Zosangalatsa

Zamkati

• Nchiyani chimayambitsa gigantism?
• Kuzindikira zizindikiro za gigantism
• Kodi gigantism imapezeka bwanji?
• Kodi gigantism imathandizidwa bwanji?
• Opaleshoni
• Mankhwala
• Kutulutsa mpeni wa Gamma
• Kuwona kwakutali kwa ana omwe ali ndi gigantism

Kodi Gigantism ndi chiyani?

Gigantism ndichikhalidwe chosowa chomwe chimayambitsa kukula kosazolowereka kwa ana. Kusintha uku ndikofunika kwambiri potengera kutalika, koma girth imakhudzidwanso. Zimachitika pamene khungu la mwana wanu limapanga mahomoni ochulukirapo, omwe amadziwika kuti somatotropin.

Kuzindikira msanga ndikofunikira. Chithandizo chofulumira chitha kuletsa kapena kuchepetsa kusintha komwe kumapangitsa mwana wanu kukula kuposa masiku onse. Komabe, vutoli limakhala lovuta kwa makolo kuzindikira. Zizindikiro za gigantism zitha kuwoneka ngati kukula koyenera kwaubwana poyamba.

Nchiyani chimayambitsa gigantism?

Chotupa cha pituitary gland nthawi zambiri chimayambitsa gigantism. Chithokomiro chotchedwa pituitary gland chili kumapeto kwa ubongo wanu. Zimapanga mahomoni omwe amayang'anira ntchito zambiri mthupi lanu. Ntchito zina zoyendetsedwa ndi gland ndi monga:

• kutentha kutentha
• chitukuko cha kugonana
• kukula
• kagayidwe
• Kupanga mkodzo

Chotupa chikamakula pamatumbo, chotupacho chimapanga mahomoni okula kwambiri kuposa omwe thupi limafunikira.

Pali zifukwa zina zochepa zomwe zimapangitsa gigantism:

• Matenda a McCune-Albright amachititsa kukula kwachilendo m'mafupa, zigamba za khungu lofiirira, komanso zovuta zina.
• Carney complex ndi mkhalidwe wobadwa nawo womwe umayambitsa zotupa zopanda khansa pamatumba olumikizana, zotupa za khansa kapena zopanda khansa, komanso mawanga akhungu lakuda.
• Multiple endocrine neoplasia mtundu 1 (MEN1) ndimatenda obadwa nawo omwe amayambitsa zotupa m'matumbo a pituitary, kapamba, kapena mafinya am'mimba.
• Neurofibromatosis ndi vuto lobadwa nalo lomwe limayambitsa zotupa mumanjenje.

Kuzindikira zizindikiro za gigantism

Ngati mwana wanu ali ndi gigantism, mutha kuzindikira kuti ndi okulirapo kuposa ana ena amsinkhu womwewo. Komanso, ziwalo zina za thupi lawo zimatha kukhala zazikulu molingana ndi ziwalo zina. Zizindikiro zodziwika ndizo:

• manja ndi mapazi akulu kwambiri
• zala zakuda ndi zala
• nsagwada ndi mphumi zotchuka
• nkhope yakutsogolo

Ana omwe ali ndi gigantism amathanso kukhala ndi mphuno zakuthwa ndi mitu yayikulu, milomo, kapena malirime.

Zizindikiro zomwe mwana wanu ali nazo zimadalira kukula kwa chotupa cha pituitary. Chotupacho chikamakula, chimatha kupanikiza misempha muubongo. Anthu ambiri amadwala mutu, amakhala ndi vuto la masomphenya, kapenanso kunyansidwa ndi zotupa m'derali. Zizindikiro zina za gigantism zitha kuphatikiza:

• thukuta kwambiri
• kupweteka kwambiri kapena mobwerezabwereza
• kufooka
• kusowa tulo ndi mavuto ena ogona
• kuchedwa kutha msinkhu mwa anyamata ndi atsikana
• msambo wosakhazikika mwa atsikana
• ugonthi

Kodi gigantism imapezeka bwanji?

Ngati dokotala wa mwana wanu akukayikira kuti ndi gigantism, atha kulimbikitsa magazi kuyeza kuchuluka kwa mahomoni okula komanso kukula kwa insulin ngati kukula 1 (IGF-1), yomwe ndi mahomoni opangidwa ndi chiwindi. Dokotala angalimbikitsenso mayeso okakamira kuloza shuga.

Mukamayesa kulolerana ndi shuga m'kamwa, mwana wanu amamwa chakumwa chapadera chomwe chili ndi shuga, mtundu wa shuga. Zitsanzo zamagazi zidzatengedwa mwana wanu asanamwe komanso atamwa.

Thupi labwinobwino, kuchuluka kwa mahomoni okutha kukula kumatsika mutadya kapena kumwa shuga. Ngati magawo a mwana wanu amakhalabe ofanana, zikutanthauza kuti thupi lawo limapanga mahomoni okula kwambiri.

Ngati kuyezetsa magazi kukuwonetsa gigantism, mwana wanu adzafunika kuyesedwa ndi MRI ya pituitary gland. Madokotala amagwiritsa ntchito sikani iyi kuti apeze chotupacho ndikuwona kukula kwake ndi malo ake.

Kodi gigantism imathandizidwa bwanji?

Chithandizo cha gigantism cholinga chake ndi kuyimitsa kapena kuchepetsa kupangitsa kwa mwana wanu mahomoni okula.

Opaleshoni

Kuchotsa chotupacho ndiye chithandizo chamankhwala cha gigantism ngati ndichomwe chimayambitsa.

Dokotalayo adzafika pa chotupacho popanga mphuno ya mwana wanu. Ma microscopes kapena makamera ang'onoang'ono atha kugwiritsidwa ntchito kuthandiza dotoloyo kuwona chotupacho. Nthaŵi zambiri, mwana wanu ayenera kubwerera kunyumba kuchokera kuchipatala tsiku lotsatira opaleshoni.

Mankhwala

Nthawi zina, kuchitidwa opaleshoni sikungakhale kosankha. Mwachitsanzo, ngati pali chiopsezo chachikulu chovulala pamitsempha yamagazi yovuta kapena mitsempha.

Dokotala wa mwana wanu angakulimbikitseni mankhwala ngati kuchitidwa opaleshoni sikungakhale kotheka. Mankhwalawa amatanthauza kuti amachepetsa chotupacho kapena kusiya kupanga mahomoni ochulukirapo.

Dokotala wanu amatha kugwiritsa ntchito mankhwala octreotide kapena lanreotide kuti ateteze kutulutsa kwa hormone yakukula. Mankhwalawa amatsanzira mahomoni ena omwe amalepheretsa kukula kwa mahomoni. Nthawi zambiri amapatsidwa ngati jakisoni kamodzi pa mwezi.

Bromocriptine ndi cabergoline ndi mankhwala omwe angagwiritsidwe ntchito kutsitsa kukula kwa mahomoni. Izi zimaperekedwa mumapiritsi. Zitha kugwiritsidwa ntchito ndi octreotide. Octreotide ndi mahomoni opangira omwe, akajambulidwa, amathanso kutsitsa kuchuluka kwa mahomoni okula ndi IGF-1.

Nthawi zomwe mankhwalawa sathandiza, kuwombera tsiku ndi tsiku kwa pegvisomant kungagwiritsidwenso ntchito. Pegvisomant ndi mankhwala omwe amaletsa zovuta zakukula kwa mahomoni. Izi zimatsitsa milingo ya IGF-1 mthupi la mwana wanu.

Kutulutsa mpeni wa Gamma

Ma radiosurgery a mpeni wa Gamma ndi njira yabwino ngati dokotala wa mwana wanu akukhulupirira kuti opaleshoni yachikhalidwe sichingatheke.

“Gamma mpeni” ndi mndandanda wa matabwa oyang'ana kwambiri ma radiation. Mitengoyi siipweteketsa minofu yoyandikana nayo, koma imatha kupereka mphamvu yayikulu pama radiation pomwe imaphatikizana ndikumenya chotupacho. Mlingo uwu ndi wokwanira kuwononga chotupacho.

Chithandizo cha mpeni wa Gamma chimatenga miyezi mpaka zaka kuti chizigwira bwino ntchito ndikubwezeretsa kukula kwa mahomoni okula bwino. Zimachitidwa mwachipatala mwachisawawa.

Komabe, popeza cheza cha opaleshoni yamtunduwu chalumikizidwa ndi kunenepa kwambiri, kulephera kuphunzira, komanso mavuto am'maganizo mwa ana, amagwiritsidwa ntchito pokhapokha ngati njira zina zamankhwala sizigwira ntchito.

Kuwona kwakutali kwa ana omwe ali ndi gigantism

Malinga ndi chipatala cha St. Joseph's and Medical Center, 80% ya milandu ya gigantism yoyambitsidwa ndi chotupa cha pituitary imachiritsidwa ndikuchitidwa opaleshoni. Ngati chotupacho chibwerera kapena ngati opaleshoni singayesedwe bwino, mankhwala atha kugwiritsidwa ntchito kuchepetsa zizindikiritso za mwana wanu ndikuwalola kuti azikhala ndi moyo wautali komanso wosangalala.