Prokinetic Agents

Zamkati

• Mitundu ya Prokinetics
• Bethanechol
• Cisapride
• Metoclopramide

Pakhosi lamunthu labwino, kumeza kumapangitsa chidwi chachikulu. Izi ndizomwe zimasokoneza chakudya chanu m'mimba mwanu ndikudutsa m'mimba mwanu. Komanso, gastroesophageal reflux imayambitsa kuphulika kwachiwiri kwamitsempha komwe kumachotsa kum'mero, kukankhira chakudya kutsika m'munsi mwa esophageal sphincter (LES) ndikulowa m'mimba.

Komabe, mwa anthu ena, a LES amatha kumasuka kapena kutseguka zokha, kulola zomwe zili m'mimba, kuphatikiza zidulo, kuti zibwererenso kumtunda. Izi zimatchedwa acid reflux ndipo zimatha kubweretsa zizindikilo monga kutentha pa chifuwa.

Ma Prokinetic agents, kapena prokinetics, ndi mankhwala omwe amathandiza kuchepetsa acid reflux. Prokinetics imathandizira kulimbitsa m'munsi esophageal sphincter (LES) ndikupangitsa zomwe zili m'mimba kutulutsa mwachangu. Izi zimapereka nthawi yocheperako kuti asidi ayambe kuchitika.

Masiku ano, ma prokinetics amagwiritsidwa ntchito ndimatenda ena a gastroesophageal reflux (GERD) kapena mankhwala owawa, monga proton pump inhibitors (PPIs) kapena H2 receptor blockers. Mosiyana ndi mankhwala enawa a acid reflux, omwe nthawi zambiri amakhala otetezeka, ma prokinetics atha kukhala ndi zovuta zoyipa, kapena zowopsa. Nthawi zambiri amagwiritsidwa ntchito pamavuto akulu kwambiri a GERD.

Mwachitsanzo, prokinetics itha kugwiritsidwa ntchito pochiza anthu omwe nawonso ali ndi matenda a shuga omwe amadalira insulin, kapena makanda ndi ana omwe ali ndi vuto la kutuluka m'mimba kapena kudzimbidwa kwakukulu komwe sikukuyankha mankhwala ena.

Mitundu ya Prokinetics

Bethanechol

Bethanechol (Urecholine) ndi mankhwala omwe amalimbikitsa chikhodzodzo ndipo amakuthandizani kupititsa mkodzo ngati mukuvutika kutulutsa chikhodzodzo. Zimathandizira kulimbitsa LES, ndikupangitsa m'mimba kukhala opanda kanthu mwachangu. Zimathandizanso kupewa nseru ndi kusanza. Ikupezeka piritsi.

Komabe, kufunikira kwake kumatha kupitilira zotsatira zoyipa zomwe zimachitika pafupipafupi. Zotsatira zake zimatha kukhala:

• nkhawa
• kukhumudwa
• Kusinza
• kutopa
• mavuto akuthupi monga kuyenda kosafunikira komanso kutuluka kwa minofu

Cisapride

Cisapride (Propulsid) imagwiritsa ntchito serotonin receptors m'mimba. Amagwiritsidwa ntchito makamaka kukonza kamvekedwe ka minofu mu LES. Komabe, chifukwa cha zovuta zake, monga kugunda kwamtima kosazolowereka, wachotsedwa pamsika m'maiko angapo, kuphatikiza United States. Amadziwika kuti anali othandiza pochiza GERD monga H2 receptor blockers monga famotidine (Pepcid). Cisapride imagwiritsidwabe ntchito nthawi zambiri kuchipatala cha ziweto.

Metoclopramide

Metoclopramide (Reglan) ndi wothandizira ma prokinetic omwe amagwiritsidwa ntchito pochizira GERD pokonzanso minyewa yam'mimba. Imapezeka m'mapiritsi ndi mawonekedwe amadzimadzi. Monga ma prokinetics ena, mphamvu ya metoclopramide imalephereka ndi zovuta zoyipa.

Zotsatira zoyipa zimatha kukhala ndi chiopsezo chowonjezeka chamanjenje monga tardive dyskinesia, yomwe imayambitsa mayendedwe obwerezabwereza. Zotsatirazi zakhala zikudziwika kuti zimachitika mwa anthu omwe amakhalabe pamankhwalawa kupitilira miyezi itatu. Anthu omwe amatenga metoclopramide ayenera kukhala osamala kwambiri poyendetsa kapena kugwiritsa ntchito makina kapena zida zolemera.

Gwiritsani ntchito ndi dokotala wanu kuti mudziwe njira yothandizira yoyenera kwa inu. Onetsetsani kuti mukutsatira malangizo omwe dokotala akukupatsani. Itanani dokotala wanu ngati mukumva kuti mankhwala anu ayambitsa zovuta.