Bedaquiline

Zamkati

• Musanamwe bedaquiline,
• Bedaquiline amatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Bedaquiline iyenera kugwiritsidwa ntchito pochiza anthu omwe ali ndi chifuwa chachikulu cha TB (MDR-TB; matenda akulu omwe amakhudza mapapu ndi ziwalo zina za thupi ndipo sangathe kulandira mankhwala osachepera awiri omwe amagwiritsidwa ntchito chithandizo) pamene mankhwala ena sangathe kugwiritsidwa ntchito. Pakafukufuku wamankhwala, panali anthu ambiri omwalira pakati pa anthu omwe amamwa bedaquiline kuposa anthu omwe sanamwe mankhwalawo. Komabe, MDR-TB ndi matenda owopsa, chifukwa chake inu ndi dokotala mutha kusankha kuti muyenera kulandira mankhwala a bedaquiline ngati mankhwala ena sangathe kugwiritsidwa ntchito.

Bedaquiline itha kubweretsa kusintha koopsa kapena koika moyo pangozi ya mtima wanu. Muyenera kukhala ndi electrocardiogram (ECG; mayeso omwe amayesa magetsi pamtima) musanalandire chithandizo komanso kangapo mukamalandira chithandizo kuti muwone momwe mankhwalawa amakhudzira kugunda kwa mtima wanu. Uzani dokotala wanu ngati inu kapena wina aliyense m'banja mwanu watenga nthawi yayitali matenda a QT (vuto losowa mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi) ndipo ngati mwakhala mukumenyedwa pang'onopang'ono kapena mosasinthasintha, matenda a chithokomiro, kuchepa kwa calcium, magnesium, kapena potaziyamu m'magazi anu, kulephera kwa mtima, kapena matenda amtima aposachedwa. Uzani dokotala wanu komanso wamankhwala ngati mukumwa mankhwala aliwonse awa: azithromycin (Zithromax), ciprofloxacin (Cipro), clarithromycin (Biaxin), clofazimine (Lamprene), erythromycin (EES, E-Mycin, Erythrocin), gemifloxacin (Factive) , levofloxacin (Levaquin), moxifloxacin (Avelox), ndi telithromycin (Ketek). Mukayamba kugunda mwamphamvu kapena mosasinthasintha kapena mukakomoka, itanani dokotala wanu mwachangu.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba kulandira mankhwala ndi bedaquiline ndipo nthawi iliyonse mukadzaza mankhwala anu. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Lankhulani ndi dokotala wanu za kuopsa kwa kumwa bedaquiline.

Bedaquiline amagwiritsidwa ntchito limodzi ndi mankhwala ena osachepera atatu ochiritsira chifuwa chachikulu cha TB (MDR-TB; matenda akulu omwe amakhudza mapapu ndi ziwalo zina za thupi ndipo sangachiritsidwe ndi mankhwala ena omwe amagwiritsidwa ntchito pochizira chikhalidwe) mwa akulu ndi ana azaka 5 kapena kupitilira apo omwe amalemera osachepera 33 lbs (15 kg) omwe akhudza mapapu. Bedaquiline sayenera kugwiritsidwa ntchito pochiza TB yomwe imakhudza mbali zina za thupi. Bedaquiline ali mgulu la mankhwala otchedwa anti-mycobacterials. Zimagwira ntchito popha mabakiteriya omwe amayambitsa MDR-TB.

Bedaquiline amabwera ngati piritsi kuti amwe pakamwa ndi madzi. Nthawi zambiri amatengedwa ndi chakudya kamodzi patsiku kwa milungu iwiri kenako katatu pamlungu kwa milungu 22. Mukamamwa bedaquiline katatu pamlungu, lolani maola osachepera 48 pakati pa mlingo. Tengani bedaquiline nthawi imodzimodzi ya tsiku komanso masiku omwewo a sabata sabata iliyonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani bedaquiline ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Ngati inu kapena mwana wanu simungathe kumeza piritsi la 20 mg lonse, mutha kuwaswa pakati.

Ngati inu kapena mwana wanu simungathe kumeza mapiritsi 20 mg wathunthu kapena theka, mapiritsiwo amatha kusungunuka mu supuni 1 (5 ml) ya madzi mumkapu womwera (osapitirira mapiritsi 5). Mutha kumwa chisakanizochi nthawi yomweyo kapena kuti musavutike, onjezerani supuni 1 (5 ml) ya madzi owonjezera, zopangira mkaka, madzi apulo, madzi a lalanje, madzi a kiranberi, kapena chakumwa cha kaboni, kapenanso, chakudya chofewa kuwonjezeredwa. Ndiye, kumeza lonse osakaniza yomweyo. Mukamwa mlingowo, tsukani kapuyo ndi pang'ono pokha zamadzimadzi zowonjezera kapena chakudya chofewa ndipo mutenge nthawi yomweyo kuti mutsimikizire kuti mulandila mlingo wonsewo. Ngati mukufuna mapiritsi opitilira 20 mg a bedaquiline, bwerezani njira zomwe zili pamwambazi mpaka mufike pamlingo woyenera.

Kapenanso, kuti zosavuta kumeza, mutha kuphwanya mapiritsi a 20 mg ndikuwonjezera ku chakudya chofewa monga yogurt, maapulosi, nthochi yosenda, kapena oatmeal ndikumeza chisakanizo chonse nthawi yomweyo. Mukamwa mlingowo, onjezerani pang'ono pang'ono zakudya zofewa ndikuzitenga nthawi yomweyo kuti mutsimikizire kuti mulandila mlingo wonsewo.

Ngati muli ndi chubu cha nasogastric (NG), dokotala wanu kapena wamankhwala akufotokozerani momwe mungakonzekerere bedaquiline kuti mupereke kudzera mu chubu cha NG.

Pitirizani kumwa bedaquiline mpaka mutsirize mankhwalawa ndipo musaphonye mankhwala, ngakhale mutakhala bwino. Mukasiya kumwa bedaquiline posachedwa kapena kudumpha mlingo, matenda anu sangachiritsidwe kwathunthu ndipo mabakiteriya amatha kulimbana ndi maantibayotiki. Izi zipangitsa kuti matenda anu azikhala ovuta kuchiza mtsogolo. Kuti musavutike kumwa mankhwala anu onse monga momwe mwalangizira, mutha kutenga nawo mbali pulogalamu yothandizidwa mwachindunji. Pulogalamuyi, wogwira ntchito yazaumoyo azikupatsani mlingo uliwonse wamankhwala ndipo azikuwonani mukamamwa mankhwalawo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanamwe bedaquiline,

• Uzani dokotala ndi wazamankhwala ngati muli ndi vuto la bedaquiline, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa m'mapiritsi a bedaquiline. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala omwe simukulembera, mavitamini, ndi zowonjezera zakudya zomwe mumamwa kapena mukukonzekera. Onetsetsani kuti mwatchula mankhwala omwe adatchulidwa mgulu la CHENJEZO CHENJEZO ndi zina mwa izi: carbamazepine (Equetro, Tegretol, Teril, ena); mankhwala ena opatsirana pogonana monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), lopinavir (ku Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra, ku Viekira Pak); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); nefazodone; phenobarbital; phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); ndi rifapentine (Priftin). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi bedaquiline, chifukwa chake onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• Uzani dokotala wanu ngati mwakhalapo ndi kachilombo ka HIV, kapena chiwindi kapena matenda a impso.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena mukuyamwitsa. Mukakhala ndi pakati mukamamwa bedaquiline, itanani dokotala wanu. Ngati mukuyamwitsa, auzeni dokotala ngati mwana wanu ali ndi maso achikasu kapena khungu kapena asintha mtundu wa mkodzo kapena chopondapo.
• pewani kumwa zakumwa zoledzeretsa mukamamwa bedaquiline. Kumwa mowa kumawonjezera chiopsezo kuti mudzakumana ndi zovuta kuchokera ku bedaquiline.

Lankhulani ndi dokotala wanu za kudya zipatso zamphesa ndi kumwa madzi amphesa pamene mukumwa mankhwalawa.

Ngati mwaphonya mlingo m'masabata awiri oyambilira amachiritso anu, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mwaphonya mlingo kuyambira sabata 3 m'masabata otsala omwe mwalandira, tengani mlingo womwe mudasowa ndi chakudya mukangokumbukira ndikupitiliza dongosolo lanu katatu pamlungu. Onetsetsani kuti pali maola osachepera 24 pakati pa kumwa mankhwala omwe mwaphonya ndi mlingo wotsatira. Musatenge mlingo wawiri kuti mupange omwe mwaphonya kapena kutenga zochuluka kuposa zomwe mumalandira mlungu uliwonse masiku asanu ndi awiri.

Bedaquiline amatha kuyambitsa mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kupweteka pamodzi
• mutu
• zidzolo

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• kutopa kwambiri
• kusowa chilakolako
• nseru
• chikasu cha khungu kapena maso
• mkodzo wachikuda
• kusuntha kwa matumbo ofiira
• kupweteka kumtunda chakumanja kwa m'mimba
• malungo
• kutsokomola magazi
• kupweteka pachifuwa

Bedaquiline amatha kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutali ndi kuwala, kutentha kwambiri ndi chinyezi (osati kubafa). Sungani phukusi la desiccant (woumitsa) mu botolo la mankhwala kuti mapiritsiwa asamaume.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira ku bedaquiline.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Sirturo^®