Lisocabtagene Maraleucel jekeseni

Zamkati

• Asanalandire lisocabtagene maraleucel,
• Lisocabtagene maraleucel imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Lisocabtagene maraleucel jekeseni imatha kuyambitsa matenda oopsa kapena owopsa omwe amatchedwa cytokine release syndrome (CRS). Dokotala kapena namwino adzakuyang'anirani mosamala mukamalowetsedwa komanso kwa milungu ingapo pambuyo pake. Uzani dokotala wanu ngati muli ndi vuto lotupa kapena ngati muli kapena mukuganiza kuti mutha kukhala ndi matenda aliwonse pano. Mupatsidwa mankhwala kwa mphindi 30 mpaka 60 musanalowetsedwe kuti muthane ndi vuto la lisocabtagene maraleucel. Ngati mukumane ndi zizindikiro zotsatirazi mukamudyetsedwa, uzani dokotala nthawi yomweyo: malungo, kuzizira, kugunda kwamtima kapena kusakhazikika, kupweteka kwa minofu, kugwedezeka, kutsegula m'mimba, kutopa, kufooka, kupuma movutikira, kupuma movutikira, chifuwa, chisokonezo, nseru, kusanza, chizungulire, kapena mutu wopepuka.

Lisocabtagene maraleucel jekeseni imatha kuyambitsa machitidwe owopsa kapena owopsa amoyo. Izi zimatha kuchitika pambuyo pothandizidwa ndi lisocabtagene maraleucel. Uzani dokotala wanu ngati mudagwidwa, kudwala sitiroko, kapena kukumbukira kukumbukira. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka mutu, chizungulire, kuvutika kugona kapena kugona, kusakhazikika, kusokonezeka, nkhawa, kugwedezeka kosalamulirika kwa gawo lina la thupi, kutaya chikumbumtima, kubvutika, kugwidwa, kutaya kusamala, kapena kuvutika kuyankhula.

Jekeseni wa Lisocabtagene maraleucel umapezeka pokhapokha pulogalamu yoletsa yogawa. Pulogalamu ya Breyanzi REMS (Risk Evaluation and Mitigation Strategy) yakhazikitsidwa chifukwa cha kuwopsa kwa CRS komanso poizoni wamitsempha. Mutha kulandila mankhwala kuchokera kwa adotolo ndi malo azaumoyo omwe amatenga nawo mbali pulogalamuyi. Funsani dokotala wanu ngati muli ndi mafunso okhudza pulogalamuyi.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi lisocabtagene maraleucel ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lisocabtagene maraleucel imagwiritsidwa ntchito pochiza mitundu ina yayikulu ya B-cell lymphoma (mtundu wa khansa womwe umayambira m'maselo oyera amwazi) mwa akulu omwe khansa yabwerera kapena yosamvera mankhwala ena awiri. Lisocabtagene maraleucel ali m'kalasi la mankhwala otchedwa autologous cellular immunotherapy, mtundu wa mankhwala omwe amakonzedwa pogwiritsa ntchito maselo ochokera m'magazi a wodwalayo. Zimagwira ntchito poyambitsa chitetezo cha mthupi (gulu la maselo, zotupa, ndi ziwalo zomwe zimateteza thupi kuti lisagwidwe ndi mabakiteriya, mavairasi, ma cell a khansa, ndi zinthu zina zomwe zimayambitsa matenda) kulimbana ndi ma cell a khansa.

Lisocabtagene maraleucel imabwera ngati kuyimitsidwa (madzi) kuti ilowe jakisoni (mumtsempha) ndi dokotala kapena namwino kuofesi ya udokotala kapena malo olowerera. Nthawi zambiri amaperekedwa ngati ma infusions awiri kwakanthawi kokwanira mphindi 30 ngati gawo limodzi. Musanalandire lisocabtagene maraleucel dose, dokotala wanu kapena namwino adzakupatsani mankhwala ena a chemotherapy kuti akonzekeretse thupi lanu kuti lisocabtagene maraleucel.

Musanaperekedwe jakisoni wanu wa lisocabtagene maraleucel, maselo anu oyera amwazi adzatengedwera kumalo osungira maselo pogwiritsa ntchito njira yotchedwa leukapheresis (njira yomwe imachotsa maselo oyera amthupi). Chifukwa mankhwalawa amapangidwa kuchokera m'maselo anu, ayenera kuperekedwa kwa inu nokha. Ndikofunika kukhala munthawi yake komanso kuti musaphonye nthawi yomwe mumakonzekera kusonkhanitsidwa kwama cell kapena kulandira mankhwala anu. Muyenera kukonzekera kukhala pafupi ndi komwe mudalandira mankhwala anu a lisocabtagene maraleucel kwa milungu yosachepera 4 mutamwa mankhwala.Wothandizira zaumoyo wanu adzawona ngati chithandizo chanu chikugwira ntchito ndikukuyang'anirani zotsatira zoyipa zilizonse. Lankhulani ndi dokotala wanu za momwe mungakonzekerere leukapheresis ndi zomwe muyenera kuyembekezera mukamachita izi.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire lisocabtagene maraleucel,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la lisocabtagene maraleucel, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu lisocabtagene maraleucel. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mudakhalapo ndi kachilombo ka hepatitis B kapena matenda a chiwindi.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Muyenera kuyezetsa mimba musanayambe lisocabtagene maraleucel. Mukakhala ndi pakati mukalandira lisocabtagene maraleucel, itanani dokotala wanu mwachangu.
• Muyenera kudziwa kuti lisocabtagene maraleucel jekeseni imatha kukupangitsani kugona komanso kuyambitsa chisokonezo, kufooka, chizungulire, khunyu, komanso mavuto amgwirizano. Osayendetsa galimoto kapena kugwiritsa ntchito makina kwa masabata osachepera 8 mutagwiritsa ntchito lisocabtagene maraleucel dose.
• musapereke magazi, ziwalo, ziwalo, kapena maselo kuti mumupatse mukalandira jekeseni wanu wa lisocabtagene maraleucel.
• funsani dokotala wanu kuti muwone ngati mukufuna kulandira katemera uliwonse. Musakhale ndi katemera musanalankhule ndi dokotala kwa milungu isanu ndi umodzi musanayambe chemotherapy, panthawi yomwe mumalandira mankhwala a lisocabtagene maraleucel, mpaka dokotala wanu atakuwuzani kuti chitetezo chamthupi chanu chayamba.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ngati mwaphonya nthawi yosankhidwa kuti mudzatenge maselo anu, muyenera kuyimbira dokotala wanu ndi malo osonkhanitsira nthawi yomweyo. Ngati mwaphonya nthawi kuti mudzalandire lisocabtagene maraleucel dose, muyenera kuyimbira dokotala nthawi yomweyo.

Lisocabtagene maraleucel imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kudzimbidwa
• kupweteka m'mimba
• kusowa chilakolako
• zidzolo
• dzanzi, kupweteka, kumva kulasalasa, kapena kutentha pamiyendo kapena manja

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kumva kutopa
• kuvulala kapena kutuluka magazi
• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• chisokonezo
• kuthamanga kapena kusakhazikika kwamtima

Lisocabtagene maraleucel imatha kukulitsa chiopsezo chokhala ndi khansa. Lankhulani ndi dokotala wanu za kuopsa kolandira mankhwalawa.

Lisocabtagene maraleucel imatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani nthawi yonse yokumana ndi dokotala wanu, malo osungira maselo, ndi labotale. Dokotala wanu amatha kuyitanitsa mayeso ena a labu asanadye, nthawi, komanso mutalandira chithandizo kuti muwone momwe thupi lanu likuyankhira jekeseni wa lisocabtagene maraleucel.

Musanayezetsedwe kwa labotale, uzani adotolo ndi omwe akuwauza kuti mukulandila lisocabtagene maraleucel.

Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudza lisocabtagene maraleucel.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Breyanzi^®