Jekeseni wa Ipilimumab

Zamkati

• Asanalandire jakisoni wa ipilimumab,
• Ipilimumab ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi zina mwazizindikirozi, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi.

Jekeseni wa Ipilimumab imagwiritsidwa ntchito:

• kuchiza melanoma (mtundu wa khansa yapakhungu) mwa akulu ndi ana azaka 12 kapena kupitilira apo omwe sangachiritsidwe ndi opareshoni kapena omwe afalikira mbali zina za thupi.
• kuthandiza kupewa khansa ya khansa kuti isabwererenso pambuyo pochitidwa opaleshoni kuti ichotse ndi ma lymph node.
• Pamodzi ndi nivolumab (Opdivo) yochizira matenda a renal cell carcinoma (RCC; mtundu wa khansa womwe umayambira m'maselo a impso).
• kuphatikiza nivolumab kuchiza mitundu ina ya khansa yamtundu wamtundu (khansa yomwe imayamba m'matumbo akulu) mwa akulu ndi ana azaka 12 kapena kupitilira zomwe zafalikira mbali zina za thupi ndipo zawonjezeka atalandira chithandizo ndi mankhwala ena a chemotherapy.
• kuphatikiza ndi nivolumab kuchiza hepatocellular carcinoma (HCC; mtundu wa khansa ya chiwindi) mwa anthu omwe kale amathandizidwa ndi sorafenib (Nexafar).
• kuphatikiza nivolumab ku mtundu wina wa khansa yamapapo (khansa ya m'mapapo yosakhala yaying'ono; NSCLC) mwa akulu omwe afalikira mbali zina za thupi.
• kuphatikiza ndi nivolumab ndi platinamu chemotherapy yochizira mtundu wina wa NSCLC mwa achikulire omwe abwerera kapena kufalikira mbali zina za thupi.
• Pamodzi ndi nivolumab yochiza malignant pleural mesothelioma (mtundu wa khansa womwe umakhudza mkati mwa mapapo ndi chifuwa) mwa achikulire omwe sangachotsedwe ndi opaleshoni.

Jekeseni wa Ipilimumab ili mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito pothandiza thupi kuchepetsa kapena kuletsa kukula kwa maselo a khansa.

Jekeseni wa Ipilimumab imabwera ngati yankho (madzi) kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino kuchipatala kapena kuchipatala. Ipilimumab ikaperekedwa kuti ichiritse khansa ya khansa, nthawi zambiri imaperekedwa kwa mphindi 90 pamasabata atatu aliwonse malinga ngati dokotala akuuzani kuti mulandire chithandizo. Pamene ipilimumab imaperekedwa ndi nivolumab kuchiza renal cell carcinoma, hepatocellular carcinoma, kapena khansa yoyipa, nthawi zambiri imaperekedwa mphindi 30 kamodzi pamasabata atatu mpaka 4. Ipilimumab ikaperekedwa ndi nivolumab kapena nivolumab ndi platinamu chemotherapy kuti ichiritse NSCLC, imaperekedwa kwamaminiti opitilira 30 kamodzi pamilungu isanu ndi umodzi malinga ngati dokotala akuuzani kuti mulandire chithandizo. Pamene ipilimumab imaperekedwa ndi nivolumab kuti ichiritse zilonda zopweteka za mesothelioma, nthawi zambiri imaperekedwa mphindi 30 kamodzi pamasabata asanu ndi limodzi bola dokotala akukulimbikitsani kuti mulandire chithandizo.

Jekeseni wa Ipilimumab imatha kuyambitsa mavuto akulu kapena owopsa panjira yolowetsedwa. Dokotala kapena namwino adzakuyang'anirani mosamala mukamakulowetsedwako ndipo posakhalitsa kulowetsedwa kuti awonetsetse kuti simukuyankha bwino mankhwalawo. Uzani dokotala wanu kapena namwino nthawi yomweyo ngati mungakhale ndi zina mwazizindikiro izi zomwe zingachitike pakulowetsedwa: kuzizira kapena kugwedeza, kuyabwa, kuthamanga, kuthamanga, kupuma movutikira, chizungulire, malungo, kapena kukomoka.

Dokotala wanu angachedwetse kulowetsedwa kwanu, kuchedwetsa, kapena kuyimitsa chithandizo chanu ndi jakisoni wa ipilimumab, kapena kukupatsirani mankhwala owonjezera kutengera kuyankha kwanu kwa mankhwala ndi zovuta zina zomwe mungakumane nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba mankhwala ndi ipilimumab ndipo nthawi iliyonse mukamadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa ipilimumab,

• uzani dokotala wanu komanso wamankhwala kuti ngati muli ndi vuto la jakisoni wa ipilimumab, mankhwala aliwonse, kapena chilichonse cha jakisoni wa ipilimumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu ngati mudalandira chiwalo chamoyo, matenda a chiwindi, kapena ngati chiwindi chanu chawonongeka ndi mankhwala kapena matenda. Komanso, auzeni dokotala ngati mwakhalapo ndi matenda omwe amadzichotsera okha (momwe chitetezo cha mthupi chimagwirira gawo labwino la thupi) monga matenda a Crohn's (momwe chitetezo cha mthupi chimagwirira ntchito m'mimba momwe zimapwetekera , kutsekula m'mimba, kuchepa thupi, ndi malungo), ulcerative colitis (vuto lomwe limayambitsa kutupa ndi zilonda mkatikati mwa matumbo [matumbo akulu] ndi rectum), lupus (vuto lomwe chitetezo chamthupi chimagunda zilonda ndi ziwalo zambiri kuphatikiza khungu, mafupa, magazi, ndi impso), kapena sarcoidosis (momwe mafupa amtundu wosakhazikika amakula m'malo osiyanasiyana amthupi kuphatikiza mapapo, khungu, ndi maso).
• Uzani dokotala wanu ngati muli ndi pakati kapena mukufuna kukhala ndi pakati. Muyenera kuyesa mayeso musanalandire ipilimumab. Muyenera kugwiritsa ntchito njira yolerera yothandiza kupewa mimba mukamalandira jakisoni wa ipilimumab komanso kwa miyezi itatu mutalandira mankhwala. Lankhulani ndi dokotala wanu za njira zolerera zomwe zingakuthandizeni. Mukakhala ndi pakati mukalandira jakisoni wa ipilimumab, itanani dokotala wanu mwachangu. Jekeseni wa Ipilimumab itha kuvulaza mwana wosabadwayo.
• auzeni dokotala ngati mukuyamwitsa kapena mukufuna kuyamwitsa. Simuyenera kuyamwa mukalandira jakisoni wa ipilimumab komanso kwa miyezi itatu mutamaliza kumwa mankhwala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Ipilimumab ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kuvuta kugona kapena kugona
• kupweteka pamodzi

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi zina mwazizindikirozi, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi.

• kuchepa pokodza, magazi mumkodzo, kutupa kwa mapazi, akakolo, kapena miyendo yakumunsi, kapena kusowa kwa njala
• kutsegula m'mimba, wamagazi kapena wakuda, wodikira, chimbudzi chomata, kupweteka kwambiri m'mimba kapena kufatsa, kapena malungo
• chifuwa, kupweteka pachifuwa, kapena kupuma movutikira
• kutopa, kusokonezeka, mavuto okumbukira zinthu, kuyerekezera zinthu m'maganizo, kugwidwa, kapena khosi lolimba
• kumva kutopa, kudya kwambiri, ludzu lowonjezeka, kukodza kwambiri, kapena kuchepa thupi
• kugunda kwamtima mwachangu, kugwedeza kosalamulirika kwa gawo lina la thupi, kuchuluka kwa njala, kapena thukuta
• kutopa kapena ulesi, kuwonjezeka kwa chidwi kuzizira, kudzimbidwa, kupweteka kwa minofu ndi kufooka, kunenepa, kulemera kuposa kusamba kwanthawi yabwinobwino, kusamba tsitsi, kupweteka mutu, chizungulire, kukwiya, kuiwala, kutsika kwa kugonana, kapena kukhumudwa
• chikasu cha khungu kapena maso, mkodzo wamdima (wonyezimira tiyi), kupweteka kumtunda chakumanja kwa m'mimba, nseru, kusanza, kapena kuvulaza kosavuta kapena magazi
• kufooka kwachilendo kwa miyendo, mikono, kapena nkhope; kapena dzanzi kapena kumva kulasalasa m'manja kapena m'mapazi
• kuthamanga kapena popanda kuyabwa, kuphulika kapena khungu, kapena zilonda zam'kamwa
• kusawona bwino, masomphenya awiri, kupweteka kwa diso kapena kufiira, kapena zovuta zina zamasomphenya

Jekeseni wa Ipilimumab ingayambitse zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Funsani wamankhwala wanu mafunso aliwonse omwe mungakhale nawo okhudza ipilimumab jakisoni.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayeso ena musanachitike komanso mukamalandira chithandizo kuti muwone ngati zili bwino kuti mulandire jekeseni wa ipilimumab ndikuwunika momwe thupi lanu likuyankhira jakisoni wa ipilimumab.

Nthawi zina, dokotala wanu amalamula kuti mukayesedwe labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi ipilimumab.

Funsani wamankhwala wanu mafunso aliwonse omwe mungakhale nawo okhudza ipilimumab jakisoni.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Yerva^®