Ma antibodies a monoclonal: zomwe ali komanso chifukwa chake amathandizira kuchiza matenda

Zamkati

• Zitsanzo za ma antibodies monoclonal
• 1. Trastuzumab
• 2. Denosumab
• 3. Obinutuzumab
• 4. Ustequinumab
• 5. Pertuzumab
• Momwe Mungatengere Ma antibodies a Monoclonal

Ma antibodies a monoclonal ndi mapuloteni omwe amagwiritsidwa ntchito ndi chitetezo cha mthupi kuti azindikire ndikusokoneza matupi akunja, omwe atha kukhala mabakiteriya, mavairasi kapenanso zotupa. Mapuloteniwa ndi achindunji, chifukwa amazindikira chandamale china, chomwe chimatchedwa antigen, chomwe chidzakhalapo m'maselo achilendo m'thupi. Mvetsetsani momwe chitetezo chamthupi chimagwirira ntchito.

Ma antibodies a monoclonal, monga denosumab, obinutuzumab kapena ustequinumab, mwachitsanzo, amapangidwa mu labotale, nthawi zambiri imafanana ndi omwe amapezeka mthupi la munthu, omwe angathandize thupi kulimbana ndi matenda ena. Chifukwa chake, kutengera mankhwala a monoclonal omwe agwiritsidwa ntchito, mankhwalawa atha kugwiritsidwa ntchito pochiza matenda ena akulu monga osteoporosis, leukemia, plaque psoriasis kapena mitundu ina ya khansa, monga khansa ya m'mawere kapena mafupa, mwachitsanzo.

Zitsanzo za ma antibodies monoclonal

Zitsanzo zina za ma antibodies monoclonal ndi awa:

1. Trastuzumab

Mankhwala oteteza monoclonal, omwe amagulitsidwa ngati Herceptin, adapangidwa ndi ukadaulo waukadaulo, ndipo amawukira makamaka protein yomwe imapezeka mwa anthu omwe ali ndi khansa ya m'mawere ndi m'mimba. Chifukwa chake, chida ichi chikuwonetsedwa ngati chithandizo cha khansa ya m'mawere koyambirira kapena metastasis ndi khansa ya m'mimba isanakwane.

2. Denosumab

Wogulitsidwa ngati Prolia kapena Xgeva, uli ndi anti-monoglonal anti-IgG2 antibody, yomwe imalepheretsa kuchita kwa mapuloteni ena omwe amalimbitsa mafupa, ndikuchepetsa mwayi wosweka. Chifukwa chake, a Denosumab amawonetsedwa pochiza kutayika kwa mafupa, kufooka kwa mafupa, khansa ya m'mafupa kapena khansa yomwe ili patsogolo kwambiri ndi metastases yamafupa (yomwe yafalikira m'mafupa).

3. Obinutuzumab

Amadziwikanso kuti Gazyva, ali ndi ma antibodies omwe amazindikira ndikumangiriza puloteni ya CD20, yomwe imapezeka pamwamba pamaselo oyera a magazi kapena ma lymphocyte a B. Amatha kuletsa kukula kosazolowereka kwama maselo oyera omwe amayambitsa matendawa.

4. Ustequinumab

Chithandizochi chimadziwikanso kuti Stelara ndipo chimapangidwa ndi anti-IgG1 monoclonal antibody, yomwe imalepheretsa mapuloteni ena omwe amachititsa psoriasis. Chifukwa chake, chida ichi chikuwonetsedwa pochizira psoriasis.

5. Pertuzumab

Amadziwikanso kuti Perjeta, amapangidwa ndi ma anti-monoclonal antibodies omwe amalumikizana ndi kukula kwa epidermalal factor 2 receptor, yomwe imapezeka m'maselo ena a khansa, ikuchepetsa kapena kuyimitsa kukula kwawo. Chifukwa chake, Perjeta imawonetsedwa pochiza khansa ya m'mawere.

Momwe Mungatengere Ma antibodies a Monoclonal

Mankhwala omwe ali ndi ma Monoclonal Antibodies ayenera kumangotengera kulandira malangizo kuchipatala, chifukwa mtundu wa mankhwala omwe angagwiritsidwe ntchito komanso kuchuluka kwake kumadalira vuto lomwe angalandire komanso kuopsa kwake.

Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito pochiza khansa, chifukwa ndi mankhwala oletsa kuphulika omwe amayenera kugwiritsidwa ntchito molingana ndi malangizo omwe adokotala amapereka komanso omwe akuyenera kuperekedwa muzipatala kapena muzipatala.