Clozapine

Zamkati

• Musanatenge clozapine,
• Clozapine imatha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:
• Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena NKHANI ZOCHITIKA, itanani dokotala wanu mwachangu:
• Zizindikiro za bongo zingaphatikizepo izi:

Clozapine imatha kubweretsa vuto lalikulu lamagazi. Dokotala wanu adzaitanitsa mayesero ena a labu musanayambe kumwa mankhwala, mukamalandira chithandizo, komanso kwa milungu 4 mutalandira chithandizo. Dokotala wanu amalamula kuyesedwa kwa labu kamodzi pa sabata koyamba ndipo atha kuyitanitsa mayesowo kangapo pomwe chithandizo chanu chikupitilira. Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kutopa kwambiri; kufooka; malungo, zilonda zapakhosi, kuzizira, kapena zizindikiro zina za chimfine kapena matenda; kumaliseche kwachilendo kapena kuyabwa; zilonda mkamwa mwako kapena mmero; mabala omwe amatenga nthawi yayitali kuti apole; kupweteka kapena kutentha pamene mukukodza; zilonda kapena zopweteka mkati mwanu kapena mozungulira dera lanu; kapena kupweteka m'mimba.

Chifukwa cha kuopsa kwa mankhwalawa, clozapine imangopezeka pokhapokha pulogalamu yoletsa yogawa. Pulogalamu yakhazikitsidwa ndi opanga ma clozapine kuti awonetsetse kuti anthu samatenga clozapine popanda kuwunika koyenera kotchedwa Clozapine Risk Evaluation and Mitigation Strategies (REMS) Program. Dokotala wanu komanso wamankhwala wanu ayenera kulembetsa nawo pulogalamu ya Clozapine REMS, ndipo wazamankhwala wanu sangakupatseni mankhwala anu pokhapokha atalandira zotsatira za kuyezetsa magazi. Funsani dokotala wanu kuti mumve zambiri za pulogalamuyi komanso momwe mungalandire mankhwala anu.

Clozapine imatha kuyambitsa khunyu. Uzani dokotala wanu ngati mwakhalapo kapena munagwapo. Osayendetsa galimoto, kugwiritsa ntchito makina, kusambira, kapena kukwera mukamatenga clozapine, chifukwa ngati mwadzidzidzi mungadziwike, mutha kudzivulaza nokha kapena ena. Ngati mukugwidwa ndi matendawa, pitani kuchipatala nthawi yomweyo kapena pitani kuchipatala mwadzidzidzi.

Clozapine imatha kuyambitsa myocarditis (kutupa kwa minofu yamtima yomwe imatha kukhala yowopsa) kapena cardiomyopathy (kukulitsa kapena kukulitsa minofu yamtima yomwe imayimitsa mtima kupopera magazi mwachizolowezi). Ngati mukumane ndi izi, uzani dokotala nthawi yomweyo: kutopa kwambiri; chimfine ngati zizindikiro; kuvuta kupuma kapena kupuma mwachangu; malungo; kupweteka pachifuwa; kapena kugunda kwamtima, kosasinthasintha, kapena kopanda.

Clozapine imatha kuyambitsa chizungulire, mutu wopepuka, kapena kukomoka mukaimirira, makamaka mukayamba kumwa kapena kuchuluka kwa kuchuluka kwanu. Uzani dokotala wanu ngati mwadwalapo kapena mwadwala mtima, mukulephera mtima, kapena mukugunda pang'onopang'ono, kapena mukumwa mankhwala a kuthamanga kwa magazi. Muuzeni adotolo ngati mukusanza kwambiri kapena kutsekula m'mimba kapena zizindikiro zakusowa madzi m'thupi tsopano, kapena ngati mukukhala ndi zizindikiritso izi nthawi iliyonse mukamalandira chithandizo. Dokotala wanu mwina angakuyambitseni pa mlingo wochepa wa clozapine ndipo pang'onopang'ono muwonjezere mlingo wanu kuti mupatse thupi lanu nthawi kuti muzolowere mankhwalawo ndikuchepetsa mwayi kuti mudzakhale ndi zotsatirazi. Lankhulani ndi dokotala ngati simutenga clozapine masiku awiri kapena kupitilira apo. Dokotala wanu angakuuzeni kuti muyambitse chithandizo chanu ndi mlingo wochepa wa clozapine.

Gwiritsani Ntchito Akulu Achikulire:

Kafukufuku wasonyeza kuti achikulire omwe ali ndi dementia (vuto laubongo lomwe limakhudza kukumbukira, kuganiza bwino, kulumikizana, ndikuchita zochitika za tsiku ndi tsiku zomwe zingayambitse kusintha kwa malingaliro ndi umunthu) omwe amatenga ma antipsychotic (mankhwala amisala) monga clozapine khalani ndi mwayi wambiri wakufa panthawi yachithandizo.

Clozapine sivomerezedwa ndi Food and Drug Administration (FDA) pochiza mavuto amachitidwe mwa achikulire omwe ali ndi vuto la misala. Lankhulani ndi dokotala yemwe adakupatsani clozapine ngati inu, wachibale wanu, kapena wina amene mumamusamalira ali ndi matenda amisala ndipo akumamwa mankhwalawa. Kuti mumve zambiri pitani patsamba la FDA: http://www.fda.gov/Drugs

Clozapine amagwiritsidwa ntchito pochiza matenda a schizophrenia (matenda amisala omwe amachititsa kusokonezeka kapena kuganiza kosazolowereka, kutaya chidwi ndi moyo, komanso kukhudzidwa mwamphamvu kapena kosayenera) mwa anthu omwe sanathandizidwe ndi mankhwala ena kapena omwe ayesera kudzipha okha ayenera kuyesa kudzipha kapena kudzipwetekanso. Clozapine ali mgulu la mankhwala otchedwa atypical antipsychotic. Zimagwira ntchito posintha zochitika za zinthu zina zachilengedwe muubongo.

Clozapine imabwera ngati piritsi, piritsi losweka pakamwa (piritsi lomwe limasungunuka mwachangu mkamwa), ndikuyimitsidwa pakamwa (madzi) kuti mutenge pakamwa. Nthawi zambiri amatengedwa kamodzi kapena kawiri tsiku lililonse. Tengani clozapine mozungulira nthawi yomweyo tsiku lililonse. Tsatirani malangizo omwe mwalandira mosamala, ndikufunsani dokotala kapena wamankhwala kuti afotokoze gawo lililonse lomwe simukumvetsa. Tengani clozapine chimodzimodzi monga mwalamulo. Musamamwe pang'ono kapena kumamwa pafupipafupi kuposa momwe adanenera dokotala.

Osayesa kukankhira piritsi lomwe likuphwanyidwa pakamwa kudzera pazovala zojambulazo. M'malo mwake, gwiritsani ntchito manja owuma kuti muchepetse zojambulazo. Nthawi yomweyo chotsani piritsilo ndikuyika lilime lanu. Piritsi limasungunuka mwachangu ndipo limatha kumezedwa ndi malovu. Palibe madzi omwe amafunikira kuti amezere mapiritsi omwe amafa.

Kuti muyese kuyimitsidwa pakamwa kwa clozapine, tsatirani izi:

1. Onetsetsani kuti kapuyo ndi yolimba pachidebe choyimitsa pakamwa potembenuza kapuyo mozungulira (kumanja). Sambani botolo mmwamba ndi pansi kwa masekondi 10 musanagwiritse ntchito.
2. Chotsani kapu ya botolo mwa kukankhira pansi pa kapuyo, kenaka mutembenuzire molowera mbali (kumanzere). Nthawi yoyamba mutatsegula botolo latsopano, kanikizani adapter mu botolo mpaka pamwamba pa adapter itakhala pamwamba pa botolo.
3. Ngati mulingo wanu ndi 1 mL kapena kuchepera, gwiritsani ntchito syringe ya pakamwa yocheperako (1 mL). Ngati mlingo wanu upitilira 1 mL, gwiritsani ntchito syringe yapakamwa (9 mL).
4. Dzazani syringe pakamwa ndi mpweya pobwezeretsanso plunger. Kenako ikani nsonga yotseguka ya sirinji ya mkamwa mu adapter. Thirani mpweya wonse kuchokera mu syringe yam'kamwa kulowa mu botolo pokankhira pansi pa plunger.
5. Mukamagwira jekeseni wamlomo pakamwa, samalani botolo mosamala. Jambulani mankhwala ena mu botolo mu syringe yam'kamwa mwa kukokera pa plunger. Samalani kuti musakoke chombocho mpaka kutuluka.
6. Mudzawona mpweya wochepa pafupi ndi kutha kwa chojambulira m'jekeseni yamlomo. Kankhani pa plunger kuti mankhwala abwerere mu botolo ndipo mpweya umatha. Bwererani pa plunger kuti mutenge mankhwala anu oyenera mu syringe yamlomo.
7. Mukadali ndi syringe ya mkamwa mu botolo, tembenuzani botolo mmwamba kuti syringe ikhale pamwamba. Chotsani syringe yapakamwa kuchokera ku adapter ya khosi la botolo popanda kukankhira pa plunger. Imwani mankhwalawo mutangowakoka m'syringe yamlomo. Osakonzekera mlingo ndikuusunga mu syringe kuti mugwiritse ntchito mtsogolo.
8. Ikani nsonga yotseguka ya sirinji yam'kamwa mbali imodzi ya pakamwa panu. Tsekani kwambiri milomo yanu kuzungulira syringe yam'kamwa ndikukankhira pobayira pang'onopang'ono madziwo akamalowa mkamwa mwanu. Kumeza mankhwalawo pang'onopang'ono mukamapita mkamwa mwako.
9. Siyani adaputala mu botolo. Ikani kapu kumbuyo kwa botolo ndikuyitembenuza mozungulira (kumanja) kuti imitseke.
10. Muzimutsuka ndi syringe wam'kamwa ndi madzi ofunda otentha mukatha kugwiritsa ntchito. Dzazani chikho ndi madzi ndikuyika nsonga ya syringe pakamwa m'madzi mu chikho. Bwererani pa plunger ndikutunga madzi mu syringe yamlomo. Kankhirani pa plunger kuti muthe madzi kulowa mosambira kapena chidebe china mpaka syringe ya mkamwa itakhala yoyera. Lolani mpweya wa m'kamwa kuti uume ndi kutaya madzi otsala otsuka.

Clozapine amalamulira schizophrenia koma samachiritsa. Zitha kutenga milungu ingapo kapena kupitilira apo musanapindule ndi clozapine. Pitirizani kutenga clozapine ngakhale mukumva bwino. Osasiya kumwa clozapine osalankhula ndi dokotala. Dokotala wanu angafune kuchepetsa mlingo wanu pang'onopang'ono.

Mankhwalawa sayenera kupatsidwa ntchito zina; funsani dokotala wanu kapena wamankhwala kuti mudziwe zambiri.

Musanatenge clozapine,

• uzani dokotala wanu komanso wamankhwala ngati muli ndi vuto la mankhwala a clozapine, mankhwala ena aliwonse, kapena chilichonse mwazomwe zimaphatikizidwa m'mapiritsi a clozapine. Funsani wamankhwala wanu kuti awonetse mndandanda wazosakaniza.
• Uzani dokotala wanu komanso wamankhwala mankhwala ndi mankhwala osapatsirana, mavitamini, zowonjezera zakudya, ndi mankhwala azitsamba omwe mukumwa kapena omwe mukufuna kumwa. Onetsetsani kuti mwatchula omwe adatchulidwa mgawo la CHENJEZO LOFUNIKA ndi zina mwa izi: antihistamines monga diphenhydramine (Benadryl); maantibayotiki monga ciprofloxacin (Cipro) ndi erythromycin (EES, E-Mycin, ena); benztropine (Cogentin); cimetidine (Tagamet); bupropion (Aplenzin, Wellbutrin, Zyban, mu Contrave); cyclobenzaprine (Amrix); escitalopram (Lexapro); mankhwala a nkhawa, kuthamanga kwa magazi, matenda amisala, kuyenda kwamisempha, kapena nseru; mankhwala a kugunda kwamtima mosasinthasintha monga encainide, flecainide, propafenone (Rythmol), ndi quinidine (ku Nuedexta); kulera pakamwa; mankhwala ogwidwa monga carbamazepine (Equetro, Tegretol, Teril, ena) kapena phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, ku Rifamate, ku Rifater); mankhwala ogonetsa; serotonin reuptake inhibitors (SSRIs) monga duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Selfemra, ena), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), ndi sertraline (Zoloft); mapiritsi ogona; terbinafine (Lamisil); ndi zotontholetsa. Dokotala wanu angafunike kusintha kuchuluka kwa mankhwala anu kapena kukuyang'anirani mosamala zotsatira zake.
• uzani dokotala wanu za mankhwala azitsamba omwe mukumwa, makamaka wort ya St.
• Kuphatikiza pa zomwe zalembedwa m'gawo LOFUNIKITSA CHENJEZO, uzani dokotala ngati inu kapena aliyense m'banja mwanu mwakhalapo ndi nthawi yayitali ya QT (vuto losowa mtima lomwe lingayambitse kugunda kwamtima, kukomoka, kapena kufa mwadzidzidzi) kapena matenda ashuga. Uzani dokotala wanu ngati mukudwala, kusuta, kusanza, kapena kupweteka m'mimba kapena kutalika; kapena ngati mwakhalapo ndi vuto ndi kwamikodzo kapena prostate (chiberekero chamwamuna); dyslipidemia (cholesterol yambiri); zilema (ziwalo zomwe chakudya sichingadutse m'matumbo); khungu; kuthamanga kapena kuthamanga kwa magazi; kuvuta kusunga malire; kapena matenda a mtima, impso, mapapo, kapena chiwindi. Uzaninso dokotala wanu ngati munasiya kumwa mankhwala a matenda amisala chifukwa cha zovuta zina.
• uzani dokotala wanu ngati muli ndi pakati, makamaka ngati muli m'miyezi ingapo yapitayo ya mimba yanu, kapena ngati mukufuna kutenga pakati kapena mukuyamwitsa. Mukakhala ndi pakati mukatenga clozapine, itanani dokotala wanu. Clozapine imatha kubweretsa mavuto kwa ana obadwa kumene atabereka ngati atengedwa m'miyezi yapitayi yamimba.
• ngati mukuchitidwa opaleshoni, kuphatikizapo opaleshoni ya mano, uzani dokotala kapena dokotala kuti mukumwa clozapine.
• Muyenera kudziwa kuti mowa umatha kuwonjezera kugona komwe kumayambitsidwa ndi mankhwalawa.
• uzani dokotala ngati mumagwiritsa ntchito fodya. Kusuta ndudu kumatha kuchepetsa mphamvu ya mankhwalawa.
• muyenera kudziwa kuti mutha kukhala ndi hyperglycemia (kuchuluka kwa shuga m'magazi anu) mukamamwa mankhwalawa, ngakhale mulibe matenda ashuga. Ngati muli ndi schizophrenia, mumakhala ndi matenda ashuga kuposa anthu omwe alibe schizophrenia, ndipo kumwa mankhwala a clozapine kapena ofanana nawo kungapangitse ngozi imeneyi. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro izi mukamamwa clozapine: ludzu kwambiri, kukodza pafupipafupi, njala yayikulu, kusawona bwino, kapena kufooka. Ndikofunika kuyimbira dokotala wanu mukangokhala ndi izi, chifukwa shuga wambiri m'magazi amatha kuyambitsa vuto lalikulu lotchedwa ketoacidosis. Ketoacidosis imatha kukhala pangozi ngati singachiritsidwe koyambirira. Zizindikiro za ketoacidosis zimaphatikizapo: pakamwa pouma, nseru ndi kusanza, kupuma movutikira, mpweya womwe umanunkhira zipatso, ndikuchepetsa chidziwitso.
• ngati muli ndi phenylketonuria (PKU, mkhalidwe wobadwa nawo momwe muyenera kudya chakudya chapadera kuti muchepetse kuchepa kwamaganizidwe), muyenera kudziwa kuti mapiritsi omwe amawonongeka pakamwa amakhala ndi aspartame yomwe imapanga phenylalanine.

Lankhulani ndi dokotala wanu zakumwa zakumwa za khofi pamene mukumwa mankhwalawa.

Tengani mlingo womwe mwaphonya mukangokumbukira. Komabe, ngati ili pafupi nthawi ya mlingo wotsatira, dumpha mlingo womwe umasowa ndikupitiliza dongosolo lanu lokhazikika. Musatenge mlingo wawiri kuti mupange omwe mwaphonya.

Ngati mwaphonya kumwa clozapine masiku opitilira 2, muyenera kuyimbira dokotala musanamwe mankhwala. Dokotala wanu angafune kuyambiranso mankhwala anu pamlingo wotsika.

Clozapine imatha kuyambitsa zovuta zina. Uzani dokotala wanu ngati zina mwazizindikirozi ndizolimba kapena sizichoka:

• Kusinza
• chizungulire, kumva kusakhazikika, kapena kukhala ndi vuto loti musamachite zinthu mopitirira malire
• kuchuluka salivation
• pakamwa pouma
• kusakhazikika
• mutu

Zotsatira zina zoyipa zingakhale zazikulu. Ngati mukumane ndi izi kapena izi zomwe zalembedwa M'CHENJEZO CHOFUNIKA kapena NKHANI ZOCHITIKA, itanani dokotala wanu mwachangu:

• kudzimbidwa; nseru; kutupa m'mimba kapena kupweteka; kapena kusanza
• kugwirana chanza komwe simungathe kulamulira
• kukomoka
• kugwa
• kuvuta kukodza kapena kutaya chikhodzodzo
• chisokonezo
• kusintha kwa masomphenya
• kugwedezeka
• kuuma kwambiri kwa minofu
• thukuta
• kusintha kwamakhalidwe
• kutuluka mwachilendo kapena kuphwanya
• kusowa chilakolako
• kukhumudwa m'mimba
• chikasu cha khungu kapena maso
• kupweteka kumtunda chakumanja kwam'mimba
• kusowa mphamvu

Clozapine imatha kubweretsa zovuta zina. Itanani dokotala wanu ngati muli ndi zovuta zina mukamamwa mankhwalawa.

Mukakumana ndi zovuta zina, inu kapena adokotala mutha kutumiza lipoti ku pulogalamu ya Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting pa intaneti (http://www.fda.gov/Safety/MedWatch) kapena pafoni ( 1-800-332-1088).

Sungani mankhwala awa mu chidebe chomwe chidabwera, chatsekedwa mwamphamvu, komanso chosafikira ana. Zisunge kutentha komanso kutalikirana ndi kutentha komanso kutentha kwambiri ndi chinyezi (osati kubafa). Osazizira kapena kuimitsa kuyimitsa pakamwa.

Ndikofunika kuti mankhwala onse asamawonekere komanso kuti ana asamafikire ngati muli zidebe zambiri (monga mapiritsi a mlungu ndi mlungu ndi omwe amatsikira m'maso, mafuta, zigamba, ndi opumira) sizolimbana ndi ana ndipo ana aang'ono amatha kuzitsegula mosavuta. Pofuna kuteteza ana ang'ono kuti asatenge poyizoni, nthawi zonse tsekani zipewa zachitetezo ndikuyika mankhwalawo pamalo otetezeka - omwe ali pamwamba ndi kutali komanso osawonekera ndi kufikira. http://www.upandaway.org

Mankhwala osafunikira ayenera kutayidwa munjira zapadera zowonetsetsa kuti ziweto, ana, ndi anthu ena sangamwe. Komabe, simuyenera kuthira mankhwalawa mchimbudzi. M'malo mwake, njira yabwino yoperekera mankhwala anu ndikadongosolo lobwezera mankhwala. Lankhulani ndi wamankhwala wanu kapena lemberani dipatimenti yakunyumba / yobwezeretsanso kwanuko kuti muphunzire zamapulogalamu obwezeretsanso mdera lanu. Onani tsamba la FDA's Disposal of Medicines webusayiti (http://goo.gl/c4Rm4p) kuti mumve zambiri ngati mulibe pulogalamu yobwezera.

Mukadwala mopitirira muyeso, itanani foni yothandizira poyizoni pa 1-800-222-1222. Zambiri zimapezekanso pa intaneti pa https://www.poisonhelp.org/help. Ngati wozunzidwayo wagwa, watenga khunyu, akuvutika kupuma, kapena sangathe kudzutsidwa, nthawi yomweyo itanani anthu azadzidzidzi ku 911.

Zizindikiro za bongo zingaphatikizepo izi:

• chizungulire
• kukomoka
• kupuma pang'ono
• kusintha kwa kugunda kwa mtima
• kutaya chidziwitso

Sungani maimidwe onse ndi dokotala wanu ndi labotale. Dokotala wanu amalamula mayeso ena a labu kuti muwone momwe thupi lanu likuyankhira pa clozapine.

Musalole kuti aliyense azimwa mankhwala anu. Funsani wamankhwala wanu mafunso aliwonse omwe muli nawo okhudzana ndi kudzaza mankhwala anu.

Ndikofunika kuti musunge mndandanda wamankhwala onse omwe mumalandira komanso osalembetsa (owerengera) omwe mukumwa, komanso zinthu zilizonse monga mavitamini, michere, kapena zakudya zina. Muyenera kubwera nawo pamndandandawu nthawi iliyonse mukapita kukaonana ndi dokotala kapena ngati mwalandiridwa kuchipatala. Ndikofunikanso kuthana nanu pakagwa mwadzidzidzi.

• Clozaril^®
• FazaClo^® ODT
• Veracloz^®