Zanubrutinib

Zamkati

• Musanatenge zanubrutinib,
• Zanubrutinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

Zanubrutinib amagwiritsidwa ntchito pochizira mantle cell lymphoma (MCL; khansa yomwe ikukula mwachangu yomwe imayamba m'maselo amthupi) mwa achikulire omwe adalandira kale mankhwala amodzi. Zanubrutinib ali mgulu la mankhwala otchedwa kinase inhibitors. Zimagwira ntchito poletsa mapuloteni achilendo omwe amawonetsa kuti ma cell a khansa achulukane. Izi zimathandiza kuletsa kufalikira kwa maselo a khansa.

Zanubrutinib amabwera ngati kapisozi woti atenge pakamwa. Nthawi zambiri amatengedwa kamodzi kapena kawiri tsiku lililonse kapena wopanda chakudya. Tengani zanubrutinib nthawi yofananira tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani zanubrutinib ndendende momwe mwalangizira. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Kumeza makapisozi lonse ndi madzi; osagawana, kutafuna, kapena kuwaphwanya.

Dokotala wanu akhoza kuchepetsa mlingo wanu, kapena kukusokonezani kapena kusiya mankhwala anu. Izi zimadalira momwe mankhwalawa amakuthandizirani komanso zovuta zomwe mumakumana nazo. Lankhulani ndi dokotala wanu za momwe mukumvera mukamalandira chithandizo. Pitirizani kutenga zanubrutinib ngakhale mutakhala bwino. Osasiya kumwa zanubrutinib osalankhula ndi dokotala.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge zanubrutinib,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la zanubrutinib, mankhwala ena aliwonse, kapena zosakaniza zilizonse mu makapisozi a zanubrutinib. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchulapo izi: mankhwala a anticoagulant ('opopera magazi') monga warfarin (Coumadin, Jantoven); antifungals monga fluconazole (Diflucan), itraconazole (Onmel, Sporanox), kapena ketoconazole; Aprepitant (Cinvanti, Emend); clarithromycin (Biaxin, mu Prevpac); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, ena); erythromycin (EES, Erythrocin, ena); mankhwala ena ochizira matenda a immunodeficiency virus (HIV) kapena matenda a immunodeficiency (AIDS) monga efavirenz (Sustiva, ku Atripla), nelfinavir (Viracept), ritonavir (Norvir, ku Kaletra), ndi saquinavir (Invirase); nefazodone; omeprazole (Prilosec); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); rifampin (Rifadin, Rifamate, Rimactane, ena); masewera; ndi steroids amlomo monga dexamethasone, methylprednisolone (Medrol), ndi prednisone (Rayos). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka St. John's Wort.
• Uzani dokotala wanu ngati muli ndi matenda kapena mwachitidwa opaleshoni posachedwapa. Komanso muuzeni dokotala ngati mwakhalapo ndi mtima wosagunda, kuthamanga kwa magazi, mavuto otaya magazi, kapena matenda amtima kapena chiwindi.
• Uzani dokotala wanu ngati muli ndi pakati, konzekerani kutenga pakati, kapena ngati mukufuna kukhala ndi mwana. Simuyenera kutenga pakati mukatenga zanubrutinib. Ngati ndinu wamkazi, muyenera kuyezetsa asanayambe kumwa mankhwala ndipo muyenera kugwiritsa ntchito njira yolerera popewa kutenga pakati mukamalandira chithandizo komanso kwa sabata limodzi mutalandira mankhwala. Ngati ndinu wamwamuna, inu ndi mnzanuyo muyenera kugwiritsa ntchito njira zakulera mukamalandira zanubrutinib ndikupitilira sabata limodzi mutatha kumwa mankhwala. Ngati inu kapena mnzanu mutakhala ndi pakati mukatenga zanubrutinib, itanani dokotala wanu mwachangu. Zanubrutinib itha kubweretsa vuto la fetus.
• uzani dokotala wanu ngati mukuyamwitsa. Musamwe mkaka pamene mukumwa zanubrutinib komanso kwa masabata awiri mutatha kumwa.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa zanubrutinib. Dokotala wanu angakuuzeni kuti musiye kumwa zanubrutinib kwa nthawi yayitali musanachite opaleshoni kapena pambuyo pake.
• konzekerani kupeŵa kuwunika kwa dzuwa kosafunikira kapena kwanthawi yayitali komanso kuvala zovala zoteteza, magalasi a dzuwa, ndi zoteteza ku dzuwa. Zanubrutinib imatha kupangitsa khungu lanu kukhala lowopsa pazowopsa za kuwala kwa dzuwa, ndipo kungakulitse chiopsezo chanu chokhala ndi khansa yapakhungu.

Lankhulani ndi dokotala wanu za kudya mphesa ndi kumwa madzi amphesa mukamamwa mankhwalawa.

Tengani mankhwala omwe mwaphonya mukangokumbukira tsiku lomwelo ndikupitiliza dongosolo lanu la dosing tsiku lotsatira. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Zanubrutinib ikhoza kuyambitsa zovuta. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• kutsegula m'mimba
• kudzimbidwa
• chifuwa
• minofu, olowa, kapena kupweteka kwa msana

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukukumana ndi zina mwazizindikirozi, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala:

• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• pokodza mopweteka, pafupipafupi, kapena mwachangu
• chifuwa, kupuma pang'ono, kupweteka pachifuwa mukamapuma kapena kutsokomola, kapena malungo
• kuvulaza kapena kutuluka mwachilendo
• magazi m'mipando yanu kapena yakuda, malo odikira; pinki kapena bulauni mkodzo; kusanza magazi kapena khofi pansi amasanza; kutsokomola magazi
• kumva chizungulire, kufooka, kapena kusokonezeka; kusintha kwa malankhulidwe; kupweteka mutu komwe kumatenga nthawi yayitali
• zidzolo
• Kuthamanga kapena kusakhazikika kwamtima, kugundana, kumva kukhala opepuka kapena ozunguza mutu, kukomoka, kupuma movutikira, kupweteka pachifuwa

Zanubrutinib akhoza kuwonjezera chiopsezo chanu chokhala ndi mitundu ina ya khansa kuphatikiza khansa yapakhungu. Lankhulani ndi dokotala wanu za kuopsa kotenga zanubrutinib.

Zanubrutinib ikhoza kuyambitsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisungeni kutentha ndi kutali ndi kutentha kwambiri ndi chinyezi (osati kubafa).

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu akhoza kuyitanitsa mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira zanubrutinib.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Brukinsa^®