Kodi Mankhwala Osokoneza Bongo Ndiwo Njira Yanji ya Matenda a Crohn?

Zamkati

• Kodi mankhwala a biologic ndi chiyani?
• Mitundu itatu ya biologics
• Mankhwala a Anti-TNF
• Zoletsa za Interleukin
• Ma anti-integrin antibodies
• Kweretsani motsutsana ndi chithandizo chokwera pamwamba
• Zotsatira zoyipa
• Malingaliro apadera
• Chifuwa chachikulu
• Matenda
• Mkhalidwe wamtima
• Nkhani zina

Chidule

Matenda a Crohn amachititsa kutupa, kutupa, ndi kukwiya m'mbali yam'mimba.

Ngati mwayesapo mankhwala ena a matenda a Crohn, kapena ngakhale mutapezeka kumene, dokotala wanu angaganize zoperekera mankhwala a biologic. Biologics ndi mankhwala akuchipatala omwe amathandiza kuchepetsa kutupa koopsa kuchokera ku matenda a Crohn.

Kodi mankhwala a biologic ndi chiyani?

Biologics ndi mankhwala opangidwa ndi majini omwe amayang'ana mamolekyulu ena mthupi omwe amayambitsa kutupa.

Madokotala nthawi zambiri amapereka biologics kwa iwo omwe ali ndi matenda a Crohn's refractory omwe samayankha mankhwala ena, kapena kwa anthu omwe ali ndi zizindikilo zowopsa.Pamaso pa biologics, panali njira zochepa zothandizira anthu omwe ali ndi matenda opatsirana.

Mankhwala osokoneza bongo amagwira ntchito kuti abweretse chikhululukiro mwachangu. Nthawi yakukhululukidwa, kutupa ndi zizindikiritso zamatumbo zimatha. Biologics itha kugwiritsidwanso ntchito kwa nthawi yayitali kuthandiza kukhalabe ndi nthawi yokhululukidwa.

Mitundu itatu ya biologics

Mtundu wa biologic womwe dokotala wanu akuwonetsa umadalira kukula kwa zizindikilo zanu komanso komwe matenda amapezeka. Aliyense ndi wosiyana. Mankhwala enaake amatha kugwira ntchito bwino kwa ena kuposa ena. Muyenera kuyesa mankhwala angapo musanapeze zomwe zingakuthandizeni.

Mankhwala ochiritsira matenda a Crohn amapezeka m'gulu limodzi mwamagawo atatu: anti-tumor necrosis factor (anti-TNF), ma interleukin inhibitors, ndi ma anti-integrin antibodies.

Mankhwala oletsa anti-TNF amayang'ana puloteni yomwe imakhudzidwa ndikutupa. Pa matenda a Crohn, mankhwala oletsa anti-TNF amagwira ntchito poletsa kutupa komwe kumachitika ndi puloteni iyi m'matumbo.

Interleukin inhibitors amagwira ntchito chimodzimodzi, potseka mapuloteni omwe amabwera mwachilengedwe omwe amachititsa kutupa m'matumbo. Anti-integrins amaletsa maselo ena amthupi omwe amachititsa kutupa.

Biologics nthawi zambiri imaperekedwa mozungulira (ndi singano kudzera pakhungu) kapena kudzera m'mitsempha (kudzera mu chubu cha IV). Amatha kupatsidwa milungu iwiri kapena isanu ndi itatu iliyonse, kutengera mankhwala. Muyenera kupita kuchipatala kapena kuchipatala kuti mukalandire mankhwala ambiriwa.

A FDA avomereza mankhwala angapo achilengedwe kuti athetse matenda a Crohn.

Mankhwala a Anti-TNF

• adalimumab (Humira, Exemptia)
• chitsimikizo cha pegol (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)

Zoletsa za Interleukin

• ustekinumab (Stelara)

Ma anti-integrin antibodies

• natalizumab (Tysabri)
• vedolizumab (Entyvio)

Kweretsani motsutsana ndi chithandizo chokwera pamwamba

Mankhwala a biologic atha kukhala chida champhamvu pochizira ndikuwongolera matenda a Crohn. Pali njira ziwiri zochizira biologic:

• Chithandizo chakuwongolera chinali njira yodziwika bwino mpaka malangizo atsopano atatulutsidwa mu 2018. Njirayi ikutanthauza kuti inu ndi adotolo muyesere mankhwala ena angapo musanayambe biologic.
• Mankhwala opatsirana kwambiri amatanthauza kuti mankhwala a biologic amayambitsidwa kale kwambiri pochiza. Imeneyi ndiyo njira yomwe anthu ambiri amaganiza kuti ndi matenda a Crohn.

Komabe, njira zosiyanasiyana zitha kugwira ntchito bwino kwa anthu osiyanasiyana kutengera kukula kwa matenda.

Zotsatira zoyipa

Biologics imakhala ndi zovuta zochepa zochepa kuposa mankhwala ena a Crohn's disease, monga corticosteroids, omwe amaletsa chitetezo chonse cha mthupi.

Komabe, pali zovuta zina zomwe muyenera kudziwa musanamwe mankhwala a biologic.

Zotsatira zoyipa zambiri za biologics ndi izi:

• kufiira, kuyabwa, mabala, kupweteka, kapena kutupa mozungulira malo obayira
• mutu
• malungo kapena kuzizira
• kuvuta kupuma
• kuthamanga kwa magazi
• ming'oma kapena zidzolo
• kupweteka m'mimba
• kupweteka kwa msana
• nseru
• chifuwa kapena zilonda zapakhosi

Malingaliro apadera

Biologics ikhoza kukhala yotetezeka kwa aliyense. Lankhulani ndi dokotala wanu ngati muli ndi chifuwa chachikulu (TB), mumakonda kutenga matenda, kapena muli ndi vuto la mtima.

Chifuwa chachikulu

Mankhwala a biologic omwe amagwiritsidwa ntchito pa matenda a Crohn atha kuwonjezera chiopsezo choyambitsanso matenda a chifuwa chachikulu cha TB mwa anthu omwe awululidwa. TB ndi nthenda yoopsa ya m'mapapo.

Dokotala wanu ayenera kukuyesani TB musanayambe mankhwala ndi biologic. Matenda a TB amatha kugona mthupi. Anthu ena omwe adakumana ndi matendawa mwina sangadziwe.

Ngati mudakhalapo ndi chifuwa chachikulu cha TB, dokotala wanu angakulimbikitseni kulandira chithandizo cha TB musanatengere biologic.

Matenda

Biologics imatha kutsitsa kuthekera kwa thupi kulimbana ndi matenda ena. Ngati mumakhala ndi matenda, dokotala wanu atha kupereka chithandizo chamtundu wina.

Mkhalidwe wamtima

Mankhwala a anti-TNF atha kukhala owopsa kwa anthu omwe ali ndi vuto linalake lamtima, monga mtima wosalimba. Kulephera kwa mtima ndipamene mtima sungapope magazi okwanira kukwaniritsa zosowa za thupi.

Uzani dokotala wanu posachedwa ngati mukumva kupuma pang'ono kapena kutupa kwa mapazi mukamamwa biologic ya matenda a Crohn. Izi zikhoza kukhala zizindikiro za kulephera kwa mtima.

Nkhani zina

Njira zochiritsira zachilengedwe nthawi zina zimalumikizidwa ndi zovuta zazikulu zathanzi. Mwa anthu omwe amamwa mankhwala a biologic, zovuta zotsatirazi sizimanenedwa kawirikawiri:

• Matenda ena am'magazi (kuvulala, kutuluka magazi)
• mavuto amitsempha (kuphatikiza, kufooka, kufooka, kumenyedwa, kapena kusokonezeka pakuwona, monga kusawona bwino, kuwona kawiri, kapena khungu pang'ono)
• lymphoma
• kuwonongeka kwa chiwindi
• aakulu thupi lawo siligwirizana

Lankhulani ndi dokotala wanu kuti mudziwe njira yabwino kwambiri yopezera zosowa zanu.