Kodi Njira Zina Zojambulidwa Ndi Ma Statins Ndi Ziti?

Zamkati

• About PCSK9 Inhibitors
• Chithandizo Chatsopano cha Inhibitor
• Kafukufuku Watsopano
• Mtengo
• Tsogolo la PCSK9 Inhibitors

Malinga ndi a, anthu pafupifupi 610,000 amafa ndi matenda amtima ku United States chaka chilichonse. Matenda amtima ndi omwe amapha kwambiri amuna ndi akazi.

Popeza cholesterol yochuluka ndi vuto lofala kwambiri, mankhwala atsopano akhala akugwira ntchito kuwongolera ndikuwongolera. PCSK9 inhibitors ndi njira yatsopano kwambiri pamankhwala olimbana ndi matenda amtima.

Mankhwala ochepetsa mafuta m'thupi oterewa amagwira ntchito kuti chiwindi chikhale ndi mphamvu yochotsa "cholesterol choyipa" cha LDL m'magazi anu motero chimachepetsa chiopsezo chodwala matenda a mtima kapena sitiroko.

Pitilizani kuwerenga kuti mupeze zatsopano za PCSK9 inhibitors, ndi momwe angakuthandizireni.

About PCSK9 Inhibitors

PCSK9 inhibitors itha kugwiritsidwa ntchito ndi kapena popanda kuwonjezera statin, komabe itha kuthandiza kuchepetsa LDL cholesterol ndi 75% ikagwiritsidwa ntchito limodzi ndi mankhwala a statin.

Izi zitha kukhala zopindulitsa makamaka kwa iwo omwe sangalolere kupweteka kwa minofu ndi zovuta zina za ma statins kapena iwo omwe sangathe kuyendetsa cholesterol yawo pogwiritsa ntchito ma statins okha.

Mlingo woyambira ndi 75 mg jekeseni kamodzi pamasabata awiri. Mlingowu utha kukulitsidwa mpaka 150 mg milungu iwiri iliyonse ngati adotolo akuwona kuti ma LDL anu sakuyankha mokwanira pamlingo wocheperako.

Ngakhale zotsatira zoyesa ndi kuyesa ndi mankhwala obayirawa akadali zatsopano, zikuwonetsa lonjezo lalikulu.

Chithandizo Chatsopano cha Inhibitor

Praluent (alirocumab) ndi Repatha (evolocumab) omwe avomerezedwa posachedwa, mankhwala oyamba ochepetsa cholesterol m'kalasi yatsopano ya PCSK9 inhibitors. Zapangidwa kuti zizigwiritsidwa ntchito limodzi ndi mankhwala a statin komanso kusintha kwa zakudya.

Zamtengo wapatali ndi Repatha ndi za akulu omwe ali ndi heterozygous family hypercholesterolemia (HeFH), mkhalidwe wobadwa nawo womwe umayambitsa kuchuluka kwa cholesterol ya LDL m'magazi, komanso iwo omwe ali ndi matenda amtenda.

Mankhwalawa ndi ma antibodies omwe amalimbana ndi protein m'thupi lotchedwa PCSK9. Mwa kulepheretsa PCSK9 kugwira ntchito, ma antibodieswa amatha kuchotsa cholesterol cha LDL m'magazi ndikuchepetsa kuchuluka kwa cholesterol cha LDL.

Kafukufuku Watsopano

Mayesero ndi kafukufuku awonetsa zotsatira zabwino kwa Promoent ndi Repatha. Poyeserera kwaposachedwa ku Repatha, omwe ali ndi HeFH ndi ena omwe ali pachiwopsezo chodwala matenda amtima kapena sitiroko adatsitsa cholesterol chawo cha LDL mwa avareji ya.

Zotsatira zoyipa kwambiri za Repatha zinali:

• matenda opatsirana apamwamba
• nasopharyngitis
• kupweteka kwa msana
• chimfine
• ndi mabala, kufiira, kapena kupweteka pamalo obayira

Zomwe zimayambitsa matendawa, kuphatikizapo ming'oma ndi zidzolo, zinawonetsedwanso.

Kuyesanso kwina kogwiritsa ntchito Promoent kunawonetsanso zotsatira zabwino. Omwe atenga nawo mbali, omwe anali kugwiritsa ntchito kale mankhwala a statin ndipo anali ndi HeFH kapena chiwopsezo chowonjezeka cha sitiroko kapena matenda amtima, adawona kutsika kwa LDL cholesterol.

kuchokera Kugwiritsa ntchito kwamtengo wapatali kunali kofanana ndi Repatha, kuphatikiza:

• kupweteka ndi kuvulala pamalo obayira
• zizindikiro ngati chimfine
• nasopharyngitis
• thupi lawo siligwirizana, monga hypersensitivity vasculitis

Mtengo

Monga momwe zimakhalira ndi kupita patsogolo kwamankhwala ambiri, mankhwala atsopanowa adzabwera ndi mtengo wokwera. Ngakhale mtengo wa odwala umadalira dongosolo la inshuwaransi, ndalama zambiri zimayamba $ 14,600 pachaka.

Poyerekeza, mankhwala osokoneza bongo a statin amawononga $ 500 mpaka $ 700 pachaka, ndipo ziwerengerozi zimatsika kwambiri ngati mukugula generic statin form.

Ofufuza akuyembekeza kuti mankhwalawa apitilira kugulitsa kwambiri munthawi yolembapo ndikubweretsa madola mabiliyoni ambiri pogulitsa.

Tsogolo la PCSK9 Inhibitors

Zoyeserera zikadapitilirabe pokhudzana ndi mphamvu ya mankhwala obayira. Akuluakulu ena azaumoyo amadandaula kuti mankhwala atsopanowa atha kukhala ndi zoopsa zamisala, chifukwa ena mwa omwe akutenga nawo mbali amafotokoza zovuta zosokonezeka komanso kulephera kumvetsera.

Mayesero akulu azachipatala adzamalizidwa mu 2017. Mpaka nthawi imeneyo akatswiri amalimbikitsa kusamala kuyambira pomwe mayeso omwe achitika mpaka pano akhala akanthawi kochepa, kuwapangitsa kuti asadziwike ngati zoletsa za PCSK9 zitha kuchepetsa chiopsezo cha matenda amtima ndikuwonjezera miyoyo.