Mayeso a TP53 Genetic

Zamkati

• Kodi mayeso a majini a TP53 ndi chiani?
• Amagwiritsidwa ntchito yanji?
• Chifukwa chiyani ndikufunika mayeso amtundu wa TP53?
• Kodi chimachitika ndi chiani pakuyesa kwa TP53?
• Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?
• Kodi pali zoopsa zilizonse pamayeso?
• Kodi zotsatirazi zikutanthauza chiyani?
• Kodi pali china chilichonse chomwe ndiyenera kudziwa pamayeso a TP53?
• Zolemba

Kodi mayeso a majini a TP53 ndi chiani?

Kuyesa kwamtundu wa TP53 kumayang'ana kusintha, kotchedwa kusintha, mu jini yotchedwa TP53 (chotupa cha protein 53). Chibadwa ndiye gawo lobadwa kuchokera kwa amayi ndi abambo ako.

TP53 ndi jini lomwe limathandiza kuletsa kukula kwa zotupa. Amadziwika kuti suppressor ya chotupa. Jini yoletsa chotupa imagwira ntchito ngati mabuleki pagalimoto. Imaika "mabuleki" m'maselo, kuti asagawane mwachangu kwambiri. Ngati muli ndi kusintha kwa TP53, jiniyo silingathe kulamulira kukula kwa maselo anu. Kukula kosalamulirika kwama cell kumatha kubweretsa khansa.

Kusintha kwa TP53 kumatha kubadwa kuchokera kwa makolo anu, kapena mungapeze mtsogolo kuchokera m'chilengedwe kapena cholakwika chomwe chimachitika mthupi lanu panthawi yamagawi.

• Kusintha komwe tidalandira kwa TP53 kumadziwika kuti Li-Fraumeni syndrome.
• Matenda a Li-Fraumeni ndizosowa zomwe zimatha kuonjezera chiopsezo cha mitundu ina ya khansa.
• Khansa izi zimaphatikizapo khansa ya m'mawere, khansa ya m'mafupa, leukemia, ndi khansa yofewa, yotchedwanso sarcomas.

Zopezeka (zotchedwanso somatic) kusintha kwa TP53 ndizofala kwambiri. Zosinthazi zapezeka pafupifupi theka la milandu yonse ya khansa, komanso mitundu ingapo ya khansa.

Mayina ena: Kusanthula kusintha kwa TP53, TP53 kusanthula kwathunthu kwa majini, TP53 somatic mutation

Amagwiritsidwa ntchito yanji?

Kuyesaku kumagwiritsidwa ntchito kuyang'ana kusintha kwa TP53. Sichomwe chimayesedwa nthawi zonse.Nthawi zambiri amaperekedwa kwa anthu kutengera mbiri ya banja, zisonyezo, kapena matenda am'mbuyomu a khansa.

Chifukwa chiyani ndikufunika mayeso amtundu wa TP53?

Mungafunike kuyesa kwa TP53 ngati:

• Mwapezeka kuti muli ndi khansa ya mafupa kapena yofewa musanafike zaka 45
• Mwapezeka kuti muli ndi khansa ya m'mawere, isanakwane msambo, chotupa muubongo, khansa ya m'magazi, kapena khansa yam'mapapo zaka za 46 zisanakwane
• Mudakhala ndi chotupa chimodzi kapena zingapo musanakwanitse zaka 46
• M'modzi kapena angapo am'banja mwanu amapezeka kuti ali ndi matenda a Li-Fraumeni komanso / kapena adadwala khansa asanakwanitse zaka 45

Izi ndi zizindikilo zomwe mungakhale ndi kusintha kwa chibadwa cha mtundu wa TP53.

Ngati mwapezeka kuti muli ndi khansa ndipo mulibe mbiri yakubadwa kwa matendawa, wothandizira zaumoyo wanu akhoza kuyitanitsa mayesowa kuti awone ngati kusintha kwa TP53 kungayambitse khansa yanu. Kudziwa ngati muli ndi kusintha kwa thupi kumatha kuthandiza wopezayo kukonzekera chithandizo ndikudziwiratu zomwe zingachitike chifukwa cha matenda anu.

Kodi chimachitika ndi chiani pakuyesa kwa TP53?

Kuyesa kwa TP53 nthawi zambiri kumachitika pamwazi kapena m'mafupa.

Ngati mukupima magazi, Katswiri wa zamankhwala adzatenga magazi kuchokera mumtsinje wamkono mwanu, pogwiritsa ntchito singano yaying'ono. Singanoyo italowetsedwa, magazi ang'onoang'ono amatengedwa mu chubu choyesera. Mutha kumva kuluma pang'ono singano ikamalowa kapena kutuluka. Izi nthawi zambiri zimatenga mphindi zosakwana zisanu.

Ngati mukupima mayeso a m'mafupa, Njira yanu itha kukhala ndi izi:

• Mudzagona chammbali kapena m'mimba, kutengera fupa liti lomwe lidzagwiritsidwe ntchito poyesa. Mayeso ambiri am'mafupa amachotsedwa m'chiuno.
• Thupi lanu lidzakutidwa ndi nsalu, kotero kuti malo okha ozungulira malo oyesera ndi omwe akuwonetsedwa.
• Tsambali lidzatsukidwa ndi mankhwala opha tizilombo.
• Mupeza jakisoni wa yankho lodzidzimutsa. Itha kuluma.
• Dera likangokhala dzanzi, wothandizira zaumoyo atenga chitsanzocho. Muyenera kunama mutayesedwa.
• Wothandizira zaumoyo adzagwiritsa ntchito chida chapadera chomwe chimapindika mufupa kuti atengeko gawo la mafupa. Mutha kumva kukakamizidwa pamalopo pomwe zitsanzo zikutengedwa.
• Pambuyo pa kuyezetsa, wothandizira zaumoyo adzaphimba malowo ndi bandeji.
• Konzani kuti wina azikuthamangitsani kupita nanu kunyumba, chifukwa mutha kukupatsani mankhwala ogonetsa musanayesedwe, zomwe zingakupangitseni kuti mugone.

Kodi ndiyenera kuchita chilichonse kukonzekera mayeso?

Nthawi zambiri simusowa kukonzekera kwapadera kokayezetsa magazi kapena m'mafupa.

Kodi pali zoopsa zilizonse pamayeso?

Pali chiopsezo chochepa kwambiri choyesedwa magazi. Mutha kukhala ndi ululu pang'ono kapena kuvulala pamalo pomwe singano idayikidwapo, koma zizindikiro zambiri zimatha msanga.

Pambuyo poyesedwa m'mafupa, mumatha kumva kuti ndinu olimba kapena opweteka pamalo obayira. Izi zimatha masiku angapo. Wothandizira zaumoyo wanu akhoza kukulangizani kapena kukupatsani mankhwala ochepetsa ululu kuti akuthandizeni.

Kodi zotsatirazi zikutanthauza chiyani?

Ngati mwapezeka kuti muli ndi matenda a Li-Fraumeni, izo satero zikutanthauza kuti muli ndi khansa, koma chiopsezo chanu ndichokwera kuposa anthu ambiri. Koma ngati mutasintha, mutha kuchitapo kanthu kuti muchepetse chiopsezo chanu, monga:

• Zowonetseratu khansa pafupipafupi. Khansa imatha kuchiritsidwa ikapezeka koyambirira.
• Kusintha moyo wanu, monga kuchita masewera olimbitsa thupi komanso kudya zakudya zabwino
• Chemoprevention, kumwa mankhwala, mavitamini, kapena zinthu zina kuti muchepetse chiopsezo kapena kuchedwetsa kukula kwa khansa.
• Kuchotsa minofu "yomwe ili pachiwopsezo"

Izi zimasiyana kutengera mbiri yaumoyo wanu komanso banja lanu.

Ngati muli ndi khansa ndipo zotsatira zanu zikuwonetsa kusinthika kwa TP53 (kusintha komwe kunapezeka, koma mulibe mbiri yabanja ya khansa kapena matenda a Li-Fraumeni), omwe amakupatsani mwayi atha kugwiritsa ntchito zidziwitsozi pofotokozera momwe matenda anu adzakhalire ndikuwongolera chithandizo.

Dziwani zambiri zamayeso a labotale, magawo owerengera, ndi zotsatira zakumvetsetsa.

Kodi pali china chilichonse chomwe ndiyenera kudziwa pamayeso a TP53?

Ngati mwapezeka kuti muli ndi matenda a Li-Fraumeni kapena mukukayikira kuti muli ndi vuto la Li-Fraumeni, zingathandize kulankhula ndi mlangizi wa majini. Phungu wamtundu ndi katswiri wophunzitsidwa mwapadera pama genetics ndi kuyesa kwa majini. Ngati simunayesedwebe, mlangizi akhoza kukuthandizani kumvetsetsa kuopsa ndi maubwino oyesedwa. Ngati mwayesedwa, mlangizi atha kukuthandizani kumvetsetsa zotsatirazo ndikukuwongolerani kuti muthandizire ntchito ndi zinthu zina.

Zolemba

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Zomwe zili patsamba lino siziyenera kugwiritsidwa ntchito m'malo mwa chithandizo chamankhwala kapena upangiri. Lumikizanani ndi othandizira azaumoyo ngati muli ndi mafunso okhudzana ndi thanzi lanu.