Mankhwala osokoneza bongo - P2Y12 inhibitors

Mipata yam'magazi ndimaselo ang'onoang'ono m'magazi anu omwe thupi lanu limagwiritsa ntchito kupanga kuundana ndikusiya magazi. Ngati muli ndi ma platelet ochulukirapo kapena mapaleti anu amaphatikana kwambiri, mumatha kupanga ziunda. Kuundana uku kumatha kuchitika mkati mwa mitsempha yanu ndipo kumayambitsa matenda amtima kapena kupwetekedwa mtima.

Mankhwala oteteza ku matenda opatsirana m'mimba amagwira ntchito kuti maplateleti anu asanyongoke ndipo potero amathandiza kuteteza magazi kuundana m'mitsempha mwanu.

• Aspirin ndi mankhwala osokoneza bongo omwe angagwiritsidwe ntchito.
• P2Y12 receptor blockers ndi gulu linanso la mankhwala osokoneza bongo. Gulu la mankhwalawa limaphatikizapo: clopidogrel, ticlopidine, ticagrelor, prasugrel, ndi cangrelor.

Mankhwala osokoneza bongo angagwiritsidwe ntchito:

• Pewani vuto la mtima kapena sitiroko kwa iwo omwe ali ndi PAD.
• Clopidogrel (Plavix, generic) itha kugwiritsidwa ntchito m'malo mwa aspirin kwa anthu omwe ali ndi mitsempha yocheperako kapena omwe adayikapo stent.
• Nthawi zina mankhwala awiri opatsirana pogonana (omwe nthawi zambiri amakhala aspirin) amaperekedwa kwa anthu omwe ali ndi angina osakhazikika, aconary coronary syndrome (angina wosakhazikika kapena zizindikiro zoyambirira za matenda amtima), kapena iwo omwe alandila stent panthawi ya PCI.
• Pofuna kupewa matenda oyamba ndi matenda a mtima, aspirin ya tsiku ndi tsiku ndiye chisankho choyambirira cha mankhwala opatsirana pogonana. Clopidogrel amalembedwa m'malo mwa aspirin kwa anthu omwe ali ndi aspirin kapena omwe sangathe kulekerera aspirin.
• Aspirin ndi mankhwala achiwiri antiplatelet nthawi zambiri amalimbikitsidwa kwa anthu omwe akudwala angioplasty ndi kapena opanda kununkhira.
• Pewani kapena kuchiza matenda amtima.
• Pewani kupwetekedwa mtima kapena kuwonongeka kwanthawi yayitali (ma TIAs ndi zizindikiro zoyambirira za sitiroko. Amatchedwanso "zikwapu.")
• Pewani kuundana kuti musapangike mkati mwa ma stents oyikamo mitsempha yanu kuti mutsegule.
• Matenda ovuta kwambiri.
• Pambuyo pochita opareshoni yolumikizira yomwe imagwiritsa ntchito yopangidwa ndi anthu kapena yokumba yopanga pamitsempha pansi pa bondo.

Wothandizira zaumoyo wanu adzasankha imodzi mwa mankhwalawa omwe angathetse vuto lanu. Nthawi zina, mungapemphedwe kuti mutenge aspirin wochepa wamankhwala limodzi ndi mankhwalawa.

Zotsatira zoyipa za mankhwalawa ndi monga:

• Kutsekula m'mimba
• Kuyabwa
• Nseru
• Ziphuphu pakhungu
• Kupweteka m'mimba

Musanayambe kumwa mankhwalawa, auzeni omwe akukuthandizani ngati:

• Mumakhala ndi mavuto otaya magazi kapena zilonda zam'mimba.
• Muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa.

Pali zovuta zina zingapo zomwe zingachitike, kutengera mankhwala omwe mwapatsidwa. Mwachitsanzo:

• Ticlopidine imatha kubweretsa kuchuluka kwama cell oyera oyera kapena matenda amthupi omwe amawononga ma platelet.
• Ticagrelor imatha kuyambitsa magawo ochepa mpweya.

Mankhwalawa amatengedwa ngati piritsi. Wopereka wanu amatha kusintha mlingo wanu nthawi ndi nthawi.

Tengani mankhwalawa ndi chakudya komanso madzi ambiri kuti muchepetse zovuta. Mungafunike kusiya kumwa clopidogrel musanachite opareshoni kapena ntchito yamano. Osangosiya kumwa mankhwala anu musanalankhule ndi omwe akukuthandizani.

Lankhulani ndi omwe amakupatsani musanamwe mankhwala awa:

• Heparin ndi ena ochepetsa magazi, monga warfarin (Coumadin)
• Mankhwala opweteka kapena nyamakazi (monga diclofenac, etodolac, ibuprofen, indomethacin, Advil, Aleve, Daypro, Dolobid, Feldene, Indocin, Motrin, Orudis, Relafen, kapena Voltaren)
• Phenytoin (Dilantin), tamoxifen (Nolvadex, Soltamox), tolbutamide (Orinase), kapena torsemide (Demadex)

Musamamwe mankhwala ena omwe angakhale ndi aspirin kapena ibuprofen musanalankhule ndi omwe amakupatsani. Werengani zolemba pamankhwala ozizira ndi chimfine. Funsani kuti ndi mankhwala ati omwe ali otetezeka kuti mutengeko ululu, chimfine, kapena chimfine.

Ngati muli ndi njira zamtundu uliwonse, mungafunike kusiya mankhwalawa masiku asanu kapena asanu ndi awiri musanabadwe. Komabe, nthawi zonse muzifunsa kaye wothandizira anu ngati kuli bwino kuyima.

Uzani omwe amakupatsani ngati muli ndi pakati kapena mukukonzekera kukhala ndi pakati, kapena kuyamwitsa kapena kukonzekera kuyamwitsa. Azimayi omwe ali mgawo lotsatira la mimba sayenera kumwa clopidogrel. Clopidogrel imatha kupatsira ana kudzera mkaka wa m'mawere.

Lankhulani ndi omwe amakupatsani ngati muli ndi matenda a chiwindi kapena impso.

Mukaphonya mlingo:

• Tengani mwamsanga, pokhapokha ngati ili nthawi ya mlingo wanu wotsatira.
• Ngati ili nthawi ya mlingo wanu wotsatira, tengani kuchuluka kwanu.
• Musamwe mapiritsi owonjezera kuti mupange mlingo womwe mwaphonya, pokhapokha dokotala atakuwuzani.

Sungani mankhwalawa ndi mankhwala ena onse pamalo ozizira, owuma. Asungeni pomwe ana sangapite kwa iwo.

Itanani ngati muli ndi zovuta izi ndipo sizichoka:

• Zizindikiro zilizonse za kutuluka mwachilendo, monga magazi mumkodzo kapena ndowe, zotuluka m'mphuno, mabala aliwonse osazolowereka, kutuluka magazi kwambiri chifukwa chodulidwa, ndowe zakuda, kutsokomola magazi, kulemera kwambiri kuposa nthawi zonse kusamba kwa magazi kapena kutuluka mwadzidzidzi kumaliseche, kusanza komwe kumawoneka ngati malo a khofi
• Chizungulire
• Zovuta kumeza
• Kulimba pachifuwa kapena pachifuwa
• Kutupa kumaso kapena m'manja
• Kuyabwa, ming'oma, kapena kumva kulira kumaso kapena m'manja
• Kupuma kapena kupuma movutikira
• Kupweteka kwambiri m'mimba
• Ziphuphu pakhungu

Oonda magazi - clopidogrel; Thandizo la antiplatelet - clopidogrel; Achinyamata

• Kapangidwe kazitsulo m'mitsempha

Abraham NS, Hlatky MA, Antman EM, ndi al. ACCF / ACG / AHA chikalata chovomerezana chaukadaulo chogwiritsa ntchito proton pump inhibitors ndi thienopyridines: chidziwitso chotsimikizika cha chikalata chovomerezana cha ACCF / ACG / AHA 2008 chothandizira kuchepetsa ngozi za m'mimba za mankhwala opatsirana pogwiritsira ntchito mankhwala a NSAID: lipoti la American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Ndine Coll Cardiol. 2010; 56 (24): 2051-2066. PMID: 21126648 pubed.ncbi.nlm.nih.gov/21126648/.

Fihn SD, Blankenship JC, Alexander KP, ndi al. Chidziwitso cha 2014 ACC / AHA / AATS / PCNA / SCAI / STS chitsogozo chazidziwitso zakuwunika ndi kuwunika kwa odwala omwe ali ndi matenda osakhazikika amtima: lipoti la American College of Cardiology / American Heart Association Task Force on Practice Guidelines, ndi American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Intervention, ndi Society of Thoracic Surgeons. Kuzungulira. 2014; 130: 1749-1767. PMID: 25070666 adasankhidwa.ncbi.nlm.nih.gov/25070666/.

Golide wa LB. Kupewa ndi kuwongolera sitiroko ya ischemic. Mu: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, olemba. Matenda a Mtima a Braunwald: Buku Lophunzitsira la Mankhwala Amtima. 11th ed. Philadelphia, PA: Elsevier; 2019: chap 65.

Januwale CT, Wann LS, Alpert JS, et al. Chitsogozo cha AHA / ACC / HRS cha 2014 pakuwongolera odwala omwe ali ndi matenda a atrial: lipoti la American College of Cardiology / American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Ndine Coll Cardiol. 2014; 64 (21): e1-e76. PMID: 24685669 pubed.ncbi.nlm.nih.gov/24685669/.

Mauri L, Bhatt DL. Kulowerera kwamphamvu kwamphamvu. Mu: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, olemba. Matenda a Mtima a Braunwald: Buku Lophunzitsira la Mankhwala Amtima. 11th ed. Philadelphia, PA: Elsevier; 2019: mutu 62.

Meschia JF, Bushnell C, Boden-Albala B, ndi al. Maupangiri othandizira kupewa kupwetekedwa: mawu a akatswiri azaumoyo ochokera ku American Heart Association / American Stroke Association. Sitiroko. 2014; 45 (12): 3754-3832. (Adasankhidwa) PMID: 25355838 pubed.ncbi.nlm.nih.gov/25355838/.

Morrow DA, de Lemos JA. Khola matenda amtima ischemic. Mu: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, olemba. Matenda a Mtima a Braunwald: Buku Lophunzitsira la Mankhwala Amtima. 11th ed. Philadelphia, PA: Elsevier; 2019: mutu 61.

Mphamvu WJ, Rabinstein AA, Ackerson T, et al. Malangizo pakuwongolera koyambirira kwa odwala omwe ali ndi sitiroko yayikulu ya ischemic: Kusintha kwa 2019 ku Malangizo a 2018 pakuwongolera koyambirira kwa odwala omwe ali ndi sitiroko yayikulu: chitsogozo cha akatswiri azaumoyo ochokera ku American Heart Association / American Stroke Association. Sitiroko. 2019; 50 (12): e344-e418. (Adasankhidwa) PMID: 31662037 adasankhidwa.ncbi.nlm.nih.gov/31662037/.

• Angina
• Angioplasty ndi stent mayikidwe - mtsempha wamagazi wa carotid
• Angioplasty ndi stent mayikidwe - zotumphukira mitsempha
• Opaleshoni ya aortic valve - yowonongeka pang'ono
• Opaleshoni ya aortic valve - yotseguka
• Njira zochotsera mtima
• Opaleshoni yamitsempha ya Carotid - yotseguka
• Matenda osokoneza bongo (COPD)
• Matenda a mtima
• Opaleshoni ya mtima
• Opaleshoni ya mtima - yowopsa pang'ono
• Mtima kulephera
• Mtima pacemaker
• Kuchuluka kwa cholesterol m'magazi
• Kuthamanga kwa magazi - akuluakulu
• Chokhazika mtima chosintha mtima
• Kuchita opaleshoni yamagetsi a Mitral - kovuta kwambiri
• Opral valve valve - yotseguka
• Malire a zotumphukira zimadutsa - mwendo
• Matenda a mtsempha wamagazi - miyendo

• Angina - kumaliseche
• Angioplasty ndi stent - mtima - kutulutsa
• Kuyika kwa Angioplasty ndi stent - mtsempha wa carotid - kutulutsa
• Angioplasty ndi stent mayikidwe - zotumphukira mitsempha - kutulutsa
• Aspirin ndi matenda amtima
• Matenda a atrial - kutulutsa
• Kukhala achangu mukakhala ndi matenda amtima
• Catheterization yamtima - kutulutsa
• Opaleshoni ya mtsempha wa Carotid - kutulutsa
• Kulamulira kuthamanga kwa magazi
• Matenda ashuga - kupewa matenda amtima komanso kupwetekedwa mtima
• Matenda a mtima - kutulutsa
• Opaleshoni ya mtima - kutulutsa
• Opaleshoni yamtima - yotulutsa pang'ono - kutulutsa
• Kulephera kwa mtima - kutulutsa
• Opaleshoni ya valve yamtima - kutulutsa
• Malire a zotumphukira zimadutsa - mwendo - kutulutsa
• Sitiroko - kumaliseche

• Operewera Magazi