Doxorubicin

Zamkati

• Asanalandire jakisoni wa doxorubicin,
• Doxorubicin angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:
• Zizindikiro za bongo zingaphatikizepo izi:

Doxorubicin ayenera kuperekedwa kokha mu mtsempha. Komabe, imatha kutayikira minofu yoyandikana nayo yomwe imakhumudwitsa kwambiri kapena kuwonongeka. Dokotala wanu kapena namwino adzayang'anira tsamba lanu loyang'anira izi. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupweteka, kuyabwa, kufiira, kutupa, matuza, kapena zilonda m'malo omwe munabayira mankhwala.

Doxorubicin imatha kubweretsa mavuto owopsa kapena owopsa pa mtima nthawi iliyonse mukamachiza kapena miyezi mpaka zaka mutatha mankhwala anu. Dokotala wanu amalamula kuyesedwa musanachitike komanso mukamalandira chithandizo kuti muwone ngati mtima wanu ukugwira ntchito bwino kuti mulandire bwino doxorubicin. Mayesowa atha kuphatikizira electrocardiogram (ECG; mayeso omwe amalemba zamagetsi zamagetsi mumtima) ndi echocardiogram (mayeso omwe amagwiritsa ntchito mafunde amawu kuti athe kuyesa mtima wanu kutulutsa magazi). Dokotala wanu angakuuzeni kuti simuyenera kulandira mankhwalawa ngati muli ndi vuto la mtima wosafunikira kapena ngati mayesero akuwonetsa kuthekera kwa mtima wanu kupopera magazi kwatsika. Uzani dokotala wanu ngati mwakhalapo kapena mudakhalapo ndi matenda amtima, matenda amtima, kapena mankhwala a radiation (x-ray) m'chifuwa. Uzani dokotala wanu komanso wamankhwala ngati mukumwa kapena munalandirapo mankhwala enaake a khansa monga cyclophosphamide (Cytoxan), daunorubicin (Cerubidine, DaunoXome), epirubicin (Ellence), idarubicin (Idamycin), mitoxantrone (Novantrone), paclitaxel (Abraxane, Abraxane, Abraxane Onxol), trastuzumab (Herceptin), kapena verapamil (Calan, Isoptin). Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kupuma movutikira; kuvuta kupuma; kutupa kwa manja, mapazi, akakolo kapena miyendo yakumunsi; kapena kugunda kwamtima, kosasinthasintha, kapena kopanda.

Doxorubicin imatha kutsitsa kwambiri kuchuluka kwama cell am'mafupa mwanu. Dokotala wanu adzaitanitsa mayeso a labotale nthawi zonse musanamwe komanso mukamalandira chithandizo. Kuchepa kwa maselo amwazi mthupi lanu kumatha kuyambitsa zizindikilo zina ndipo kumatha kuonjezera chiwopsezo kuti mutenge matenda akulu kapena magazi. Uzani dokotala wanu komanso wamankhwala ngati mukumwa kapena mwalandira azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), kapena progesterone (Provera, Depo-Provera). Ngati mukumane ndi izi, itanani dokotala wanu nthawi yomweyo: malungo, zilonda zapakhosi, kutsokomola kosalekeza komanso kuchulukana, kapena zizindikilo zina za matenda; kutuluka mwachilendo kapena kuvulala; wamagazi kapena wakuda, malo obisalira; kusanza kwamagazi; kapena kusanza magazi kapena zinthu zofiirira zomwe zikufanana ndi khofi.

Doxorubicin imatha kukulitsa chiopsezo chotenga khansa ya m'magazi (khansa yamagazi oyera), makamaka ikaperekedwa kwambiri kapena limodzi ndi mankhwala ena a chemotherapy ndi radiation (x-ray).

Uzani dokotala wanu ngati mwakhalapo kapena mukudwala matenda a chiwindi. Dokotala wanu angakuuzeni kuti simuyenera kulandira mankhwalawa kapena mutha kusintha mlingo wanu ngati muli ndi matenda a chiwindi.

Doxorubicin ayenera kuperekedwa kokha moyang'aniridwa ndi dokotala wodziwa kugwiritsa ntchito mankhwala a chemotherapy.

Doxorubicin imagwiritsidwa ntchito limodzi ndi mankhwala ena kuti athetse mitundu ina ya chikhodzodzo, m'mawere, m'mapapo, m'mimba, ndi khansa ya m'mimba; Hodgkin's lymphoma (matenda a Hodgkin) ndi non-Hodgkin's lymphoma (khansa yomwe imayamba m'maselo amthupi); ndi mitundu ina ya khansa ya m'magazi (khansa yamagazi oyera), kuphatikiza khansa ya m'magazi (ALL) ndi acute myeloid leukemia (AML, ANLL). Doxorubicin imagwiritsidwanso ntchito yokha komanso kuphatikiza mankhwala ena ochizira mitundu ina ya khansa ya chithokomiro ndi mitundu ina ya minofu yofewa kapena mafupa a sarcomas (khansa yomwe imapanga minofu ndi mafupa). Amagwiritsidwanso ntchito pochiza neuroblastoma (khansa yomwe imayamba m'mitsempha yamitsempha ndipo imachitika makamaka mwa ana) ndi chotupa cha Wilms (mtundu wa khansa ya impso yomwe imapezeka mwa ana). Doxorubicin ali mgulu la mankhwala otchedwa anthracyclines. Zimagwira pochepetsa kapena kuletsa kukula kwa maselo a khansa mthupi lanu.

Doxorubicin imabwera ngati yankho (madzi) kapena ngati ufa wosakanikirana ndi madzi kuti alowe jakisoni (mumtsempha) ndi dokotala kapena namwino kuchipatala. Nthawi zambiri amaperekedwa kamodzi masiku 21 mpaka 28. Kutalika kwa chithandizo kumatengera mitundu ya mankhwala omwe mukumwa, momwe thupi lanu limayankhira, komanso mtundu wa khansa yomwe muli nayo.

Funsani wamankhwala kapena dokotala wanu kuti mumupatseko zidziwitso za wopanga kwa wodwalayo.

Doxorubicin nthawi zina amagwiritsidwanso ntchito pochiza khansa ya m'mimba, endometrium (mzere wa chiberekero), ndi khomo pachibelekeropo (kutsegula kwa chiberekero); kansa ya Prostate (khansa ya ziwalo zoberekera zamwamuna); khansa ya kapamba; khansa ya adrenocortical (khansa m'matenda a adrenal); khansa ya chiwindi; Kaposi's sarcoma yokhudzana ndi matenda a immunodeficiency syndrome (AIDS); Ewing’s sarcoma (mtundu wa khansa ya mafupa) mwa ana; mesothelioma (khansara pakatikati mwa chifuwa kapena pamimba); angapo myeloma (mtundu wa khansa ya m'mafupa); ndi khansa ya m'magazi (CLL; mtundu wa khansa yamagazi oyera). Lankhulani ndi dokotala wanu za kuopsa kogwiritsa ntchito mankhwalawa ngati muli ndi vuto lanu.

Mankhwalawa amatha kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Asanalandire jakisoni wa doxorubicin,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la doxorubicin, daunorubicin (Cerubidine, DaunoXome), epirubicin (Ellence), idarubicin (Idamycin), mankhwala ena aliwonse, kapena chilichonse chazomwe zili mu jakisoni wa doxorubicin. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• auzeni adotolo komanso asayansi yanu mankhwala ena omwe mungalandire kapena omwe simukulembera, mavitamini, zowonjezera zakudya, komanso mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula mankhwala omwe atchulidwa mgawo la CHENJEZO CHENJEZO ndi zina mwa izi: mankhwala ena a chemotherapy monga cytarabine (DepoCyt), dexrazoxane (Zinecard), mercaptopurine (Purinethol), streptozocin (Zanosar); phenobarbital (Luminal Sodium); kapena phenytoin (Dilantin). Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake. Mankhwala ena amathanso kulumikizana ndi doxorubicin, chifukwa chake onetsetsani kuti muwauze adotolo za mankhwala omwe mukumwa, ngakhale omwe sapezeka pamndandandawu.
• uzani dokotala wanu ngati mwakhalapo kapena munakhalapo ndi matenda ena aliwonse.
• muyenera kudziwa kuti doxorubicin imatha kusokoneza msambo mwa amayi ndipo imatha kusiya umuna mwa amuna. Komabe, simuyenera kuganiza kuti simungatenge mimba kapena kuti simungapatse wina mimba. Amayi omwe ali ndi pakati kapena akuyamwitsa ayenera kuuza adokotala asanayambe kulandira mankhwalawa. Simuyenera kutenga pakati kapena kuyamwitsa mukalandira jekeseni wa doxorubicin. Mukakhala ndi pakati mukalandira doxorubicin, itanani dokotala wanu. Gwiritsani ntchito njira yodalirika yolerera popewa kutenga pakati. Doxorubicin akhoza kuvulaza mwana wosabadwayo.
• mulibe katemera popanda kulankhula ndi dokotala.

Pokhapokha dokotala atakuwuzani zina, pitirizani kudya zomwe mumadya.

Doxorubicin angayambitse mavuto. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• nseru
• kusanza
• zilonda mkamwa ndi pakhosi
• kusowa chilakolako (ndi kuchepa thupi)
• kunenepa
• kupweteka m'mimba
• kutsegula m'mimba
• ludzu lowonjezeka
• kutopa kapena kufooka kosazolowereka
• chizungulire
• kutayika tsitsi
• kulekanitsidwa kwa zikhadabo kapena zala zazitali kuchokera ku msomali
• kuyabwa, kufiira, madzi, kapena kukwiya
• kupweteka kwa diso
• kupweteka, kuwotcha, kapena kumva kulasalasa m'manja kapena m'mapazi
• mkodzo wofiira (kwa masiku 1 kapena 2 mutatha mlingo)

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa MUCHENJEZO CHENJEZO, itanani dokotala wanu mwachangu:

• ming'oma
• zotupa pakhungu
• kuyabwa
• kuvuta kupuma kapena kumeza
• kugwidwa

Doxorubicin angayambitse mavuto ena. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• zilonda mkamwa ndi pakhosi
• malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za matenda
• kutuluka mwachilendo kapena kuphwanya
• mipando yakuda ndi yodikira
• magazi ofiira m'mipando
• masanzi amagazi
• zinthu zosanza zomwe zimawoneka ngati malo a khofi

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena kuti aone momwe thupi lanu limayankhira doxorubicin.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Adriamycin^®¶
• Rubex^®¶

• Hydroxydaunomycin Hydrochloride
• Hydroxydoxorubicin Hydrochloride

^¶ Chogulitsa ichi sichikupezeka pamsika. Njira zina zitha kupezeka.