Jekeseni wa Atezolizumab

Zamkati

• Jekeseni ya Atezolizumab imagwiritsidwa ntchito:
• Asanalandire jakisoni wa atezolizumab,
• Jekeseni wa Atezolizumab imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

Jekeseni ya Atezolizumab imagwiritsidwa ntchito:

• kuchiza mitundu ina ya khansa ya m'mitsempha (khansara ya chikhodzodzo ndi mbali zina zam'mimba) zomwe zafalikira kapena sizingachotsedwe ndi opaleshoni mwa anthu omwe sangathe kulandira chemotherapy ya platinamu (carboplatin, cisplatin),
• payekha kapena ndi mankhwala ena a chemotherapy ngati chithandizo choyamba cha mitundu ina ya khansa ya m'mapapo yaing'ono (NSCLC) yomwe yafalikira mbali zina za thupi,
• kuchiza mtundu wina wa NSCLC womwe wafalikira mbali zina za thupi ndipo zomwe zaipiraipira panthawi kapena pambuyo pothandizidwa ndi mankhwala ena a chemotherapy,
• pamodzi ndi mankhwala ena a chemotherapy ngati chithandizo choyamba cha mtundu wina wa khansa ya m'mapapo yam'mapapo (SCLC) yomwe yafalikira m'mapapu kapena mbali zina za thupi,
• pamodzi ndi mankhwala ena a chemotherapy monga chithandizo cha mtundu wina wa khansa ya m'mawere yomwe yafalikira mbali zina za thupi kapena sangathe kuchotsedwa ndi opaleshoni,
• kuphatikiza ndi bevacizumab (Avastin) kuchiza hepatocellular carcinoma (HCC) yomwe yafalikira kapena singachotsedwe ndi opaleshoni mwa anthu omwe sanalandire chemotherapy m'mbuyomu, ndipo
• kuphatikiza ndi cobimetinib (Cotellic) ndi vemurafenib (Zelboraf) kuchiza mitundu ina ya khansa ya khansa (mtundu wa khansa yapakhungu) yomwe imafalikira kapena siyingachotsedwe ndi opareshoni.

Jekeseni ya Atezolizumab ili mgulu la mankhwala otchedwa monoclonal antibodies. Zimagwira ntchito poletsa mapuloteni ena m'maselo a khansa. Izi zimathandiza chitetezo cha mthupi la munthu kumenyana ndi maselo a khansa, komanso kumathandiza kuchepetsa kukula kwa chotupa.

Jekeseni ya Atezolizumab imabwera ngati madzi olowetsedwa mumtsinje kwa mphindi 30 mpaka 60 ndi dokotala kapena namwino kuchipatala kapena kuchipatala. Pamene jakisoni ya atezolizumab imagwiritsidwa ntchito pochiza khansa ya muubongo, NSCLC, SCLC, kapena hepatocellular carcinoma, imabayidwa kamodzi pamasabata awiri, 3, kapena 4 kutengera mulingo wanu malinga ngati dokotala akuuzani kuti mulandire chithandizo. Pamene jakisoni wa atezolizumab amagwiritsidwa ntchito pochiza khansa ya m'mawere nthawi zambiri amabayidwa masiku 1 ndi 15 ngati gawo la masiku 28. Mukamagwiritsa ntchito jakisoni wa atezolizumab pochiza khansa ya khansa, nthawi zambiri imabayidwa milungu iwiri iliyonse. Kutalika kwa chithandizo chanu kumadalira momwe thupi lanu limayankhira ndi mankhwala komanso zovuta zomwe mumakumana nazo.

Jekeseni ya Atezolizumab imatha kuyambitsa mavuto ena pakulowetsedwa kwa mankhwala. Dokotala kapena namwino adzakuyang'anirani mosamala mukalandira mankhwala. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kutentha, kutentha thupi, kuzizira, kugwedezeka, chizungulire, kukomoka, kupuma movutikira, kupuma movutikira, kuyabwa, zidzolo, kupweteka msana kapena khosi, kapena kutupa kwa nkhope kapena milomo .

Dokotala wanu angafunike kuchepetsa kulowetsedwa kwanu, kuchedwetsa kapena kuyimitsa chithandizo chanu, kapena kukuthandizani ndi mankhwala ena mukakumana ndi zovuta zina. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha jakisoni wa atezolizumab.

Dokotala wanu kapena wamankhwala adzakupatsani pepala lazidziwitso za wopanga (Medication Guide) mukayamba chithandizo ndi jakisoni wa atezolizumab ndipo nthawi iliyonse yomwe mumalandira mankhwalawo. Werengani nkhaniyi mosamala ndikufunsani dokotala kapena wamankhwala ngati muli ndi mafunso. Muthanso kuyendera tsamba la Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kapena tsamba laopanga kuti mupeze Medication Guide.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa atezolizumab,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la atezolizumab, mankhwala ena aliwonse, kapena zosakaniza zilizonse za jekeseni ya atezolizumab. Funsani wamankhwala wanu kapena onani Chithandizo cha Mankhwala kuti mupeze mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• auzeni dokotala wanu ngati mukuchiritsidwa matenda. Muuzeni dokotala wanu ngati mwakhala ndikudalilapo kapena mwakhalapo; mavuto am'mapapo kapena kupuma; Matenda omwe amakhudza dongosolo lanu lamanjenje monga myasthenia gravis (vuto lamanjenje lomwe limayambitsa kufooka kwa minofu) kapena matenda a Guillain-Barre (kufooka, kugwedezeka, komanso ziwalo zotheka chifukwa cha kuwonongeka kwamitsempha mwadzidzidzi); matenda amthupi (momwe chitetezo cha mthupi chimagwirira gawo labwino la thupi) monga matenda a Crohn (momwe chitetezo cha mthupi chimagwirira ntchito m'mimba momwe zimapwetekera, kutsekula m'mimba, kuwonda, ndi malungo), ulcerative colitis ( mkhalidwe womwe umayambitsa kutupa ndi zilonda mkatikati mwa kholingo [matumbo akulu] ndi rectum) kapena lupus (momwe chitetezo cha mthupi chimagwirira ziwalo ndi ziwalo zambiri kuphatikiza khungu, malo, magazi, ndi impso); kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, kapena konzekerani kutenga pakati. Simuyenera kutenga pakati mukamalandira chithandizo komanso kwa miyezi 5 mutatha kumwa mankhwala. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito mukamachiza. Mukakhala ndi pakati mukalandira jakisoni wa atezolizumab, itanani dokotala wanu mwachangu.
• Uzani dokotala wanu ngati mukuyamwitsa. Dokotala wanu angakuuzeni kuti musamamwe mkaka mukamamwa mankhwala komanso kwa miyezi 5 mutatha kumwa mankhwala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Jekeseni wa Atezolizumab imatha kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• msana, khosi, kapena kupweteka kwamalumikizidwe
• zidzolo
• kuyabwa
• kuvuta kugona kapena kugona
• kutopa kwambiri
• khungu lotumbululuka
• kumva kuzizira
• kutupa kwa mikono
• kusowa chilakolako
• nseru
• kusanza
• kutsegula m'mimba
• kudzimbidwa
• kutayika tsitsi
• kuzama kwa mawu kapena kukodola
• kunenepa

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo kapena mupeze chithandizo chadzidzidzi:

• kutsekula m'mimba, kupweteka m'mimba, magazi kapena ntchofu mu chopondapo, kapena wakuda mochedwa, womata, ndowe
• kupweteka kosalekeza komwe kumayambira kumtunda kumanzere kapena pakati pamimba koma kumafalikira kumbuyo, malungo, nseru, kusanza
• kudzimbidwa ndi kutupa m'mimba kapena kutupa
• malungo, zilonda zapakhosi, chifuwa, kuzizira, matenda onga chimfine, pafupipafupi, mwachangu, movutikira, kapena kupweteka, kapena zizindikiro zina za matenda
• pinki, wofiira, kapena mkodzo wakuda
• kuchepa pokodza, kutupa m'miyendo mwanu, akakolo, kapena mapazi
• ofunda, ofiira, otupa, kapena mwendo wofewa
• chifuwa chatsopano kapena chowonjezeka chomwe chingakhale chamagazi, kupuma pang'ono, kapena kupweteka pachifuwa
• chikasu cha khungu kapena maso, kutopa kwambiri, kutuluka magazi kapena kuvulaza mosavuta, nseru kapena kusanza, kupweteka m'mimba, mkodzo wamdima wakuda, kuchepa kwa njala
• kupweteka kwa mutu komwe sikudzatha kapena kupweteka kwachilendo, kuchuluka kwa ludzu kapena kukodza, masomphenya amasintha, kutsitsa kugonana
• kugunda kwamtima mwachangu, kudya kwambiri, kuonda mwadzidzidzi, kumva kutentha, kusintha kwa malingaliro
• kufooka kwa minofu, kufooka kapena kumenyedwa m'manja, mapazi, mikono, kapena miyendo, malungo, chisokonezo, kusintha kwa malingaliro kapena machitidwe, kuzindikira kuwala, kuuma khosi
• kusawona bwino kapena masomphenya awiri, kapena zovuta zina zamaso, kupweteka kwamaso kapena kufiira
• chizungulire kapena kumva kukomoka
• kumva njala kapena ludzu kuposa masiku onse, kukodza kwambiri, kutopa kwambiri, kufooka, mpweya womwe umanunkhira zipatso
• kusintha kwamalingaliro kapena machitidwe (kuchepa kwa kuyendetsa kugonana, kukwiya, kusokonezeka, kapena kuyiwala)
• kupweteka pachifuwa, kupuma pang'ono, kugunda kwamtima mosasinthasintha, kutupa kwa akakolo, osatha kuchita masewera olimbitsa thupi monga kale

Jekeseni ya Atezolizumab imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukalandira mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu musanachitike komanso mukamalandira chithandizo cha jakisoni ya atezolizumab kuti muwone momwe thupi lanu lingayankhire mankhwala. Nthawi zina, dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu itha kuchiritsidwa ndi atezolizumab.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Zamgululi^®