Larotrectinib

Zamkati

• Musanayambe kumwa larotrectinib,
• Larotrectinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mgulu la ZOCHITIKA ZOKHUDZA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

Larotrectinib amagwiritsidwa ntchito pochiza mtundu wina wa zotupa zolimba mwa akulu ndi ana azaka 1 zakubadwa kapena kupitilira apo zomwe zafalikira mbali zina za thupi kapena sizingachiritsidwe bwino ndi opaleshoni. Mankhwalawa amagwiritsidwa ntchito pokhapokha ngati kulibe mankhwala ena alionse ndipo zotupa zaipiraipira atalandira chithandizo china. Larotrectinib ali m'gulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amauza maselo a khansa kuti achulukane. Izi zitha kuthandiza kuchepetsa kukula kwa zotupa.

Larotrectinib imabwera ngati kapisozi komanso ngati yankho (madzi) kuti mutenge pakamwa. Nthawi zambiri amatengedwa wopanda chakudya kawiri patsiku. Tengani larotrectinib mozungulira nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani larotrectinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; musatafune kapena kuwaphwanya.

Gwiritsani ntchito syringe yapakamwa (choyezera) kuti muyese molondola ndikumwa mankhwala anu a larotrectinib solution. Funsani wamankhwala wanu kuti akalandire jakisoni wamlomo ngati wina sangaphatikizidwe ndi mankhwala anu. Musagwiritse ntchito supuni ya tiyi kuti muyere yankho. Sinthanitsani sirinji iliyonse yam'kamwa mukatha kuigwiritsa ntchito masiku 7 kapena ikawonongeka. Tsatirani malangizo a wopanga momwe angagwiritsire ntchito ndi kuyeretsa jakisoni wamlomo. Funsani dokotala wanu kapena wamankhwala ngati muli ndi mafunso.

Ngati mukupereka yankho kwa mwana, ikani nsonga ya jekeseni wamlomo mkamwa mwa mwanayo mkati mwa tsaya. Sungani mwanayo pamalo owongoka kwa mphindi zochepa atangomupatsa mlingo wa larotrectinib. Ngati mwana akulavulira mlingo kapena simukudziwa kuti wapatsidwa mlingo wonse, musamupatsenso mlingo wina.

Ngati musanza mutangotenga larotrectinib, musabwereze mlingowo. Pitirizani dongosolo lanu lokhazikika.

Dokotala wanu angafunikire kuyimitsa chithandizo chanu kwakanthawi kapena kwanthawi zonse kapena kuchepetsa mlingo wanu wa larotrectinib mukamalandira chithandizo. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Onetsetsani kuti muuze dokotala momwe mukumvera mukamalandira chithandizo cha larotrectinib.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanayambe kumwa larotrectinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la larotrectinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a larotrectinib kapena yankho. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: ma antifungal ena monga itraconazole (Onmel, Sporanox) ndi ketoconazole; avanafil (Stendra); busipulo; clarithromycin (Biaxin, mu PrevPac); mankhwala ena opatsirana pogonana (HIV) kapena matenda opatsirana m'thupi (AIDS) monga efavirenz (Sustiva, ku Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); mankhwala ena omwe amaletsa chitetezo cha mthupi monga everolimus (Afinitor, Zortress), sirolimus (Rapamune), ndi tacrolimus (Astagraf, Envarsus XR, Prograf); lovastatin; masewera; nefazodone; pioglitazone (Actos); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); mankhwala ena ogwidwa monga carbamazepine (Carbatrol, Epitol, Tegretol, ena), phenobarbital, ndi phenytoin (Dilantin, Phenytek); sildenafil (Revatio, Viagra), simvastatin (Flolipid, Zocor); ndi vardenafil (Levitra, Staxyn). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena ambiri amathanso kulumikizana ndi larotrectinib, choncho onetsetsani kuti muwauze adotolo zamankhwala onse omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St. Musatenge wort ya St. John mukamamwa larotrectinib.
• uzani dokotala wanu ngati mwakhalapo kapena munakhalapo ndi vuto lomwe limakhudza dongosolo lamanjenje kapena matenda a chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kulandira chithandizo ndikugwiritsa ntchito njira zakulera kuti muchepetse mimba mukamalandira chithandizo komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira chithandizo komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza. Lankhulani ndi dokotala wanu za njira zolerera zomwe mungagwiritse ntchito. Larotrectinib ikhoza kuchepetsa kubereka mwa amayi. Komabe, simuyenera kuganiza kuti simungakhale ndi pakati. Ngati inu kapena mnzanu mutakhala ndi pakati, itanani dokotala wanu nthawi yomweyo. Larotrectinib ikhoza kuvulaza mwana wosabadwayo.
• Uzani dokotala wanu ngati mukuyamwitsa. Simuyenera kuyamwa mukamamwa mankhwala komanso kwa sabata limodzi mutapatsidwa mankhwala omaliza.
• muyenera kudziwa kuti larotrectinib itha kubweretsa kugona, chizungulire, kapena kusokonezeka. Osayendetsa galimoto kapena kugwiritsa ntchito makina mpaka mutadziwa momwe mankhwalawa amakukhudzirani.

Musadye zipatso zamphesa kapena kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati pasanathe maola 6 musanalandire mlingo wina wotsatira, tulukani mlingo womwe mwaphonya ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Larotrectinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• chifuwa
• kudzimbidwa
• kutsegula m'mimba
• nseru
• kusanza
• kupweteka m'mimba
• mutu
• Kuchuluka kwa mphuno
• kunenepa
• minofu, olowa, kapena kupweteka kwa msana
• kufooka kwa minofu
• ludzu lowonjezeka; kusintha kuchuluka kapena mtundu wa mkodzo; khungu louma; kapena kukomoka

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi kapena zomwe zili mgulu la ZOCHITIKA ZOKHUDZA, itanani dokotala wanu mwachangu kapena pitani kuchipatala mwadzidzidzi:

• mawu odekha kapena ovuta; kugwa mwangozi; kapena kumva kulasalasa, kuchita dzanzi, kapena kutentha m'manja ndi m'mapazi
• malungo
• kutupa m'manja, mapazi, akakolo, kapena miyendo yakumunsi
• kupuma movutikira
• kutopa kapena kufooka kosazolowereka; kapena khungu lotumbululuka
• kusowa chilakolako; nseru; kusanza; chikasu cha khungu kapena maso; kapena kupweteka kumtunda chakumanja kwam'mimba

Larotrectinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Sungani makapisozi kutentha ndikutentha ndi kutentha kwambiri ndi chinyezi (osati kubafa). Sungani yankho lakamwa mufiriji ndikutseka mwamphamvu; osazizira. Chotsani njira iliyonse yosagwiritsidwa ntchito pakamwa patatha masiku 90 mutatsegula botolo kwa nthawi yoyamba.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu adzaitanitsa mayesero ena a labu asanakwane komanso akamalandira chithandizo kuti muwone momwe thupi lanu likuyankhira ku larotrectinib. Nthawi zina, dokotala wanu amalamula kuyesedwa kwa labu musanayambe mankhwala anu kuti muwone ngati khansa yanu ingathe kuchiritsidwa ndi larotrectinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• VitrakviI^®