Brigatinib

Zamkati

• Asanatenge brigatinib,
• Brigatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Brigatinib imagwiritsidwa ntchito pochiza khansa ina yam'mapapo (NSCLC) yomwe yafalikira kumadera ena amthupi. Brigatinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa proteni yachilendo yomwe imawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuchepetsa kapena kuletsa kufalikira kwa maselo a khansa.

Brigatinib imabwera ngati piritsi kuti itenge pakamwa. Nthawi zambiri amatengedwa popanda chakudya kamodzi patsiku. Tengani brigatinib nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani brigatinib ndendende monga momwe adauzira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza mapiritsi lonse; musatafune kapena kuwaphwanya.

Ngati musanza mutatenga brigatinib, musamwe mlingo wina. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu akhoza kukuyambitsani pamlingo wochepa wa brigatinib ndikuwonjezera mlingo wanu kamodzi pakatha masiku 7 achipatala.

Dokotala wanu angafunikire kuyimitsa chithandizo chanu kwakanthawi kapena kosatha kapena kuchepetsa kuchuluka kwa brigatinib kapena mankhwala ena omwe mukumwa, kutengera zovuta zomwe mumakumana nazo mukamalandira chithandizo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Osasiya kumwa brigatinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanatenge brigatinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi matupi awo sagwirizana ndi brigatinib, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa pamapiritsi a brigatinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungal monga itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, buprenorphine ndi naloxone (Suboxone), carbamazepine (Equetro, Tegretol, Teril, ena), clarithromycin, cyclosporine (Gengraf, Neoral ), diltiazem (Cardizem, Cartia, Diltzac, ena), efavirenz (Sustiva, ku Atripla, Symfi), erythromycin (EES, Eryc, Erythrocin), indinavir (Crixivan), nefazodone, nelfinavir (Viracept), nevirapine (Viracept) ; phenytoin (Dilantin, Phenytek), pioglitazone (Actos, ku Actoplus Met, Duetact, Oseni), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater), ritonavir (Norvir, ku Kaletra, Technivie, sirolimus (Rapamune), tacrolimus (Astagraf, Envarsus, Prograf), kapena verapamil (Calan, Verelan, ku Tarka). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi brigatinib, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• auzeni dokotala ngati mwakhalapo kapena munakhalapo ndi matenda othamanga magazi; kugunda pang'onopang'ono; matenda a shuga kapena mavuto ena a shuga; kapena matenda a impso kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena konzekerani kukhala ndi mwana. Brigatinib itha kusokoneza njira yolerera yapa mahomoni (mapiritsi oletsa kubala, zigamba, mphete, zopangira, kapena jakisoni), chifukwa chake simuyenera kugwiritsa ntchito njira yokhayo yolerera panthawi yachipatala. Muyenera kugwiritsa ntchito njira yolera yopanda mahomoni monga chotchinga (chotchinga chomwe chimatseketsa umuna kuti usalowe muchiberekero monga kondomu kapena diaphragm). Funsani dokotala wanu kuti akuthandizeni kusankha njira yolerera yomwe ingakuthandizeni. Ngati ndinu wamkazi, muyenera kugwiritsa ntchito njira yolera yopanda mahomoni mukamalandira chithandizo komanso kwa miyezi 4 mutatha kumwa. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo ndikupitiliza kugwiritsa ntchito njira yolerera kwa miyezi itatu mutatha kumwa. Brigatinib atha kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala ndi brigatinib komanso mpaka sabata limodzi mutatha kumwa.
• Muyenera kudziwa kuti mankhwalawa amachepetsa kubereka mwa amuna. Lankhulani ndi dokotala wanu za kuopsa kwa kutenga brigatinib.

Pewani kudya zipatso zamphesa ndikumwa madzi amphesa mukamamwa brigatinib.

Pitani muyezo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mwaphonya kutenga brigatinib masiku 14 kapena kupitilira apo, lankhulani ndi dokotala musanayambirenso kumwa. Muyenera kuti muyambenso kuyitenga pamlingo wotsika.

Brigatinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kutsegula m'mimba
• kusanza
• kudzimbidwa
• kutopa
• zidzolo
• mutu
• dzanzi, kupweteka, kumva kulasalasa, kapena kutentha pamiyendo kapena manja
• kupweteka kumbuyo kapena kumalumikizana
• kusowa chilakolako
• kuvuta kugona kapena kugona

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• kupuma movutikira kapena kupuma movutikira
• kupweteka pachifuwa
• kutsokomola ndi kapena wopanda ntchofu
• malungo
• kupweteka mutu, chizungulire, mutu wopepuka, kapena kumva kukomoka
• kusawona bwino kapena masomphenya awiri
• powona kuwala kwa kuwala
• kuwala kukupweteketsani maso anu
• powona '' zoyandama '' kapena timadontho tating'ono
• ludzu lokwanira, kukodza pafupipafupi, njala yayikulu, kusawona bwino, kapena kufooka
• kupweteka kwa m'mimba komwe kumatha kufalikira kumbuyo kapena kuwonjezeka ndikudya; kuonda; kapena nseru
• kugunda pang'onopang'ono kapena kosasinthasintha
• kupweteka kwa minofu, kupweteka, kufooka, kapena kufooka

Brigatinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzakonzekeretsani labu musanayambe kumwa mankhwala kuti muwone ngati khansa yanu ingathe kuthandizidwa ndi brigatinib. Dokotala wanu amalamuliranso mayeso ena a labu ndikuwunika kuthamanga kwa magazi anu musanachitike komanso mukamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira brigatinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Alunbrig^®