Epoetin Alfa, jekeseni

Zamkati

• Musanagwiritse ntchito jakisoni wa epoetin alfa,
• Mankhwala a epoetin alfa jekeseni amatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, kapena zomwe zalembedwa mgulu la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:
• Zizindikiro za bongo zingaphatikizepo:

Jekeseni wa epoetin alfa ndi jakisoni wa epoetin alfa-epbx ndi mankhwala a biologic (mankhwala opangidwa kuchokera kuzinthu zamoyo). Jekeseni wa Biosimilar epoetin alfa-epbx ndi wofanana kwambiri ndi jakisoni wa epoetin alfa ndipo imagwira ntchito chimodzimodzi ndi jakisoni wa epoetin alfa mthupi. Chifukwa chake, mawu akuti epoetin jekeseni wazogwiritsidwa ntchito kuyimira mankhwalawa pazokambirana izi.

Odwala onse:

Kugwiritsa ntchito mankhwala opangira jakisoni wa epoetin alfa kumawonjezera ngozi kuti magazi amaundana amapangika kapena kusunthira kumapazi, mapapo, kapena ubongo. Uzani dokotala wanu ngati mwakhalapo ndi matenda amtima, sitiroko, thrombosis yozama (DVT; magazi m'miyendo mwanu), pulmonary embolus (PE; magazi a m'mapapu anu), kapena ngati mupita kuchipatala . Musanachite opareshoni iliyonse, ngakhale opaleshoni ya mano, uzani dokotala wanu kapena wamano kuti mukumulandira mankhwala a epoetin alfa, makamaka ngati mukuchita opareshoni ya mtsempha wamagazi kapena CABG) kapena opaleshoni ya mafupa. Dokotala wanu akhoza kukupatsani mankhwala ochepetsa magazi ('magazi ochepera magazi') kuti ateteze kuundana kwa nthawi yopanga opaleshoni. Itanani dokotala wanu nthawi yomweyo kapena mupeze chithandizo chamankhwala mwadzidzidzi mukakumana ndi izi: kupweteka, kukoma mtima, kufiira, kutentha, ndi / kapena kutupa m'miyendo; kuzizira kapena kupindika pamikono kapena mwendo; kuvuta kupuma kapena kupuma movutikira; kupweteka pachifuwa; zovuta mwadzidzidzi kulankhula kapena kumvetsetsa mawu; kusokonezeka mwadzidzidzi; kufooka kwadzidzidzi kapena dzanzi la mkono kapena mwendo (makamaka mbali imodzi ya thupi) kapena nkhope; kuyenda modzidzimutsa, chizungulire, kapena kutayika bwino kapena kulumikizana; kapena kukomoka. Ngati mukuchiritsidwa ndi hemodialysis (mankhwala ochotsera zonyansa zamagazi pomwe impso sizikugwira ntchito), magazi amatha kukhala m'mitsempha yanu (pomwe hemodialysis tubing imalumikizana ndi thupi lanu). Uzani dokotala wanu ngati kupezeka kwanu kwamphamvu sikukugwira ntchito mwachizolowezi.

Dokotala wanu amasintha mulingo wanu wa epoetin alfa jakisoni kuti hemoglobin yanu (kuchuluka kwa mapuloteni omwe amapezeka m'maselo ofiira amwaziwo) ndikokwanira mokwanira kuti simufunikira kuthiridwa magazi ofiira (kusamutsa maselo ofiira amunthu m'modzi) thupi la munthu wina kuti amuthandize kuchepa magazi m'thupi). Ngati mulandira mankhwala okwanira a epoetin alfa kuti muwonjezere hemoglobin yanu kukhala yovomerezeka kapena yofanana, pamakhala chiopsezo chachikulu kuti mungakhale ndi sitiroko kapena kukhala ndi mavuto owopsa kapena owopsa amoyo kuphatikizapo kuwonongeka kwa mtima kapena mtima. Itanani dokotala wanu nthawi yomweyo kapena mulandire chithandizo chamankhwala mwadzidzidzi mukakumana ndi izi: kupweteka pachifuwa, kupanikizika, kapena kulimba; kupuma movutikira; nseru, mutu wopepuka, thukuta, ndi zizindikiro zina zoyambirira za matenda amtima; kusapeza kapena kupweteka m'manja, phewa, khosi, nsagwada, kapena kumbuyo; kapena kutupa kwa manja, mapazi, kapena akakolo.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti aone momwe thupi lanu lingayankhire mankhwala a epoetin alfa. Dokotala wanu akhoza kuchepetsa mlingo wanu kapena angakuuzeni kuti musiye kugwiritsa ntchito mankhwala opangira jakisoni wa epoetin alfa kwakanthawi ngati mayeserowa akuwonetsa kuti muli pachiwopsezo chokumana ndi zovuta zina. Tsatirani malangizo a dokotala mosamala.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi epoetin alfa injection product ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwala a epoetin alfa.

Odwala khansa:

M'maphunziro azachipatala, anthu omwe ali ndi khansa ina omwe adalandira jakisoni wa epoetin alfa adamwalira msanga kapena akumana ndi chotupa, khansa yawo, kapena khansa yomwe imafalikira posachedwa kuposa anthu omwe sanalandire mankhwalawo. Muyenera kulandira mankhwala opangidwa ndi jakisoni wa epoetin alfa kuti muchepetse kuchepa kwa magazi komwe kumachitika chifukwa cha chemotherapy ngati chemotherapy yanu ikuyenera kupitilira kwa miyezi iwiri mutayamba mankhwala anu ndi epoetin alfa jekeseni ndipo ngati mulibe mwayi woti khansa yanu ichiritsidwa. Chithandizo cha mankhwala a jakisoni wa epoetin alfa chiyenera kuimitsidwa pakutha kwa chemotherapy.

Odwala opaleshoni:

Mutha kupatsidwa mankhwala opangira jakisoni wa epoetin alfa kuti muchepetse chiopsezo choti mungakhale ndi kuchepa kwa magazi ndikufunika kuthiridwa magazi chifukwa chotaya magazi munthawi zamankhwala ena. Komabe, kulandira mankhwala opangidwa ndi jakisoni wa epoetin alfa musanachite opaleshoni kapena pambuyo pake kumatha kuonjezera chiopsezo kuti mungadzaze magazi oopsa nthawi kapena pambuyo pochita opaleshoni. Dokotala wanu angakupatseni mankhwala othandizira kupewa magazi.

Mankhwala opangidwa ndi jakisoni wa Epoetin alfa amagwiritsidwa ntchito pochiza kuchepa kwa magazi m'thupi (kuchuluka kocheperako kwama cell ofiira ofiira) mwa anthu omwe ali ndi vuto la impso (vuto lomwe impso zimasiya kugwira ntchito kwakanthawi). Mankhwala opangidwa ndi jakisoni wa Epoetin alfa amagwiritsidwanso ntchito kuthana ndi kuchepa kwa magazi m'thupi komwe kumachitika chifukwa cha chemotherapy mwa anthu omwe ali ndi mitundu ina ya khansa kapena yoyambitsidwa ndi zidovudine (AZT, Retrovir, ku Trizivir, ku Combivir), mankhwala omwe amachiza kachilombo ka HIV. Mankhwala opangira jakisoni wa Epoetin alfa amagwiritsidwanso ntchito isanachitike komanso itatha mitundu ina ya opareshoni kuti muchepetse mwayi woti kuthiridwa magazi (kusamutsa magazi a munthu wina kupita mthupi la munthu wina) kudzafunika chifukwa chotaya magazi panthawi yochita opaleshoni. Mankhwala opangira jakisoni wa Epoetin alfa sayenera kugwiritsidwa ntchito pochepetsa chiopsezo choti kuthiridwa magazi kudzafunika kwa anthu omwe akuchitidwa opaleshoni pamtima kapena pamitsempha yamagazi. Mankhwala opangira jakisoni wa Epoetin alfa sayeneranso kugwiritsidwa ntchito pochiza anthu omwe angathe komanso ofunitsitsa kupereka magazi asanafike opaleshoni kuti magazi awa asinthidwe m'matupi awo nthawi kapena pambuyo pochita opaleshoni. Mankhwala opangira jakisoni wa Epoetin alfa sangathe kugwiritsidwa ntchito m'malo mwakuikidwa magazi ofiira kuti athetse kuchepa kwa magazi ndipo sanawonetsedwe kuti atopetsa kapena kukhala ndi thanzi labwino lomwe lingayambitsidwe ndi kuchepa kwa magazi. Mankhwala a Epoetin alfa ali mgulu la mankhwala otchedwa erythropoiesis-stimulating agents (ESAs). Amagwira ntchito poyambitsa mafupa (minofu yofewa mkati mwa mafupa pomwe magazi amapangidwira) kuti apange maselo ofiira ochulukirapo.

Mankhwala opangira jekeseni wa Epoetin alfa amabwera ngati yankho (madzi) kuti alowetse subcutaneous (pansi pa khungu) kapena kudzera m'mitsempha (mumtsempha). Nthawi zambiri amabayidwa kamodzi kapena katatu pamlungu. Pamene mankhwala opangira jakisoni wa epoetin alfa amagwiritsidwa ntchito pochepetsa chiopsezo choti kuthiridwa magazi kudzafunika chifukwa cha opareshoni, nthawi zina amabayidwa kamodzi tsiku lililonse kwa masiku 10 asanachite opareshoni, patsiku la opareshoni komanso masiku anayi atachitidwa opaleshoni. Kapenanso, mankhwala opangira jakisoni wa epoetin alfa nthawi zina amabayidwa kamodzi sabata iliyonse, kuyambira milungu itatu asanakachite opareshoni komanso patsiku la opareshoni.

Dokotala wanu akuyambitsani pamlingo wochepa wa epoetin alfa jekeseni wamankhwala ndikusintha mulingo wanu kutengera zotsatira za labu yanu ndi momwe mukumvera, nthawi zambiri osapitilira kamodzi pamwezi. Dokotala wanu amathanso kukuuzani kuti musiye kugwiritsa ntchito mankhwala a epoetin alfa kwa kanthawi. Tsatirani malangizowa mosamala.

Mankhwala a jekeseni wa Epoetin alfa angakuthandizeni kuchepetsa kuchepa kwa magazi pokhapokha mutapitiliza kuigwiritsa ntchito. Zitha kutenga milungu iwiri kapena kupitilira apo kuti mumve phindu la epoetin alfa jekeseni. Osasiya kugwiritsa ntchito epoetin alfa jekeseni popanda kulankhula ndi dokotala.

Mankhwala opangira jekeseni wa Epoetin alfa atha kuperekedwa ndi adokotala kapena namwino, kapena atha kuuzidwa kuti mubayire mankhwala kunyumba. Ngati mukufuna kubaya mankhwala kunyumba, tsatirani malangizo omwe mwalandira mosamala ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Gwiritsani ntchito epoetin alfa jekeseni wopangira ndendende monga mwalamulo. Kukuthandizani kukumbukira kukumbukira kugwiritsa ntchito epoetin alfainjection mankhwala, lembani kalendala kuti muzindikire nthawi yomwe mudzalandire mlingo. Osamagwiritsa ntchito zocheperako kapena kuzigwiritsa ntchito pafupipafupi kuposa momwe adanenera dokotala.

Ngati mukugwiritsa ntchito jakisoni wa epoetin alfa kunyumba, wothandizira zaumoyo adzakuwonetsani momwe mungabayire mankhwalawo. Onetsetsani kuti mukumvetsetsa izi. Musanagwiritse ntchito epoetin alfaproduct kwa nthawi yoyamba, inu ndi munthu amene akupatsani jakisoniyo muyenera kuwerenga zidziwitso za wopanga za wodwala yemwe amabwera nazo. Funsani wothandizira zaumoyo wanu ngati muli ndi mafunso okhudza komwe muyenera kubaya mankhwala m'thupi lanu, momwe mungaperekere jakisoni, jakisoni wamtundu wanji kuti mugwiritse ntchito, kapena momwe mungathetsere masingano ndi majekeseni mutagwiritsa ntchito mankhwala. Nthawi zonse sungani syringe yopuma ndi singano pamanja.

Musagwedeze epoetin alfa jakisoni mankhwala. Ngati mutagwedeza mankhwalawo, angawoneke ngati opanda thovu ndipo sayenera kugwiritsidwa ntchito.

Mutha kubaya jakisoni wa epoetin alfa pansi pa khungu paliponse kunja kwa mikono yanu yapakatikati, pakati pa ntchafu zakutsogolo, m'mimba (kupatula malo a mainchesi awiri) mozungulira mchombo [batani lamimba] , kapena malo akunja a matako. Osabaya jakisoni wa epoetin alfa pamalo ofewa, ofiira, otunduka, olimba, kapena okhala ndi zipsera kapena zotambalala. Sankhani malo atsopano nthawi iliyonse mukabaya mankhwala, monga mwauzidwa ndi dokotala wanu.

Ngati mukukumana ndi dialysis (chithandizo chotsani zinyalala m'magazi pomwe impso sizikugwira ntchito), adokotala angakuuzeni kuti mulowetse mankhwalawo padoko lanu lofikira. Funsani dokotala wanu ngati muli ndi mafunso okhudza momwe mungabayire mankhwala anu.

Nthawi zonse yang'anani yankho musanalibaye. Onetsetsani kuti botolo lili ndi dzina lolondola ndi mphamvu ya mankhwala ndi tsiku lotha ntchito lomwe silinadutse. Onaninso kuti yankho lake ndi lomveka bwino komanso lopanda utoto ndipo mulibe zotumphukira, kapena mabala. Ngati pali zovuta zilizonse ndi mankhwala anu, itanani wamankhwala wanu kuti musamuyimbe.

Mankhwalawa amatha kupatsidwa ntchito zina. Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa ngati muli ndi vuto lanu.

Musanagwiritse ntchito jakisoni wa epoetin alfa,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la epoetin alfa, epoetin alfa-epbx, darbepoetin alfa (Aranesp), mankhwala ena aliwonse, kapena chilichonse chazomwe zimaphatikizidwa mu mankhwala a epoetin alfa. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni adotolo ngati mwadwala kapena muli ndi matenda othamanga magazi komanso ngati mudakhalapo ndi cell red red aplasia (PRCA; mtundu wa kuchepa kwa magazi m'thupi komwe kumachitika mutalandira chithandizo ndi ESA monga jakisoni wa darbepoetin alfa kapena jakisoni wa epoetin alfa).Dokotala wanu akhoza kukuwuzani kuti musagwiritse ntchito mankhwala a epoetin alfa.
• uzani dokotala wanu ngati mwakhalapo kapena munagwapo. Ngati mukugwiritsa ntchito mankhwala opangira jakisoni wa epoetin alfa kuti muchepetse kuchepa kwa magazi komwe kumayambitsidwa ndi matenda a impso, uzani adotolo ngati mwadwalapo khansa.
• uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukamagwiritsa ntchito jakisoni wa epoetin alfa, itanani dokotala wanu.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukugwiritsa ntchito mankhwala a epoetin alfa.

Dokotala wanu angakupatseni zakudya zapadera kuti zithandizire kuchepetsa kuthamanga kwa magazi ndikuthandizani kukulitsa mayendedwe achitsulo kuti mankhwala a epoetin alfa jekeseni azigwira ntchito momwe angathere. Tsatirani malangizowa mosamala ndikufunsani dokotala kapena katswiri wa zamankhwala ngati muli ndi mafunso.

Itanani dokotala wanu kuti akufunseni zoyenera kuchita ngati mwaphonya mlingo wa mankhwala a epoetin. Musagwiritse ntchito mlingo wawiri kuti mupange omwe mwaphonya.

Mankhwala a epoetin alfa jekeseni amatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• mutu
• kupweteka kwa minofu kapena minofu, kupweteka, kapena kupweteka
• nseru
• kusanza
• kuonda
• zilonda mkamwa
• kuvuta kugona kapena kugona
• kukhumudwa
• kutuluka kwa minofu
• kutuluka m'mphuno, kuyetsemula, ndi kuchulukana
• malungo, chifuwa, kapena kuzizira
• kufiira, kutupa, kupweteka, kapena kuyabwa pamalo obayira

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, kapena zomwe zalembedwa mgulu la CHENJEZO LOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• zidzolo
• ming'oma
• kuyabwa
• kutupa kwa nkhope, mmero, lilime, milomo, kapena maso
• zotupa pakhungu kapena khungu losenda
• kupuma
• kuvuta kupuma kapena kumeza
• kutopa kwachilendo
• kusowa mphamvu
• chizungulire
• kukomoka
• kugwidwa

Mankhwala opangidwa ndi jakisoni wa epoetin alfa angayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamagwiritsa ntchito mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe munabwera kuti muteteze ku kuwala, kutsekedwa mwamphamvu, komanso komwe ana sangakwanitse. Sungani epoetin alfa ndi epoetin alfa-epbx mufiriji, koma musayimitse. Chotsani mankhwala aliwonse oundana. Kutaya botolo la epoetin alfa jekeseni masiku 21 mutangoyamba kuligwiritsa ntchito.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo:

• kuthamanga kapena kuthamanga kwa mtima

Sungani maimidwe onse ndi dokotala wanu. Dokotala wanu amayang'anira kuthamanga kwa magazi kwanu nthawi zambiri mukamamwa mankhwala a epoetin alfa.

Musanayesedwe mu labotale, uzani adotolo ndi ogwira nawo ntchito kuti mukugwiritsa ntchito mankhwala a epoetin alfa.

Musalole kuti wina aliyense agwiritse ntchito mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Epogen^®(Epoetin Alpha)
• Eprex^®(Epoetin Alpha)^¶
• Wochenjera^® (Epoetin Alpha)
• Kubwezeretsanso^®(Zowonjezera Alpha-epbx)

• EPO
• Erythropoietin Munthu Glycoform alpha (Recombinant)
• rHuEPO-alpha

^¶ Chogulitsa ichi sichikupezeka pamsika. Njira zina zitha kupezeka.