Orencia (wopha nyama)

Zamkati

• Orencia ndi chiyani?
• Kuchita bwino
• Orencia generic
• Zotsatira za Orencia
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Zotsatira zoyipa
• Mlingo wa Orencia
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa nyamakazi ya nyamakazi
• Mlingo wa nyamakazi ya psoriatic
• Mlingo wa matenda a nyamakazi a achinyamata
• Mlingo wa ana
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Orencia amagwiritsa ntchito
• Orencia ya nyamakazi ya nyamakazi
• Orencia yamatenda a psoriatic
• Orencia ya matenda a nyamakazi a achinyamata
• Orencia pazinthu zina
• Orencia kwa ana
• Orencia ntchito ndi mankhwala ena
• Orencia ndi mankhwala ena a nyamakazi
• Orencia ndi mankhwala ena a ana idiopathic nyamakazi
• Njira zina zopangira Orencia
• Njira zina zamatenda a nyamakazi
• Njira zina zamatenda a psoriatic
• Njira zina zamankhwala zamatsenga za ana
• Orencia vs. Humira
• Zonse
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Orencia vs. Enbrel
• Zonse
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Orencia ndi mowa
• Kuyanjana kwa Orencia
• Orencia ndi mankhwala ena
• Orencia ndi zitsamba ndi zowonjezera
• Momwe Orencia amagwirira ntchito
• Kodi matenda omwe amadzimadzimadzimadzimodzi ndi ati?
• Kodi Orencia amatani?
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Orencia ndi mimba
• Orencia ndi kulera
• Orencia ndi kuyamwitsa
• Mtengo wa Orencia
• Thandizo lazachuma komanso inshuwaransi
• Momwe mungatengere Orencia
• Orencia mwa kulowetsedwa mkati
• Orencia anatengedwa ndi subcutaneous jakisoni
• Nthawi yoti mutenge
• Mafunso wamba okhudza Orencia
• Kodi ndingatenge Orencia ngati ndili ndi COPD?
• Kodi ndingapeze katemera ndikugwiritsa ntchito Orencia?
• Ngati nditha kutenga matenda ndikamagwiritsa ntchito Orencia, nditha kumwa maantibayotiki?
• Kodi ndingamutengere Orencia kunyumba?
• Kodi ndingagwiritse ntchito Orencia ngati ndili ndi matenda ashuga?
• Kodi Orencia angathandize kutaya tsitsi?
• Kodi ndingayende ngati ndikumwa Orencia?
• Kodi ndikufunika chilolezo choyambirira kuti ndipeze Orencia?
• Njira zotetezera ku Orencia
• Orencia bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Kutha kwa Orencia, kusunga, ndi kutaya
• Yosungirako
• Kutaya
• Zambiri zamaphunziro a Orencia
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Orencia ndi chiyani?

Orencia ndi mankhwala omwe amamwa mankhwala omwe amagwiritsidwa ntchito pochiza izi:

• Matenda a nyamakazi (RA). Orencia imavomerezedwa kuti igwiritsidwe ntchito kwa achikulire omwe ali ndi RA yochita zolimbitsa thupi. Itha kumwedwa yokha kapena kuphatikiza ndi mankhwala ena omwe amagwiritsidwanso ntchito pochizira RA.
• Matenda a Psoriatic (PsA). Orencia imavomerezedwa kuti igwiritsidwe ntchito kwa akulu omwe ali ndi PsA. Itha kumwedwa yokha kapena kuphatikiza ndi mankhwala ena omwe amagwiritsidwanso ntchito kuchiza PsA.
• Matenda achichepere a nyamakazi (JIA). Orencia imavomerezedwa kuti igwiritsidwe ntchito kwa ana azaka zapakati pa 2 kapena kupitilira apo JIA yochita zolimbitsa thupi. Pachifukwa ichi, Orencia itha kugwiritsidwa ntchito payokha kapena kuphatikiza mankhwala ena otchedwa methotrexate.

Orencia ili ndi mankhwala ophera mankhwala, omwe ndi mankhwala osokoneza bongo. Biologics amapangidwa kuchokera ku maselo amoyo (monga aja ochokera ku zomera kapena nyama) osati ndi mankhwala.

Orencia amabwera m'njira ziwiri: mawonekedwe amadzimadzi ndi mawonekedwe a ufa. Mutha kumwa mankhwalawa mwa njira izi:

• Kulowetsedwa mkati (IV). Maonekedwe a ufa wa Orencia amagwiritsidwa ntchito popanga madzi omwe amalowetsedwa m'mitsempha yanu. Fomu iyi ya Orencia imapezeka mwamphamvu imodzi: 250 milligrams (mg).
• Subcutaneous jakisoni. Maonekedwe a madzi a Orencia amabayidwa pansi pa khungu lanu. Fomu iyi ya Orencia imapezeka mwamphamvu imodzi: mamiligalamu 125 pamamililita (mg / mL).

Kuchita bwino

M'maphunziro azachipatala, Orencia anali othandiza pochiza RA yovuta kwambiri. Atatengedwa pamodzi ndi methotrexate, Orencia adachita bwino kuthana ndi matenda. M'maphunzirowa, ziwerengero za ACR (zotchedwa American College of Rheumatology) zidagwiritsidwa ntchito kuyeza mayankho a anthu kuchipatala. Kukhala ndi mphambu 20 za ACR kumatanthauza kuti zizindikilo za RA za anthu zidasintha ndi 20%.

Mwa anthu omwe amatenga Orencia kuphatikiza methotrexate, 62% adakwanitsa kuchuluka kwa ACR 20 patadutsa miyezi itatu. Mwa anthu omwe amamwa methotrexate ndi placebo (chithandizo chopanda mankhwala osokoneza bongo), 37% adakhala ndi zotsatira zofananira.

Orencia adagwiranso ntchito bwino mwa anthu omwe amatenga Orencia okha, popanda methotrexate. Mwa iwo omwe amatenga Orencia okha, 53% adakwanitsa kufika 20 pa ACR patatha miyezi itatu. Mwa anthu omwe sanalandire chithandizo ndi Orencia kapena methotrexate koma omwe adatenga malowa, 31% adakhala ndi zotsatira zofananira.

Kuti mumve zambiri zantchito ya Orencia pazinthu zina, chonde onani gawo la "Orencia uses" pansipa.

Orencia generic

Orencia imangopezeka ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe a biosimilar.

Mankhwala osokoneza bongo amafanana ndi mankhwala achibadwa. Mankhwala achibadwa ndi mtundu wa mankhwala wamba (omwe amapangidwa ndi mankhwala). Mankhwala osokoneza bongo amapangidwa kuti akhale ofanana ndi mankhwala a biologic (omwe amapangidwa kuchokera ku maselo amoyo).

Onse omwe ali ndi ma generic komanso biosimilars ali ndi chitetezo chofananira komanso ngati mankhwala omwe amapangidwa kuti azitsanzira. Komanso, amakhala otsika mtengo poyerekeza ndi mankhwala osokoneza bongo.

Zotsatira za Orencia

Orencia imatha kuyambitsa zovuta zochepa kapena zoyipa. Mndandanda wotsatira uli ndi zovuta zina zomwe zingachitike mukamamwa Orencia. Mndandandawu mulibe zovuta zonse zomwe zingachitike.

Kuti mumve zambiri paza zotsatira za Orencia, lankhulani ndi dokotala kapena wamankhwala. Amatha kukupatsirani malangizo amomwe mungathetsere mavuto omwe angakhale ovuta.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Orencia zitha kuphatikiza:

• matenda opuma opuma, monga chimfine kapena matenda a sinus
• mutu
• nseru

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Orencia sizodziwika, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa, zomwe zafotokozedwa pansipa mu "Zotsatira zoyipa," zitha kuphatikizira izi:

• matenda akulu, monga chibayo
• kwambiri thupi lawo siligwirizana
• kuyambiranso kwa kachilombo ka hepatitis B (kuwonongeka kwa kachilomboka ngati kuli kale m'thupi lanu)
• khansa

Zotsatira zoyipa

Mutha kudabwa kuti zovuta zina zimachitika kangati ndi mankhwalawa, kapena ngati zovuta zina zake zimakhudza. Nazi zina mwazinthu zingapo zomwe mankhwalawa angapangitse kapena sangayambitse.

Matenda akulu

Mutha kukhala ndi chiopsezo chachikulu chotenga matenda opatsirana mukamamwa Orencia. Izi ndichifukwa choti mankhwalawa amapangitsa chitetezo chanu chamthupi kuti chisakutetezeni ku matenda.

M'maphunziro azachipatala, anthu 54% omwe amatenga Orencia anali ndi matenda. Matendawa amawerengedwa kuti ndi ofunika mwa 3% mwa anthu omwe amatenga Orencia m'maphunziro. Mwa iwo omwe adatenga placebo (mankhwala osagwiritsa ntchito mankhwala), 48% anali ndi matenda. Matendawa amawoneka kuti ndi ovuta mwa anthu 1.9% omwe adatenga malowa. Matenda ofala kwambiri amakhudza mapapu a anthu, khungu, thirakiti, m'matumbo, ndi impso.

Zizindikiro za matenda zimasiyana, kutengera gawo lomwe thupi lanu limakhudzidwa. Zitha kuphatikiza:

• malungo
• kumva kutopa kwambiri
• chifuwa
• zizindikiro ngati chimfine
• malo ofunda, ofiira, kapena opweteka pakhungu lanu

Adziwitseni dokotala ngati muli ndi zizindikilo za matenda. Angakulimbikitseni mayeso ena kuti muwone mtundu wamatenda omwe muli nawo. Ngati kuli kotheka, adzaperekanso mankhwala ochizira matenda anu.

Nthawi zina, zingakhale zovuta kuchiza matenda opatsirana pamene mukumwa Orencia. Ngati muli ndi matenda, dokotala angakulimbikitseni kuti musiye kumwa Orencia mpaka matenda anu atatha.

Komanso, dokotala wanu adzafuna kutsimikiza kuti mulibe matenda a chifuwa chachikulu (TB) musanayambe kumwa Orencia. TB imakhudza mapapu anu, ndipo itha kapena isapangitse zizindikiro. Ngati sizimayambitsa zizindikiro, mwina simudziwa kuti muli ndi matendawa. Kudziwa ngati muli ndi chifuwa chachikulu kumathandiza madokotala kudziwa ngati Orencia ndiotetezeka kuti mugwiritse ntchito.

Matupi awo sagwirizana

Monga momwe zimakhalira ndi mankhwala ambiri, anthu ena amatha kusokonezeka atalandira Orencia. M'maphunziro azachipatala, ochepera 1% mwa anthu omwe amatenga Orencia adakumana ndi zovuta. Zizindikiro za kuchepa pang'ono zimatha kuphatikiza:

• zotupa pakhungu
• kuyabwa
• Kutentha (kutentha ndi kufiira pakhungu lanu)

Zomwe zimayambitsa matendawa zimakhala zochepa koma ndizotheka. Zizindikiro za kuyanjana kwambiri ndi izi:

• kutupa pansi pa khungu lanu, makamaka m'makope anu, milomo, manja, kapena mapazi
• kutupa lilime, pakamwa, kapena pakhosi
• kuvuta kupuma

Itanani dokotala wanu nthawi yomweyo ngati muli ndi vuto lalikulu ku Orencia. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Chiwindi B

Ngati mudakhala ndi kachilombo ka hepatitis B (HBV) m'mbuyomu, mutha kukhala pachiwopsezo chotenga kachilomboka (kuyambiranso) mukamamwa Orencia.

HBV ndi matenda m'chiwindi chanu obwera chifukwa cha kachilombo. Anthu omwe ali ndi HBV nthawi zambiri amamwa mankhwala kuti athetse matendawa. Koma ndizosatheka kuchotsa kachilomboka mthupi lanu.

Orencia itha kupangitsa kuti HBV iphulike mthupi lanu. Izi ndichifukwa choti Orencia amachepetsa mphamvu yama chitetezo amthupi anu kuti athane ndi matendawa. Ngati kachilomboka kayambiranso, zizindikiro zanu za HBV zimatha kubwerera, ndipo matendawo akhoza kukulirakulira.

Zizindikiro za matenda a HBV atha kukhala:

• kutopa (kusowa mphamvu)
• malungo
• kuchepetsa kudya
• kumva kufooka
• kupweteka kwamafundo anu kapena minofu yanu
• kusapeza bwino m'mimba mwanu (m'mimba)
• mkodzo wamtundu wakuda
• jaundice (khungu lanu loyera kapena khungu lanu)

Lolani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro za HBV. Dokotala wanu angafune kukuyesani matenda a hepatitis B musanayambe Orencia. Ngati muli ndi HBV, atenga kachilomboka asanayambe Orencia. Kuchiza HBV kumathandizanso kuti matenda anu azitha.

Khansa

Mutha kukhala ndi chiopsezo chowonjezeka cha khansa mukatenga Orencia. Mankhwalawa amatha kukhudza momwe ma cell anu amagwirira ntchito ndipo amatha kukulira momwe maselo anu amakulira ndikuchulukirachulukira (kupanga maselo ambiri). Izi zimatha kuyambitsa khansa.

M'maphunziro azachipatala, 1.3% ya anthu omwe amatenga Orencia adadwala khansa. Mwa iwo omwe samatenga Orencia, koma omwe adatenga placebo (mankhwala osagwiritsa ntchito mankhwala osokoneza bongo), 1.1% adakhala ndi zotsatira zofananira. Nthawi zambiri, khansara imachitika m'mapapu ndi m'magazi a anthu.

Sizikudziwika ngati khansara idayamba chifukwa chogwiritsa ntchito Orencia. Ndizotheka kuti zinthu zina zidathandizira pakukula kwake.

Zizindikiro za khansa zimatha kusiyanasiyana kutengera dera lomwe lakhudzidwa. Zizindikiro zimaphatikizapo:

• kusintha kwamitsempha (monga kupweteka mutu, kugwidwa, kuwona kapena mavuto akumva, kapena kufooka pankhope panu)
• kutuluka magazi kapena kuphwanya mosavuta kuposa masiku onse
• chifuwa
• kutopa (kusowa mphamvu)
• malungo
• kutupa
• ziphuphu
• kunenepa kapena kuonda

Uzani dokotala wanu ngati muli ndi zizindikiro zilizonse za khansa. Adzakupatsani mayesero ena kuti muwone ngati mwadwala khansa. Ngati muli ndi khansa, amalangiza chithandizo chake. Akambirananso nanu ngati zili zotetezeka kuti mutenge Orencia.

Ziphuphu pakhungu

M'maphunziro azachipatala, zotupa pakhungu sizinali zoyipa kwenikweni kwa anthu omwe amatenga Orencia. Mwa anthu omwe ali ndi RA omwe adatenga Orencia, 4% anali ndi zotupa panthawi yamaphunziro. Mwa iwo omwe adatenga placebo (chithandizo chopanda mankhwala osokoneza bongo), 3% anali ndi zotupa. Kutupa pang'ono pakhungu kumatha kuchitika m'thupi lanu komwe Orencia amabayidwa.

Nthawi zina, kutupa kwa khungu kumatha kukhala chizindikiritso chosagwirizana. (Onani gawo la "Allergic reaction" pamwambapa.)

Ngati muli ndi zotupa pakhungu zomwe sizimatha mukamagwiritsa ntchito Orencia, uzani dokotala wanu. Akambirana nanu pazomwe zingayambitse khungu lanu. Amatha kufunsa ngati muli ndi zizindikilo zakusokonekera. Ngati mukugwidwa ndi vuto linalake, dokotala wanu adzakupatsani mankhwala kuti muchepetse zizindikilo zanu, ndipo mwina atha kusiya Orencia.

Kulemera (osati zotsatira zoyipa)

Pakati pa maphunziro azachipatala, kunenepa sikunali vuto lina mwa anthu omwe amatenga Orencia.

Ngati mukuda nkhawa ndi kunenepa mukamagwiritsa ntchito Orencia, lankhulani ndi dokotala wanu.

Kutaya tsitsi (osati zotsatira zoyipa)

M'maphunziro azachipatala, kutayika kwa tsitsi sikunali mbali yovuta mwa anthu omwe amatenga Orencia. Koma tsitsi limatha kupezeka mwa anthu omwe ali ndi mitundu ina ya nyamakazi, kuphatikiza omwe Orencia angagwiritsidwe ntchito pochiza.

Adziwitseni dokotala ngati mukudandaula za kutayika kwa tsitsi, kapena ngati muli ndi tsitsi lomwe mukugwiritsa ntchito Orencia. Angalimbikitse mayeso kuti ayesere kudziwa chifukwa chake zikuchitika ndikupatseni njira zokuthandizani kuthana ndi zotsatirapo zake.

Kutopa (osati zotsatira zoyipa)

Kutopa (kusowa kwa mphamvu) sizinali zoyipa mwa anthu omwe amatenga Orencia panthawi yamaphunziro azachipatala. Koma anthu ena omwe ali ndi matenda a nyamakazi osiyanasiyana (monga omwe Orencia amagwiritsidwa ntchito pochizira) amatha kutopa.

Uzani dokotala wanu ngati muli ndi kutopa komwe sikumatha mukamagwiritsa ntchito Orencia. Iwo akulangizani mayesero ena kuti akuthandizeni kudziwa chomwe chimayambitsa kutopa kwanu. Ngati zingafunike, amathanso kukupatsirani mankhwala othandizira kuti muchepetse kutopa kwanu.

Mlingo wa Orencia

Mlingo wa Orencia omwe dokotala amakupatsani umadalira pazinthu zingapo. Izi zikuphatikiza:

• mtundu ndi kuuma kwa chikhalidwe chomwe mukugwiritsa ntchito Orencia kuchiza
• kulemera kwako
• mawonekedwe a Orencia omwe mumatenga

Nthawi zambiri, dokotala wanu amakupangitsani muyeso wamba. Kenako azisintha pakapita nthawi kuti akwaniritse zomwe zikukuyenerani. Dokotala wanu pomaliza adzakupatsani mlingo wochepa kwambiri womwe umafunikira.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Orencia amabwera m'njira ziwiri: ufa ndi madzi. Mitunduyi ili ndi mphamvu zosiyanasiyana.

Mawonekedwe ufa

Fomu ya ufa:

• amapezeka mwamphamvu imodzi: 250 mg (milligrams)
• imasakanizidwa ndi madzi kuti mupeze yankho lomwe mwapatsidwa ngati kulowetsedwa mkati mwa mtsempha (IV) (jekeseni mumitsempha yanu yomwe imaperekedwa kwakanthawi)

Fomu yamadzimadzi

Mawonekedwe amadzimadzi:

• amapezeka mwamphamvu imodzi: 125 mg / mL (mamiligalamu pa mamililita)
• amakupatsani ngati jakisoni wochepa (jakisoni pansi pa khungu lanu)
• amabwera m'makina oyendetsera magalasi omwe amakhala ndi 0.4 mL, 0.7 mL, ndi 1.0 mL wamadzi
• imabweranso ndi botolo la 1-mL lomwe limayikidwa muchida chotchedwa ClickJect autoinjector

Mlingo wa nyamakazi ya nyamakazi

Mlingo wa Orencia wa nyamakazi (RA) chimadalira momwe mumamwa mankhwalawa. Mlingo wa kulowetsedwa mu mtsempha wa magazi (IV) ndi jakisoni wocheperako wafotokozedwa pansipa.

Kulowetsedwa mkati

Mlingo wa Orencia pa kulowetsedwa kulikonse kwa IV kumadalira kulemera kwanu. Mlingo woyenera wa Orencia ndi:

• 500 mg ya anthu olemera makilogalamu ochepera 60 (pafupifupi mapaundi 132)
• 750 mg ya anthu olemera makilogalamu 60 mpaka 100 (pafupifupi mapaundi 132 mpaka 220)
• 1,000 mg ya anthu olemera makilogalamu oposa 100 (pafupifupi mapaundi 220)

Kulowetsedwa kulikonse kwa IV kumatha pafupifupi mphindi 30.

Pambuyo pa mlingo wanu woyamba wa Orencia, mudzapatsidwa mankhwala ena awiri milungu iwiri iliyonse. Pambuyo pake, mlingo uliwonse umaperekedwa milungu inayi iliyonse.

Subcutaneous jakisoni

Mlingo woyenera wa Orencia wa jakisoni wocheperako ndi: 125 mg kamodzi sabata iliyonse.

Jekeseni wanu woyamba wochepetsedwa ungaperekedwe kapena sangaperekedwe mutakhala ndi mlingo woyambirira wa Orencia kudzera mu kulowetsedwa kwa IV. Ngati mwakhala ndi kulowetsedwa kwa IV kwa Orencia, nthawi zambiri mumamwa jakisoni wanu woyamba wamankhwala patsiku lotsatira chithandizo chanu cha IV.

Mlingo wa nyamakazi ya psoriatic

Mlingo wa Orencia wa psoriatic arthritis (PsA) zimadalira momwe mumamwa mankhwalawa. Mlingo wa kulowetsedwa kwamitsempha yamitsempha (IV) ndi jakisoni wocheperako amawerengedwa pansipa.

Kulowetsedwa mkati

Mlingo wa Orencia pa kulowetsedwa kulikonse kwa IV kumadalira kulemera kwanu. Mlingo woyenera wa Orencia ndi:

• 500 mg kwa omwe amalemera makilogalamu ochepera 60 (pafupifupi mapaundi 132)
• 750 mg kwa iwo omwe amalemera makilogalamu 60 mpaka 100 (pafupifupi mapaundi 132 mpaka 220)
• 1,000 mg kwa iwo olemera makilogalamu oposa 100 (pafupifupi mapaundi 220)

Kulowetsedwa kulikonse kwa IV kumatha pafupifupi mphindi 30.

Pambuyo pa mlingo wanu woyamba wa Orencia, mudzapatsidwa mankhwala ena awiri milungu iwiri iliyonse. Pambuyo pake, mlingo uliwonse umaperekedwa milungu inayi iliyonse.

Subcutaneous jakisoni

Mlingo woyenera wa Orencia wa jakisoni wocheperako ndi 125 mg kamodzi sabata iliyonse.

Mlingo wa matenda a nyamakazi a achinyamata

Mlingo wa Orencia wa achinyamata idiopathic arthritis (JIA) chimadalira momwe mumamwa mankhwalawa. Mlingo wa kulowetsedwa kwamitsempha yamitsempha (IV) ndi jakisoni wocheperako amawerengedwa pansipa.

Kulowetsedwa mkati

Mlingo wa Orencia pa kulowetsedwa kulikonse kwa IV kumatha kudalira kulemera kwanu kapena kwa mwana wanu. Mlingo wamba wa Orencia mwa ana azaka 6 kapena kupitilira apo ndi awa:

• 10 mg / kg (mamiligalamu amtundu wa kilogalamu ya kulemera kwa thupi) kwa iwo omwe amalemera makilogalamu ochepera 75 (pafupifupi mapaundi 165)
• 750 mg kwa omwe amalemera makilogalamu 75 ndi ma 100 kilogalamu (pafupifupi mapaundi 165 mpaka mapaundi 220)
• 1,000 mg kwa iwo olemera makilogalamu oposa 100 (pafupifupi mapaundi 220)

Mwachitsanzo, munthu amene amalemera makilogalamu 50 (pafupifupi mapaundi 110) amatenga 500 mg ya Orencia. Awa ndi mamiligalamu 10 a mankhwala pa kilogalamu iliyonse yolemera thupi lawo.

Pambuyo pa mlingo woyamba wa Orencia wanu kapena mwana wanu, mankhwala ena awiri adzapatsidwa milungu iwiri iliyonse. Pambuyo pake, mlingo uliwonse umaperekedwa milungu inayi iliyonse.

Kuwongolera kwa IV kwa Orencia sikuvomerezeka kwa ana ochepera zaka 6.

Subcutaneous jakisoni

Mlingo wa Orencia wa jakisoni wocheperako umadalira kulemera kwanu kapena kwa mwana wanu. Mlingo woyenera wa Orencia mwa ana azaka 2 kapena kupitirira ndi:

• 50 mg kwa omwe amalemera makilogalamu 10 mpaka makilogalamu ochepera 25 (pafupifupi mapaundi 22 mpaka ochepera mapaundi 55)
• 87.5 mg wa iwo omwe amalemera makilogalamu 25 mpaka ochepera 50 kilogalamu (pafupifupi mapaundi 55 mpaka ochepera pafupifupi mapaundi 110)
• 125 mg kwa omwe amalemera makilogalamu 50 kapena kupitilira apo (pafupifupi mapaundi 110 kapena kupitilira apo)

Mwa anthu azaka 6 kapena kupitilira apo, jakisoni wawo woyamba wa Orencia atha kapena sangaperekedwe atalandira kulowetsedwa kwa IV kwa mankhwalawa. Ngati kulowetsedwa kwa IV kwa Orencia kwapatsidwa kale, jakisoni woyamba wa mankhwalawo amaperekedwa tsiku lotsatira kulowetsedwa kwa IV.

Mlingo wa ana

Mlingo woyenera wa Orencia umasiyanasiyana kutengera momwe amatengedwera komanso kulemera kwa munthu amene akutenga. Kuti mumve zambiri za kuchuluka kwa mlingo wa ana, onani gawo la "Mlingo wa ana idiopathic arthritis" pamwambapa.

Ndingatani ngati ndaphonya mlingo?

Zomwe mungachite pakusowa kwa mlingo zimadalira momwe mumamutengera Orencia. Koma pazochitika zonsezi, zikumbutso zamankhwala zitha kuthandiza kuwonetsetsa kuti simuphonya mlingo.

Kulowetsedwa mkati

Ngati mwaphonya nthawi yokumana ndi vuto lanu la IV la Orencia, pitani kuchipatala chanu nthawi yomweyo. Adzakonza nthawi yatsopano kuti mudzalandire chithandizo cha Orencia IV.

Subcutaneous jakisoni

Ngati mwaphonya jakisoni wa Orencia, itanani dokotala nthawi yomweyo. Akuthandizani kuti mupange ndandanda yatsopano yazomwe mungatsatire.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Muyenera. Zomwe Orencia amagwiritsidwa ntchito pochiza ndi matenda osachiritsika (a nthawi yayitali). Orencia itha kugwiritsidwa ntchito kwa nthawi yayitali ngati inu ndi adotolo mukuwona kuti mankhwalawa ndi otetezeka komanso ogwira ntchito kwa inu.

Orencia amagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Orencia kuti athetse mavuto ena. Orencia ndi wovomerezeka ndi FDA kuti athetse mitundu itatu yamatenda a nyamakazi: nyamakazi ya nyamakazi, nyamakazi ya psoriatic, ndi nyamakazi yachinyamata ya idiopathic.

Orencia ya nyamakazi ya nyamakazi

Orencia amavomerezedwa ndi FDA kuti athetse matenda a nyamakazi (RA) ochepa. Amagwiritsidwa ntchito makamaka kwa akuluakulu omwe ali ndi zizindikiro za matendawa.

RA ndi matenda omwe amadzichititsa okha omwe amawononga ziwalo zanu. Zizindikiro za RA zimatha kuphatikizira kupweteka, kutupa, ndi kuuma mthupi lanu lonse.

Orencia ikulimbikitsidwa ndi akatswiri ngati chithandizo cha RA. Dokotala wanu angafune kuti muzigwiritsa ntchito nokha kapena kuphatikiza mankhwala ena, kuphatikiza methotrexate. Mankhwalawa nthawi zina amatchedwa mankhwala osintha matenda (DMARDs).

Kuchita bwino kwa nyamakazi ya nyamakazi

Pakafukufuku wina wamankhwala, Orencia adapatsidwa mankhwala a methotrexate kwa anthu 424 omwe ali ndi RA yochepa. Orencia anapatsidwa ndi kulowetsedwa kwa intravenous (IV) (jakisoni m'mitsempha ya anthu). Mwa iwo omwe amatenga Orencia, anthu 62% adachepetsedwa ndi 20% pazizindikiro zawo za RA atatha miyezi itatu yothandizidwa. Mwa iwo omwe amatenga placebo (chithandizo chopanda mankhwala osokoneza bongo) ndi methotrexate, 37% adakhala ndi zotsatira zofananira.

Kafukufuku wina wazachipatala adayang'ana chithandizo cha Orencia mwa anthu omwe ali ndi RA. Anthu adapatsidwa onse Orencia ndi methotrexate. Koma mu phunziroli, kuphatikiza kwa mankhwala kunaperekedwa ndi jakisoni wocheperako (jakisoni pansi pa khungu la anthu) pagulu limodzi. Ndipo gulu lina linapatsidwa mankhwalawo ndikulowetsedwa ndi IV.

Pambuyo pa chithandizo cha miyezi itatu, anthu 68% omwe amamwa mankhwalawa kudzera mu jakisoni wocheperako anali ndi kuchepa kwa 20% pazizindikiro zawo za RA. Izi zikufaniziridwa ndi 69% ya anthu omwe adamwa mankhwalawo pomulowetsa m'mitsempha.

Orencia yamatenda a psoriatic

Orencia amavomerezedwa ndi FDA kuti azichiza achikulire omwe ali ndi nyamakazi ya psoriatic (PsA). Amagwiritsidwa ntchito makamaka mwa anthu omwe ali ndi zizindikilo za matendawa. M'malo mwake, malingaliro apano ndi akatswiri akuwonetsa kugwiritsa ntchito Orencia mwa anthuwa.

PsA ndi mtundu wamatenda omwe amapezeka mwa anthu omwe ali ndi psoriasis. Zizindikiro za vutoli nthawi zambiri zimaphatikizapo zigamba zofiira, zopukutira khungu, ndi zilonda, zotupa.

Kuchita bwino kwa nyamakazi ya psoriatic

Pakafukufuku wina wamankhwala, Orencia adapatsidwa kwa anthu 40 omwe ali ndi PsA pogwiritsa ntchito kulowetsedwa kwamitsempha (IV) (jakisoni mumitsempha yawo). Pambuyo pa chithandizo cha milungu 24, 47.5% ya anthu omwe amatenga Orencia adachepetsa 20% pazizindikiro zawo za PsA. Mwa iwo omwe amamwa malowa (mankhwala osagwiritsa ntchito mankhwala), 19% adakhala ndi zotsatira zofananira.

Pakafukufuku wina wamankhwala, Orencia adapatsidwa anthu 213 omwe ali ndi PsA pogwiritsa ntchito jakisoni wochepetsera (jakisoni pansi pa khungu lawo). Pambuyo pa chithandizo cha milungu 24, 39.4% mwa omwe adatenga Orencia adachepetsedwa ndi 20% pazizindikiro zawo za PsA. Mwa iwo omwe amatenga malowa (mankhwala osagwiritsa ntchito mankhwala), 22.3% adakhala ndi zotsatira zofananira.

Orencia ya matenda a nyamakazi a achinyamata

Orencia ndi wovomerezeka ndi FDA kuti azitha kuchiza ana achichepere (JIA). Matendawa ndi omwe amafala kwambiri nyamakazi mwa ana. Zimayambitsa kupweteka pamfundo, kutupa, ndi kuuma.

Orencia iyenera kugwiritsidwa ntchito kwa ana omwe JIA imakhudza ziwalo zawo zambiri. Zimavomerezedwa kuti zigwiritsidwe ntchito kwa ana azaka 2 kapena kupitilira apo.

Akatswiri pakadali pano amalimbikitsa kugwiritsa ntchito Orencia mwa anthuwa. Mankhwalawa atha kugwiritsidwa ntchito paokha kapena mophatikiza ndi methotrexate.

Kuchita bwino kwa nyamakazi yachinyamata ya idiopathic

Pakafukufuku wina wamankhwala, Orencia adapatsidwa ana 190 okhala ndi JIA omwe anali azaka 6 mpaka 17. Anawo adalandira Orencia kudzera mu kulowetsedwa kwamitsempha (IV) (jakisoni mumitsempha yawo). Ambiri mwa ana nawonso adalandira methotrexate. Pamapeto pa phunziroli, 65% ya ana omwe amatenga Orencia adachepetsa 30% pazizindikiro zawo za JIA.

Pakafukufuku wina wamankhwala, Orencia adalandira jakisoni wochepetsera (jakisoni pansi pa khungu lawo) kwa ana 205 omwe ali ndi JIA. Ana anali atalandira kale mankhwala ena ochiritsira JIA yawo, komabe anali ndi zizindikilo za vutoli. Pakutha phunziroli, Orencia anali othandiza kuchepetsa zizindikiro za JIA. Zotsatira za kafukufukuyu zinali zofanana ndi zotsatira za kafukufuku wolowetsedwa wa IV.

Orencia pazinthu zina

Mutha kudabwa ngati Orencia imagwiritsidwa ntchito pazinthu zina. M'munsimu muli zinthu zomwe Orencia nthawi zina amatha kugwiritsidwa ntchito ngati mankhwala osagwiritsidwa ntchito. Kugwiritsa ntchito mankhwala osokoneza bongo kumatanthauza kuti mankhwalawa amagwiritsidwa ntchito pochiza vuto ngakhale kuti sivomerezedwa ndi FDA kutero.

Orencia wa lupus (osagwiritsa ntchito zilembo)

Orencia sivomerezedwa ndi FDA kuti ichiritse lupus, koma nthawi zina imagwiritsidwa ntchito ngati chizindikiro cha vutoli.

Akatswiri ena amakhulupirira kuti Orencia ikhoza kukhala yothandiza pochepetsa zizindikiro za lupus. Koma maphunziro azachipatala aposachedwa sanathe kuwonetsa momwe Orencia amathandizira bwino vutoli. Zambiri zimafunika kudziwa ngati Orencia ali otetezeka komanso othandiza kugwiritsa ntchito anthu omwe ali ndi lupus.

Lankhulani ndi dokotala ngati muli ndi lupus ndipo mukufuna kutenga Orencia. Akambirana momwe mungasamalire ndi kukupatsani mankhwala omwe ndi otetezeka ndi othandiza kwa inu.

Orencia ya ankylosing spondylitis (yophunzira)

Orencia sivomerezedwa ndi FDA kuti ichiritse ankylosing spondylitis (AS). Komanso, akatswiri samalimbikitsa kugwiritsa ntchito mankhwalawa kuchiza matendawa.

Koma maphunziro ena akuchitika kuti awone momwe Orencia angachiritse AS. Zambiri zimafunika kudziwa kuti mankhwalawa ndi otetezeka komanso othandiza kuchiritsa AS.

Lankhulani ndi dokotala wanu ngati muli ndi AS ndipo mukufuna kutenga Orencia. Akambirana za mbiri ya chithandizo chanu ndikupatsirani mankhwala abwino kwambiri.

Orencia kwa ana

Orencia ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito kwa ana omwe ali ndi matenda amisala a ana osagwirizana kwambiri (JIA). Kuti mumve zambiri, onani gawo la "Orencia for juvenile idiopathic arthritis" pamwambapa.

Orencia ntchito ndi mankhwala ena

Orencia itha kugwiritsidwa ntchito yokha kapena kuphatikiza mankhwala ena. Dokotala wanu angakulimbikitseni ngati mukufuna kumwa mankhwala ena ndi Orencia kuti muthane ndi matenda anu. Izi zimachitika kwambiri kwa anthu omwe ali ndi nyamakazi kapena nyamakazi ya achinyamata.

Orencia ndi mankhwala ena a nyamakazi

Orencia ndivomerezedwa ndi FDA kuti azichiza achikulire omwe ali ndi nyamakazi yamagetsi yovuta kwambiri (RA). Mankhwalawa atha kugwiritsidwa ntchito paokha kapena kuphatikiza ndi mankhwala ena. Komabe, ngati agwiritsidwa ntchito ndi mankhwala ena, mankhwalawa sayenera kukhala mgulu la mankhwala omwe amatchedwa anti-TNFs. (Onani gawo la "Kuyanjana kwa Orencia" pansipa kuti mumve zambiri.)

M'maphunziro azachipatala, Orencia adagwira ntchito bwino atamwedwa ndi mankhwala ena ndi achikulire omwe ali ndi RA yovuta kwambiri. Mankhwala omwe amapezeka ndi Orencia anali mankhwala osintha matenda (DMARDs), kuphatikiza methotrexate.

Orencia ndi mankhwala ena a ana idiopathic nyamakazi

Orencia ndi wovomerezeka ndi FDA kuti azisamalira ana omwe ali ndi nyamakazi ya achinyamata (JIA). Mankhwalawa amavomerezedwa kuti agwiritsidwe ntchito okha kapena kuphatikiza methotrexate.

M'maphunziro azachipatala, Orencia adagwira bwino ntchito pochiza JIA mwa ana mankhwalawo atapatsidwa methotrexate. Zotsatira zake, akatswiri pakadali pano amalimbikitsa kuti Orencia igwiritsidwe ntchito ndi methotrexate m'malo mongokhala okha pochiza JIA.

Njira zina zopangira Orencia

Mankhwala ena alipo omwe angathetse vuto lanu. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina kuposa Orencia, lankhulani ndi dokotala wanu. Amatha kukuwuzani zamankhwala ena omwe atha kukuthandizani.

Zindikirani: Mankhwala ena omwe atchulidwa pano amagwiritsidwa ntchito ngati zilembo kuti athetse vutoli.

Njira zina zamatenda a nyamakazi

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito kuchiza nyamakazi (RA) ndi awa:

• methotrexate (Otrexup, Rasuvo, Trexall, Xatmep)
• sulfasalazine (Azulfidine, Azulfidine EN)
• hydroxychloroquine (Plaquenil)
• adalimumab (Humira)
• chitsimikizo cha pegol (Cimzia)
• etanercept (Enbrel)
• golimumab (Simponi)
• infliximab (Remicade, Inflectra, Renflexis)
• alirazamalik (Alirazamalik)

Njira zina zamatenda a psoriatic

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochiza matenda a psoriatic (PsA) ndi awa:

• methotrexate (Otrexup, Rasuvo, Trexall, Xatmep)
• sulfasalazine (Azulfidine, Azulfidine EN)
• cyclosporine (Gengraf, Neoral, Sandimmune)
• leflunomide (Arava)
• chifuwa chachikulu (Otezla)
• adalimumab (Humira)
• chitsimikizo cha pegol (Cimzia)
• etanercept (Enbrel)
• golimumab (Simponi)
• infliximab (Remicade, Inflectra, Renflexis)
• ustekinumab (Stelara)
• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)
• alirazamalik (Alirazamalik)

Njira zina zamankhwala zamatsenga za ana

Zitsanzo za mankhwala ena omwe angagwiritsidwe ntchito pochiza matenda a ana (JIA) ndi awa:

• methotrexate (Otrexup, Rasuvo, Trexall, Xatmep)
• sulfasalazine (Azulfidine, Azulfidine EN)
• leflunomide (Arava)
• adalimumab (Humira)
• etanercept (Enbrel)
• golimumab (Simponi)
• infliximab (Remicade, Inflectra, Renflexis)
• tocilizumab (Actemra)

Orencia vs. Humira

Mutha kudabwa momwe Orencia amafanizira ndi mankhwala ena omwe amapatsidwa ntchito zofananira. Apa tikuwona momwe Orencia ndi Humira alili ofanana komanso osiyana.

Zonse

Orencia ili ndi mankhwala ophera mankhwala. Humira ali ndi mankhwala adalimumab. Mankhwalawa amagwira ntchito mosiyanasiyana mthupi lanu, ndipo ndi amitundu yosiyanasiyana ya mankhwala.

Ntchito

Orencia ndi Humira onse amavomerezedwa ndi Food and Drug Administration (FDA) kuti athetse matenda a nyamakazi (RA) ndi psoriatic arthritis (PsA) mwa akulu. Mankhwalawa amavomerezedwanso kuchiza matenda aamuna a idiopathic arthritis (JIA) mwa ana azaka 2 kapena kupitirira.

Humira ndi wovomerezeka ndi FDA kuti athetse izi:

• ankylosing spondylitis mwa akulu
• Matenda a Crohn mwa akulu ndi ana azaka 6 kapena kupitilira apo
• anam`peza matenda am`matumbo mwa akuluakulu
• plaque psoriasis mwa akulu
• hidradenitis suppurativa mwa akulu ndi ana azaka 12 kapena kupitirira
• uveitis kwa akulu ndi ana azaka zapakati pa 2 kapena kupitilira apo

Mafomu azamankhwala ndi makonzedwe

Orencia amabwera m'njira ziwiri, zomwe zimakhala ndi mphamvu zosiyana. Mafomu awa ndi awa:

• mawonekedwe a ufa
  • amapezeka mwamphamvu imodzi: 250 mg (milligrams)
  • imasakanizidwa ndi madzi kuti mupeze yankho lomwe mwapatsidwa ngati kulowetsedwa mkati mwa mtsempha (IV) (jekeseni mumitsempha yanu yomwe imaperekedwa kwakanthawi)
• mawonekedwe amadzimadzi
  • amapezeka mwamphamvu imodzi: 125 mg / mL (mamiligalamu pa mamililita)
  • amakupatsani ngati jakisoni wochepa (jakisoni pansi pa khungu lanu)
  • amabwera m'makina oyendetsera magalasi omwe amakhala ndi 0.4 mL, 0.7 mL, ndi 1.0 mL wamadzi
  • imabweranso ndi botolo la 1-mL lomwe limayikidwa muchida chotchedwa ClickJect autoinjector

Humira imabwera ngati yankho lomwe limaperekedwa ndi jakisoni wocheperako (jakisoni pansi pa khungu lanu). Ipezeka mu mphamvu ziwiri zotsatirazi:

• 100 mg / mL: amabwera m'mitsuko yomwe imakhala ndi 0.8 mL, 0.4 mL, 0.2 mL, ndi 0.1 mL yankho
• 50 mg / mL: amabwera m'mitsuko yomwe imakhala ndi 0.8 mL, 0.4 mL, ndi 0.2 mL yankho

Zotsatira zoyipa ndi zoopsa

Orencia ndi Humira ali ndi mankhwala osiyanasiyana. Koma mankhwala onsewa amakhudza momwe chitetezo chamthupi chanu chimagwirira ntchito. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Orencia, ndi Humira, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Orencia:
  • nseru
• Zitha kuchitika ndi Humira:
  • khungu limachita mdera lozungulira jekeseni wanu
  • zotupa pakhungu
• Zitha kuchitika ndi Orencia ndi Humira:
  • matenda opuma opuma, monga chimfine kapena matenda a sinus
  • mutu

Zotsatira zoyipa

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Orencia, ndi Humira, kapena ndi mankhwala onsewa (akamwedwa payekha).

• Zitha kuchitika ndi Orencia:
  • matenda akulu, monga chibayo
• Zitha kuchitika ndi Humira:
  • mavuto ndi dongosolo lanu lamanjenje (dzanzi kapena kumva kulira, kusintha kwa masomphenya, kufooka m'manja kapena miyendo, kapena chizungulire)
  • magulu otsika am'magazi ena, monga ma cell oyera ndi ma platelets
  • mavuto amtima, monga mtima kulephera
  • Matenda akulu, monga chifuwa chachikulu (TB) *
  • mavuto a chiwindi, monga kulephera kwa chiwindi
• Zitha kuchitika ndi Orencia ndi Humira:
  • matenda akulu
  • khansa *
  • kuyambiranso kwa kachilombo ka hepatitis B (kutulutsa kachilomboka ngati kuli kale mkati mwa thupi lanu)
  • kwambiri thupi lawo siligwirizana

Kuchita bwino

Onse Orencia ndi Humira ndi ovomerezeka ndi FDA kuti azitha kuchiza nyamakazi, psoriatic nyamakazi, ndi ana idiopathic nyamakazi. Kugwiritsa ntchito mankhwala onsewa pochiza matendawa akuyerekezedwa pansipa.

Kuchita bwino pochiza nyamakazi ya nyamakazi

Orencia ndi Humira amafanizidwa mwachindunji pakafukufuku wamankhwala monga njira zochizira nyamakazi (RA).

Phunziroli, akulu akulu a 646 omwe anali ndi RA yovuta kwambiri anali kutenga Orencia kapena Humira: Anthu 318 adatenga Orencia, pomwe anthu 328 adatenga Humira. Magulu onse awiriwa adatenganso methotrexate. Pambuyo pa chithandizo cha zaka 2, mankhwala onsewa anali othandizanso pochiza RA.

Mwa iwo omwe amatenga Orencia, 59.7% ya anthu adachepetsa 20% pazizindikiro zawo za RA. Mwa anthu omwe amatenga Humira, 60.1% adakhala ndi zotsatira zofananira.

Kuchita bwino pochiza nyamakazi ya psoriatic

Orencia ndi Humira sanafanane mwachindunji m'mayesero azachipatala ngati njira zamankhwala zamankhwala a psoriatic arthritis (PsA). Koma maphunziro osiyana apeza kuti mankhwala onsewa ndi othandiza kuthana ndi vutoli.

Kuchita bwino pochiza nyamakazi yachinyamata ya idiopathic

Orencia ndi Humira adafaniziridwa pakuwunika kwamankhwala monga njira zamankhwala zamankhwala amwana idiopathic arthritis (JIA). Pambuyo pa kuwunikaku, akatswiri adapeza kuti mankhwala onsewa anali ndi chitetezo chofananira komanso chothandiza.

Mtengo

Orencia ndi Humira onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya Orencia yomwe ilipo. Mankhwala osokoneza bongo amafanana ndi mankhwala achibadwa. Mankhwala achibadwa ndi mtundu wa mankhwala wamba (omwe amapangidwa ndi mankhwala). Mankhwala osokoneza bongo amapangidwa kuti akhale ofanana ndi mankhwala a biologic (omwe amapangidwa kuchokera ku maselo amoyo).

Mankhwala osokoneza bongo a Humira amapezeka m'njira yomwe imaperekedwa ndi kulowetsedwa kwa intravenous (IV). Akatswiri amalimbikitsa kugwiritsa ntchito ma biosimilars kuti muchiritse RA, PsA, ndi JIA mukakhala otetezeka komanso ogwira ntchito ku matenda anu. Lankhulani ndi dokotala wanu kuti mudziwe ngati biosimilar ili yoyenera kwa inu.

Mankhwala omwe amatchulidwa ndi dzina nthawi zambiri amakhala okwera mtengo kuposa mankhwala osokoneza bongo.

Malinga ndi kuyerekezera kwa GoodRx.com, Humira amawononga ndalama zochepa kuposa zomwe Orencia amachita. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Orencia vs. Enbrel

Mutha kudabwa momwe Orencia amafanizira ndi mankhwala ena omwe amapatsidwa ntchito zofananira. Apa tikuwona momwe Orencia ndi Enbrel alili ofanana komanso osiyana.

Zonse

Orencia ili ndi mankhwala ophera mankhwala. Enbrel ili ndi mankhwala etanercept. Mankhwalawa ndi amitundu yosiyanasiyana ya mankhwala, ndipo amagwira ntchito mosiyanasiyana mthupi lanu.

Ntchito

Orencia ndi Enbrel amavomerezedwa ndi Food and Drug Administration (FDA) kuti athe kuchiza nyamakazi (RA) ndi psoriatic arthritis (PsA) mwa akulu. Mankhwala onsewa amavomerezanso kuchiza matenda aamuna (JIA) omwe ali ndi zaka ziwiri kapena kupitilira apo.

Enbrel amavomerezedwa ndi FDA kuti athetse mavuto ena awiri:

• ankylosing spondylitis mwa akulu
• plaque psoriasis kwa akulu ndi ana azaka 4 kapena kupitirira

Mafomu azamankhwala ndi makonzedwe

Orencia amabwera m'njira ziwiri, zomwe zimakhala ndi mphamvu zosiyana. Mafomu awa ndi awa:

• mawonekedwe a ufa
  • amapezeka mwamphamvu imodzi: 250 mg (milligrams)
  • imasakanizidwa ndi madzi kuti mupeze yankho lomwe mwapatsidwa ngati kulowetsedwa mkati mwa mtsempha (IV) (jekeseni mumitsempha yanu yomwe imaperekedwa kwakanthawi)
• mawonekedwe amadzimadzi
  • amapezeka mwamphamvu imodzi: 125 mg / mL (mamiligalamu pa mamililita)
  • amakupatsani ngati jakisoni wochepa (jakisoni pansi pa khungu lanu)
  • amabwera m'makina oyendetsera magalasi omwe amakhala ndi 0.4 mL, 0.7 mL, ndi 1.0 mL wamadzi
  • imabweranso ndi botolo la 1-mL lomwe limayikidwa muchida chotchedwa ClickJect autoinjector

Enbrel amaperekedwa kudzera mu jakisoni wamagetsi. Zimabwera motere:

• mawonekedwe a ufa
  • amapezeka mphamvu imodzi: 25 mg
  • imasakanizidwa ndi madzi kuti apange yankho
• mawonekedwe amadzimadzi
  • imapezeka mu mphamvu imodzi: 50 mg / mL
  • amabwera m'mitsuko yomwe imakhala ndi 0,5 mL ndi 1.0 mL wamadzi

Zotsatira zoyipa ndi zoopsa

Orencia ndi Enbrel ali ndi mankhwala osiyanasiyana. Koma mankhwala onsewa amagwira ntchito m'thupi lanu. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Orencia kapena ndi Enbrel.

• Zitha kuchitika ndi Orencia:
  • matenda, monga chimfine kapena matenda a sinus
  • mutu
  • nseru
• Zitha kuchitika ndi Enbrel:
  • khungu limachita mdera lozungulira jekeseni wanu
• Zitha kuchitika ndi onse Orencia ndi Enbrel:
  • Palibe zovuta zomwe anthu ambiri amakhala nazo

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Orencia, ndi Enbrel, kapena ndi mankhwala onse (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Orencia:
  • Palibe zovuta zoyipa zilizonse
• Zitha kuchitika ndi Enbrel:
  • mavuto amanjenje anu (multiple sclerosis, khunyu, kutupa kwa mitsempha)
  • magulu otsika am'magazi ena, monga ma cell oyera ndi ma platelets
  • mavuto amtima, monga mtima kulephera
  • mavuto a chiwindi, monga kulephera kwa chiwindi
  • Matenda akulu, monga chifuwa chachikulu (TB) *
• Zitha kuchitika ndi onse Orencia ndi Enbrel:
  • khansa *
  • kuyambiranso kwa kachilombo ka hepatitis B (kutulutsa kachilomboka ngati kuli kale mkati mwa thupi lanu)
  • matenda akulu, monga chibayo
  • kwambiri thupi lawo siligwirizana

Kuchita bwino

Onse Orencia ndi Enbrel ndi ovomerezeka ndi FDA kuti athe kuchiza nyamakazi ya nyamakazi, psoriatic nyamakazi, ndi ana idiopathic arthritis. Mphamvu ya mankhwala onsewa pochiza matendawa ikufanizidwa pansipa.

Kuchita bwino pochiza nyamakazi ya nyamakazi

Mankhwalawa sanafanane mwachindunji m'mayesero azachipatala. Koma maphunziro osiyana apeza kuti onse Orencia ndi Enbrel ndi othandiza pochiza nyamakazi (RA).

Kuchita bwino pochiza nyamakazi ya psoriatic

Mankhwalawa sanafanane mwachindunji m'mayesero azachipatala. Koma maphunziro apadera apeza kuti onse Orencia ndi Enbrel ndi othandiza pochiza psoriatic arthritis (PsA).

Kuchita bwino pochiza nyamakazi yachinyamata ya idiopathic

Kuwunikanso kwamaphunziro kunayang'ana momwe Orencia ndi Enbrel amagwirira ntchito pochiza ana a idiopathic arthritis (JIA) mwa ana. Pamapeto pa kuwunikiraku, akatswiri adagwirizana kuti mankhwala onsewa ali ndi chitetezo chofananira komanso chothandiza pochizira vutoli.

Mtengo

Orencia ndi Enbrel onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu ya Orencia yomwe ilipo. Mankhwala osokoneza bongo amafanana ndi mankhwala achibadwa. Mankhwala achibadwa ndi mtundu wa mankhwala wamba (omwe amapangidwa ndi mankhwala). Mankhwala osokoneza bongo amapangidwa kuti akhale ofanana ndi mankhwala a biologic (omwe amapangidwa kuchokera ku maselo amoyo).

Mankhwala osokoneza bongo a Enbrel amapezeka mu mawonekedwe omwe amaperekedwa ndi kulowetsedwa kwa intravenous (IV). Akatswiri amalimbikitsa kugwiritsa ntchito ma biosimilars kuti muchiritse RA, PsA, ndi JIA mukakhala otetezeka komanso ogwira ntchito ku matenda anu. Lankhulani ndi dokotala wanu kuti mudziwe ngati biosimilar ili yoyenera kwa inu.

Mankhwala omwe amatchulidwa ndi dzina nthawi zambiri amakhala okwera mtengo kuposa mankhwala osokoneza bongo.

Malinga ndi kuyerekezera kwa GoodRx.com, Enbrel atha kukhala ochepa kuposa Orencia. Mtengo weniweni womwe mudzalipire mankhwalawa umadalira dongosolo lanu la inshuwaransi, komwe mumakhala, komanso mankhwala omwe mumagwiritsa ntchito.

Orencia ndi mowa

Palibe kuyanjana kulikonse komwe kumadziwika pakati pa Orencia ndi mowa. Koma kumwa mowa kwambiri kumatha kukulitsa matenda anu a nyamakazi komanso kukula kwa matendawa. Komanso mowa umatha kulumikizana ndi mankhwala ena omwe mukumwa.

Lankhulani ndi dokotala wanu za kuchuluka kwa zakumwa zoledzeretsa zomwe mungamwe. Akambirana za chithandizo chanu chamankhwala chamatenda ndikulangizani ngati mowa ndiwotheka.

Kuyanjana kwa Orencia

Orencia amatha kulumikizana ndi mankhwala ena angapo. Itha kulumikizananso ndi zowonjezera zowonjezera komanso zakudya zina.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, kulumikizana kwina kumatha kusokoneza momwe mankhwala amagwirira ntchito. Kuyanjana kwina kumatha kukulitsa zovuta zina kapena kuwapangitsa kukhala owopsa.

Orencia ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe angagwirizane ndi Orencia. Mndandandawu mulibe mankhwala onse omwe angagwirizane ndi Orencia.

Musanatenge Orencia, lankhulani ndi dokotala komanso wamankhwala. Auzeni zamankhwala onse omwe mumalandira, pa-pakauntala, ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Anti-TNFs

Anti-TNFs ndi gulu la mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza nyamakazi (RA), psoriatic arthritis (PsA), ndi ana idiopathic arthritis (JIA). Mankhwalawa amagwira ntchito polumikizira ndikuletsa ntchito ya protein yotchedwa tumor necrosis factor (TNF).

Zitsanzo za mankhwala oletsa anti-TNF ndi awa:

• adalimumab (Humira)
• etanercept (Enbrel)
• infliximab (Kutulutsa)

Onse Orencia ndi anti-TNFs amachepetsa kuthekera kwa thupi lanu kulimbana ndi matenda atsopano kapena omwe alipo.Kutenga mankhwalawa palimodzi kungapangitse chiopsezo chanu chotenga matenda atsopano ndikuchepetsa kuthana ndi matenda omwe ali kale mthupi lanu.

Lankhulani ndi dokotala wanu ngati mukumwa kapena mukukonzekera kuyamba kumwa mankhwala a anti-TNF mukamagwiritsa ntchito Orencia. Dokotala wanu akhoza kukambirana zosowa zanu ndikukulimbikitsani mankhwala omwe ndi abwino.

Mankhwala ena a rheumatic

Onse Orencia ndi mankhwala ena a rheumatic, kuphatikiza Xeljanz, amakhudza chitetezo cha mthupi lanu. Mankhwalawa amachepetsa chitetezo cha mthupi lanu polimbana ndi matenda. Kutenga Orencia ndi mankhwala ena a rheumatic kumachepetsa chitetezo chamthupi chanu kwambiri. Izi zitha kukulitsa chiopsezo chotenga matenda.

Uzani dokotala wanu ngati mukumwa mankhwala ena aliwonse a rheumatic kupatula Orencia. Dokotala wanu amatha kuyitanitsa mayeso kuti muwone momwe chitetezo chamthupi chanu chikugwirira ntchito ndikukulimbikitsani njira yabwino yothandizira.

Orencia ndi zitsamba ndi zowonjezera

Palibe zitsamba zilizonse kapena zowonjezera zomwe zimadziwika mogwirizana ndi Orencia. Komabe, muyenera kuonana ndi dokotala kapena wazamankhwala musanagwiritse ntchito zowonjezera zilizonse mukamamwa Orencia.

Momwe Orencia amagwirira ntchito

Orencia imavomerezedwa kuchiza matenda ena amthupi okha. Imagwira ntchito mthupi lanu kuthandiza kuchepetsa zizindikilo ndikuchepetsa kukula (kukulira) kwa matendawa.

Kodi matenda omwe amadzimadzimadzimadzimodzi ndi ati?

Chitetezo cha mthupi lanu chimateteza thupi lanu ku matenda. Imachita izi polimbana ndi mabakiteriya ndi ma virus omwe amalowa mkati kapena omwe ali kale m'thupi lanu.

Koma nthawi zina chitetezo cha mthupi lanu chimasokonezeka, ndipo chimayamba kuwononga maselo anu. Ngati sichitha, imayambitsa matenda omwe amadzichotsera okha. Ndi matendawa, chitetezo chanu chamthupi chimagunda ma cell omwe amapanga minofu ndi ziwalo za thupi lanu.

Matenda a nyamakazi (RA), nyamakazi ya psoriatic (PsA), ndi nyamakazi yachinyamata ya idiopathic (JIA) zonse zimangokhala zokha. Izi zikutanthauza kuti ngati muli ndi izi, chitetezo chamthupi chanu chikuukira thupi lanu.

Kodi Orencia amatani?

Orencia imagwira ntchito pophatikiza mapuloteni awiri (otchedwa CD80 ndi CD86) omwe amapezeka m'ma cell ena amthupi. Mapuloteni a CD80 ndi CD86 amachititsa mtundu wina wa chitetezo cha mthupi, chotchedwa T cell. Maselo anu a T ndi mtundu winawake wamaselo omwe amathandiza chitetezo cha mthupi lanu kulimbana ndi matenda.

Mwa kuphatikiza mapuloteniwa, Orencia amaletsa ma T kuti agwire bwino ntchito. Izi zimalepheretsa chitetezo chanu cha mthupi kuti chiwononge maselo anu, ziphuphu, ndi ziwalo zanu.

Orencia imathandizira kuchepetsa kukula (kukulira) kwa nyamakazi ya nyamakazi, nyamakazi ya psoriatic, ndi nyamakazi yachinyamata ya idiopathic. Mankhwalawa amachepetsanso zizindikiro za izi, kukupangitsani kuti mukhale bwino.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Orencia ayamba kugwira ntchito mthupi lanu mukangoyamba kumwa. Koma nyamakazi ya nyamakazi, psoriatic nyamakazi, ndi ana idiopathic nyamakazi ndizochitika zomwe zimatenga nthawi kuchiza. M'maphunziro azachipatala, anthu adasintha pamavuto awo ndipo amagwira ntchito mkati mwa miyezi itatu atayamba kulandira chithandizo. Komabe, yankho la munthu aliyense ku Orencia lidzakhala lapadera.

Orencia amayenera kutengedwa ngati mankhwala a nthawi yayitali. Zimagwira ntchito tsiku lililonse m'thupi lanu kuti matenda anu azichiritsidwa. Mukasiya kuzitenga mwadzidzidzi, zizindikiro zanu zimatha kubwereranso.

Osasiya kumwa Orencia pambuyo poti matenda anu atha. Ngati mukufuna kusiya kumwa mankhwalawa, lankhulani ndi dokotala wanu. Awonanso momwe muliri komanso awone ngati mukufunabe kutenga Orencia.

Orencia ndi mimba

Palibe maphunziro okwanira mwa anthu oti adziwe ngati Orencia ali otetezeka kugwiritsa ntchito nthawi yapakati. Kafukufuku wa zinyama akuwonetsa kuti Orencia imatha kukhudza mwana wosabadwa ngati agwiritsidwa ntchito panthawi yapakati. Koma maphunziro a nyama samaneneratu nthawi zonse zomwe zimachitika mwa anthu.

Adziwitseni dokotala ngati muli ndi pakati kapena muli ndi pakati mukamagwiritsa ntchito Orencia. Adzakambirana njira zomwe mungasamalire ndikukulimbikitsani ngati mukugwiritsa ntchito Orencia ndikotetezedwa mukakhala ndi pakati.

Kalata yolembetsera imapezeka kwa azimayi omwe adatenga kapena akumwa Orencia panthawi yapakati. Ngati muli ndi pakati komanso mutenga Orencia, adokotala angakufunseni kuti mulembetse. Kaundula amalola madokotala kuti asonkhanitse zidziwitso zachitetezo cha ntchito ya Orencia mwa amayi apakati. Kuti mudziwe zambiri za registry, imbani 877-311-8972 kapena pitani patsamba la registry.

Orencia ndi kulera

Sidziwika ngati Orencia ali otetezeka kutenga nthawi yapakati. Ngati inu kapena mnzanuyo mutha kutenga pakati, lankhulani ndi dokotala wanu zakufunika kwanu poletsa kugwiritsa ntchito mankhwalawa.

Orencia ndi kuyamwitsa

Palibe maphunziro aliwonse mwa anthu omwe ayang'ana chitetezo cha Orencia chomwe chimagwiritsidwa ntchito mwa amayi omwe akuyamwitsa. Kafukufuku wazinyama awonetsa kuti Orencia amadutsa mkaka wa m'mawere wa nyama zomwe zimapatsidwa mankhwala. Koma sizikudziwika ngati mankhwalawa amakhudza nyama zomwe zimadya mkaka wa m'mawere.

Kumbukirani kuti maphunziro a nyama samaneneratu nthawi zonse zomwe zimachitika mwa anthu.

Uzani dokotala wanu ngati mukuyamwitsa kapena mukukonzekera kuyamwa mukamamwa Orencia. Adzakulangizani njira yotetezeka kwambiri yodyetsera mwana wanu.

Mtengo wa Orencia

Monga mankhwala onse, mtengo wa Orencia umasiyana.

Mtengo weniweni womwe mudzalipira umadalira dongosolo la inshuwaransi yanu, komwe mumakhala, komanso malo ogulitsira mankhwala omwe mumagwiritsa ntchito.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Orencia, kapena ngati mukufuna thandizo kuti mumvetsetse inshuwaransi yanu, thandizo lilipo.

Bristol-Myers Squibb, wopanga Orencia, amapereka pulogalamu ya copay kwa anthu omwe akugwiritsa ntchito mawonekedwe a Orencia. Kuti mumve zambiri komanso kuti mudziwe ngati mukuyenera kuthandizidwa, imbani 800-ORENCIA (800-673-6242) kapena pitani patsamba lino.

Ngati mukulandira Orencia kudzera mu infravenous (IV) infusions, mutha kulumikizana ndi gulu la Bristol-Myers Squibb Access Support kuti muphunzire zamomwe mungasungire ndalama. Kuti mudziwe zambiri, imbani 800-861-0048 kapena pitani patsamba lino.

Momwe mungatengere Orencia

Muyenera kutenga Orencia malinga ndi malangizo a dokotala kapena wothandizira zaumoyo.

Orencia mwa kulowetsedwa mkati

Nthawi zina, dokotala wanu angakulimbikitseni kuti mulandire Orencia kudzera mu kulowetsedwa kwa intravenous (IV) (jakisoni mumtsempha wanu womwe umaperekedwa kwakanthawi).

Poterepa, muyenera kukonzekera nthawi yokumana kuchipatala chanu. Mukakhala kuchipatala kuti mulowetsedwe, ogwira ntchito zachipatala adzakutengerani kuchipinda chabwino. Adzalowetsa singano mumitsempha yanu ndikugwirizanitsa singanoyo ndi thumba lodzaza ndi madzi omwe ali ndi Orencia.

Kulowetsedwa kwanu kumatenga pafupifupi mphindi 30. Munthawi imeneyi, madzi omwe ali ndi Orencia adzachoka m'thumba la IV, kudzera mu singano, ndikulowa mumtsinje wanu.

Mutalandira madzi onse a Orencia, singanoyo imachotsedwa pamitsempha yanu. Dokotala wanu angafune kukuyang'anirani kwa kanthawi musanachoke kuchipatala. Izi zachitika kuti muwonetsetse kuti mulibe zovuta zina mukalandira Orencia.

Orencia anatengedwa ndi subcutaneous jakisoni

Dokotala wanu angakulimbikitseni kuti mulandire Orencia kudzera mu jakisoni wocheperako (jakisoni pansi pa khungu lanu).

Poyamba, wothandizira zaumoyo wanu angafune kukupatsirani jakisoni wa Orencia. Izi zimawathandiza kuti afotokoze za jakisoni ndikukuwonetsani momwe mungachitire. Dokotala wanu atakuwonetsani m'mene mungapangire jakisoni wa Orencia, angakufunseni kuti muyambe kudzipatsa jakisoni wa mankhwalawa.

Jekeseni iliyonse ya Orencia itha kuthekera kudzera pazida zosiyanasiyana: jakisoni woyikapo kale kapena chojambulira cha ClickJect autoinjector. Chida chilichonse chimabwera ndi kuchuluka kwa Orencia komwe dokotala wanu adakupatsani. Simusowa kuyeza mlingo wanu wa Orencia pa jakisoni aliyense. Othandizira azaumoyo anu amakupatsani tsatane-tsatane malangizo amomwe mungagwiritsire ntchito chida chomwe mwapatsidwa.

Funsani dokotala ngati simukudziwa momwe mungadzibayitsire Orencia. Awonanso njirayi ndi inu. Muthanso kuyendera tsamba la Orencia kuti muwerenge zambiri za momwe mungadziperekere mankhwalawa.

Nthawi yoti mutenge

Mukayamba kutenga Orencia kwa nthawi yoyamba, mudzalandira dosing schedule. Muyenera kutenga Orencia malinga ndi ndandanda imeneyo.

Zikumbutso zamankhwala zitha kukuthandizani kuti muwonetsetse kuti mukutsatira dongosolo lanu.

Mafunso wamba okhudza Orencia

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Orencia.

Kodi ndingatenge Orencia ngati ndili ndi COPD?

Mutha kutero. Orencia nthawi zina amalimbikitsidwa kuti agwiritsidwe ntchito kwa anthu omwe ali ndi mitundu ya nyamakazi omwe amakhalanso ndi matenda osokoneza bongo (COPD). Koma anthuwa ayenera kuyang'aniridwa bwino akamagwiritsa ntchito mankhwalawa.

Ngati muli ndi COPD, kutenga Orencia kumatha kuwonjezera chiopsezo chanu chokhala ndi zovuta zina. M'malo mwake, zitha kukulitsa chiopsezo chanu chokhala ndi vuto lalikulu ndikupuma. Ngati muli ndi COPD ndipo mukugwiritsa ntchito mankhwalawa, dokotala wanu akhoza kukuyang'anirani mosamala kuti atsimikizire kuti Orencia ndi otetezeka kwa inu.

Uzani dokotala wanu ngati muli ndi COPD ndipo mukuvutika kupuma mukamamwa Orencia. (Onani gawo la "Zodzitetezera" pansipa kuti mumve zambiri.) Dokotala wanu akhoza kukulangizani ngati Orencia ali otetezeka kuti mugwiritse ntchito. Ngati sizabwino, angakupatseni mankhwala ena omwe ndi otetezeka kwa inu.

Kodi ndingapeze katemera ndikugwiritsa ntchito Orencia?

Mutha kukhala ndi katemera wina pa nthawi ya chithandizo cha Orencia. Komabe, simuyenera kulandira katemera amoyo mukamamwa Orencia, kapena kwa miyezi itatu mutalandira mankhwala anu omaliza.

Katemera wamoyo ali ndi kachilombo kofooka kapena mabakiteriya. Pamene mukutenga Orencia, chitetezo chanu cha mthupi sichitha kulimbana ndi matenda monga momwe zimakhalira. Ngati mutalandira katemera wamoyo pomwe mukumwa Orencia, mutha kutenga matenda omwe katemerayu amatanthauza kukutetezani.

Ngati mungapeze katemera wopanda moyo panthawi ya chithandizo cha Orencia, mwina sizingagwire ntchito kukutetezani ku matenda omwe amayenera kuchitidwa. Koma mukuloledwa kupeza katemera wamtunduwu panthawi yachipatala.

Onetsetsani kuti katemera wanu wonse kapena wa mwana wanu ali watsopano musanayambe chithandizo cha Orencia. Ngati muli ndi mafunso okhudzana ndi katemera, kambiranani ndi dokotala. Adzakulangizani ngati katemera angachedwetsedwe.

Ngati nditha kutenga matenda ndikamagwiritsa ntchito Orencia, nditha kumwa maantibayotiki?

Inde. Palibe kulumikizana kulikonse komwe kumadziwika pakati pa Orencia ndi maantibayotiki.

Ngati mutenga kachilombo katsopano mukamamwa Orencia, funsani dokotala ngati mukufuna kumwa maantibayotiki. Amatha kukupatsani mankhwala oti azigwira bwino ntchito akamamwa ndi Orencia.

Kodi ndingamutengere Orencia kunyumba?

Zimatengera momwe dokotala akukulangizani kuti mutenge Orencia.

Dokotala wanu angafune kuti mutenge Orencia kudzera mu kulowetsedwa kwa intravenous (IV). Izi zikutanthauza kuti wothandizira zaumoyo adzaika singano mumtsempha wanu, ndipo mudzalandira mankhwalawo kudzera mu singano ngati kulowetsedwa. Poterepa, simungatenge Orencia kunyumba. Muyenera kupita kuchipatala kuti mukalandire chithandizo.

Kupanda kutero, dokotala angafune kuti mutenge Orencia kudzera mu jakisoni wocheperako. Poterepa, Orencia adzabayidwa ndi singano pansi pa khungu lanu. Jekeseni woyamba ayenera kuchitika kuchipatala ndi achipatala. Koma zitatha izi, mudzatha kudzipangira Orencia kunyumba.

Kodi ndingagwiritse ntchito Orencia ngati ndili ndi matenda ashuga?

Inde, koma muyenera kukhala osamala ngati mutenga Orencia kudzera mu kulowetsedwa kwa intravenousous (IV). Poterepa, Orencia amapatsidwa ngati jakisoni mumitsempha yanu.

Mawonekedwe a Orencia ntchito IV infusions lili ndi maltose. Izi sizigwira ntchito m'thupi lanu kuti zithetse vuto lanu, koma zimakhudza momwe zida zina zimayeza kuchuluka kwa shuga m'magazi anu. Mukakhala ndi maltose, oyang'anira shuga (m'magazi) amatha kuwonetsa kuti muli ndi shuga wambiri kuposa momwe mumakhalira.

Dokotala wanu adziwe ngati muli ndi matenda ashuga ndipo mukutenga Orencia kudzera mu infusions IV. Adzakulangizani njira yabwino kwambiri yodziwira kuchuluka kwa shuga wamagazi mukamalandira chithandizo.

Kodi Orencia angathandize kutaya tsitsi?

Orencia sanatsimikizire kukhala wothandiza poletsa kutayika kwa tsitsi. Ngakhale kafukufuku wina wazachipatala adawunika momwe amagwiritsidwira ntchito pothothoka tsitsi, kafukufukuyu anali ochepa ndipo anali ndi anthu 15 okha.

Lankhulani ndi dokotala wanu ngati mukudandaula za kutayika kwa tsitsi. Angakulangizeni momwe mungachitire ndi izi ndipo atha kukupatsirani mankhwala kuti muwongolere.

Kodi ndingayende ngati ndikumwa Orencia?

Inde, mutha kuyenda, koma muyenera kuwonetsetsa kuti simuphonya mulingo uliwonse wa Orencia.

Ngati mukulandira Orencia kuchipatala chaumoyo, lankhulani ndi omwe amakuthandizani pa zaumoyo wanu. Aonetsetsa kuti dongosolo lanu la mlingo silikusokoneza ulendo wanu.

Ngati mukudzibaya jekeseni Orencia, onetsetsani kuti mutha kumwa mankhwalawo ngati mungafune mlingo wanu mukakhala kuti mulibe nyumba. Funsani dokotala wanu kapena wamankhwala momwe mungapangire ndikusunga Orencia mukamayenda.

Kodi ndikufunika chilolezo choyambirira kuti ndipeze Orencia?

Zimatengera dongosolo lanu la inshuwaransi. Mapulani ambiri a inshuwaransi amapempha chilolezo musanakhale ndi inshuwaransi ya Orencia.

Kuti mupemphe chilolezo chisanachitike, dokotala wanu adzaza zolemba za kampani yanu ya inshuwaransi. Kampani ya inshuwaransi iwonanso zolembazi ndikudziwitsani ngati pulani yanu ikhudza Orencia.

Njira zotetezera ku Orencia

Musanatenge Orencia, kambiranani ndi dokotala za mbiri yanu. Orencia sangakhale oyenera kwa inu ngati muli ndi matenda ena kapena zina zomwe zimakhudza thanzi lanu. Izi zikuphatikiza:

• Kugwiritsa ntchito mankhwala a anti-TNF. Ngati mukumwa mankhwala a anti-TNF (omwe akuphatikizapo Humira, Enbrel, ndi Remicade) ndi Orencia, kuthekera kwa chitetezo chanu cha mthupi kuthana ndi matenda kumatha kuchepetsedwa kwambiri. Izi zimawonjezera chiopsezo chanu chotenga matenda, komanso nthawi zina. Lankhulani ndi dokotala wanu za mankhwala onse omwe mukumwa musanayambe Orencia.
• Mbiri ya matenda obwerezabwereza kapena obisika. Ngati muli ndi matenda obwerezabwereza (matenda omwe amabwerera pafupipafupi), kutenga Orencia kumachulukitsa chiopsezo chanu chobwerezabwereza. Ngati muli ndi matenda obisika (matenda opanda zizindikiro zilizonse), kutenga Orencia kumatha kuwonjezera chiopsezo chanu chotenga matendawa. Matenda omwe amabwera kawirikawiri amaphatikizapo chifuwa chachikulu (TB) ndi kachilombo ka hepatitis B. Lankhulani ndi dokotala wanu za mbiri yanu ya matenda musanayambe Orencia.
• Kufunika kwa katemera. Ngati mulandira katemera mukamamwa Orencia, katemerayo atha kugwira bwino ntchito mthupi lanu. Lankhulani ndi dokotala wanu za katemera aliyense amene mungafunike musanayambe kumwa Orencia.
• Matenda osokoneza bongo (COPD). Ngati muli ndi COPD, kutenga Orencia kumatha kukulitsa zizindikilo zanu za COPD. Chifukwa cha izi, mungafunike kuyang'anitsitsa mukamamwa mankhwalawa. Ngati muli ndi mbiri ya COPD, lankhulani ndi dokotala musanayambe kumwa Orencia.
• Zowopsa kwambiri ku Orencia. Simuyenera kutenga Orencia ngati mwakhala mukugwidwa ndi mankhwalawa m'mbuyomu. Ngati simukudziwa ngati mwayamba kudwala, kambiranani ndi dokotala musanayambe Orencia.
• Mimba. Orencia amagwiritsira ntchito panthawi yoyembekezera sanaphunzire mwa anthu. Lankhulani ndi dokotala wanu ngati Orencia ali otetezeka kugwiritsa ntchito panthawi yoyembekezera. Kuti mumve zambiri, onani gawo la "Orencia and pregnancy" pamwambapa.
• Kuyamwitsa. Sidziwika ngati Orencia ali otetezeka kutenga pamene mukuyamwitsa. Kuti mumve zambiri, onani gawo la "Orencia ndi yoyamwitsa" pamwambapa.

Zindikirani: Kuti mumve zambiri za zovuta zomwe zingachitike chifukwa cha Orencia, onani gawo la "Zotsatira za Orencia" pamwambapa.

Orencia bongo

Kugwiritsa ntchito mopitilira muyeso wa Orencia kumatha kubweretsa zovuta zoyipa. Kuti mumve zambiri pazovuta zoyipa, chonde onani gawo la "Zotsatira za Orencia" pamwambapa.

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwamwa kwambiri mankhwalawa, itanani dokotala wanu. Muthanso kuyitanitsa American Association of Poison Control Center ku 800-222-1222 kapena kugwiritsa ntchito chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Kutha kwa Orencia, kusunga, ndi kutaya

Mukapeza Orencia kuchokera ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito pazolemba pa botolo. Tsikuli limakhala chaka chimodzi kuyambira tsiku lomwe adapereka mankhwalawo.

Tsiku lothera ntchito limathandizira kutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito. Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Yosungirako

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mungasungire mankhwalawo.

Orencia iyenera kusungidwa m'firiji kutentha kwa 36 ° F mpaka 46 ° F (2 ° C mpaka 8 ° C). Muyenera kusunga mankhwalawa kuti asawalitsidwe komanso kusungidwa mkati mwake. Simuyenera kuloleza Orencia (mkati mwa ma syringe oyikapo kale kapena ma Clickinct autoinjectors) kuti azizire.

Kutaya

Ngati simukufunikiranso kumwa Orencia ndikukhala ndi mankhwala otsala, ndikofunika kuwataya mosamala. Izi zimathandiza kupewa ena, kuphatikiza ana ndi ziweto, kuti amwe mankhwalawo mwangozi. Zimathandizanso kuti mankhwalawa asawononge chilengedwe.

Tsamba la FDA limapereka malangizo angapo othandiza pakutha mankhwala. Muthanso kufunsa wamankhwala wanu kuti mumve momwe mungathere mankhwala anu.

Zambiri zamaphunziro a Orencia

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Orencia ndi mankhwala a biologic omwe amawonetsedwa pochiza:

• yogwira, yovuta kwambiri ku nyamakazi ya nyamakazi (RA) mwa akulu
• Matenda a psoriatic arthritis (PsA) mwa akulu
• yogwira, yochepetsetsa mpaka yoopsa kwambiri ya ana yotchedwa idiopathic arthritis (JIA) mwa ana azaka 2 kapena kupitirira

Pazithandizo za RA, Orencia itha kugwiritsidwa ntchito payokha, kapena ngati polytherapy ngati iphatikizidwa ndi mankhwala osintha matenda (DMARDs) osintha matenda. Pazithandizo za JIA, Orencia itha kugwiritsidwa ntchito yokha kapena kuphatikiza methotrexate.

Ngakhale atathandizidwa bwanji, Orencia sayenera kuperekedwa limodzi ndi mankhwala a anti-TNF.

Njira yogwirira ntchito

Orencia amamangiriza kuma cell-protein CD80 ndi CD86, omwe amapezeka mu khungu la ma cell a antigen. Kumanga kumeneku kumalepheretsa kukonzanso kwa CD28 protein. CD28 ndiyofunikira kuti yambitsa ma T-lymphocyte. Kukhazikitsa ma T-lymphocyte kumachita gawo lofunikira pakuwongolera kwa RA ndi PsA.Kuletsa kutsegulaku kumachepetsa kukula kwa matendawa.

Kafukufuku wa in-vitro akuwonetsa kuti kumangiriza CD80 ndi CD86 kumakhala ndi zotsatira zina zamagetsi. Pogwiritsa ntchito ma T-lymphocyte, Orencia amachepetsa kuchuluka kwawo. Zimaletsanso kupanga ma cytokines ofunikira omwe ali ofunikira pama chitetezo amthupi angapo. Ma cytokines awa ndi TNF-alpha, INF-gamma, ndi IL-2.

Komanso, mitundu yazinyama yawonetsa zowonjezera zomwe zimawonedwa pambuyo pa kayendedwe ka Orencia. Kafukufuku adawonetsa kuti Orencia amatha kupondereza kutupa ndikuchepetsa kupanga ma antibodies motsutsana ndi collagen. Ikhozanso kuchepetsa kupanga ma antigen omwe amayang'ana INF-gamma. Kaya izi ndi zofunika kuti Orencia azigwira bwino ntchito sizidziwikabe.

Pharmacokinetics ndi metabolism

Pharmacokinetics ndi kagayidwe kake ka Orencia kamasiyana malinga ndi momwe akuchiritsira. Zimasiyananso kutengera njira yoyendetsera.

Kafukufuku mwa anthu onse odwala akuwonetsa chizolowezi chotsimikiza pamankhwala osokoneza bongo ndikulemera thupi kwambiri. Komabe, palibe kusiyana kwakukulu pakumasulidwa komwe kumanenedwa pakugwiritsidwa ntchito kwa anthu azaka zosiyanasiyana kapena amuna kapena akazi. M'maphunziro, kugwiritsa ntchito methotrexate, anti-TNFs, NSAIDs, kapena corticosteroids sizinayambitse kusintha kwakukulu.

RA: Kulowetsa mkati

Mlingo wambiri wa 10 mg / kg kwa odwala omwe ali ndi nyamakazi (RA) adadzetsa kuchuluka kwa 295 mcg / mL. Kutha kwa theka la moyo kumawonedwa patsiku la 13.1, ndikuchotsa kwa 0.22 mL / h / kg.

Odwala omwe ali ndi RA, Orencia amakula molingana pakati pa mlingo ndi msinkhu wake. Chiyanjano pakati pa mlingo ndi dera lomwe lili pansi pa mphika (AUC) chimatsata chimodzimodzi. Komanso, kufalitsa kwake kumafikira pa chiŵerengero cha 0,07 L / kg.

Kutsata miyezo ingapo ya 10 mg / kg, kukhazikika kumawonedwa patsiku la 60. Ndende yokhazikika yomwe idafikiridwa ndi 24 mcg / mL.

Kukhazikitsa kwa Orencia pamwezi sikuyambitsa kudzikundikira kwamankhwala.

RA: Subcutaneous administration

Mukamagwiritsidwa ntchito mozungulira, Orencia amafikira 32.5 mcg / mL komanso 48.1 mcg / mL, motsatana, patsiku la 85. Ngati mulibe katundu woloza ndi intravenous, Orencia amafika pa 12.6 mcg / mL 2.

Chilolezo chokhazikika chimafika pa 0.28 mL / h / kg, ndikuchuluka kwa magawidwe a 0.11 L / kg. Kucheperako kwa bioavailability ndi 78.6%., Ndi theka la moyo wamasiku 14.3.

PsA: Kulowetsa mkati

Orencia akuwonetsa mzere wama pharmacokinetics pamiyeso pakati pa 3 mg / kg ndi 10 mg / kg. Mukaperekedwa kwa 10 mg / kg, Orencia imafika pakhazikikidwe ka boma masana 57. Makina am'miyeso ndi 24.3 mcg / mL patsiku la 169.

PsA: Kuyendetsa pang'onopang'ono

Kulamulira kwa Orencia 125 mg mlungu uliwonse kumabweretsa chikhomo cha 25.6 mcg / mL patsiku la 169. Dziko lokhazikika limafika patsiku 57.

JIA: Kulowetsa mkati

Kwa ana azaka zapakati pa 6 mpaka 17, Orencia amafikira pamlingo wotsika ndi 11.9 mcg / mL ndi 217 mcg / mL, motsatana, pokhazikika. Chilolezo chimatanthauza 0.4 mL / h / kg.

Maphunziro a Pharmacokinetics a ana ochepera zaka zisanu ndi chimodzi sakupezeka popeza Orencia kudzera pakulowetsedwa m'mitsempha sikuvomerezedwa kuti igwiritsidwe ntchito m'derali.

JIA: Makina oyendetsa pang'onopang'ono

Kwa ana azaka zapakati pa 2 mpaka 17, oyang'anira masabata ochepa a Orencia amafika pokhazikika tsiku 85.

Kutanthauza kuti kuchuluka kwa Orencia kumasiyana kutengera mlingo. Masana 113, Orencia amafikira 44.4 mcg / mL, 46.6 mcg / mL, ndi 38.5 mcg / mL pamiyeso ya 50 mg, 87.5 mg, ndi 125 mg, motsatana.

Zotsutsana

Palibe zotsutsana pakugwiritsa ntchito Orencia. Komabe, zodzitetezera ziyenera kutengedwa nthawi isanakwane komanso ikamadutsa. Kuti mumve zambiri, onani gawo la "zodzitetezera ku Orencia" pamwambapa.

Yosungirako

Mukaperekedwa ngati chidebe chokhala ndi ufa wa lyophilized, Orencia iyenera kukhala mufiriji kutentha kwa 36 ° F mpaka 46 ° F (2 ° C mpaka 8 ° C). Mbaleyo iyenera kusungidwa mkati mwa phukusi lake loyambirira ndikutetezedwa ku kuwala kuti zisawonongeke.

Masirinji odzazidwa kapena ma autoinjector a ClickJect a Orencia ayeneranso kukhala m'firiji pamatentha a 36 ° F mpaka 46 ° F (2 ° C mpaka 8 ° C). Kutentha kuyenera kuyang'aniridwa kupewa kuzizira kwa yankho. Komanso, zida izi ziyenera kusungidwa mkati mwazinthu zoyambirira ndikutetezedwa ku kuwala kuti zisawonongeke.

Chodzikanira: Medical News Today yachita kuyesetsa konse kuti zitsimikizidwe kuti zowona zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.