha zomwe zimatha pafupifupi maola 24), mawonekedwe obwereranso (matenda omwe zizindikiro zimayamba kuwonjezeka nthawi ndi nthawi), kapena mitundu yachiwiri yopitilira (matenda omwe amabwereranso amapezeka pafupipafupi). Ozanimod ali mgulu la mankhwala otchedwa sphingosine l-phosphate receptor modulators. Zimagwira ntchito pochepetsa kuchepa kwa maselo amthupi omwe angayambitse mitsempha.

Ozanimod imabwera ngati kapisozi kuti itenge pakamwa. Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Tengani ozanimod mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani ozanimod ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse; osatsegula, kutafuna, kapena kuwaphwanya.

Dokotala wanu mwina angakuyambitseni ndi ozanimod wocheperako ndipo pang'onopang'ono muwonjezere mlingo wanu sabata yoyamba.

Ozanimod itha kuthandizira kuthana ndi ziwalo zambiri, koma siziwachiza. Dokotala wanu amakuyang'anirani mosamala kuti awone momwe ozanimod imagwirira ntchito kwa inu. Ndikofunika kuuza dokotala momwe mukumvera mukamalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Chithandizo cha Mankhwala) mukayamba mankhwala ndi ozanimod ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge ozanimod,

• Uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la ozanimod, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a ozanimod. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• uzani dokotala wanu ngati mukumwa MAO inhibitor monga isocarboxazid (Marplan), linezolid (Zyvox), methylene buluu, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), kapena tranylcypromine (Parnate) kapena mwasiya kumwa chimodzi mankhwalawa mkati mwa masabata awiri apitawa. Dokotala wanu angakuuzeni kuti simuyenera kutenga ozanimod panthawiyi. Mukasiya kumwa ozanimod, muyenera kudikirira masiku osachepera 14 musanayambe kumwa MAO inhibitor.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: clopidogrel (Plavix); cyclosporine (Gengraf, Neoral, Sandimmune); eltrombopag (Promacta); erythromycin (EES, Erythromycin, ena); gemfibrozil (Lopid); mankhwala a kugunda kwamtima mosasinthasintha monga amiodarone (Nexterone, Pacerone), procainamide, ndi quinidine (ku Nuedexta); mankhwala opioid (narcotic) monga meperidine (Demerol), methadone (Dolophine, Methadose), ndi tramadol; rifampin (Rifadin, Rimactane, ku Rifamate, ena); serotonin-reuptake inhibitors monga citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, mu Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), ndi sertraline (Zoloft); ndi serotonin ndi norepinephrine reuptake inhibitors monga desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), ndi venlafaxine (Effexor); ndi sotalol (Betapace, Sorine, Sotylize). Komanso uzani dokotala ngati mukumwa mankhwala aliwonse otsatirawa, kapena ngati mwawamwa posachedwapa: alemtuzumab (Campath, Lemtrada); corticosteroids monga dexamethasone, methylprednisolone (Medrol), ndi prednisone (Rayos); mankhwala a khansa; ndi mankhwala ofooketsa kapena kuwongolera chitetezo cha mthupi monga glatiramer (Copaxone, Glatopa) ndi interferon beta (Betaseron, Extavia, Plegridy). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi ozanimod, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala ngati mwadwala matenda a mtima, kupweteka pachifuwa, kupwetekedwa kapena kupwetekedwa pang'ono, kapena kulephera kwa mtima m'miyezi 6 yapitayi. Komanso, uzani dokotala ngati muli ndi vuto la kugunda kwamtima kosakonzedwa ndi pacemaker, kapena ngati muli ndi vuto la kupuma tulo (kusiya kupuma kwakanthawi kochepa mukamagona). Dokotala wanu angakuuzeni kuti musatenge ozanimod.
• Uzani dokotala wanu ngati muli ndi malungo, zilonda zapakhosi, chifuwa, kuzizira, zilonda zotupa, kapena zizindikilo zina za matenda, ngati muli ndi matenda omwe amabwera ndikutha kapena omwe samatha, kapena ngati simungathe kulimbana ndi matenda chifukwa cha matenda ena. Komanso, uzani dokotala ngati mwakhalapo ndi kuthamanga kwa magazi, kugunda kwa mtima pang'ono, matenda ashuga, uveitis (kutupa kwa diso) kapena mavuto ena amaso, kapena matenda amtima kapena chiwindi.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kugwiritsa ntchito njira yolerera yoyenerera mukamachiza ozanimod komanso kwa miyezi itatu mutamaliza kumwa mankhwala. Mukakhala ndi pakati mukatenga ozanimod, itanani dokotala wanu mwachangu.
• uzani dokotala wanu ngati mwalandira katemera m'masiku 30 apitawa musanayambe mankhwala anu ndi ozanimod. Musakhale ndi katemera aliyense mukamalandira chithandizo kapena kwa miyezi itatu mutatha kumwa komaliza musanalankhule ndi dokotala.
• uzani dokotala wanu ngati simunakhalepo ndi nthomba ndipo simunalandire katemera wa nkhuku (varicella). Dokotala wanu akhoza kuyitanitsa kuyezetsa magazi kuti muwone ngati mwapezeka ndi nthomba. Mungafunike kulandira katemera wa nthomba ndikudikirira mwezi umodzi musanayambe kumwa mankhwala ndi ozanimod.
• muyenera kudziwa kuti ozanimod imatha kuyambitsa chizungulire, mutu wopepuka, komanso kukomoka mukaimirira mwachangu pamalo abodza. Izi ndizofala kwambiri mukayamba kumwa ozanimod. Pofuna kupewa vutoli, tulukani pabedi pang'onopang'ono, ndikupumitsa mapazi anu pansi kwa mphindi zingapo musanayimirire.

Mutha kukhala ndi vuto lalikulu mukamadya zakudya zomwe zili ndi tyramine yambiri mukamalandira ozanimod. Tyramine imapezeka mu zakudya ndi zakumwa zambiri, kuphatikiza nyama, nkhuku, nsomba, kapena tchizi zomwe zasuta, kukalamba, kusungidwa molakwika, kapena kuwonongeka; zipatso, ndiwo zamasamba, ndi nyemba; zakumwa zoledzeretsa; ndi zopangira yisiti zofufumitsa. Dokotala wanu kapena wazakudya zakuwuzani zakudya zomwe muyenera kupewa kwathunthu, ndi zakudya zomwe mungadye pang'ono. Ngati mumadya chakudya chomwe chili ndi tyramine yambiri mukamamwa ozanimod, funsani dokotala wanu.

Ngati mwaphonya mlingo umodzi kapena zingapo m'masiku 14 oyamba a chithandizo, lankhulani ndi dokotala musanayambirenso kumwa. Muyenera kuyambiranso mankhwalawo pamlingo wotsika ndikuwonjezera pang'onopang'ono.

Ngati mwaphonya mlingo pambuyo pa masiku 14 oyamba a chithandizo, pitirizani kuchuluka kwanu tsiku lililonse. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ozanimod imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kupweteka kwa msana

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi izi, siyani kumwa ozanimod ndipo itanani dokotala wanu mwachangu kapena mupeze chithandizo chadzidzidzi:

• malungo, chifuwa, zilonda zapakhosi, mphuno yothamanga, kapena kupweteka kowawa pafupipafupi mukamachiritsidwa komanso kwa miyezi itatu mutatha kumwa
• kupweteka kwa mutu, kuuma kwa khosi, malungo, kuzindikira kuwala, nseru, kapena kusokonezeka mukamalandira chithandizo kwa miyezi itatu mutatha kumwa
• nseru, kusanza, kusowa chilakolako, kupweteka m'mimba, chikasu cha khungu kapena maso, kapena mkodzo wakuda
• blurry, mithunzi, kapena malo akhungu pakati pa masomphenya anu; kutengeka ndi kuwala; mtundu wachilendo pamasomphenya anu kapena zovuta zina zamasomphenya
• kupweteka mutu modzidzimutsa, kusokonezeka, kusintha masomphenya, kapena kugwidwa
• kufooka mbali imodzi ya thupi kapena kusakhazikika kwa mikono kapena miyendo yomwe imakulira pakapita nthawi; kusintha kwa malingaliro anu, kukumbukira, kapena kulinganiza; chisokonezo kapena kusintha kwa umunthu; kapena kutaya mphamvu
• zidzolo; ming'oma; kapena kutupa kwa milomo, nkhope, kapena lilime
• kupuma kwatsopano kapena kukulira
• chizungulire, kutopa, kupweteka pachifuwa, kapena kugunda kwapang'onopang'ono kapena kosasintha

Ozanimod atha kuwonjezera chiopsezo chokhala ndi khansa yapakhungu. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa.

Kuwonjezeka kwadzidzidzi kwa zizindikiro za MS ndikuwonjezeka kwaulema kumatha kuchitika mutasiya kumwa ozanimod. Uzani dokotala wanu ngati matenda anu a MS achulukirachulukira mukasiya kumwa ozanimod.

Ozanimod imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Mudzalandira electrocardiogram (ECG; kuyesa komwe kumalemba zochitika zamagetsi zamtima) musanamwe mankhwala anu oyamba. Dokotala wanu adzaitanitsanso mayeso ena a labu, mayeso amaso, ndikuwunika kuthamanga kwa magazi anu musanachitike komanso mukamalandira chithandizo kuti mutsimikizire kuti zili bwino kuti muyambe kumwa kapena kupitiriza kumwa ozanimod.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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