Kodi Vitamini D Ingachepetse Kuopsa Kwa COVID-19?

Zamkati

• Kodi vitamini D imakhudza bwanji chitetezo cha mthupi?
• Kodi kumwa vitamini D kungateteze ku COVID-19?
• Mfundo yofunika

Vitamini D ndi mavitamini osungunuka mafuta omwe amatenga mbali yayikulu mthupi lanu.

Chakudyachi ndichofunikira kwambiri pamatenda amthupi, kusiya anthu ambiri akudzifunsa ngati kuwonjezera mavitamini D kungathandize kuchepetsa chiopsezo chotenga coronavirus yatsopano yomwe imayambitsa COVID-19.

Ngakhale pakadali pano palibe mankhwala a COVID-19, njira zodzitetezera monga kudzilimbitsa thupi ndi ukhondo woyenera zingakutetezeni kuti musatenge kachilomboka.

Komanso, kafukufuku wina akuwonetsa kuti kukhala ndi vitamini D wathanzi kumatha kuthandiza chitetezo cha mthupi mwanu komanso kuteteza matenda opuma.

Kafukufuku waposachedwa adawonetsa kuti odwala omwe agonekedwa mchipatala ndi COVID-19 omwe anali ndi mavitamini D okwanira anali ndi chiopsezo chotsika pazotsatira zoyipa ndikufa ().

Nkhaniyi ikufotokoza momwe vitamini D imakhudzira thanzi lamthupi komanso momwe kuwonjezera ndi michere imeneyi kungatetezere ku kupuma.

Kodi vitamini D imakhudza bwanji chitetezo cha mthupi?

Vitamini D ndiyofunikira kuti magwiridwe antchito amthupi anu azigwira bwino ntchito - yomwe ndi njira yoyamba yodzitetezera kumatenda ndi matenda.

Vitamini ameneyu amatenga gawo lofunikira pakulimbikitsa kuyankha kwamatenda. Ili ndi zotsutsana ndi zotupa komanso chitetezo chamthupi, ndipo ndizofunikira pakukhazikitsa chitetezo cha mthupi ().

Vitamini D amadziwika kuti amathandizira kugwira ntchito kwama cell a chitetezo, kuphatikiza ma T cell ndi macrophages, omwe amateteza thupi lanu ku tizilombo toyambitsa matenda ().

M'malo mwake, vitamini ndiwofunika kwambiri pantchito yoteteza thupi kuti mavitamini D ochepa amapezeka ndi chiwopsezo chotenga matenda, matenda, komanso zovuta zokhudzana ndi chitetezo chamthupi ().

Mwachitsanzo, mavitamini D otsika amakhala ndi chiopsezo chowonjezeka cha matenda opuma, kuphatikizapo chifuwa chachikulu, mphumu, ndi matenda osokoneza bongo (COPD), komanso matenda opatsirana a ma virus ndi bakiteriya (,,,).

Kuphatikiza apo, kuchepa kwa vitamini D kumalumikizidwa ndi kuchepa kwamapapu, komwe kumatha kukhudza kulimbana ndi matenda opuma (,).

Vitamini D ndiyofunikira kwambiri pantchito yoteteza thupi. Kuperewera kwa michere imeneyi kumatha kusokoneza chitetezo cha mthupi ndikuwonjezera chiopsezo chotenga matenda komanso matenda.

Kodi kumwa vitamini D kungateteze ku COVID-19?

Pakadali pano, palibe mankhwala kapena chithandizo cha COVID-19, ndipo kafukufuku wowerengeka adafufuza momwe mavitamini D amathandizira kapena kusowa kwa vitamini D pachiwopsezo chotenga kachilombo koyambitsa matendawa, SARS-CoV-2.

Komabe, kafukufuku waposachedwa watsimikiza kuti mulingo wamagazi wa 25-hydroxyvitamin D osachepera 30 ng / mL akuwoneka kuti akuthandizira kuchepetsa mwayi wazotsatira zoyipa zamankhwala ndikufa kwa odwala omwe ali mchipatala omwe ali ndi COVID-19.

Zambiri zachipatala za odwala 235 omwe ali ndi COVID-19 zidawunikidwa.

Odwala omwe ali ndi zaka zopitilira 40, omwe anali ndi mavitamini D okwanira anali 51.5% ochepera kukhala ndi zotsatira zoyipa, kuphatikiza kukhala osazindikira, hypoxia, ndi imfa, poyerekeza ndi odwala omwe alibe vitamini D. ().

Komabe, kafukufuku wina wasonyeza kuti kusowa kwa vitamini D kumatha kuwononga chitetezo cha mthupi ndikuwonjezera chiopsezo chanu chodwala matenda opuma ().

Kuphatikiza apo, kafukufuku wina wasonyeza kuti mavitamini D owonjezera amatha kupititsa patsogolo chitetezo cha mthupi komanso kuteteza kumatenda opumira.

Kafukufuku waposachedwa yemwe adaphatikiza anthu 11,321 ochokera kumayiko 14 adawonetsa kuti kuwonjezera ndi vitamini D kunachepetsa chiopsezo cha matenda opatsirana opuma (ARI) mwa onse omwe anali ndi mavitamini D. osakwanira komanso okwanira.

Ponseponse, kafukufukuyu adawonetsa kuti zowonjezera mavitamini D zimachepetsa chiopsezo chokhala ndi ARI imodzi ndi 12%. Mphamvu zoteteza zinali zamphamvu kwambiri kwa iwo omwe ali ndi mavitamini D ochepa ().

Kuphatikiza apo, kuwunikiraku kunapeza kuti mavitamini D othandizira amathandiza kwambiri kuthana ndi ARI akamamwa tsiku lililonse kapena sabata iliyonse m'mayeso ang'onoang'ono osagwira ntchito akamamwa mankhwala ena akulu ().

Zowonjezera mavitamini D zawonetsedwanso kuti zimachepetsa kufa kwa okalamba, omwe ali pachiwopsezo chachikulu chotenga matenda opuma ngati COVID-19 ().

Kuphatikiza apo, kuchepa kwa vitamini D kumadziwika kuti kumathandizira njira yotchedwa "cytokine storm" ().

Cytokines ndi mapuloteni omwe ndi gawo limodzi lamagulu amthupi. Amatha kukhala ndi zotupa komanso zotupa ndipo amatha kugwira ntchito yofunika, yothandiza kuteteza kumatenda ndi matenda (,).

Komabe, ma cytokines amathanso kuyambitsa kuwonongeka kwa minofu nthawi zina.

Mkuntho wa cytokine umatanthawuza kumasulidwa kosalamulirika kwa ma cytokines omwe amatulutsa matenda omwe amachitika chifukwa cha matenda kapena zinthu zina. Kutulutsa kosakwanira komanso kosakwanira kwa ma cytokines kumabweretsa kuwonongeka kwakukulu kwa minofu ndipo kumawonjezera kukula kwa matenda komanso kuuma ().

Ndipotu, ndicho chifukwa chachikulu cha ziwalo zambiri zolephera ndi matenda opatsirana (ARDS), komanso chinthu chofunikira pakukula ndi kuuma kwa COVID-19 ().

Mwachitsanzo, odwala omwe ali ndi vuto lalikulu la COVID-19 awonetsedwa kuti amasula ma cytokines ambiri, makamaka interleukin-1 (IL-1) ndi interleukin-6 (IL-6) ().

Kuperewera kwa Vitamini D kumalumikizidwa ndi kuchepa kwa chitetezo chamthupi ndipo kumatha kupititsa patsogolo chimphepo cha cytokine.

Mwakutero, ofufuza akuti kusowa kwa vitamini D kumatha kuonjezera chiopsezo cha zovuta zazikulu za COVID-19, komanso kuti kuwonjezeranso vitamini D kumachepetsa zovuta zokhudzana ndi mkuntho wa cytokine ndi kutupa kosalamulirika kwa anthu omwe ali ndi COVID-19 (, 21).

Pakadali pano, mayesero angapo azachipatala akufufuza za vitamini D supplementation (pamiyeso mpaka 200,000 IU) mwa anthu omwe ali ndi COVID-19 (, 22).

Ngakhale kafukufuku mderali akupitilira, ndikofunikira kumvetsetsa kuti kumwa vitamini D wowonjezera sikungakutetezeni pakupanga COVID-19.

Komabe, kusowa kwa vitamini D kumatha kukulitsa chiopsezo ku kachirombo ndi matenda mwa kuwononga chitetezo cha mthupi.

Izi ndizodetsa nkhawa makamaka chifukwa anthu ambiri alibe vitamini D, makamaka achikulire omwe ali pachiwopsezo chotenga zovuta zazikulu zokhudzana ndi COVID-19 ().

Pazifukwa izi, ndibwino kuti wothandizira zaumoyo wanu ayese mavitamini D anu kuti adziwe ngati muli ndi vuto la michere iyi. Izi ndizofunikira makamaka m'miyezi yachisanu.

Kutengera magazi anu, kuwonjezera pa 1,000-4,000 IU wa vitamini D patsiku kumakhala kokwanira kwa anthu ambiri. Komabe, iwo omwe ali ndi magazi otsika nthawi zambiri amafunikira kuchuluka kwakukulu kuti akweze milingo yake kufikira mulingo woyenera ().

Ngakhale malingaliro pazomwe zimapanga mulingo woyenera wa mavitamini D amasiyana, akatswiri ambiri amavomereza kuti mavitamini D abwino kwambiri amakhala pakati pa 30-60 ng / mL (75-150 nmol / L) (,).

Ngakhale kafukufuku akupitilizabe, umboni woti mavitamini D owonjezera amachepetsa chiopsezo chotenga COVID-19 akadali ochepa. Kukhala ndi mavitamini D athanzi kumatha kukulitsa thanzi lamthupi ndipo kungathandize anthu omwe ali ndi COVID-19.

Mfundo yofunika

Vitamini D imagwira ntchito zofunika kwambiri mthupi lanu, kuphatikiza kulimbikitsa chitetezo chamthupi.

Kafukufuku wasayansi akuwonetsa kuti kuwonjezera pa vitamini D kungateteze kumatenda opumira, makamaka pakati pa omwe alibe vitamini.

Kafukufuku waposachedwa akuwonetsa kuti mavitamini D okwanira atha kuthandiza anthu omwe ali ndi COVID-19 kupewa zotsatira zoyipa.

Komabe, sitikudziwa ngati kumwa mavitamini D kumachepetsa chiopsezo chanu chokhala ndi COVID-19 chifukwa chodwala coronavirus.

Lankhulani ndi dokotala wanu za kuwonjezera pa vitamini D kuti mukhale ndi chitetezo chamthupi.