Upangiri Wosavuta ku Endocannabinoid System

Zamkati

• Zimagwira bwanji?
• Mapeto
• Mapuloteni a Endocannabinoid
• Mavitamini
• Ntchito zake ndi ziti?
• Kodi THC imagwirizana bwanji ndi ECS?
• Kodi CBD imagwirizana bwanji ndi ECS?
• Nanga bwanji kusowa kwa endocannabinoid?
• Mfundo yofunika

Endocannabinoid system (ECS) ndi makina ovuta kuwonetsa ma cell omwe amadziwika koyambirira kwa zaka za m'ma 1990 ndi ofufuza omwe akuyang'ana THC, odziwika bwino cannabinoid. Cannabinoids ndi mankhwala omwe amapezeka mu cannabis.

Akatswiri akuyesetsabe kumvetsetsa za ECS. Koma pakadali pano, tikudziwa kuti imathandizira pakuwongolera ntchito zosiyanasiyana, kuphatikizapo:

• tulo
• maganizo
• njala
• kukumbukira
• kubereka ndi kubereka

ECS ilipo ndipo ikugwira ntchito m'thupi lanu ngakhale simugwiritsa ntchito mankhwala osokoneza bongo.

Pemphani kuti mudziwe zambiri za ECS kuphatikiza momwe imagwirira ntchito komanso yolumikizana ndi cannabis.

Zimagwira bwanji?

ECS imakhudza zinthu zitatu zofunika kwambiri: endocannabinoids, receptors, ndi michere.

Mapeto

Endocannabinoids, yotchedwanso zamkati cannabinoids, ndi mamolekyu opangidwa ndi thupi lanu. Amakhala ofanana ndi ma cannabinoids, koma amapangidwa ndi thupi lanu.

Akatswiri apeza ma endocannabinoids awiri mpaka pano:

• anandamide (AEA)
• 2-arachidonoylglyerol (2-AG)

Izi zimathandizira kuti ntchito zamkati ziziyenda bwino. Thupi lanu limazipanga momwe zingafunikire, zomwe zimapangitsa kuti zikhale zovuta kudziwa magawo omwe ali aliyense.

Mapuloteni a Endocannabinoid

Ma receptors awa amapezeka mthupi lanu lonse. Endocannabinoids amamangirira kwa iwo kuti asonyeze kuti ECS ikuyenera kuchitapo kanthu.

Pali mitundu iwiri yayikulu ya endocannabinoid receptors:

• Ma CB1 receptors, omwe amapezeka kwambiri mkati mwa dongosolo lamanjenje
• Ma CB2 receptors, omwe amapezeka kwambiri mumanjenje am'mitsempha yanu, makamaka ma cell a chitetezo

Endocannabinoids imatha kumangiriza kulandila lililonse. Zotsatira zomwe zimakhalapo zimadalira komwe cholandirira chili komanso kuti ndi endocannabinoid yomwe imamangiriza.

Mwachitsanzo, endocannabinoids itha kuloza ma CB1 receptors mumitsempha ya msana kuti athetse ululu. Ena amatha kumangirira kulandila kwa CB2 m'maselo anu oteteza thupi kuti awonetse kuti thupi lanu likukumana ndi zotupa, chizindikiro chodziwika chazovuta zama auto.

Mavitamini

Ma enzyme ali ndi udindo wowononga ma endocannabinoids akangomaliza kugwira ntchito.

Pali michere iwiri yayikulu yomwe imayambitsa izi:

• mafuta acid amide hydrolase, omwe amawononga AEA
• monoacylglycerol acid lipase, yomwe imaphwanya 2-AG

Ntchito zake ndi ziti?

ECS ndi yovuta, ndipo akatswiri sanadziwebe momwe imagwirira ntchito kapena zonse zomwe zingagwire ntchito.

walumikiza ECS ndi njira izi:

• njala ndi chimbudzi
• kagayidwe
• kupweteka kosalekeza
• kutupa ndi mayankho ena amthupi
• maganizo
• kuphunzira ndi kukumbukira
• kuyendetsa galimoto
• tulo
• mtima dongosolo ntchito
• kupanga minofu
• kukonzanso mafupa ndi kukula
• chiwindi chimagwira
• ziwalo zoberekera zimagwirira ntchito
• nkhawa
• ntchito ya khungu ndi mitsempha

Ntchito zonsezi zimathandizira homeostasis, zomwe zikutanthauza kukhazikika kwanuko. Mwachitsanzo, ngati mphamvu yakunja, monga ululu wovulala kapena malungo, itaya homeostasis ya thupi lanu, ECS yanu imalowerera kuti muthandizire thupi lanu kubwerera kuntchito yake yabwino.

Lero, akatswiri amakhulupirira kuti kusunga homeostasis ngati gawo lalikulu la ECS.

Kodi THC imagwirizana bwanji ndi ECS?

Tetrahydrocannabinol (THC) ndi imodzi mwazinthu zazikuluzikulu zomwe zimapezeka mu cannabis. Ndi kampani yomwe imakupangitsani "kukwera."

Kamodzi mthupi lanu, THC imalumikizana ndi ECS yanu pomangiriza kuma receptors, monga endocannabinoids. Ndi yamphamvu mwina chifukwa imatha kumangiriza onse CB1 ndi CB2 zolandilira.

Izi zimalola kukhala ndi zotsatira zingapo mthupi lanu ndi malingaliro anu, zina zofunika kwambiri kuposa zina. Mwachitsanzo, THC itha kuthandiza kuchepetsa ululu ndikupangitsa kukhala ndi chidwi chofuna kudya. Komanso zimatha kuyambitsa misala komanso nkhawa nthawi zina.

Akatswiri pano akuyang'ana njira zopangira kupanga THC cannabinoids zomwe zimalumikizana ndi ECS m'njira zokhazokha.

Kodi CBD imagwirizana bwanji ndi ECS?

Nthendayi yayikulu yomwe imapezeka mu cannabis ndi cannabidiol (CBD). Mosiyana ndi THC, CBD sichimakupangitsani kukhala "okwera" ndipo samayambitsa zovuta zilizonse.

Akatswiri sadziwa kwenikweni momwe CBD imagwirira ntchito ndi ECS. Koma amadziwa kuti sizimangiriza kwa CB1 kapena CB2 zolandilira momwe THC imathandizira.

M'malo mwake, ambiri amakhulupirira kuti zimagwira ntchito poletsa ma endocannabinoids kuti asawonongeke. Izi zimawathandiza kuti akhale ndi gawo lalikulu m'thupi lanu. Ena amakhulupirira kuti CBD imamangiriza kulandila komwe sikunapezeke.

Pomwe zambiri za momwe zimagwirira ntchito zikutsutsanabe, kafukufuku akuwonetsa kuti CBD imatha kuthandizira kumva kupweteka, kunyansidwa, ndi zizindikilo zina zomwe zimakhudzana ndimikhalidwe yambiri.

Nanga bwanji kusowa kwa endocannabinoid?

Akatswiri ena amakhulupirira chiphunzitso chotchedwa clinical endocannabinoid defence (CECD). Izi zikusonyeza kuti kuchuluka kwa ma endocannabinoid mthupi lanu kapena kusokonekera kwa ECS kumatha kuthandizira kukulitsa zinthu zina.

Kafukufuku wopitilira zaka 10 pamutuwu akuwonetsa kuti chiphunzitsochi chitha kufotokozera chifukwa chomwe anthu ena amayamba kudwala mutu waching'alang'ala, fibromyalgia, komanso matenda opweteka m'mimba.

Palibe chilichonse mwazomwezi chimakhala ndi chifukwa chomveka. Nthawi zambiri amalimbana ndi chithandizo ndipo nthawi zina amachitika limodzi.

Ngati CECD imagwira nawo gawo lililonse pazinthu izi, kuloza ku ECS kapena endocannabinoid yopanga ikhoza kukhala njira yosowa kuchipatala, koma kafukufuku wina amafunika.

Mfundo yofunika

ECS imagwira ntchito yayikulu pakusungitsa dongosolo lanu lamkati lokhazikika. Koma pali zambiri zomwe sitikudziwa za izi. Akatswiri akamamvetsetsa bwino za ECS, pamapeto pake imatha kukhala ndi chinsinsi chochizira matenda angapo.