Kodi ma cell a dendritic ndi chiyani ndipo ndiotani

Zamkati

• Zomwe zili zofunika
• Mitundu yama cell dendritic
• Momwe angathandizire kuchiza khansa

Maselo opatsirana, kapena DC, ndi maselo omwe amapangidwa m'mafupa omwe amapezeka m'magazi, pakhungu komanso m'mimba ndi m'mapepala opumira, mwachitsanzo, omwe ndi gawo la chitetezo cha mthupi, omwe ali ndi udindo wodziwa matendawa ndikupanga chitetezo cha mthupi yankho.

Chifukwa chake, chitetezo chamthupi chikakhala pachiwopsezo, maselowa amakhala akugwira ntchito kuti azindikire omwe akupatsiranawo ndikulimbikitsa kuwachotsa. Chifukwa chake, ngati ma cell a dendritic sakugwira ntchito bwino, chitetezo chamthupi chimakhala ndi zovuta zambiri poteteza thupi, chimakhala ndi mwayi waukulu wopeza matenda kapena khansa.

Zomwe zili zofunika

Maselo opatsirana ali ndi udindo wolanda tizilombo toyambitsa matenda ndikuwonetsa ma antigen, omwe amapezeka pamwamba pake, a T lymphocyte, kuyambitsa chitetezo cha mthupi motsutsana ndi wothandizirayo, kumenya matendawa.

Chifukwa choti amalanda ndikupereka ma antigen pamtunda wawo, omwe ndi mbali ya opatsirana, ma cell a dendritic amatchedwa Antigen-Presenting Cells, kapena APCs.

Kuphatikiza pakulimbikitsa kuyankha koyamba kwa chitetezo cha mthupi motsutsana ndi wothandizirayo komanso kutsimikizira chitetezo chamatenda, maselo opunduka ndi ofunikira pakukula kwa chitetezo chokwanira, chomwe ndi chomwe chimapangitsa kuti ma cell kukumbukira azipangika, kuti zisadzachitikenso kapena modekha .kutenga kachilombo ndi thupi lomwelo.

Mvetsetsani momwe chitetezo chamthupi chimagwirira ntchito.

Mitundu yama cell dendritic

Maselo operewera amatha kugawidwa molingana ndi momwe amasamukira, mawonekedwe amawu pamwamba, malo ndi magwiridwe antchito. Chifukwa chake, ma cell a dendritic amatha kugawa m'magulu awiri:

• Maselo opangira ma Plasmocytoid, zomwe zimapezeka makamaka m'magazi ndi ziwalo zam'mimba, monga ndulu, thymus, mafupa ndi ma lymph node, mwachitsanzo. Maselowa amachita makamaka motsutsana ndi ma virus ndipo, chifukwa chakutha kwawo kupanga Interferon alpha ndi beta, omwe ndi mapuloteni omwe amayang'anira chitetezo cha mthupi, amakhalanso ndi anti-chotupa nthawi zina, kuwonjezera pa mphamvu yoletsa ma virus.
• Maselo a Myeloid dendritic, zomwe zimapezeka pakhungu, magazi ndi mucosa. Maselo omwe amapezeka m'magazi amatchedwa yotupa DC, yomwe imatulutsa TNF-alpha, yomwe ndi mtundu wa cytokine womwe umayambitsa kufa kwa zotupa ndi zotupa. Minyamayo, maselowa amatha kutchedwa kuti interstitial kapena mucosal DC ndipo, akakhala pakhungu, amatchedwa maselo a Langerhans kapena maselo osunthira, popeza atatha kuyambitsa, amasuntha kudzera pakhungu kupita kumalo am'mimba, komwe amapereka ma antigen kwa ma lymphocyte a T.

Chiyambi cha ma dendritic cell chimaphunziridwabe, koma akuti chitha kukhala kuti chimachokera ku mtundu wa lymphoid ndi myeloid. Kuphatikiza apo, pali malingaliro awiri omwe amayesa kufotokoza magwero amaselowa:

1. Ntchito Yogwiritsira Ntchito Pulasitiki, yemwe amawona kuti mitundu yosiyanasiyana yama cell dendritic imayimira magawo osiyanasiyana osasitsa a selo limodzi, ntchito zosiyanasiyana ndizotsatira za komwe akukhalako;
2. Chitsanzo Cha mibadwo Yapadera, yemwe amawona kuti mitundu yosiyanasiyana yama cell a dendritic amachokera m'maselo osiyanasiyana, ndiye chifukwa cha ntchito zosiyanasiyana.

Amakhulupirira kuti malingaliro onsewa ali ndi maziko komanso kuti m'thupi mwake mwina malingaliro awiriwa adzachitika nthawi imodzi.

Momwe angathandizire kuchiza khansa

Chifukwa chofunikira pantchito yoteteza chitetezo cha m'thupi komanso kuthekera kokonza njira zonse zokhudzana ndi chitetezo chamthupi, kafukufuku wachitika ndi cholinga chotsimikizira kuti ndi othandiza pantchito yothana ndi khansa, makamaka ngati katemera.

Mu labotale, ma cell a dendritic amayikidwa molumikizana ndi zitsanzo za chotupacho ndipo kuthekera kwawo kuthana ndi maselo a khansa kumatsimikiziridwa. Ngati zapezeka kuti zotsatira za mayeso pazoyesera ndi nyama ndizothandiza, ndizotheka kuti mayeso a katemera wa khansa wokhala ndi ma cell a dendritic atha kupezeka kwa anthu. Ngakhale kulonjeza, maphunziro enanso amafunika pakukula kwa katemerayu, komanso mtundu wa khansa yomwe katemerayu angalimbane nayo.

Kuphatikiza pa kugwiritsidwa ntchito polimbana ndi khansa, kugwiritsa ntchito maselo a dendritic kwawerengedwanso pochiza Edzi ndi systemic sporotrichosis, omwe ndi matenda akulu ndipo amachititsa kuchepa kwa chitetezo cha mthupi. Nazi njira zina zowonjezera ndi kulimbitsa chitetezo chanu cha mthupi.