Mlembi: Marcus Baldwin
Tsiku La Chilengedwe: 18 Kuni 2021
Sinthani Tsiku: 19 Novembala 2024
Anonim
Posaconazole (Non Inferiority Trial) vs Voriconazole in Invasive Aspergillosis
Kanema: Posaconazole (Non Inferiority Trial) vs Voriconazole in Invasive Aspergillosis

Zamkati

Mapiritsi otulutsidwa mochedwa Posaconazole ndi kuyimitsidwa pakamwa amagwiritsidwa ntchito popewa matenda opatsirana a fungus mwa akulu ndi achinyamata azaka 13 kapena kupitilira apo omwe ali ndi vuto lotha kulimbana ndi matenda. Kuyimitsidwa pakamwa kwa Posaconazole kumagwiritsidwanso ntchito pochiza matenda yisiti mkamwa ndi kukhosi kuphatikiza matenda a yisiti omwe sangachiritsidwe bwino ndi mankhwala ena. Posaconazole ali mgulu la mankhwala otchedwa azole antifungals. Zimagwira ntchito pochepetsa kukula kwa bowa komwe kumayambitsa matenda.

Posaconazole imabwera ngati kuyimitsidwa pakamwa (madzi) komanso ngati kuchedwa-kutulutsidwa (kumatulutsa mankhwala m'matumbo kuti athane ndi kuwonongeka kwa mankhwala ndi zidulo zam'mimba) piritsi loti atenge pakamwa. Mapiritsi otulutsidwa mochedwa nthawi zambiri amatengedwa ndi chakudya kawiri tsiku lililonse tsiku loyamba ndiyeno kamodzi patsiku. Kuyimitsidwa pakamwa nthawi zambiri kumatengedwa katatu patsiku ndi chakudya chokwanira kapena pasanathe mphindi 20 mutadya. Ngati simungathe kuyimitsidwa pakamwa ndi chakudya chokwanira, imwani ndi chowonjezera chakumwa chopatsa thanzi kapena chakumwa cha asidi monga ginger ale. Dokotala wanu adzazindikira kuti muyenera kugwiritsa ntchito mankhwalawa nthawi yayitali bwanji. Tengani posaconazole mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani posaconazole ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.


Sambani kuyimitsidwa pakamwa musanagwiritse ntchito kusakaniza mankhwala mofanana.

Nthawi zonse mugwiritse ntchito supuni ya dosing yomwe imabwera ndi posaconazole kuyimitsidwa pakamwa kuti muyese mlingo wanu. Simungalandire mankhwala okwanira ngati mutagwiritsa ntchito supuni ya banja kuti muyese mlingo wanu. Supuni iyenera kutsukidwa bwino ndimadzi mukamagwiritsa ntchito komanso musanasunge.

Kumeza mapiritsi a posaconazole otulutsidwa mochedwa; osagawana, kutafuna, kapena kuwaphwanya. Ngati simungathe kumeza mapiritsi otulutsidwa mochedwa, uzani dokotala wanu.

Mankhwala aliwonse a posaconazole amatulutsa mankhwala mosiyanasiyana mthupi lanu ndipo sangathe kugwiritsidwa ntchito mosinthana.Ingotengani mankhwala a posaconazole omwe adokotala anu akusintha ndipo musasinthe kupita ku chinthu china cha posaconazole pokhapokha dokotala atanena kuti muyenera kutero.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.


Asanatenge posaconazole,

  • auzeni dokotala komanso wamankhwala ngati muli ndi vuto la posaconazole; mankhwala ena antifungal monga fluconazole (Diflucan), isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), kapena voriconazole (Vfend); simethicone; mankhwala ena aliwonse; kapena chilichonse chosakaniza ndi mankhwala a posaconazole. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
  • uzani dokotala ngati mutamwa mankhwala aliwonse awa: atorvastatin (Lipitor, ku Caduet), mankhwala amtundu wa ergot monga bromocriptine (Cycloset, Parlodel), cabergoline, dihydroergotamine (DHE 45, Migranal), ergoloid mesylates (Hydergine), ergonovine , ergotamine (Ergomar, ku Cafergot, ku Migergot), ndi methylergonovine (Methergine); lovastatin (Altoprev, mwa Advicor); pimozide (Orap); quinidine (mu Nuedexta); simvastatin (Zocor, ku Simcor, ku Vytorin); kapena sirolimus (Rapamune). Dokotala wanu angakuuzeni kuti musamwe posaconazole ngati mukumwa mankhwala amodzi kapena angapo.
  • auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: benzodiazepines monga alprazolam (Xanax), diazepam (Valium), midazolam, ndi triazolam (Halcion); ma calcium blockers monga diltiazem (Cardizem, Cartia, Tiazac, ena), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), ndi verapamil (Calan, Covera, Verelan, ena); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); efavirenz (Sustiva, ku Atripla); erythromycin (EES, ERYC, Erythrocin, ena), fosamprenavir (Lexiva); glipizide (Glucotrol); phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); ritonavir (Norvir) yotengedwa ndi atazanavir (Reyataz); tacrolimus (Astagraf, Envarsus XR, Prograf); vinblastine; ndi vincristine (Marquibo Kit). Ngati mukumira posaconazole kuyimitsidwa pakamwa, uzani dokotala wanu ngati mukumwa cimetidine (Tagamet), esomeprazole (Nexium, ku Vimovo), kapena metoclopramide (Reglan). Mankhwala ena ambiri amathanso kulumikizana ndi posaconazole, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
  • auzeni adotolo ngati mwakhala mukugunda pang'onopang'ono kapena mosasinthasintha; nthawi yayitali ya QT (vuto losowa la mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi); mavuto ndi kayendedwe ka magazi; kashiamu, magnesium, kapena potaziyamu wochepa m'magazi anu; kapena impso, kapena matenda a chiwindi.
  • uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga posaconazole, itanani dokotala wanu.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.


Ngati mukuyimitsidwa pakamwa, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mukumwa mapiritsi otulutsidwa omwe akuchedwa, tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati mkati mwa maola 12 a mlingo wanu wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Posaconazole angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

  • malungo
  • mutu
  • kuzizira kapena kunjenjemera
  • chizungulire
  • kufooka
  • kutupa kwa manja, mapazi, akakolo, kapena miyendo yakumunsi
  • kutsegula m'mimba
  • kusanza
  • kupweteka m'mimba
  • kudzimbidwa
  • kutentha pa chifuwa
  • zidzolo
  • kuyabwa
  • msana kapena kupweteka kwa minofu
  • zilonda pamilomo, mkamwa, kapena pakhosi
  • kuvuta kugona kapena kugona
  • thukuta lowonjezeka
  • mwazi wa m'mphuno
  • chifuwa
  • chikhure

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zalembedwa mu gawo la MAWONEKEDWE OTHANDIZA, pitani kuchipatala nthawi yomweyo:

  • kuvulaza kapena kutuluka mwachilendo
  • kutopa kwambiri
  • kusowa mphamvu
  • kusowa chilakolako
  • nseru
  • kupweteka kumtunda chakumanja kwam'mimba
  • chikasu cha khungu kapena maso
  • zizindikiro ngati chimfine
  • mkodzo wakuda
  • mipando yotumbululuka
  • kusala kudya, kugunda, kapena kugunda kwamtima kosazolowereka
  • kutaya mwadzidzidzi
  • kupuma movutikira

Posaconazole angayambitse mavuto ena. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa). Osazizira kuyimitsidwa pakamwa.

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira posaconazole.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu. Ngati muli ndi zizindikilo za matenda mukamaliza kumwa posaconazole, itanani dokotala wanu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

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