Zomwe Muyenera Kudziwa Zokhudza MTHFR Gene

Zamkati

• Zosintha za MTHFR
• Zizindikiro za kusintha kwa MTHFR
• Kuyesa zosintha za MTHFR
• Chithandizo cha zovuta zokhudzana ndi thanzi
• Zovuta pa mimba
• Zowonjezera zowonjezera
• Malingaliro azakudya
• Kutenga

Timaphatikizapo zinthu zomwe timaganiza kuti ndizothandiza kwa owerenga athu. Ngati mutagula maulalo omwe ali patsamba lino, titha kupeza ndalama zochepa. Nayi njira yathu.

MTHFR ndi chiyani?

Mwinamwake mwawonapo chidule cha "MTHFR" chikupezeka m'nkhani zaposachedwa zaumoyo. Zitha kuwoneka ngati mawu otemberera poyang'ana koyamba, koma kwenikweni amatanthauza kusintha kwamtundu wamba.

MTHFR imayimira methylenetetrahydrofolate reductase. Ikukhala ndi chidwi chifukwa cha kusintha kwa majini komwe kumatha kubweretsa kuchuluka kwa homocysteine ​​m'magazi komanso kuchuluka kwama folate ndi mavitamini ena.

Pakhala pali nkhawa kuti mavuto ena azaumoyo amakhudzana ndi kusintha kwa MTHFR, chifukwa chake kuyezetsa kwakhala kofala kwambiri pazaka zambiri.

Zosintha za MTHFR

Mutha kukhala ndi kusintha kamodzi kapena kawiri - kapena ayi - pa jini la MTHFR. Kusintha kumeneku nthawi zambiri kumatchedwa mitundu. Zosiyanasiyana ndi gawo la DNA ya jini yomwe imakhala yosiyana, kapena yosiyana, kuchokera kwa munthu ndi munthu.

Kukhala ndi mtundu umodzi - heterozygous - sikungathandize pazinthu zathanzi. Anthu ena amakhulupirira kuti kusintha kwa mitundu iwiri - homozygous - kumatha kubweretsa zovuta zazikulu. Pali mitundu iwiri, kapena mitundu, ya kusintha komwe kumatha kuchitika pa jini la MTHFR.

Mitundu yapadera ndi iyi:

• Zamgululi Pafupifupi 30 mpaka 40 peresenti ya anthu aku America atha kusintha masinthidwe amtundu wawo Zamgululi Pafupifupi 25 peresenti ya anthu ochokera ku Puerto Rico, ndipo 10 mpaka 15 peresenti ya mbadwa za ku Caucasus, ndi osangalala chifukwa cha izi.
• Zamgululi Pali kafukufuku wochepa wokhudzana ndi izi. Kafukufuku omwe amapezeka nthawi zambiri amakhala amitundu kapena amitundu. Mwachitsanzo, kafukufuku yemwe adachitika mchaka cha 2004 adalunjika kwa opereka magazi okwanira 120 ochokera ku Ireland. Mwa omwe adapereka, 56, kapena 46.7%, anali heterozygous pazosiyanazi, ndipo 11, kapena 14.2 peresenti, anali homozygous.
• Ndikothekanso kupeza zonse kusintha kwa C677T ndi A1298C, yomwe ndi mtundu umodzi wa iliyonse.

Kusintha kwa majini ndikobadwa, zomwe zikutanthauza kuti mumazipeza kuchokera kwa makolo anu. Pamimba, mumalandira mtundu umodzi wa MTHFR kuchokera kwa kholo lililonse. Ngati onse awiri asintha, chiopsezo chanu chokhala ndi kusintha kwa homozygous ndichokwera.

Zizindikiro za kusintha kwa MTHFR

Zizindikiro zimasiyanasiyana munthu ndi munthu komanso kuchokera pamitundu yosiyanasiyana. Ngati mufufuza mwachangu pa intaneti, mutha kupeza masamba ambiri omwe amati MTHFR imayambitsa zovuta zingapo.

Kumbukirani kuti kafukufuku wozungulira MTHFR ndi zotsatira zake akadasinthabe. Umboni wolumikiza zambiri zathanzi ili ndi MTHFR pakadali pano ukusowa kapena sanatsutsidwe.

Zowonjezera, pokhapokha mutakhala ndi mavuto kapena kuyezetsa, simudzazindikira za kusintha kwanu kwa MTHFR.

Zinthu zomwe akuti akuphatikizidwa ndi MTHFR ndi monga:

• matenda amtima ndi thromboembolic (makamaka magazi kuundana, sitiroko, embolism, ndi matenda amtima)
• kukhumudwa
• nkhawa
• matenda ochititsa munthu kusinthasintha zochitika
• schizophrenia
• khansa ya m'matumbo
• khansa ya m'magazi
• kupweteka kosalekeza komanso kutopa
• kupweteka kwa mitsempha
• mutu waching'alang'ala
• kusokonekera kwa amayi omwe ali ndi zaka zambiri
• kutenga pakati ndi zotupa za neural tube, monga msana bifida ndi anencephaly

Phunzirani zambiri za kukhala ndi pakati ndi MTHFR.

Chiwopsezo chimatha kuwonjezeka ngati munthu ali ndi mitundu iwiri yamtundu wamtundu kapena ali ndi vuto losintha MTHFR.

Kuyesa zosintha za MTHFR

Mabungwe osiyanasiyana azaumoyo - kuphatikiza American College of Obstetricians and Gynecologists, College of American Pathologists, American College of Medical Genetics, ndi American Heart Association - samalimbikitsa kuyesedwa kwa mitundu kusiyanasiyana pokhapokha ngati munthu ali ndi milingo yayikulu kwambiri ya homocysteine ​​kapena zisonyezo zina zathanzi.

Komabe, mutha kukhala ndi chidwi chofuna kudziwa momwe mulili MTHFR. Ganizirani zopita kukaonana ndi dokotala kuti mukambirane za ubwino ndi kuipa kwa kuyesedwa.

Kumbukirani kuti kuyesa kwa majini sikungapezeke ndi inshuwaransi yanu. Itanani wonyamulira wanu ngati mukuganiza zokayezetsa kuti mufunse za mtengo.

Makina ena oyesera majini kunyumba amayang'aniranso MTHFR. Zitsanzo ndi izi:

• 23andMe ndichisankho chodziwika bwino chomwe chimapereka chidziwitso chakubadwa ndi zidziwitso zaumoyo. Imakhalanso yotsika mtengo ($ 200). Kuti muchite izi, mumayika malovu mu chubu ndikuzitumiza kudzera ku labu. Zotsatira zimatenga milungu isanu ndi umodzi kapena isanu ndi itatu.
• Kunyumba kwanga MTHFR ($ 150) ndi njira ina yomwe imangoyang'ana pakusintha. Kuyesaku kumachitika potola DNA kuchokera mkati mwa tsaya lanu ndi swabs. Mukatumiza chitsanzocho, zotsatira zimatenga sabata imodzi kapena ziwiri.

Chithandizo cha zovuta zokhudzana ndi thanzi

Kukhala ndi mtundu wa MTHFR sikutanthauza kuti mukufunika chithandizo chamankhwala. Zitha kungotanthauza kuti muyenera kutenga vitamini B chowonjezera.

Chithandizochi chimafunika mukakhala ndi milingo yayikulu kwambiri ya homocysteine, pafupifupi nthawi zonse pamlingo wokhudzana ndi mitundu yambiri ya MTHFR. Dokotala wanu ayenera kufotokoza zina zomwe zingayambitse homocysteine, yomwe ingachitike kapena popanda mitundu ya MTHFR.

Zoyambitsa zina za homocysteine ​​ndizo:

• hypothyroidism
• matenda monga matenda ashuga, cholesterol, komanso kuthamanga kwa magazi
• kunenepa kwambiri komanso kusagwira ntchito
• mankhwala ena, monga atorvastatin, fenofibrate, methotrexate, ndi nicotinic acid

Kuchokera pamenepo, chithandizocho chimadalira chifukwa chake ndipo sizitengera MTHFR. Kupatula apo ndi pamene mwapezeka kuti muli ndi zinthu zonsezi nthawi imodzi:

• milingo yayikulu ya homocysteine
• kusinthidwa kwa MTHFR
• mavitamini a folate, choline, kapena mavitamini B-12, B-6, kapena riboflavin

Pazochitikazi, adokotala angakupatseni chithandizo chowonjezera kuti athane ndi zofooka pamodzi ndi mankhwala kapena mankhwala kuti athane ndi matendawa.

Anthu omwe ali ndi kusintha kwa MTHFR amathanso kufunafuna njira zodzitetezera kuti achepetse kuchuluka kwa ma homocysteine. Njira imodzi yodzitetezera ndikusintha njira zina, zomwe zingathandize popanda kugwiritsa ntchito mankhwala. Zitsanzo ndi izi:

• kusiya kusuta, ngati mumasuta
• kuchita zolimbitsa thupi zokwanira
• kudya chakudya chopatsa thanzi

Zovuta pa mimba

Zolakwika zaposachedwa ndi zotupa za neural tube zimatha kuphatikizidwa ndi MTHFR. Genetic and Rare Diseases Information Center yati kafukufuku akuwonetsa kuti azimayi omwe ali ndi mitundu iwiri ya C677T ali pachiwopsezo chowonjezeka chokhala ndi mwana yemwe ali ndi vuto la neural tube.

Kafukufuku wa 2006 adayang'ana amayi omwe ali ndi mbiri yakusokonekera komwe kumabweranso. Zinapeza kuti 59 peresenti ya iwo anali ndi mitundu ingapo ya ma homozygous gene, kuphatikiza MTHFR, yokhudzana ndi kuphwanya magazi, motsutsana ndi 10% yokha ya azimayi omwe ali mgululi.

Lankhulani ndi dokotala wanu za kuyezetsa ngati zinthu izi zikukukhudzani:

• Mwakumana ndi zotayidwa zingapo zosamveka.
• Wakhala ndi mwana yemwe ali ndi vuto la neural tube.
• Mukudziwa kuti muli ndi kusintha kwa MTHFR, ndipo muli ndi pakati.

Ngakhale pali umboni wocheperako, madokotala ena amalimbikitsa kumwa mankhwala ozunguza magazi. Zowonjezeranso za folate zitha kulimbikitsidwanso.

Zowonjezera zowonjezera

Kusintha kwa majini a MTHFR kumalepheretsa momwe thupi limagwirira ntchito folic acid ndi mavitamini ena ofunika a B. Kusintha kuchirikiza kwa michere imeneyi ndikofunikira kuthana ndi zovuta zake.

Folic acid kwenikweni ndi mtundu wopangidwa ndi anthu, chopatsa thanzi mwachilengedwe chomwe chimapezeka mu zakudya. Kutenga mtundu wosawoneka bwino wa folate - methylated folate - zitha kuthandizira thupi lanu kuyamwa mosavuta.

Anthu ambiri amalimbikitsidwa kumwa ma multivitamin omwe amakhala osachepera 0,4 milligrams a folic acid tsiku lililonse.

Amayi oyembekezera samalimbikitsidwa kusintha mavitamini asanabadwe kapena chisamaliro potengera momwe alili MTHFR okha. Izi zikutanthauza kutenga mlingo wokhazikika wa mamiligalamu 0,6 a folic acid tsiku lililonse.

Amayi omwe ali ndi mbiri yolemala ya neural tube amayenera kulankhula ndi dokotala kuti awalangize.

Mavitamini ambiri okhala ndi methylated folate ndi awa:

• Thorne Basic Zakudya 2 / Tsiku
• Mathalauza Anzeru Wamkulu Wokwanira
• Mavitamini Amayi Amayi Wobereka

Lankhulani ndi dokotala musanasinthe mavitamini ndi zowonjezera. Ena atha kusokoneza mankhwala ena kapena mankhwala omwe mukulandira.

Dokotala wanu angathenso kupereka mavitamini a mankhwala omwe ali ndi folate ndi folic acid. Kutengera ndi inshuwaransi yanu, mitengo yazosankhazi imatha kusiyanasiyana poyerekeza ndi mitundu yotsatsa.

Malingaliro azakudya

Kudya zakudya zokhala ndi thanzi labwino kumatha kuthandiza mwachilengedwe mavitamini ofunikirawa. Komabe, kuwonjezera kungakhale kofunikira.

Zakudya zabwino ndi monga:

• mapuloteni monga nyemba zophika, nandolo, ndi mphodza
• nkhumba monga sipinachi, katsitsumzukwa, letesi, beets, broccoli, chimanga, ziphuphu za Brussels, ndi bok choy
• zipatso monga cantaloupe, uchi, nthochi, rasipiberi, manyumwa, ndi strawberries
• timadziti monga lalanje, chinanazi cha m'zitini, manyumwa, phwetekere, kapena madzi ena a masamba
• chiponde
• mbewu za mpendadzuwa

Anthu omwe ali ndi kusintha kwa MTHFR angafune kupewa zakudya zomwe zimakhala ndi mtundu wa folate, folic acid - ngakhale umboniwo sukuwonekeratu kuti ndiwofunikira kapena wopindulitsa.

Onetsetsani kuti mwayang'ana zolemba, popeza vitamini iyi imawonjezeredwa m'minda yambiri yolemera, monga pasitala, chimanga, buledi, ndi ufa wopangidwa ndi malonda.

Phunzirani zambiri za kusiyana pakati pa folate ndi folic acid.

Kutenga

Udindo wanu wa MTHFR mwina ungakhudze thanzi lanu. Kafufuzidwe kafukufuku amafunika kuti adziwe zomwe zingachitike, ngati zilipo, zogwirizana ndi mitundu yosiyanasiyana.

Apanso, mabungwe ambiri olemekezeka azachipatala samalimbikitsa kuyesa kusinthaku, makamaka popanda zisonyezo zina zamankhwala. Lankhulani ndi dokotala wanu za maubwino ndi zoopsa zoyesedwa, komanso zovuta zina zomwe mungakhale nazo.

Pitirizani kudya bwino, kuchita masewera olimbitsa thupi, ndikuchita zizolowezi zina kuti mukhale ndi thanzi labwino.