Kuwongolera Cholesterol: PCSK9 Inhibitors vs. Statins
Zamkati
- Za ma statins
- Momwe amagwirira ntchito
- Mitundu
- About PCSK9 zoletsa
- Akapatsidwa mankhwala
- Momwe amagwirira ntchito
- Zotsatira zoyipa
- Kuchita bwino
- Mtengo
- Lankhulani ndi dokotala wanu
- Lankhulani ndi dokotala wanu
Chiyambi
Pafupifupi anthu 74 miliyoni aku America ali ndi cholesterol yambiri, malinga ndi. Komabe, ochepera theka akulandira chithandizo chake. Izi zimawaika pachiwopsezo chachikulu chodwala matenda a mtima ndi sitiroko. Ngakhale kuchita masewera olimbitsa thupi komanso kudya zakudya zopatsa thanzi kumatha kuthandizira kuchepetsa mafuta m'thupi, nthawi zina mankhwala amafunikira.
Mitundu iwiri yamankhwala omwe amaperekedwa kuti athetse cholesterol wambiri ndi ma statins ndi PCSK9 inhibitors. Statins ndi mankhwala odziwika omwe akhala akupezeka kuyambira ma 1980. PCSK9 inhibitors, komano, ndi mtundu watsopano wa mankhwala a cholesterol. Adavomerezedwa ndi Food and Drug Administration mu 2015.
Pamene inu ndi adotolo mukuganiza zakumwa mankhwala a kolesterolini, mungaganizire zina monga zoyipa, mtengo wake, komanso mphamvu yake. Werengani kuti mudziwe zambiri za mankhwalawa komanso momwe mitundu iwiriyi ikufananirana.
Za ma statins
Ma Statins ndi amodzi mwamankhwala omwe amagwiritsidwa ntchito kuthandiza kuchepetsa cholesterol. Ngati muli ndi cholesterol kapena mavuto ena amtima, dokotala angakuuzeni kuti muyambe kutenga statin. Nthawi zambiri amagwiritsidwa ntchito ngati mankhwala oyamba a cholesterol. Izi zikutanthauza kuti ndiwo mankhwala oyamba omwe dokotala angafune.
Momwe amagwirira ntchito
Statins imagwira ntchito poletsa chinthu chotchedwa HMG-CoA reductase. Ichi ndi gawo lomwe chiwindi chanu chimafunikira kupanga cholesterol. Kuletsa izi kumachepetsa kuchuluka kwa cholesterol yomwe chiwindi chanu chimapanga. Statins imagwiranso ntchito pothandiza thupi lanu kuyambiranso cholesterol iliyonse yomwe yasonkhana pamakoma amitsempha yanu. Kuti mudziwe zambiri, werengani momwe ma statins amagwirira ntchito.
Mitundu
Statins imabwera ngati mapiritsi kapena makapisozi omwe mumamwa. Pali mitundu yambiri yama statins yomwe ikupezeka ku United States masiku ano. Zikuphatikizapo:
- atorvastatin (Lipitor)
- fluvastatin (Lescol)
- lovastatin (Altoprev)
- pravastatin (Pravachol)
- rosuvastatin (Crestor)
- simvastatin (Zocor)
- pitavastatin (Livalo)
About PCSK9 zoletsa
Statins imatha kuperekedwa kwa anthu ambiri omwe ali ndi cholesterol yambiri, koma PCSK9 inhibitors imangotchulidwa kwa mitundu ina ya anthu. Chifukwa ma statins akhala akuzungulira nthawi yayitali, tikudziwa zambiri za momwe amathandizira. PCSK9 inhibitors ndi yatsopano ndipo chifukwa chake amakhala ndi chidziwitso chachitetezo chanthawi yayitali.
Komanso, PCSK9 inhibitors ndiokwera mtengo kwambiri poyerekeza ndi ma statins.
PCSK9 inhibitors amapatsidwa jekeseni wokha. Pali ma PCSK9 Inhibitors awiri okha omwe alipo ku United States: Praluent (alirocumab) ndi Repatha (evolocumab).
Akapatsidwa mankhwala
American College of Cardiology ikukulimbikitsani kuti inu ndi dokotala muganizire zoletsa PCSK9 pokhapokha ngati:
- mumawerengedwa kuti muli pachiwopsezo chachikulu cha vuto la mtima ndi cholesterol yanu siyiyang'aniridwa ndi ma statins kapena mankhwala ena ochepetsa mafuta m'thupi
- muli ndi chibadwa chomwe chimatchedwa banja hypercholesterolemia, chomwe chimakhudza kuchuluka kwama cholesterol
Pazochitika zonsezi, PCSK9 inhibitors imaperekedwa pambuyo poti mitundu iwiri ya mankhwala siikuthandizeni kuchepetsa mafuta m'thupi. Mwachitsanzo, dokotala wanu amatha kukupatsani statin.Ngati izi sizikuchepetsa kuchuluka kwama cholesterol anu mokwanira, dokotala wanu atha kunena ezetimibe (Zetia) kapena mankhwala omwe amatchedwa resin ya bile acid. Zitsanzo za izi ndi cholestyramine (Locholest), colesevelam (Welchol), kapena colestipol (Colestid).
Ngati cholesterol yanu ikadali yayikulu kwambiri pambuyo pa mtundu wachiwiri wa mankhwalawa, dokotala wanu atha kupereka lingaliro la PCSK9 inhibitor.
Momwe amagwirira ntchito
PCSK9 inhibitors itha kugwiritsidwa ntchito kuwonjezera kapena m'malo mwa ma statins. Mankhwalawa amagwira ntchito mosiyanasiyana. PCSK9 inhibitors amayang'ana protein m'chiwindi yotchedwa proprotein convertase subtilisin kexin 9, kapena PCSK9. Mwa kuchepetsa kuchuluka kwa PCSK9 mthupi lanu, PCSK9 inhibitors amalola thupi lanu kuchotsa cholesterol bwino kwambiri.
Zotsatira zoyipa
Statins ndi PCSK9 inhibitors amatha kuyambitsa zovuta zoyipa komanso zoyipa, ndipo zotsatirapo zake ndizosiyana pakati pa mankhwalawa.
| Zolemba | PCSK9 zoletsa | |
| Zotsatira zoyipa | • kupweteka kwa minofu ndi molumikizana mafupa • nseru • kupweteka m'mimba • kudzimbidwa • kupweteka mutu | • kutupa pamalo obayira • kupweteka kwa miyendo kapena minofu yanu • kutopa |
| Zotsatira zoyipa | • kuwonongeka kwa chiwindi • kuchuluka kwa magazi m'magazi • chiopsezo chachikulu cha matenda amtundu wa 2 • mavuto amalingaliro (amisala) • kuwonongeka kwa minofu komwe kumabweretsa rhabdomyolysis | • matenda ashuga • mavuto a chiwindi • mavuto a impso • matenda amisala |
Kuchita bwino
Ma Statins awonetsedwa kuti amachepetsa cholesterol mwa anthu ambiri. Zakhala zikugwiritsidwa ntchito kuyambira ma 1980 ndipo zotsatira zake zawerengedwa mwa anthu masauzande ambiri omwe amatenga ma statins kuti athane ndi vuto la mtima ndi sitiroko.
Mosiyana ndi izi, ma PCSK9 inhibitors adavomerezedwa posachedwa, chifukwa chake chidziwitso cha chitetezo cha nthawi yayitali sichabwino. Komabe PCSK9 inhibitors ndiyothandiza kwambiri kwa anthu ena.Kafukufuku wina adawonetsa kuti alirocumab yachepetsa mafuta a cholesterol ndi 61 peresenti. Zachepetsanso mwayi wamatenda amtima monga matenda amtima komanso kupwetekedwa mtima. Kafukufuku wina adapeza zotsatira zofananira ndi evolocumab.
Mtengo
Ma Statin amapezeka m'maina odziwika ndi mawonekedwe achibadwa. Zowonjezera nthawi zambiri zimakhala zotsika mtengo kuposa mitundu yamtundu, motero ma statins amatha kutsika mtengo.
Ma PCSK9 inhibitors ndi atsopano, chifukwa chake alibe mitundu yachilengedwe yomwe ikupezeka pano. Pachifukwa ichi, ndiokwera mtengo kuposa ma statins. Mtengo wa ma PCSK9 inhibitors ukhoza kukhala wopitilira $ 14,000 pachaka. Kuphatikiza apo, kuti ndalamazi zikhale ndi inshuwaransi yanu, muyenera kukhala m'gulu limodzi mwamagawo awiri omwe akulimbikitsidwa kugwiritsa ntchito PCSK9 inhibitors. Ngati simukugwirizana ndi amodzi mwamagawo amenewo, mungafunikire kulipira choletsa PCSK9 nokha.
Lankhulani ndi dokotala wanu
Statins ndi PCSK9 inhibitors ndizofunikira pakusankha mankhwala pochiza mafuta ambiri. Ngakhale mitundu yonse ya mankhwala imathandizira kutsitsa cholesterol, pali kusiyana kwakukulu. Gome ili m'munsi likufotokoza zakusiyanaku pang'onopang'ono.
| Zolemba | PCSK9 zoletsa | |
| Chaka chilipo | 1987 | 2015 |
| Fomu ya mankhwala osokoneza bongo | mapiritsi otengedwa pakamwa | jakisoni yekha |
| Yolembedwa kuti | anthu omwe ali ndi mafuta ambiri | anthu omwe ali ndi mafuta ambiri omwe amakwaniritsa zofunikira ziwiri |
| Zotsatira zoyipa kwambiri | kupweteka kwa minofu, kupweteka mutu, komanso mavuto am'mimba | kutupa kwa tsamba la jakisoni, kupweteka kwamiyendo kapena minofu, ndi kutopa |
| Mtengo | zotsika mtengo | okwera mtengo |
| Kupezeka kwapadera | zowonjezera zilipo | palibe zowonjezera zomwe zilipo |
Lankhulani ndi dokotala wanu
Ngati muli ndi mafuta ambiri m'thupi ndipo mukuganiza kuti mankhwalawa akhoza kukhala oyenera kwa inu, choyamba muyenera kulankhula ndi dokotala. Amatha kukuwuzani zambiri za mankhwalawa komanso njira zina zomwe mungasamalire. Mafunso ena oti mukambirane ndi dokotala akhoza kukhala awa:
- Kodi mankhwala ndi gawo lotsatira kwa ine poletsa cholesterol yanga yambiri?
- Kodi ndikwaniritsa zofunikira ziwiri kwa anthu omwe angathe kupatsidwa PCSK9 inhibitors?
- Kodi ndiyenera kulankhula ndi katswiri wa lipid?
- Kodi ndiyambe kuchita masewera olimbitsa thupi kuti ndithandizire kuchepetsa mafuta m'thupi?
- Kodi munganditumizireko katswiri wazakudya kuti andithandize kuchepetsa mavutowa?
Zambiri
Kulephera kwa Vertebrobasilar
