Jekeseni wa Methotrexate

Zamkati

• Asanalandire jakisoni wa methotrexate,
• Methotrexate imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo izi:

Methotrexate imatha kubweretsa zovuta zoyipa kwambiri. Muyenera kulandira jakisoni wa methotrexate wokha khansa yowopsa, kapena zina zomwe ndizovuta kwambiri zomwe sizingachiritsidwe ndi mankhwala ena. Lankhulani ndi dokotala wanu za kuopsa kolandila jakisoni wa methotrexate pa matenda anu.

Uzani dokotala wanu ngati mwakhalapo ndi madzi owonjezera m'mimba mwanu kapena malo ozungulira mapapu anu komanso ngati mwakhalapo ndi matenda a impso. Komanso uzani dokotala ngati mukumwa mankhwala osagwiritsa ntchito zotupa (ma NSAID) monga aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), kapena salsalate. Izi ndi mankhwala atha kukulitsa chiopsezo kuti mungakhale ndi zotsatirapo zoyipa za methotrexate. Dokotala wanu adzakuyang'anirani mosamala kwambiri ndipo angafunike kukupatsirani mankhwala ochepa a methotrexate kapena kuyimitsa mankhwala anu ndi methotrexate.

Methotrexate ingayambitse kuchepa kwa maselo amwazi omwe amapangidwa ndi mafupa. Uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi nambala yocheperako yamaselo amwazi kapena vuto lina lililonse lama cell amwazi wanu. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi izi: zilonda zapakhosi, kuzizira, malungo, kutsokomola kosalekeza komanso kuchulukana, kapena zizindikilo zina za matenda; kuvulaza kapena kutuluka mwachilendo; kutopa kapena kufooka kosazolowereka; khungu lotumbululuka; kapena kupuma movutikira.

Methotrexate imatha kuwononga chiwindi, makamaka ikamamwa nthawi yayitali. Uzani dokotala wanu ngati mumamwa kapena mumamwa mowa wambiri kapena ngati mwakhalapo ndi matenda a chiwindi. Dokotala wanu sangakonde kuti mulandire jakisoni wa methotrexate pokhapokha mutakhala ndi khansa yowopsa pamoyo wanu chifukwa pali chiopsezo chachikulu choti mungawononge chiwindi. Chiwopsezo choti chiwindi chimatha kuwonanso chimakhala chachikulu ngati ndinu okalamba, onenepa kwambiri, kapena muli ndi matenda ashuga. Funsani dokotala wanu za zakumwa zoledzeretsa pamene mukulandira jakisoni wa methotrexate. Uzani dokotala wanu ngati mukumwa mankhwala aliwonse awa: acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), kapena tretinoin (Vesanoid). Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi izi: kunyansidwa, kutopa kwambiri, kusowa mphamvu, kusowa njala, kupweteka kumtunda kwakumimba, chikasu pakhungu kapena m'maso, kapena zizindikiro ngati chimfine. Dokotala wanu amatha kuyitanitsa ma biopsies a chiwindi (kuchotsa kachidutswa kakang'ono ka chiwindi kuti kayezedwe mu labotale) musanachitike komanso mukamalandira mankhwala a methotrexate.

Methotrexate imatha kuwononga mapapo. Uzani dokotala wanu ngati mwakhalapo ndi matenda am'mapapo. Itanani dokotala wanu nthawi yomweyo ngati mukukumana ndi izi: chifuwa chouma, malungo, kapena kupuma movutikira.

Methotrexate imatha kuwononga mkamwa mwanu, m'mimba kapena m'matumbo. Uzani dokotala wanu ngati mwakhalapo ndi zilonda zam'mimba kapena ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda mkatikati mwa matumbo [matumbo akulu] ndi thumbo). Itanani dokotala wanu nthawi yomweyo mukakumana ndi izi: zilonda zam'kamwa, kutsegula m'mimba, zakuda, kuchepa, kapena malo amwazi, ndikusanza, makamaka ngati masanzi ali ndi magazi kapena akuwoneka ngati khofi.

Kugwiritsa ntchito methotrexate kumawonjezera chiopsezo choti mungakhale ndi lymphoma (khansa yomwe imayamba m'maselo amthupi). Ngati mukukhala ndi lymphoma, imatha kutha popanda mankhwala mukasiya kumwa methotrexate, kapena mungafunike kuthandizidwa ndi chemotherapy.

Ngati mukumwa methotrexate kuchiza khansa, mutha kukhala ndi zovuta zina zomwe zitha kukhala zowopsa kapena zowopsa pamoyo wanu popeza methotrexate imagwira ntchito yowononga ma cell a khansa. Dokotala wanu amayang'anitsitsa mosamala ndikuchiza mavutowa akachitika.

Methotrexate imatha kuyambitsa khungu kapena kuwononga khungu. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: malungo, zotupa, zotupa, kapena khungu losenda.

Methotrexate imatha kuchepa chitetezo chamthupi mwanu, ndipo mutha kudwala matenda akulu. Uzani dokotala wanu ngati muli ndi matenda amtundu uliwonse ndipo ngati mwakhalapo kapena mudakhalapo ndi vuto lililonse lomwe limakhudza chitetezo chamthupi. Dokotala wanu angakuuzeni kuti simuyenera kulandira methotrexate pokhapokha mutakhala ndi khansa yoopsa. Mukakhala ndi zizindikilo za matenda monga zilonda zapakhosi, chifuwa, malungo, kapena kuzizira, itanani dokotala wanu mwachangu.

Ngati mulandira methotrexate mukamalandira chithandizo cha radiation kwa khansa, methotrexate imatha kuonjezera ngozi kuti mankhwalawa atha kuwononga khungu, mafupa, kapena ziwalo zina za thupi lanu.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayesero ena a labu asanayambe, nthawi, komanso mutalandira chithandizo chanu kuti muwone momwe thupi lanu likuyankhira ku methotrexate ndikuthandizira zovuta zisanakhale zovuta.

Uzani dokotala wanu ngati inu kapena mnzanu muli ndi pakati kapena mukufuna kutenga pakati. Ngati ndinu wamkazi, muyenera kuyesa mayeso musanalandire methotrexate. Gwiritsani ntchito njira yodalirika yolerera kuti inu kapena mnzanu musakhale ndi pakati mukamalandira mankhwala kapena mukangomaliza kumene kulandira mankhwala. Ngati ndinu wamwamuna, inu ndi akazi anu muyenera kupitiliza kugwiritsa ntchito njira zakulera kwa miyezi itatu mutasiya kugwiritsa ntchito methotrexate. Ngati ndinu wamkazi, muyenera kupitiriza kugwiritsa ntchito njira zakulera mpaka mutasiya kusamba kamodzi mutasiya kugwiritsa ntchito methotrexate. Ngati inu kapena mnzanu mutakhala ndi pakati, itanani dokotala wanu nthawi yomweyo. Methotrexate itha kuvulaza kapena kupha mwana wosabadwayo.

Jekeseni wa Methotrexate imagwiritsidwa ntchito yokha kapena kuphatikiza mankhwala ena kuti athetse zotupa za gestational trophoblastic (mtundu wa chotupa chomwe chimapanga mkati mwa chiberekero cha mayi ali ndi pakati), khansa ya m'mawere, khansa yam'mapapo, khansa ina yamutu ndi khosi; mitundu ina ya khansa ya m'magazi (khansa yamagazi oyera), kuphatikiza khansa ya m'magazi (ALL) ndi meningeal leukemia (khansa yomwe ili pachikopa cha msana ndi ubongo); mitundu ina ya non-Hodgkin's lymphoma (mitundu ya khansa yomwe imayamba mumtundu wama cell oyera omwe nthawi zambiri amalimbana ndi matenda); T-cell lymphoma (CTCL, khungu la khansa la chitetezo cha mthupi lomwe limayamba kuwoneka ngati zotupa pakhungu); ndi osteosarcoma (khansa yomwe imapangika m'mafupa) atachitidwa opaleshoni kuti achotse chotupacho. Jekeseni wa Methotrexate imagwiritsidwanso ntchito pochizira psoriasis (matenda akhungu momwe mawonekedwe ofiira, amphako m'madera ena amthupi) omwe sangathe kuwongoleredwa ndi mankhwala ena. Jekeseni wa Methotrexate imagwiritsidwanso ntchito limodzi ndi kupumula, mankhwala opatsirana komanso nthawi zina mankhwala ena ochizira nyamakazi (RA; vuto lomwe thupi limagunda mafupa ake, kupweteketsa, kutupa, ndi kutayika kwa ntchito) zomwe sizingayang'aniridwe ndi mankhwala ena. Methotrexate ili mgulu la mankhwala otchedwa antimetabolites. Methotrexate imathandizira khansa pochepetsa kukula kwa maselo a khansa. Methotrexate imathandizira psoriasis pochepetsa kukula kwa khungu pakhungu kuti zileke masikelo kuti asapangidwe. Methotrexate imatha kuchiza nyamakazi pochepetsa chitetezo chamthupi.

Jekeseni wa Methotrexate umabwera ngati ufa wosakanikirana ndi madzi kuti alowetse jakisoni (mu mnofu), kudzera m'mitsempha (mumtsempha), mkati mwawo (mumitsempha), kapena mkati mwathu ). Kutalika kwa chithandizo kumatengera mitundu ya mankhwala omwe mukumwa, momwe thupi lanu limayankhira, ndi mtundu wa khansa kapena momwe muliri.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Methotrexate imagwiritsidwanso ntchito limodzi ndi mankhwala ena kuti athetse khansa ya chikhodzodzo. Nthawi zina amagwiritsidwanso ntchito pochiza matenda a Crohn (momwe chitetezo cha mthupi chimagwirira ntchito m'mimba, kupweteketsa, kutsegula m'mimba, kuchepa thupi ndi malungo) ndi matenda ena amthupi okhaokha (zomwe zimachitika chitetezo cha mthupi chitakumana ndi maselo athanzi thupi molakwitsa). Funsani dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa chifukwa cha matenda anu.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa methotrexate,

• Uzani dokotala ndi wamankhwala ngati muli ndi vuto la methotrexate, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jakisoni wa methotrexate. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe alembedwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: maantibayotiki ena monga chloramphenicol (Chloramycetin), penicillin, ndi tetracylcines; folic acid (imapezeka yokha kapena ngati chophatikiza mu ma multivitamini ena); mankhwala ena a nyamakazi; phenytoin (Dilantin); ma probenecid (Benemid); proton pump inhibitors (PPIs) monga esomeprazole (Nexium), omeprazole (Prilosec, Prilosec OTC, Zegerid), pantoprazole (Protonix); sulfonamides monga co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), ndi sulfisoxazole (Gantrisin); ndi theophylline (Theochron, Theolair). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mwakhala mukukhalapo ndi zina mwazomwe zatchulidwa mgawo la CHENJEZO LOFUNIKA kapena mulingo wochepa wamagazi m'magazi anu.
• osayamwa mkaka mukalandira jakisoni wa methotrexate.
• muyenera kudziwa kuti methotrexate imatha kuyambitsa chizungulire kapena kukupangitsani kugona. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.
• konzekerani kupeŵa kuwunika kosafunikira kapena kwakanthawi kwa kuwala kwa dzuwa kapena kuwala kwa ultraviolet (mabedi ofufuta ndi zowunikira) ndi kuvala zovala zoteteza, magalasi a dzuwa, ndi zotchinga dzuwa. Methotrexate imapangitsa khungu lanu kuzindikira kuwala kwa dzuwa kapena kuwala kwa ultraviolet. Ngati muli ndi psoriasis, zilonda zanu zitha kukulirakulira mukayika khungu lanu padzuwa mukalandira methotrexate.
• mulibe katemera uliwonse mukamalandira mankhwala a methotrexate osalankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Methotrexate imatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kulumikizana kapena kupweteka kwa minofu
• maso ofiira
• Kutupa m'kamwa
• kutayika tsitsi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kusanza
• kusawona bwino kapena kutaya masomphenya mwadzidzidzi
• malungo mwadzidzidzi, mutu wopweteka kwambiri, ndi khosi lolimba
• kugwidwa
• kusokonezeka kapena kuiwalika
• kufooka kapena kuvuta kusuntha mbali imodzi kapena zonse ziwiri za thupi
• kuyenda movutikira kapena kuyenda mosakhazikika
• kutaya chidziwitso
• kusalankhula bwino
• kuchepa pokodza
• kutupa kwa nkhope, mikono, manja, mapazi, akakolo, kapena miyendo yakumunsi
• ming'oma
• kuyabwa
• zotupa pakhungu
• kuvuta kupuma kapena kumeza

Methotrexate imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• zilonda mkamwa ndi pakhosi
• zilonda zapakhosi, kuzizira, malungo, kutsokomola kosalekeza komanso kuchulukana, kapena zizindikilo zina za matenda
• kuvulaza kapena kutuluka mwachilendo
• wakuda ndi wodikira kapena chimbudzi chamagazi
• masanzi amagazi
• zinthu zosanza zomwe zimawoneka ngati malo a khofi

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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