Zomwe Aliyense amene ali ndi Psoriasis Ayenera Kudziwa Zokhudza PDE4 Inhibitors

Zamkati

• Chidule
• Kodi zoletsa za PDE4 ndi chiyani?
• Kodi amagwira ntchito bwanji psoriasis?
• Mankhwala a PDE4 inhibitor motsutsana ndi mankhwala ena a psoriasis
• Zopindulitsa
• Zotsatira zoyipa ndi machenjezo
• Kutenga

Chidule

Plaque psoriasis ndichikhalidwe chokhazikika chokha. Ndiye kuti chitetezo cha mthupi chimalowerera molakwika thupi. Zimayambitsa zigamba zofiira, zonyezimira pakhungu. Zilondazi nthawi zina zimatha kumva kuyabwa kapena kupweteka.

Njira zochiritsira zimachepetsa izi. Chifukwa kutupa ndiko komwe kumayambitsa matenda a psoriasis, cholinga cha mankhwala ambiri ndikuchepetsa chitetezo chamthupi ndikukhazikitsa bwino.

Ngati mukukhala ndi psoriasis yolemera pang'ono kapena yolemera, PDE4 inhibitor itha kukhala chida chothandiza pakuwongolera zizindikilo.

Komabe, mankhwalawa si a aliyense. Muyenera kukambirana ndi dokotala za zomwe mungachite.

Kodi zoletsa za PDE4 ndi chiyani?

PDE4 inhibitors ndi mankhwala atsopano. Amagwira ntchito yopondereza chitetezo cha mthupi, chomwe chimachepetsa kutupa. Amagwira ntchito yamagulu kuti aletse kupanga enzyme yochulukirapo yotchedwa PDE4.

Ofufuza akudziwa kuti phosphodiesterases (PDEs) imachepetsa cyclic adenosine monophosphate (cAMP). cAMP imathandizira kwambiri pakuwonetsa mayendedwe pakati pama cell.

Poyimitsa PDE4s, msasa ukuwonjezeka.

Malinga ndi kafukufuku wa 2016, kuchuluka kwakukulu kwa msasawo kumatha kukhala ndi zotsutsana ndi zotupa, makamaka kwa anthu omwe ali ndi psoriasis ndi atopic dermatitis.

Kodi amagwira ntchito bwanji psoriasis?

PDE4 inhibitors, monga apremilast (Otezla), imagwira ntchito mthupi kuti iteteze kutupa.

Monga njira yodzitetezera, zitha kukhala zabwino kwa anthu omwe ali ndi psoriasis kuthana ndi kutupa. Kuchepetsa kutupa kumatha kupangitsa kuti miliri isafike pafupipafupi komanso kuti ichepetse.

Zitha kupewetsa kapena kupewa kupita patsogolo kwa matenda kuti zibweretse psoriatic arthritis (PsA).

Mwa iwo omwe amakhala ndi mtundu uliwonse wa psoriasis, pafupifupi 30% pamapeto pake amakhala ndi PsA, yomwe imapweteka pang'ono. PsA ikhoza kuchepetsa moyo wanu.

Mankhwala a PDE4 inhibitor motsutsana ndi mankhwala ena a psoriasis

Apremilast, PDE4 inhibitor, amatengedwa pakamwa. Imachitanso panjira yofunikira posokoneza kuyankha kotupa komwe kumathandizira kuzizindikiro za plaque psoriasis.

Mankhwala a biologic monga adalimumab (Humira), etanercept (Enbrel), ndi infliximab (Remicade) amalowetsedwa m'thupi.

Mankhwala ena ojambulidwa ndi biologic ndi awa:

• Ustekinumab (IL-12/23 choletsa)
• secukinumab (IL-17A choletsa)
• ixekizumab (IL-17A choletsa)
• guselkumab (IL-23 choletsa)
• risankizumab (IL-23 choletsa)

Tofacitinib ndi Janus kinase (JAK) inhibitor yomwe imavomerezedwa ngati mankhwala akumwa.

Abatacept ndi T-cell activation inhibitor yomwe imaperekedwa ngati kulowetsedwa kwa intravenous (IV) kapena jakisoni.

Zopindulitsa

Apremilast imalimbikitsidwa kwa anthu omwe amakhala ndi psoriasis yolimbitsa thupi kwambiri omwe amafunikanso kulandira mankhwala kapena phototherapy.

Mu, anthu ochulukirapo omwe amatenga apremilast adachita bwino pa Physician's Global Assessment (sPGA) ndi Psoriasis Area and Severity Index (PASI) poyerekeza ndi omwe amatenga placebo.

Zotsatira zoyipa ndi machenjezo

Ngakhale zoletsa za PDE4 zikuwonetsa lonjezo lalikulu, sizili za aliyense. Apremilast sanayesedwe mwa amayi apakati kapena oyamwitsa. Pakadali pano, ndi zovomerezeka kwa akulu okha.

Ndikofunikanso kuyeza zoopsa zomwe zingachitike komanso maubwino a zoletsa za PDE4.

Apremilast imabwera ndi zoopsa zina.

Anthu omwe amatenga apremilast amatha kuchitapo kanthu monga:

• nseru
• kutsegula m'mimba
• matenda opatsirana apamwamba
• mutu

Anthu ena amakhalanso ndi kuchepa kwakukulu.

Apremilast amathanso kukulitsa kukhumudwa komanso malingaliro ofuna kudzipha.

Kwa anthu omwe ali ndi mbiri yakukhumudwa kapena kudzipha, akulimbikitsidwa kuti alankhule ndi adotolo kuti awathandize kuwunika mosamala phindu lomwe lingakhalepo ndi mankhwalawa pangozi.

Ngati mukumana ndi zovuta zina, dokotala wanu angakulimbikitseni kusiya mankhwalawo.

Kutenga

Psoriasis ndichinthu chosatha - koma chosatheka -. Udindo womwe kutupa kumayang'ana ndichithandizo ndi kafukufuku.

Ngati dokotala wanu atsimikiza kuti plaque psoriasis yanu ndiyofatsa kapena yosamalidwa bwino, atha kulimbikitsa mankhwala osagwiritsa ntchito anti-inflammatory (NSAIDs). Angathenso kulangiza chithandizo cham'mutu.

Ayeneranso kuyesa malangizowo onse asanaganize zogwiritsa ntchito PDE4 inhibitor kapena ma modulators ena amthupi.

Ofufuza apeza zambiri zamomwe zimapangidwira kutupa mthupi. Izi zathandiza pakupanga mankhwala atsopano omwe angapereke mpumulo kwa iwo omwe ali ndi psoriasis.

PDE4 inhibitors ndizatsopano kwambiri, koma zimadza ndi zoopsa. Inu ndi dokotala muyenera kulingalira mosamala izi musanayambe mtundu wina wa chithandizo.