Kuyanjana kwa CBD ndi Mankhwala: Zomwe Muyenera Kudziwa

Zamkati

• CBD ingasinthe momwe thupi lanu limapangidwira mankhwala ena
• Mankhwala osokoneza bongo ndi ma CYP450 michere
• Chifukwa chiyani CYP450 imakhala yofunika zikafika ku CBD ndi mankhwala?
• Kuyesa CBD mosamala mukamwa mankhwala
• Kuyanjana komwe kungachitike ndi mankhwala
• Fufuzani chenjezo la zipatso zamphesa
• Mitundu ya mankhwala omwe nthawi zambiri amakhala ndi chenjezo la mphesa
• Kafukufuku wapano wazokhudzana pakati pa CBD ndi mankhwala
• Chitetezo ndi zotsatirapo
• Zotsatira zoyipa zomwe muyenera kuyang'anira
• Lankhulani ndi dokotala wanu

Kupangidwa ndi Jamie Herrmann

CBD ingasinthe momwe thupi lanu limapangidwira mankhwala ena

Cannabidiol (CBD), yatchuka ndi anthu ambiri pazotheka kuthana ndi tulo, nkhawa, kupweteka kwakanthawi, komanso zovuta zina zambiri.

Ndipo ngakhale maphunziro akupitilira momwe CBD imagwirira ntchito, anthu ambiri akuyesa.

Kafukufuku mpaka pano akuwonetsa kuti CBD nthawi zambiri imakhala yotetezeka ndipo imakhala ndi zovuta zochepa, ngati zilipo, zochepa. Koma pali chenjezo limodzi lalikulu: CBD imatha kulumikizana ndi mankhwala. Chodabwitsachi chimakhudzana ndi momwe thupi limagwirira zinthu zina.

Musanayese CBD, ndikofunikira kuti mulankhule ndi dokotala za mavitamini onse, zowonjezera mavitamini, mankhwala ndi mankhwala omwe mumamwa. Pano pali kuyang'ana kwakukulu kwa chifukwa chake kukambirana kuli kofunika.

Mankhwala osokoneza bongo ndi ma CYP450 michere

Mukamamwa mankhwala kapena chinthu china, thupi lanu limayenera kulipukusa, kapena kuwononga. Kugwiritsa ntchito mankhwala osokoneza bongo kumachitika mthupi lonse, monga m'matumbo, koma chiwindi chimagwiranso ntchito.

Banja la ma enzyme lotchedwa limagwira ntchito yofunikira yosandutsa zinthu zakunja kuti athe kuchotsedwa mthupi.

Koma mankhwala kapena zinthu zina zimakhudza CYP450, mwina pochepetsa kapena kufulumizitsa kagayidwe ka mankhwala. Kusintha kwa kagayidwe kamwedwe kameneka kumatha kusintha momwe thupi lanu limapangidwira mankhwala kapena zomwe mumamwa - chifukwa chake kulumikizana kwa mankhwala.

Chifukwa chiyani CYP450 imakhala yofunika zikafika ku CBD ndi mankhwala?

Banja la CYP450 la ma enzyme limayambitsa mavitamini angapo, kuphatikiza CBD, kafukufuku akuwonetsa. Makamaka, CYP3A4, enzyme yofunikira m'banja la CYP450, imagwira ntchitoyo. Koma panthawiyi, CBD imasokonezanso CYP3A4.

Enzyme ya CYP3A4 ndi yomwe imayang'anira kupukusa pafupifupi 60 peresenti ya mankhwala omwe adalandira kuchipatala. Koma ngati CBD ikuletsa CYP3A4, siyingagwire bwino ntchito kuti iwononge mankhwala m'dongosolo lanu.

Chotsatiracho chikhoza kuchitika, naponso. Mankhwala ambiri amaletsa CYP3A4. Ngati mutenga CBD mukamamwa mankhwalawa, thupi lanu silingagwire bwino ntchito CBD.

Ngati thupi lanu likupukusa mankhwala pang'onopang'ono, mutha kukhala ndi mankhwala ochulukirapo m'dongosolo lanu nthawi imodzi kuposa momwe mumafunira - ngakhale mutakhala omvera ku mlingo wanu wabwinobwino. Kuchuluka kwa mankhwala m'dongosolo lanu kumatha kukokomeza zotsatira zake, kuphatikiza zovuta zosafunikira kapena zoyipa.

Zinthu zina zimathandizanso kuti ntchito ya banja la enzyme ya CYP450 igwire ntchito. Ngati thupi lanu limagwiritsa ntchito mankhwala mwachangu kwambiri chifukwa chinthu china chimayambitsa ma enzyme, mwina simungakhale ndi mankhwala okwanira m'dongosolo lanu nthawi imodzi kuti muthane ndi mavuto azaumoyo.

Kuyesa CBD mosamala mukamwa mankhwala

Ngati mukufuna kuyesa CBD ngati mankhwala owonjezera kuti muchepetse zizindikiro za vuto linalake, kambiranani ndi dokotala poyamba.

Amatha kuthandizira kudziwa za mankhwala a CBD, mlingo, ndi dongosolo lomwe lili lotetezeka ndi mankhwala anu. Nthawi zina, dokotala wanu angafune kuwunika kuchuluka kwa madzi am'magazi mumankhwala ena omwe mumamwa.

Osayimitsa mankhwala anu kuti ayesere CBD, pokhapokha dokotala atanena kuti ndibwino kutero.

Kumbukirani kuti CBD yapakhungu, monga mafuta odzola, mafuta, ndi mchere, itha kukhalanso njira. Mosiyana ndi mafuta, zakudya, ndi njira zothetsera vutoli, topicals samalowa m'magazi - bola ngati si njira yothetsera transdermal yomwe imayenera kutero.

Kuyanjana komwe kungachitike ndi mankhwala

Fufuzani chenjezo la zipatso zamphesa

Ngakhale maphunziro akupitilirabe kuti athe kudziwa kuyanjana komwe kungachitike pakati pa CBD ndi mankhwala ena, pali lamulo limodzi lazithunzi zomwe zingathandize ogula pakadali pano: Pewani CBD ngati mankhwala anu ali ndi chenjezo la mphesa cholembedwapo.

Chenjezo ili likuwonetsa kuti anthu omwe amamwa mankhwalawa ayenera kupewa kumwa zipatso zamtengo wapatali kapena madzi amphesa.

Malinga ndi, kumwa zipatso zamtengo wapatali panthawi imodzi mwa mankhwalawa kumatha kubweretsa mankhwala ochulukirapo m'magazi komanso zovuta zina kapena kuwonjeza kuchuluka kwa mankhwala osokoneza bongo.

Mankhwala opitilira 85 amalumikizana ndi zipatso zamphesa ndi timadziti tina tofanana ndi ma citrus - monga malalanje a Seville, pomelos, ndi tangelos. Izi ndichifukwa choti mankhwala am'mamphesa omwe amadziwika kuti furanocoumarins amaletsa CYP3A4, chimodzimodzi ngati CBD. Zotsatira zake ndizochepetsa kuchepa kwa mankhwala.

Machenjezo a mphesa amapezeka m'mitundu ingapo ya mankhwala, koma si mankhwala onse m'gululi omwe amafunika kupewa zipatso zamphesa. Onani zambiri zamankhwala anu kapena mufunse dokotala.

Mitundu ya mankhwala omwe nthawi zambiri amakhala ndi chenjezo la mphesa

• maantibayotiki ndi maantimicrobial
• mankhwala anticancer
• mankhwala oletsa
• mankhwala a antiepileptic (AEDs)
• mankhwala a kuthamanga kwa magazi
• oonda magazi
• mankhwala a cholesterol
• corticosteroids
• mankhwala osokoneza bongo a erectile
• Mankhwala a GI, monga kuchiza GERD kapena nseru
• mankhwala a mtima
• chitetezo cha mthupi
• mankhwala amisala, monga kuchiza nkhawa, kukhumudwa, kapena matenda amisala
• mankhwala opweteka
• mankhwala a prostate

Kafukufuku wapano wazokhudzana pakati pa CBD ndi mankhwala

Ofufuzawo akuyesetsa kudziwa momwe kulumikizirana pakati pa CBD ndi mankhwala osiyanasiyana. Kafukufuku wachitidwa munyama zamankhwala ena, koma nthawi zambiri, asayansi akadali kudziwa momwe zotsatirazi zimamasulira kwa anthu.

Mayesero ang'onoang'ono azachipatala achitika. Mwachitsanzo, pa kafukufuku wina wa ana 25 omwe ali ndi khunyu lovuta kuchiza, ana 13 adapatsidwa clobazam ndi CBD. Ofufuzawa adapeza milingo yayikulu ya clobazam mwa ana awa. Amanenanso kuti kutenga CBD ndi clobazam palimodzi ndizabwino, koma amalangiza kuwunika milingo ya mankhwala mukamalandira chithandizo.

Pakafukufuku wina, akulu 39 ndi ana 42 omwe amatenga ma AED adapatsidwanso CBD ngati Epidiolex. Mlingo wa CBD udakulitsidwa milungu iwiri iliyonse.

Ochita kafukufuku adayang'anitsitsa ma seramu a AEDs m'maphunziro pakapita nthawi. Ngakhale kuchuluka kwa seramu kumakhalabe munjira yovomerezeka ya ambiri a iwo, mankhwala awiri - clobazam ndi desmethylclobazam - anali ndi ma seramu kunja kwa njira zochiritsira.

Kafukufuku woyambirira akuwonetsa kuti CBD imatha kusokonekera ndimankhwala m'dongosolo lanu, ngakhale mutamwa mlingo woyenera. Koma kafukufuku amafunika kuti azindikire kuopsa kwa kulumikizana kwa CBD pamankhwala osiyanasiyana ndikupanga malingaliro oyenera kuwatenga limodzi ndi CBD.

Chitetezo ndi zotsatirapo

Mothandizidwa ndi dokotala wanu, mutha kugwiritsabe ntchito CBD ndi mankhwala, ngakhale omwe ali ndi chenjezo la mphesa.

Ngati ndi kotheka, dokotala wanu amatha kuwunika ma seramu am'magazi omwe mumamwa. Akhozanso kusankha kuwunika momwe chiwindi chanu chikuyendera.

Ngati mukumwa CBD ndi mankhwala, ndikofunikira kuti muzisamala ndi zomwe zingasinthe momwe mankhwala kapena CBD amakukhudzirani.

Zotsatira zoyipa zomwe muyenera kuyang'anira

• kuchuluka kapena zovuta zina zamankhwala, monga:
  • Kusinza
  • kukhalitsa
  • nseru
• kuchepa kwa mankhwala othandiza, monga:
  • kugwidwa kwakukulu
• Zotsatira zoyipa za CBD kapena kusintha kwa iwo, monga:
  • kutopa
  • kutsegula m'mimba
  • kusintha kwa njala
  • kusintha kwa kulemera

Lankhulani ndi dokotala wanu

Chofunika ndikuti nthawi zonse muzifunsa dokotala ngati mukufuna kuyesa CBD, makamaka ngati muli ndi thanzi labwino komanso mukumwa mankhwala. Osasiya kumwa mankhwala anu kuti muyesere CBD, pokhapokha mutakhala ndi zomwe mumachita kuchokera kwa dokotala wanu.

Mankhwala omwe amabwera ndi chenjezo la mphesa atha kulumikizana ndi CBD. Komabe, ngakhale mutatenga imodzi mwa mankhwalawa, adokotala atha kupanga pulani yomwe ingakuthandizeni poyang'anitsitsa magawo amankhwala m'dongosolo lanu. Mwanjira imeneyi, mutha kugwiritsa ntchito mankhwala anu komanso CBD ngati mankhwala.

Dokotala wanu kapena wamankhwala atha kulangizanso mankhwala abwino a CBD ogwirizana ndi zosowa zanu. Muthanso kupeza zinthu zodziwika bwino mukamafufuza pang'ono komanso momwe mungawerengere zolemba za CBD.

Kodi CBD Ndi Yovomerezeka? Zogulitsa za CBD zopangidwa ndi hemp (zosakwana 0,3% THC) ndizovomerezeka pamilandu yaboma, komabe ndizosaloledwa ndi malamulo ena aboma. Zogulitsa za CBD zosuta chamba ndizosaloledwa pamilandu yaboma, koma ndizovomerezeka pamalamulo ena aboma.Onani malamulo amchigawo chanu komanso a kulikonse komwe mungapite. Kumbukirani kuti zinthu zomwe sizinalembedwe za CBD sizovomerezeka ndi FDA, ndipo zitha kulembedwa molondola.

A Jennifer Chesak ndi mtolankhani wa zamankhwala pazofalitsa zingapo zadziko, wophunzitsa kulemba, komanso mkonzi wa mabuku wodziyimira pawokha. Anamupatsa Master of Science mu utolankhani kuchokera ku Northwestern's Medill. Alinso mkonzi woyang'anira magazini yolemba, Shift. Jennifer amakhala ku Nashville koma akuchokera ku North Dakota, ndipo pamene sakulemba kapena kumata mphuno m'buku, nthawi zambiri amayendetsa misewu kapena kuyenda ndi dimba lake. Tsatirani iye pa Instagram kapena Twitter.