Proton Pump Inhibitors

Zamkati

• Kodi Proton Pump Pump Inhibitors Amagwira Ntchito Motani?
• Kodi Pali Mitundu Yosiyanasiyana ya Proton Pump Inhibitors?
• Kodi Ndizoopsa Zotani Zogwiritsa Ntchito Proton Pump Inhibitors?
• Zotsatira Zotsatira

Chithandizo cha matenda a reflux am'mimba (GERD) nthawi zambiri amakhala ndi magawo atatu. Magawo awiri oyamba akuphatikiza kumwa mankhwala ndikusintha zakudya komanso kusintha kwa moyo. Gawo lachitatu ndi opaleshoni. Opaleshoni imagwiritsidwa ntchito ngati njira yomaliza pamavuto akulu a GERD omwe amakumana ndi zovuta.

Anthu ambiri adzapindula ndi mankhwala oyamba mwa kusintha momwe amadyera, liti komanso zomwe amadya. Komabe, kusintha kwa zakudya ndi kusintha kwa moyo pakokha mwina sikungakhale kothandiza kwa ena. M'maphunziro amenewa, madokotala amalimbikitsa kugwiritsa ntchito mankhwala omwe amachepetsa kapena kuletsa kupanga asidi m'mimba.

Proton pump inhibitors (PPIs) ndi mtundu umodzi wamankhwala omwe angagwiritsidwe ntchito kuchepetsa asidi wam'mimba ndikuchepetsa zizindikiritso za GERD. Mankhwala ena omwe amatha kuchiza asidi m'mimba amaphatikizapo ma H2 receptor blockers, monga famotidine (Pepcid AC) ndi cimetidine (Tagamet). Komabe, ma PPI nthawi zambiri amakhala othandiza kuposa ma H2 receptor blockers ndipo amatha kuchepetsa zizindikilo mwa anthu ambiri omwe ali ndi GERD.

Kodi Proton Pump Pump Inhibitors Amagwira Ntchito Motani?

Ma PPI amagwira ntchito poletsa ndikuchepetsa kutulutsa kwa asidi m'mimba. Izi zimapatsa nthawi yowonongeka yam'mimba nthawi yochira. Ma PPI amathandizanso kupewa kutentha pa chifuwa, kutentha komwe kumatsagana ndi GERD. Ma PPI ndi amodzi mwamankhwala amphamvu kwambiri pothana ndi zizolowezi za GERD chifukwa ngakhale asidi wocheperako amatha kuyambitsa zizindikilo zazikulu.

Ma PPI amathandizira kuchepetsa asidi m'mimba kwa milungu inayi kapena 12. Nthawi yochulukayi imalola kuti machiritso am'mimba azichiritsidwa bwino. Zitha kutenga nthawi yayitali kuti PPI ichepetse matenda anu kuposa H2 receptor blocker, yomwe nthawi zambiri imayamba kuchepetsa asidi m'mimba pasanathe ola limodzi. Komabe, kupumula kwa zizindikiro kuchokera ku ma PPI kumatha nthawi yayitali. Chifukwa chake mankhwala a PPI amakhala oyenera kwambiri kwa omwe ali ndi GERD.

Kodi Pali Mitundu Yosiyanasiyana ya Proton Pump Inhibitors?

Ma PPI amapezeka pamakalata komanso pamankhwala. Ma PPI owerengera ndi awa:

• lansoprazole (Prevacid 24 HR)
• omeprazole (Prilosec)
• esomeprazole (Wowonjezera)

Lansoprazole ndi omeprazole amapezekanso mwa mankhwala, monga ma PPI otsatirawa:

• dexlansoprazole (Wosokoneza, Kapidex)
• pantoprazole sodium (Protonix)
• rabeprazole sodium (Aciphex)

Mankhwala ena omwe amadziwika kuti Vimovo amapezekanso pochiza GERD. Lili ndi kuphatikiza kwa esomeprazole ndi naproxen.

Mphamvu zamankhwala komanso ma PCIs owoneka ngati akugwira ntchito mofananamo popewa zizindikiritso za GERD.

Lankhulani ndi dokotala ngati zizindikiro za GERD sizikusintha ndi pa-counter kapena ma PPIs akuchipatala mkati mwa milungu ingapo. Mutha kukhala ndi Helicobacter pylori (H. pylori) matenda a bakiteriya. Matenda amtunduwu amafunikira chithandizo chovuta kwambiri. Komabe, matendawa samayambitsa zizindikiro nthawi zonse. Zizindikiro zikayamba, zimakhala zofanana kwambiri ndi zizindikiritso za GERD. Izi zimapangitsa kuti zikhale zovuta kusiyanitsa pakati pazikhalidwe ziwirizi. Zizindikiro za H. pylori Matendawa atha kukhala:

• nseru
• kubowola pafupipafupi
• kusowa chilakolako
• kuphulika

Ngati dokotala akukayikira kuti muli ndi H. pylori Matendawa, amayesa mayeso osiyanasiyana kuti atsimikizire kuti ali ndi vutoli. Kenako adzawona njira yothandiza yothandizira.

Kodi Ndizoopsa Zotani Zogwiritsa Ntchito Proton Pump Inhibitors?

Ma PPI amaonedwa kuti ndi mankhwala otetezeka komanso ololedwa bwino. Komabe, kafukufuku tsopano akuwonetsa kuti zoopsa zina zitha kuphatikizidwa ndi kugwiritsa ntchito mankhwalawa kwakanthawi.

Kafukufuku waposachedwa adapeza kuti anthu omwe amagwiritsa ntchito ma PPI nthawi yayitali amakhala ndizosiyanasiyana m'matumbo mwawo. Kuperewera kwa mitundu yosiyanasiyana kumawaika pachiwopsezo chowonjezeka cha matenda opatsirana, kuphwanya kwa mafupa, komanso kuchepa kwa vitamini ndi mchere. M'matumbo mwanu muli mabakiteriya mabiliyoni ambiri. Ngakhale ena mwa mabakiteriyawa ndi "oyipa," ambiri mwa iwo alibe vuto lililonse ndipo amathandizira pazonse kuyambira chimbudzi mpaka kukhazikika kwamalingaliro. Ma PPI amatha kusokoneza mabakiteriya pakapita nthawi, ndikupangitsa kuti mabakiteriya "oyipa" apitirire mabakiteriya "abwino". Izi zitha kubweretsa matenda.

Kuphatikiza apo, US Food and Drug Administration (FDA) idatulutsa mu 2011 yomwe idati kugwiritsa ntchito mankhwala osokoneza bongo a PPIs nthawi yayitali kumatha kuphatikizidwa ndi magulu otsika a magnesium. Izi zitha kubweretsa zovuta zathanzi, kuphatikiza kuphwanya kwa minofu, kugunda kwamtima kosasinthasintha, ndi kukomoka. Pafupifupi 25 peresenti ya milandu yomwe FDA idawunikiranso, kuphatikiza kwa magnesium kokha sikunapangitse milingo yotsika ya serum magnesium. Zotsatira zake, ma PPI amayenera kuthetsedwa.

Komabe a FDA akugogomezera kuti pali chiopsezo chochepa chokhala ndi michere yotsika yamagetsi mukamagwiritsa ntchito ma PPI owonjezera monga akuwuzira. Mosiyana ndi ma PPIs am'makalata, mitundu yotsatsa imagulitsidwa pamlingo wochepa. Amapangidwanso kuti azichita chithandizo cha milungu iwiri osapitilira katatu pachaka.

Ngakhale zovuta zoyipa, ma PPI nthawi zambiri amakhala mankhwala othandiza kwa GERD. Inu ndi dokotala wanu mutha kukambirana za zoopsa zomwe zingachitike ndikuwona ngati ma PPI ndiye njira yabwino kwambiri kwa inu.

Zotsatira Zotsatira

Mukasiya kumwa ma PPI, mutha kuwonjezeka pakupanga acid. Kuwonjezeka kumeneku kumatha miyezi ingapo. Dokotala wanu amatha kukutayitsani mankhwalawa pang'onopang'ono kuti athandize kupewa izi. Angalimbikitsenso kutenga njira zotsatirazi kuti muchepetse kusowa mtendere kwanu pazizindikiro zilizonse za GERD:

• kudya magawo ang'onoang'ono
• kudya mafuta ochepa
• kupewa kupezeka pansi kwa maola osachepera awiri mutadya
• kupewa zokhwasula-khwasula musanagone
• kuvala zovala zotayirira
• kukweza mutu wa bedi pafupifupi mainchesi sikisi
• kupewa mowa, fodya, ndi zakudya zomwe zimayambitsa zizindikilo

Onetsetsani kuti mwaonana ndi dokotala musanamwe mankhwala omwe akupatsani.