Matenda a paget a fupa

Matenda a Paget ndi matenda omwe amawononga mafupa osazolowereka ndikubwezeretsanso. Izi zimapangitsa kuwonongeka kwa mafupa omwe akhudzidwa.

Zomwe zimayambitsa matenda a Paget sizikudziwika. Zitha kukhala chifukwa cha majini, komanso zimatha kukhala chifukwa cha matenda a tizilombo koyambirira.

Matendawa amapezeka padziko lonse lapansi, koma amapezeka ku Europe, Australia, ndi New Zealand. Matendawa akucheperachepera pazaka 50 zapitazi.

Mwa anthu omwe ali ndi matenda a Paget, pali kuwonongeka kwachilendo kwa mafupa m'malo ena. Izi zimatsatiridwa ndikupanga mafupa osazolowereka. Dera latsopano la mafupa ndi lokulirapo, koma lofooka. Fupa latsopano limadzazidwanso ndi mitsempha yatsopano yamagazi.

Fupa lomwe lakhudzidwa limangokhala gawo limodzi kapena awiri am'mafupa, kapena m'mafupa osiyanasiyana mthupi. Nthawi zambiri zimakhudza mafupa a mikono, kolala, miyendo, m'chiuno, msana, ndi chigaza.

Anthu ambiri omwe ali ndi vutoli alibe zizindikilo. Matenda a Paget nthawi zambiri amapezeka ngati x-ray yachitika pa chifukwa china. Ikhozanso kupezeka poyesera kupeza chifukwa cha kuchuluka kwa calcium m'magazi ambiri.

Ngati zichitika, zizindikilo zimatha kuphatikiza:

• Kupweteka kwa mafupa, kupweteka kwa mafupa kapena kuuma, ndi kupweteka kwa khosi (kupweteka kumatha kukhala kovuta ndipo kumakhalapo nthawi zambiri)
• Kugwada kwamiyendo ndi zina zopindika
• Kukulitsa mutu ndi zigaza
• Kupasuka
• Mutu
• Kutaya kwakumva
• Kutalika kwachepa
• Khungu lofunda pamfupa lomwe lakhudzidwa

Mayeso omwe angawonetse matenda a Paget ndi awa:

• Kujambula mafupa
• X-ray ya mafupa
• Zizindikiro zazikulu za kuwonongeka kwa mafupa (mwachitsanzo, N-telopeptide)

Matendawa amathanso kukhudza zotsatira za mayeso otsatirawa:

• Alkaline phosphatase (ALP), mafupa a isoenzyme
• Seramu calcium

Sikuti anthu onse omwe ali ndi matenda a Paget amafunika kuthandizidwa. Anthu omwe sangasowe chithandizo ndi omwe:

• Ingoyesani magazi pang'ono modabwitsa
• Osakhala ndi zisonyezo komanso palibe umboni wa matenda opatsirana

Matenda a Paget amachiritsidwa nthawi zambiri aka:

• Mafupa ena, monga mafupa onyamula zolemera, amatengapo gawo ndipo chiopsezo chothyoka chimakhala chachikulu.
• Kusintha kwa mafupa kukukulirakulira mwachangu (chithandizo chitha kuchepetsa chiopsezo cha mafupa).
• Zofooka za Bony zilipo.
• Munthu amakhala ndi ululu kapena zisonyezo zina.
• Chigaza chakhudzidwa. (Izi ndikuti tipewe kutayika kwakumva.)
• Mulingo wa calcium umakwezedwa ndikupangitsa zizindikilo.

Mankhwala amathandiza kupewa kuwonongeka kwa mafupa ndikupanga. Pakadali pano pali mitundu ingapo yamankhwala omwe amagwiritsidwa ntchito kuchiza matenda a Paget. Izi zikuphatikiza:

• Bisphosphonates: Mankhwalawa ndiye mankhwala oyamba, ndipo amathandiza kuchepetsa kukonzanso mafupa. Mankhwala amamwa kwambiri pakamwa, koma amathanso kuperekedwa kudzera mumitsempha (kudzera m'mitsempha).
• Calcitonin: Hormone iyi imakhudzidwa ndimafupa am'magazi. Itha kuperekedwa ngati mankhwala amphuno (Miacalcin), kapena ngati jakisoni pansi pa khungu (Calcimar kapena Mithracin).

Acetaminophen (Tylenol) kapena mankhwala osagwiritsa ntchito anti-inflammatory (NSAIDs) amathanso kuperekedwa chifukwa cha ululu. Zikakhala zovuta kwambiri, pamafunika opaleshoni ya mafupa kuti athetse vuto kapena kupasuka.

Anthu omwe ali ndi vutoli atha kupindula kutenga nawo mbali m'magulu othandizira anthu omwe akumana ndi zomwezi.

Nthawi zambiri, vutoli limatha kuwongoleredwa ndi mankhwala. Anthu ochepa atha kukhala ndi khansa ya fupa lotchedwa osteosarcoma. Anthu ena adzafunika kuchitidwa opaleshoni yolowa m'malo limodzi.

Zovuta zingaphatikizepo:

• Mafupa amathyoka
• Kugontha
• Zofooka
• Mtima kulephera
• Matenda a Hypercalcemia
• Paraplegia
• Matenda a msana

Itanani omwe akukuthandizani ngati mukukula ndi matenda a Paget.

Osteitis opunduka

• X-ray

Ralston SH. Matenda a paget. Mu: Goldman L, Schafer AI, olemba. Mankhwala a Goldman-Cecil. 26 wa. Philadelphia, PA: Elsevier; 2020: chap 233.

Woyimba FR. Matenda a Paget a mafupa. Mu: Jameson JL, De Groot LJ, de Kretser DM, et al, olemba. Endocrinology: Akuluakulu ndi Ana. Wachisanu ndi chiwiri. Philadelphia, PA: Elsevier Saunders; 2016: chap 72.