Soliqua 100/33 (insulini glargine / lixisenatide)

Zamkati

• Kodi Soliqua 100/33 ndi chiyani?
• Kuchita bwino
• Soliqua 100/33 generic
• Mlingo wa Soliqua 100/33
• Mitundu ya mankhwala ndi mphamvu
• Mlingo wa Soliqua 100/33
• Ndingatani ngati ndaphonya mlingo?
• Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?
• Zotsatira zoyipa za Soliqua 100/33
• Zotsatira zofala kwambiri
• Zotsatira zoyipa
• Mtengo wa Soliqua 100/33
• Thandizo lazachuma komanso inshuwaransi
• Momwe mungatenge Soliqua 100/33
• Momwe mungayendetsere
• Kusunga nthawi
• Kutenga Soliqua 100/33 ndi chakudya
• Njira Zina ku Soliqua 100/33
• Soliqua 100/33 vs. Xultophy
• Ntchito
• Mafomu azamankhwala ndi makonzedwe
• Zotsatira zoyipa ndi zoopsa
• Kuchita bwino
• Mtengo
• Soliqua 100/33 vs. mankhwala ena
• Soliqua 100/33 vs. Lantus
• Soliqua 100/33 vs. Victoza
• Soliqua 100/33 vs. Toujeo
• Soliqua 100/33 vs. Adlyxin
• Soliqua 100/33 imagwiritsa ntchito
• Soliqua 100/33 amagwiritsanso ntchito mankhwala ena
• Soliqua 100/33 ndi mowa
• Kuyanjana kwa Soliqua 100/33
• Soliqua 100/33 ndi mankhwala ena
• Soliqua 100/33 ndi zitsamba ndi zowonjezera
• Momwe Soliqua 100/33 imagwirira ntchito
• Momwe insulin imakhudzira shuga wamagazi
• Zomwe Soliqua 100/33 amachita
• Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?
• Soliqua 100/33 ndi mimba
• Soliqua 100/33 ndi kuyamwitsa
• Mafunso wamba pa Soliqua 100/33
• Kodi Soliqua 100/33 imapangitsa kunenepa?
• Kodi Soliqua 100/33 insulin?
• Kodi Soliqua 100/33 ikugwira ntchito yayitali?
• Kodi Soliqua 100/33 ingagwiritsidwe ntchito pochiza matenda amtundu woyamba 1?
• Machenjezo a Soliqua 100/33
• Soliqua 100/33 bongo
• Zizindikiro zambiri za bongo
• Zomwe muyenera kuchita mukamagwiritsa ntchito bongo
• Kutha kwa Soliqua 100/33 ndikusunga
• Zambiri zamaluso za Soliqua 100/33
• Zisonyezero
• Njira yogwirira ntchito
• Pharmacokinetics ndi metabolism
• Zotsutsana
• Yosungirako

Kodi Soliqua 100/33 ndi chiyani?

Soliqua 100/33 ndi mankhwala odziwika ndi dzina la mankhwala. Amagwiritsidwa ntchito ndi zakudya ndi masewera olimbitsa thupi kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda a shuga amtundu wa 2.

Soliqua 100/33 ili ndi mankhwala awiri:

• insulini glargine, yomwe ndi insulin yayitali
• lixisenatide, yomwe ili m'gulu la mankhwala otchedwa glucagon-like peptide 1 (GLP-1) receptor agonists

Soliqua 100/33 imabwera ngati cholembera chojambulidwa chomwe chimagwiritsidwa ntchito kudzipangira jekeseni pakhungu (subcutaneous). Cholembera chilichonse chimakhala ndi 3 mL ya mankhwala, ndi magawo 100 a insulin glargine ndi 33 mcg wa lixisenatide pa mL yankho. Zolembera zimagwiritsidwa ntchito ndi masingano a pensulo, omwe sanaphatikizidwe ndi zolembera.

Kuchita bwino

Soliqua 100/33 yapezeka yothandiza pochiza matenda amtundu wa 2. Pakafukufuku wina wamankhwala, Soliqua 100/33 adayesedwa mwa anthu omwe ali ndi matenda a shuga amtundu wa 2 omwe amachiritsidwa ndi insulini yayitali kwa miyezi isanu ndi umodzi. Pambuyo pakulandira milungu 30 ndi Soliqua 100/33, anthuwa adachepetsa hemoglobin A1c (HbA1c) ndi 1.1 peresenti. Anachepetsanso kusala kwa magazi m'magazi a 5.7 mg / dL.

Pakafukufuku wina wamankhwala, Soliqua 100/33 idagwiritsidwa ntchito ndi metformin kwa masabata 30. Kafukufukuyu anali okhudzana ndi anthu omwe anali atachiritsidwa kale ndi metformin okha, kapena ndi metformin ndi mankhwala ena a shuga. Mankhwalawa ndi Soliqua 100/33 ndi metformin adachepetsa HbA1c ndi 1.6 peresenti. Zachepetsanso kuchepa kwa shuga m'magazi ndi 59.1 mg / dL.

Soliqua 100/33 generic

Soliqua 100/33 imangopezeka ngati mankhwala odziwika ndi dzina. Sikupezeka pakadali pano mu mawonekedwe achibadwa.

Soliqua 100/33 ili ndi mankhwala awiri ogwira ntchito: insulin glargine ndi lixisenatide. Palibe mankhwala omwe amapezeka m'njira yofananira.

Insulini glargine ndi insulini yayitali yomwe imapezeka yokha ngati mankhwala odziwika ngati Lantus, Toujeo, ndi Basaglar. Lixisenatide ndi gulu la mankhwala otchedwa glucagon-like peptide 1 (GLP-1) receptor agonists. Ilipo ngati dzina lodziwika bwino la mankhwala osokoneza bongo a Adlyxin.

Mlingo wa Soliqua 100/33

Nthawi zambiri, dokotala wanu amakupangitsani kuti muchepetse Soliqua 100/33 ndikusintha pakapita nthawi kuti mufike pamlingo woyenera kwa inu. Kusintha uku kumatchedwa titration. Dokotala wanu pomaliza adzakupatsani mlingo wochepa kwambiri womwe umafunikira.

Chidziwitso chotsatirachi chimalongosola miyezo yomwe amagwiritsidwa ntchito kwambiri kapena amalimbikitsidwa. Komabe, onetsetsani kuti mwatenga mlingo womwe dokotala akukulemberani. Dokotala wanu adzazindikira mlingo woyenera kuti ugwirizane ndi zosowa zanu.

Mitundu ya mankhwala ndi mphamvu

Phukusi lililonse la Soliqua 100/33 limakhala ndi zolembera zisanu zotayidwa, zopangira kale za Soliqua 100/33 pa bokosi lililonse. Masingano a cholembera samaphatikizidwa ndi zolembera. (Nthawi zambiri, mutha kugula masingano a pensi ku pharmacy. Mungafunike mankhwala.)

Cholembera chilichonse cha jakisoni chimakhala ndi 3 mL ya mankhwala, ndi mayunitsi 300 a insulin glargine ndi 100 mcg wa lixisenatide.

Makola ojambulidwa a Soliqua 100/33 amafunika kuti azigwiritsidwa ntchito kangapo. Chiwerengero cha nthawi chimatha kuyambira 5 mpaka 20 nthawi, kutengera kuchuluka kwanu. Cholembera chilichonse chitha kugwiritsidwa ntchito mpaka masiku 28 mutagwiritsa ntchito koyamba. Pambuyo pa nthawi imeneyo, muyenera kutaya cholembera, ngakhale chikadali ndi mankhwala ena.

Masingano a cholembera ayenera kugwiritsidwa ntchito kamodzi kokha.

Mlingo wa Soliqua 100/33

Soliqua 100/33 imayikidwa mu jakisoni umodzi wa mayunitsi 15 mpaka 60 iliyonse. Mawu oti "mayunitsi" ndi mtundu wa muyeso womwe umagwiritsidwa ntchito pa insulin glargine yomwe ili mu Soliqua 100/33. Mlingo waukulu wa jakisoni ndi mayunitsi 60, zomwe zingatanthauze mayunitsi 60 a insulin glargine ndi 20 mcg lixisenatide.

Kuyambira mlingo

Mlingo woyambira wa Soliqua 100/33 umadalira mankhwala anu am'mbuyomu ashuga.

Zindikirani: Musanayambe Soliqua 100/33, muyenera kusiya mankhwala ena onse ndi lixisenatide kapena insulin yayitali.

Mlingo wa kusamalira

Mukayamba Soliqua 100/33, dokotala wanu amayang'anira kuchuluka kwa shuga m'magazi anu ndipo amatha kusintha mlingo wanu kuti mufike pamlingo woyenera. Wopanga mankhwalawa amalimbikitsa kuti titizing mlingo wokwera kapena wotsika ndi mayunitsi awiri kapena anayi sabata iliyonse pakufunika kukwaniritsa zolinga za shuga m'magazi.

Mlingo kusintha

Inu ndi dokotala mudzagwirira ntchito limodzi kuti mupange dongosolo loti mukwaniritse zolinga za shuga.

Pansipa pali chitsanzo cha kusintha kwa mankhwala komwe dokotala angakulimbikitseni. Dokotala wanu adzasankha ngati mukufuna kusintha kumeneku. Onetsetsani kuti mwamwa mlingo womwe dokotala akukulangizani. (Musasinthe mlingo wanu popanda kuvomerezedwa ndi dokotala.)

Ndingatani ngati ndaphonya mlingo?

Ngati mwaphonya mlingo wa Soliqua 100/33, tulukani mulingo womwewo ndikupitiliza muyeso wanu wotsatira. Musayese kutenga pogwiritsira ntchito mlingo wowonjezera kapena kuwonjezera mlingo wotsatira. Izi zitha kuyambitsa zovuta zina.

Kodi ndiyenera kugwiritsa ntchito mankhwalawa nthawi yayitali?

Ngati Soliqua 100/33 ndiyothandiza komanso yotetezeka kwa inu, mutha kugwiritsa ntchito mankhwalawa nthawi yayitali. Soliqua 100/33 imagwiritsidwa ntchito nthawi yayitali pochiza matenda amtundu wa 2.

Zotsatira zoyipa za Soliqua 100/33

Soliqua 100/33 imatha kuyambitsa zovuta zoyipa kapena zoyipa. Mndandanda wotsatirawu muli zina mwazovuta zomwe zingachitike mukamamwa Soliqua 100/33. Mndandandawu sungaphatikizepo zovuta zonse zomwe zingachitike.

Kuti mumve zambiri pazomwe zingachitike chifukwa cha Soliqua 100/33, kapena maupangiri amomwe mungathanirane ndi zovuta zoyipa, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zofala kwambiri

Zotsatira zofala kwambiri za Soliqua 100/33 zitha kuphatikiza:

• nseru
• matenda opuma monga chimfine kapena chimfine
• kutsegula m'mimba
• mutu
• hypoglycemia (shuga wotsika magazi)

Zambiri mwa zotsatirazi zimatha kutha masiku angapo kapena milungu ingapo. Ngati ali ovuta kwambiri kapena osapita, lankhulani ndi dokotala kapena wamankhwala.

Zotsatira zoyipa

Zotsatira zoyipa zochokera ku Soliqua 100/33 sizodziwika, koma zimatha kuchitika. Itanani dokotala wanu nthawi yomweyo ngati muli ndi zovuta zina. Itanani 911 ngati zizindikiro zanu zikuwopseza moyo kapena ngati mukuganiza kuti mukukumana ndi vuto lachipatala.

Zotsatira zoyipa komanso zizindikilo zake zimatha kukhala izi:

• Kwambiri matupi awo sagwirizana anachita. Zizindikiro zimatha kuphatikiza:
• zidzolo
• kuchapa
• kutupa
• khungu loyabwa
• kuvuta kupuma
• kuthamanga kwa magazi
• Pancreatitis (kutupa kwa kapamba). Zizindikiro zimatha kuphatikiza:
• kupweteka kapena kukoma m'mimba mwako
• kupweteka kwa msana
• nseru
• kusanza
• malungo
• kuonda
• Kuwonongeka kwa impso. Zizindikiro zimatha kuphatikiza:
• kuchepetsa kukodza
• kutupa miyendo yanu, akakolo, kapena mapazi
• chisokonezo
• kutopa
• nseru
• kupweteka pachifuwa kapena kupanikizika
• kugunda kwamtima kosasintha
• kugwidwa
• Hypokalemia (potaziyamu wochepa). Zizindikiro zimatha kuphatikiza:
• kufooka
• kutopa
• kudzimbidwa
• kuphwanya minofu
• kugunda kwamtima kosasintha

Kulemera kapena kuwonda

M'mayesero azachipatala, Soliqua 100/33 sanapezeke kuti amathandizira kusintha kwamafuta. Komabe, mu kafukufuku wina wamankhwala, anthu omwe adatenga Soliqua 100/33 kwamasabata 30 adataya pafupifupi mapaundi 1.5.

Kuphatikiza apo, mankhwala omwe ali mu Soliqua 100/33 alumikizidwa ndi kusintha kwa kunenepa. Soliqua 100/33 ili ndi insulin glargine, insulini yayitali. Mankhwala omwe ali ndi insulini amatha kuyambitsa kunenepa.

Soliqua 100/33 ilinso ndi lixisenatide, glucagon-ngati peptide 1 (GLP-1) receptor agonist. M'maphunziro osiyanasiyana azachipatala, mankhwala omwe ali mgulu la mankhwala la GLP-1 awonetsa kuchepa kwa thupi ngati mbali ina.

Ngati muli ndi nkhawa zakusintha kwa kunenepa mukamagwiritsa ntchito Soliqua 100/33, lankhulani ndi dokotala wanu.

Matenda osokoneza bongo

Insulini, imodzi mwa mankhwala ku Soliqua 100/33, imagwiritsidwa ntchito kuthandiza kutsitsa shuga m'magazi. Komabe, kuchuluka kwa shuga wamagazi kumatha kutsitsidwa kwambiri, zomwe zimabweretsa hypoglycemia. Hypoglycemia ndiye vuto lofala kwambiri lomwe limayambitsidwa ndi mankhwala a insulin, kuphatikiza Soliqua 100/33.

M'maphunziro azachipatala, hypoglycemia idachitika mu 8.1 mpaka 17.8 peresenti ya anthu omwe amatenga Soliqua 100/33. Ndipo hypoglycemia yoopsa idachitika pafupifupi 1% ya anthu omwe amamwa mankhwalawa.

Zinthu zambiri zimatha kuwonjezera chiopsezo cha hypoglycemia. Izi zikuphatikiza kumwa kwambiri mankhwala anu ashuga ndikumwa mankhwala opitilira shuga amodzi. Zinthu zina zomwe zingakhudze chiopsezo chanu ndi monga kudya ndi kuchita masewera olimbitsa thupi, komanso ngati mukumwa mankhwala ena.

Zizindikiro za hypoglycemia zitha kuchitika modzidzimutsa ndipo zimatha kuphatikizika, kutopa, kugona, komanso kusokonezeka. Kuchepetsa hypoglycemia kumatha kubweretsa zovuta zoyipa monga khunyu kapena imfa. Lankhulani ndi dokotala wanu za kuchuluka kwa nthawi yomwe muyenera kuyesa kuchuluka kwa shuga m'magazi anu kuti mupewe hypoglycemia mukamamwa Soliqua 100/33.

Matenda okhumudwa kapena khungu lakuthwa

Mumatenga Soliqua 100/33 ndi jakisoni wocheperako, kutanthauza kuti mumayibaya pansi pa khungu lanu. Jakisoni wocheperako amatha kuyambitsa lipodystrophy (kukhumudwa kapena khungu kukulira) mozungulira malo opangira jakisoni.

Kuti muchepetse chiopsezo cha lipodystrophy, sinthanitsani malo omwe mumabaya mankhwalawo. Mwachitsanzo, tsiku lina mutha kubaya mankhwalawo m'mimba mwanu, ndipo tsiku lotsatira mutha kugwiritsa ntchito ntchafu yanu yakunja.

Ngati mukuda nkhawa ndi zotsatira za khungu chifukwa chobayira Soliqua 100/33, lankhulani ndi dokotala wanu.

Kuwonongeka kwa impso

Kuwonongeka kwa impso sikunkawonekere m'maphunziro azachipatala a Soliqua 100/33. Komabe, pakhala pali malipoti okhudza kuwonongeka kwa impso mwa anthu omwe amalandira mankhwala osokoneza bongo a peptide 1 (GLP-1) a glucagon. Lixisenatide, yomwe ndi imodzi mwa mankhwala ku Soliqua 100/33, ndi mankhwala a GLP-1.

Zizindikiro za kuwonongeka kwa impso zitha kuphatikiza:

• kutupa kwa miyendo, akakolo, kapena mapazi
• kutopa
• nseru
• kusanza

Kuwonongeka kwa impso kumachitika mwa anthu omwe adasowa madzi m'thupi chifukwa cha zovuta zina za Soliqua 100/33, monga nseru, kusanza, ndi kutsekula m'mimba.

Ngati mukukula zizindikilo izi mukamamwa Soliqua 100/33, kapena mukudandaula za thanzi lanu la impso, lankhulani ndi dokotala wanu.

Mtengo wa Soliqua 100/33

Monga mankhwala onse, mtengo wa Soliqua 100/33 umasiyana.

Mtengo wanu weniweni umatengera inshuwaransi yanu.

Thandizo lazachuma komanso inshuwaransi

Ngati mukufuna thandizo lazachuma kuti mulipire Soliqua 100/33, thandizo lilipo. Sanofi Aventis, yemwe amapanga Soliqua 100/33, akupereka Soliqua 100/33 Savings Card. Kuti mumve zambiri, pitani patsamba lino.

Momwe mungatenge Soliqua 100/33

Pansipa pali malangizo ofunikira momwe mungadziperekere jakisoni pogwiritsa ntchito cholembera cha Soliqua 100/33. Nthawi zonse onetsetsani kuti mumatenga Soliqua 100/33 malinga ndi malangizo a dokotala kapena wothandizira zaumoyo.

Momwe mungayendetsere

Gawo 1. Konzani ndikuwona cholembera chanu.

Ngati mukugwiritsa ntchito koyamba, chotsani cholembera m'firiji ndikulola cholembacho kufikira kutentha.

• Sonkhanitsani swabs zakumwa zoledzeretsa, singano yatsopano, ndi chidebe chanu chakuthwa.
• Sambani manja anu.
• Chotsani cholembera ndipo onetsetsani kuti mankhwalawo ndiwosavuta komanso alibe mtundu. (Musagwiritse ntchito ngati yankho silikumveka bwino komanso lopanda utoto. Mpweya wabwino uli bwino.)
• Sambani chisindikizo cha mphira ndi swab ya mowa.

Gawo 2. Khomani singano yatsopano.

Pa jakisoni aliyense, gwiritsani ntchito singano yatsopano nthawi zonse. Onetsetsani kuti singano ingagwiritsidwe ntchito ndi Soliqua 100/33. Ngati simukudziwa kuti ndi singano ziti zomwe mungagwiritse ntchito, funsani dokotala kapena wamankhwala.

• Chotsani singano ya pensulo phukusi lake loteteza.
• Kuyika singano ya singano molunjika, pindani pa cholembera.
• Chotsani kapu yakunja ya singano ndikuiyika pambali. (Sungani kuti mugwiritse ntchito pambuyo pa jekeseni.)
• Chotsani kapu yamkati ya singano ndikuitaya mu zinyalala.

Gawo 3. Yesani chitetezo.

Nthawi zonse yesani mayeso asanakwane jekeseni iliyonse kuti muwonetsetse kuti cholembera ndi singano zikugwira ntchito moyenera.

• Sinthani kauntala wa mlingo kuti muwerenge mayunitsi awiri.
• Sakanizani batani la jekeseni kwathunthu ndikuyang'ana pang'ono mankhwala kuti mutuluke kunsonga ya singano. Izi zikachitika, pitilizani gawo 4.
• Ngati palibe mankhwala omwe akutuluka, bwerezaninso mayeso achitetezo mpaka katatu.
• Ngati palibe mankhwala omwe adzatuluke mutayesedwa katatu, sinthanitsani singano ndikubwereza mayeso a chitetezo.
• Ngati palibe mankhwala omwe amatuluka mutalowetsa singano, musagwiritse ntchito cholembera chifukwa chitha kuwonongeka. Gwiritsani cholembera chatsopano.

Gawo 4. Sankhani mlingo wanu.

• Sinthani kauntala wa mankhwalawa kufikira mutafikira mlingo woyenera.

Gawo 5. Jekeseni mlingo.

Pali magawo atatu m'thupi lanu omwe mungagwiritse ntchito jekeseni: mimba yanu (kupatula mkati mwa mainchesi awiri amimba), kumbuyo kwa mkono wanu wakumtunda (malo amafuta), ndi ntchafu yanu yakunja.

• Sankhani malo opangira jekeseni ndikupukuta khungu pamalopo ndi swab ya mowa.
• Pamalo opangira jekeseni, ikani singano pakhungu lanu pang'onopang'ono.
• Sindikizani batani la jekeseni kwathunthu ndikugwira mpaka mutayang'ana "0" pazenera la mlingo.
• Pomwe kauntala atembenukira ku "0," werengani mpaka 10 musanatulutse batani la jekeseni ndikuchotsa singano. Kupuma uku kumathandiza kuti muwoneke bwino.
• Tulutsani batani la jekeseni ndikuchotsa singano pakhungu lanu.

Gawo 6. Taya singano ndikusunga cholembera.

• Ikani chikopa chakunja cha singano kumbuyo pa singano.
• Chotsani singano m'khola lojambulidwa ndipo nthawi yomweyo ponyani singanoyo mumtsuko wakuthwa. (Kutaya nthawi yomweyo kuti musasokoneze ndi singano yatsopano.)
• Bweretsani cholembera.
• Sungani cholembera kutentha kwapakati mutagwiritsa ntchito koyamba.

Kusunga nthawi

Muyenera kutenga Soliqua 100/33 pasanathe ola limodzi musanadye chakudya choyamba tsikulo.

Kutenga Soliqua 100/33 ndi chakudya

Soliqua 100/33 sayenera kutengedwa ndi chakudya. Iyenera kutengedwa mkati mwa ola limodzi musanadye chakudya chanu choyamba tsikulo.

Njira Zina ku Soliqua 100/33

Mankhwala ena alipo omwe angachiritse matenda amtundu wa 2. Ena akhoza kukuyenererani kuposa ena. Ngati mukufuna kupeza njira ina Soliqua 100/33, lankhulani ndi dokotala kuti mudziwe zambiri zamankhwala ena omwe atha kukuthandizani.

Soliqua 100/33 ili ndi mankhwala awiri: insulini yogwira ntchito yayitali yotchedwa insulin glargine, ndi glucagon ngati peptide 1 (GLP-1) receptor agonist yotchedwa lixisenatide.

Zitsanzo za mankhwala omwe angagwiritsidwe ntchito m'malo mwa Soliqua 100/33 ndi awa:

• ma insulini okhala nthawi yayitali, monga:
• insulin glargine (Lantus, Toujeo)
• Insulini yotulutsa insulin (Levemir)
• GLP-1 olandila agonists, monga:
• kutulutsa (Bydureon, Byetta)
• liraglutide (Victoza, Saxenda)
• lixisenatide (Adlyxin)
• semaglutide (Ozempic)
• dipeptidyl peptidase-4 (DPP-4) zoletsa, monga:
• alogliptin (Nesina)
• linagliptin (Chikhalidwe)
• saxagliptin (Onglyza)
• sitagliptin (Januvia)
• meglitinides, monga:
• repaglinide (Prandin)
• mtundu (Starlix)
• metformin (Glucophage, Glumetza, Riomet)
• sodium-glucose cotransporter 2 (SGLT2) inhibitors, monga:
• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• sulfonylureas, monga:
• glimepiride (Amaryl)
• glipizide (Glucotrol)
• glyburide (DiaBeta, Glynase)
• thiazolidinediones, monga:
• pioglitazone (Actos)
• rosiglitazone (Avandia)

Soliqua 100/33 vs. Xultophy

Mutha kudabwa momwe Soliqua 100/33 ikufananirana ndi mankhwala ena omwe amapatsidwa ntchito zofananira.Apa tikuwona momwe Soliqua 100/33 ndi Xultophy alili ofanana komanso osiyana.

Ntchito

Soliqua 100/33 ndi Xultophy onse amavomerezedwa ndi FDA kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda amtundu wachiwiri. Zonsezi zimaperekedwa kuti zigwiritsidwe ntchito posintha zakudya komanso kuchita masewera olimbitsa thupi.

Soliqua 100/33 ndi Xultophy onse ali ndi mankhwala awiri, ndipo mankhwalawa ndi amitundu imodzimodzi ya mankhwala. Izi zikutanthauza kuti amagwira ntchito mofananira mthupi.

Soliqua 100/33 ili ndi:

• insulin glargine (insulini yayitali)
• lixisenatide (peputayidi wonga glucagon ngati peputayidi 1 [GLP-1] receptor agonist)

Xultophy ili ndi:

• insulin degludec (insulini yayitali)
• liraglutide (GLP-1 receptor agonist)

Mafomu azamankhwala ndi makonzedwe

Soliqua 100/33 ndi Xultophy onse amabwera ngati njira yothetsera madzi mu cholembera chotayika. Onsewo amadzibaya okha pansi pa khungu (subcutaneous) kamodzi patsiku.

Zotsatira zoyipa ndi zoopsa

Soliqua 100/33 ndi Xultophy zimakhala ndi zovuta zofananira mthupi motero zimayambitsa zovuta zina zofanana.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi mankhwala onse (akatengedwa payekha).

• Zitha kuchitika ndi Soliqua 100/33 ndi Xultophy:
• matenda opuma monga chimfine kapena chimfine
• nseru
• kutsegula m'mimba
• mutu
• hypoglycemia (shuga wotsika magazi)

Zotsatira zoyipa

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zingachitike ndi Soliqua 100/33, ndi Xultophy, kapena ndi mankhwala onse awiri (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
• zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi Xultophy:
• khansa ya chithokomiro *
• matenda a ndulu
• Zitha kuchitika ndi Soliqua 100/33 ndi Xultophy:
• kwambiri thupi lawo siligwirizana
• hypoglycemia (shuga wotsika kwambiri wamagazi)
• kapamba (kutupa kwa kapamba)
• kuwonongeka kwa impso
• hypokalemia (potaziyamu otsika)

* Xultophy ili ndi chenjezo lolembedwa kuchokera ku FDA lokhudza khansa ya chithokomiro. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Soliqua 100/33 ndi Xultophy sizinafanizidwe mwachindunji m'maphunziro azachipatala, koma zonsezi zapezeka zothandiza pochiza matenda amtundu wa 2.

M'maphunziro osiyana, Soliqua 100/33 ndi Xultophy onse anali othandiza kuchepetsa ma HbA1c komanso kusala kwama shuga.

• Pakafukufuku wamankhwala, Soliqua 100/33 yachepetsa hemoglobin A1c (HbA1c) ndi 1.1 peresenti ndikusala magazi m'magazi ndi 5.7 mg / dL patatha milungu 30.
• M'maphunziro azachipatala, Xultophy idachepetsa HbA1c ndi 1.31 mpaka 1.94 peresenti ndikusala magazi m'magazi ndi 49.9 mg / dL mpaka 63.5 mg / dL pambuyo pa masabata 26 achipatala. Anthu omwe amagwiritsa ntchito Xultophy adapezanso mapaundi pafupifupi 4.4 kupitilira milungu 26 yamankhwala.

Zindikirani: Ndikofunika kukumbukira kuti momwe mankhwalawa angachepetsere HbA1c kapena shuga m'magazi angadalire pazinthu zambiri, kuphatikiza:

• shuga m'magazi anu mukamayamba mankhwalawa
• zakudya zanu ndi masewera olimbitsa thupi
• mankhwala ena ashuga omwe mumamwa
• mumatsata kwambiri mankhwala anu

Mtengo

Soliqua 100/33 ndi Xultophy onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Kutengera kuwerengera kochokera ku GoodRx.com, Xultophy itha kukhala yoposa Soliqua 100/33. Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani anu a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Soliqua 100/33 vs. mankhwala ena

Palinso mankhwala ena kupatula Soliqua 100/33 ndi Xultophy (pamwambapa) omwe angagwiritsidwe ntchito pochiza matenda amtundu wachiwiri. Pansipa pali kufananiza pakati pa Soliqua 100/33 ndi mankhwala ena angapo.

Soliqua 100/33 vs. Lantus

Soliqua 100/33 ili ndi mankhwala awiri:

• insulini glargine, yomwe ndi insulin yayitali
• lixisenatide, yomwe ili m'gulu la mankhwala otchedwa glucagon-like peptide 1 (GLP-1) receptor agonists

Insulini glargine ndi mankhwala omwe amapezeka ku Lantus. Chifukwa Soliqua 100/33 ndi Lantus amagawana chinthu chogwira ntchito, zimagwiranso ntchito mofananira mthupi.

Ntchito

Soliqua 100/33 ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito pakusintha kwa zakudya ndi masewera olimbitsa thupi kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda amtundu wa 2.

Lantus amavomerezedwa ndi FDA kuti athetse shuga m'magazi mwa akulu ndi ana omwe ali ndi matenda a shuga amtundu woyamba, komanso akulu omwe ali ndi matenda ashuga amtundu wa 2.

Mafomu azamankhwala ndi makonzedwe

Soliqua 100/33 imabwera ngati yankho lamadzi m khola lojambulidwa. Lantus imabwera ngati yankho lamadzi mumtsuko wamagulu angapo kapena mu cholembera chotayira. Mankhwala onsewa amadzibaya okha pansi pa khungu (subcutaneous) kamodzi patsiku.

Zotsatira zoyipa ndi zoopsa

Soliqua 100/33 ndi Lantus onse ali ndi insulin yofanana, insulin glargine. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Soliqua 100/33, ndi Lantus, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • nseru
  • matenda opuma monga chimfine kapena chimfine
  • mutu
  • kutsegula m'mimba
• Zitha kuchitika ndi Lantus:
  • kunenepa
  • lipodystrophy (kutsekemera kapena khungu lakuda pamalo opangira jekeseni)
  • jakisoni malo zochita
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Lantus:
  • hypoglycemia (shuga wotsika magazi)

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Soliqua 100/33, ndi Lantus, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • kapamba (kutupa kwa kapamba)
  • kuwonongeka kwa impso
• Zitha kuchitika ndi Lantus:
  • zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Lantus:
  • kwambiri thupi lawo siligwirizana
  • hypoglycemia (shuga wotsika kwambiri wamagazi)
  • magulu otsika a potaziyamu (hypokalemia)

Kuchita bwino

Kuchita bwino kwa Soliqua 100/33 ndi Lantus kwafaniziridwa mwachindunji m'maphunziro awiri. Pakafukufuku woyamba, mankhwala awiriwa adagwiritsidwa ntchito payekha. Kachiwiri, onsewa adagwiritsidwa ntchito limodzi ndi metformin (mankhwala oswa mkamwa).

Gwiritsani ntchito nokha

Kafukufuku woyamba adayang'ana kwambiri kwa achikulire omwe ali ndi matenda amtundu wa 2 omwe amathandizidwapo kale ndi ma insulini okhalitsa. Idawonetsa kuti Soliqua 100/33 itha kugwira ntchito bwino pang'ono kuposa Lantus yochepetsera hemoglobin A1c (HbA1c), koma osati kuchepetsa kusala kwa magazi.

Pambuyo pa chithandizo cha milungu 30, Soliqua 100/33 adachepetsa HbA1c ndi 1.1 peresenti, komanso kusala kwama shuga m'magazi ndi 5.7 mg / dL. Munthawi yomweyo, Lantus adachepetsa HbA1c ndi 0.6 peresenti, ndikusala magazi a shuga ndi 7.0 mg / dL.

Gwiritsani ntchito metformin

Kafukufuku wachiwiri adayesa Soliqua 100/33 ndi metformin motsutsana ndi Lantus wokhala ndi metformin mwa akulu omwe ali ndi matenda amtundu wa 2. Anthu awa anali atathandizidwapo kale ndi metformin yokha, kapena ndi metformin ndi mankhwala ena amtundu wa shuga.

Kupitilira masabata 30, Soliqua 100/33 yokhala ndi metformin inali yothandiza pang'ono kuposa Lantus yokhala ndi metformin. Soliqua 100/33 yokhala ndi metformin yachepetsa HbA1c ndi 1.6 peresenti ndikusala magazi m'magazi ndi 59.1 mg / dL. Lantus ndi metformin, mbali inayo, adachepetsa HbA1c ndi 1.3 peresenti ndipo kusala kwa shuga wamagazi kumachepetsa ndi 55.8 mg / dL.

Zindikirani: Ndikofunika kukumbukira kuti momwe mankhwalawa angachepetsere HbA1c kapena shuga m'magazi angadalire pazinthu zambiri, kuphatikizapo:

• shuga m'magazi anu mukamayamba mankhwalawa
• zakudya zanu ndi masewera olimbitsa thupi
• mankhwala ena ashuga omwe mumamwa
• mumatsata kwambiri mankhwala anu

Mtengo

Soliqua 100/33 ndi Lantus onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, Lantus nthawi zambiri amawononga ndalama zochepa kuposa Soliqua 100/33. Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani anu a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Soliqua 100/33 vs. Victoza

Soliqua 100/33 ili ndi mankhwala awiri:

• insulini glargine, yomwe ndi insulin yayitali
• lixisenatide, yomwe ili m'gulu la mankhwala otchedwa glucagon-like peptide 1 (GLP-1) receptor agonists

Victoza muli mankhwala a liraglutide, yemwenso ndi GLP-1 receptor agonist. Chifukwa Soliqua 100/33 ndi Victoza amagawana nawo zinthu zamagulu omwewo, amagwiranso ntchito mofananira mthupi.

Ntchito

Soliqua 100/33 ndivomerezedwa ndi FDA kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda amtundu wachiwiri. Amayikidwa kuti azigwiritsidwa ntchito pakusintha zakudya komanso kuchita masewera olimbitsa thupi.

Victoza imavomerezedwanso kuti ipangitse shuga m'magazi mwa achikulire omwe ali ndi matenda amtundu wa 2 kuphatikiza kuphatikiza zakudya zabwino komanso masewera olimbitsa thupi. Kuphatikiza apo, ndivomerezedwa kuti achepetse mavuto azovuta zazikulu zamtima monga matenda amtima ndi sitiroko mwa anthu omwe ali ndi matenda amtundu wa 2 komanso matenda amtima.

Mafomu azamankhwala ndi makonzedwe

Onse awiri a Soliqua 100/33 ndi a Victoza amabwera ngati njira yothetsera madzi m'khola lojambulidwa. Mankhwala onsewa amadzibaya okha pansi pa khungu (subcutaneous) kamodzi patsiku.

Zotsatira zoyipa ndi zoopsa

Chifukwa Soliqua 100/33 ndi Victoza onse ali ndi mankhwala omwe ali mgulu la mankhwala la GLP-1, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Soliqua 100/33, ndi Victoza, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • hypoglycemia (shuga wotsika magazi)
  • matenda opuma monga chimfine kapena chimfine
  • mutu
• Zitha kuchitika ndi Victoza:
  • kuchepa kudya
  • kusanza
  • kudzimbidwa
  • kukhumudwa m'mimba
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Victoza:
  • nseru
  • kutsegula m'mimba

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Soliqua 100/33, ndi Victoza, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • hypokalemia (potaziyamu otsika)
• Zitha kuchitika ndi Victoza:
  • khansa ya chithokomiro *
  • matenda a ndulu
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Victoza:
  • kwambiri thupi lawo siligwirizana
  • hypoglycemia (shuga wotsika kwambiri wamagazi)
  • kapamba (kutupa kwa kapamba)
  • kuwonongeka kwa impso

Victoza ali ndi chenjezo lolembedwa kuchokera ku FDA la khansa ya chithokomiro. Chenjezo la nkhonya ndiye chenjezo lamphamvu kwambiri lomwe a FDA amafunikira. Imachenjeza madokotala ndi odwala za zovuta zamankhwala zomwe zitha kukhala zowopsa.

Kuchita bwino

Soliqua 100/33 ndi Victoza sizinafananidwe mwachindunji m'maphunziro azachipatala, koma zonsezi zapezeka zothandiza pochiza matenda amtundu wa 2.

M'maphunziro osiyana, onse a Soliqua 100/33 ndi a Victoza adatsitsa HbA1c ndikusala magazi m'magazi mwa anthu omwe ali ndi matenda ashuga amtundu wa 2.

• Pakafukufuku wamankhwala, atalandira chithandizo kwa milungu 30, Soliqua 100/33 yachepetsa hemoglobin A1c (HbA1c) ndi 1.1 peresenti ndikusala magazi m'magazi ndi 5.7 mg / dL.
• M'maphunziro ena azachipatala, milungu yopitilira 52 ya chithandizo, Victoza adachepetsa HbA1c ndi pafupifupi 0.8 mpaka 1.1 peresenti ndikusala magazi msinkhu ndi 15 mpaka 26 mg / dL.

Kafukufuku wosiyana wazachipatala adawonetsa kuti a Victoza adachepetsa chiopsezo chamatenda akulu amtima monga kugunda kwa mtima ndi sitiroko ndi 13 peresenti. Zotsatira izi sizinaphunzire pakufufuza kwa Soliqua 100/33.

Zindikirani: Ndikofunika kukumbukira kuti momwe mankhwalawa angachepetsere HbA1c kapena shuga m'magazi angadalire pazinthu zambiri, kuphatikiza:

• shuga m'magazi anu mukamayamba mankhwalawa
• zakudya zanu ndi masewera olimbitsa thupi
• mankhwala ena ashuga omwe mumamwa
• mumatsata kwambiri mankhwala anu

Mtengo

Soliqua 100/33 ndi Victoza onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, a Victoza amatenga ndalama zambiri kuposa Soliqua 100/33. Mtengo weniweni womwe mungalipire mankhwalawa umadalira kuchuluka kwanu, mapulani anu a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Soliqua 100/33 vs. Toujeo

Soliqua 100/33 ili ndi mankhwala awiri:

• insulini glargine, yomwe ndi insulin yayitali
• lixisenatide, yomwe ili m'gulu la mankhwala otchedwa glucagon-like peptide 1 (GLP-1) receptor agonists

Insulini glargine ndi mankhwala omwe amapezeka ku Toujeo. Chifukwa Soliqua 100/33 ndi Toujeo amagawana chinthu chogwira ntchito, zimagwiranso ntchito mofananira mthupi.

Ntchito

Soliqua 100/33 ndivomerezedwa ndi FDA kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda amtundu wachiwiri. Zimavomerezedwa kuti zigwiritsidwe ntchito ndikusintha kwa zakudya ndi masewera olimbitsa thupi.

Toujeo amavomerezedwa ndi FDA kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda a shuga amtundu wa 2, komanso akulu ndi ana omwe ali ndi matenda a shuga amtundu woyamba.

Mafomu azamankhwala ndi makonzedwe

Soliqua 100/33 ndi Toujeo onse amabwera ngati njira yothetsera madzi m'khola lojambulidwa. Mankhwala onsewa amadzibaya okha pansi pa khungu (subcutaneous) kamodzi patsiku.

Soliqua 100/33 imabwera mumtengo umodzi. Cholembera chilichonse chimakhala ndi 3 mL ya mankhwala, ndi magawo 300 a insulin glargine ndi 100 mcg wa lixisenatide. Mlingo waukulu wa jakisoni ndi mayunitsi 60, zomwe zingatanthauze mayunitsi 60 a insulin glargine ndi 20 mcg lixisenatide.

Toujeo amabwera m'magulu awiri osiyana:

• Toujeo SoloStar lili ndi mayunitsi 450 a insulin glargine mu 1.5 mL wa yankho, wokhala ndi mulingo wokwanira wa mayunitsi 80 pa jakisoni.
• Toujeo Max SoloStar lili ndi mayunitsi 900 a insulin glargine mu 3 mL wa yankho, wokhala ndi mulingo wokwanira wa mayunitsi 160 pa jakisoni.

Zotsatira zoyipa ndi zoopsa

Soliqua 100/33 ndi Toujeo onse amagawana insulin yofanana, insulin glargine. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Soliqua 100/33, ndi Toujeo, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • nseru
  • kutsegula m'mimba
  • mutu
• Zitha kuchitika ndi Toujeo:
  • kunenepa
  • jakisoni malo zochita
  • lipodystrophy (kudzimbidwa kapena kukhumudwa pamalo obayira)
  • kuyabwa
  • zidzolo
  • kutupa miyendo yanu, akakolo, kapena mapazi
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Toujeo:
  • matenda opuma monga chimfine kapena chimfine
  • hypoglycemia (shuga wotsika magazi)

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Soliqua 100/33, ndi Toujeo, kapena ndi mankhwala onsewa (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • kapamba (kutupa kwa kapamba)
  • kuwonongeka kwa impso
• Zitha kuchitika ndi Toujeo:
  • zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Toujeo:
  • kwambiri thupi lawo siligwirizana
  • hypoglycemia (shuga wotsika kwambiri wamagazi)
  • hypokalemia (potaziyamu otsika)

Kuchita bwino

Soliqua 100/33 ndi Toujeo sanafanane mwachindunji m'maphunziro azachipatala. Komabe, kafukufuku payekha wasonyeza kuti onse Toujeo ndi Soliqua 100/33 atha kukhala othandiza kuchepetsa ma HbA1c komanso kusala kwama shuga.

• Pakafukufuku wamankhwala, Soliqua 100/33 yachepetsa hemoglobin A1c (HbA1c) ndi 1.1 peresenti ndikusala magazi m'magazi ndi 5.7 mg / dL patatha milungu 30.
• M'maphunziro ena azachipatala, Toujeo adachepetsa HbA1c ndi pafupifupi 0.73 mpaka 1.42 peresenti ndikusala magazi m'magazi ndi 18 mpaka 61 mg / dL pamasabata a 26 achipatala.

Zindikirani: Ndikofunika kukumbukira kuti momwe mankhwalawa angachepetsere HbA1c kapena shuga m'magazi angadalire pazinthu zambiri, kuphatikiza:

• shuga m'magazi anu mukamayamba mankhwalawa
• zakudya zanu ndi masewera olimbitsa thupi
• mankhwala ena ashuga omwe mumamwa
• mumatsata kwambiri mankhwala anu

Mtengo

Soliqua 100/33 ndi Toujeo onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, Toujeo nthawi zambiri amawononga ndalama zoposa Soliqua 100/33. Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani anu a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Soliqua 100/33 vs. Adlyxin

Soliqua 100/33 ili ndi mankhwala awiri:

• insulini glargine, yomwe ndi insulin yayitali
• lixisenatide, yomwe ili m'gulu la mankhwala otchedwa glucagon-like peptide 1 (GLP-1) receptor agonists

Lixisenatide ndi mankhwala omwe amapezeka mu Adlyxin. Chifukwa Soliqua 100/33 ndi Adlyxin amagawana chinthu chogwira ntchito, zimagwiranso ntchito mofananamo mthupi.

Ntchito

Soliqua 100/33 ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito posintha zakudya ndi masewera olimbitsa thupi kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda a shuga amtundu wa 2.

Adlyxin amavomerezedwa ndi FDA kuti azigwiritsa ntchito zakudya komanso kuchita masewera olimbitsa thupi kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda amtundu wachiwiri.

Mafomu azamankhwala ndi makonzedwe

Soliqua 100/33 ndi Adlyxin onse amabwera ngati yankho lamadzi m khola lojambulidwa. Mankhwala onsewa amadzibaya okha pansi pa khungu (subcutaneous) kamodzi patsiku.

Cholembera cha Soliqua 100/33 chimabwera chimodzimodzi. Cholembera chilichonse chimakhala ndi 3 mL ya mankhwala, ndi magawo 100 a insulin glargine ndi 33 mcg wa lixisenatide pa mL. Mlingo waukulu wa jakisoni ndi mayunitsi 60, zomwe zingatanthauze mayunitsi 60 a insulin glargine ndi 20 mcg lixisenatide.

Cholembera cha Adlyxin chimabwera mosiyanasiyana:

• Cholembera cha Adlyxin chobiriwira chimakhala ndi 50 mcg / mL mu 3 mL yankho, wokhala ndi mlingo wa 10 mcg pa jakisoni.
• Phukusi la burgundy Adlyxin lili ndi 100 mcg / mL mu 3 mL yankho, wokhala ndi mlingo wa 20 mcg pa jakisoni.

Zotsatira zoyipa ndi zoopsa

Soliqua 100/33 ndi Adlyxin onse ali ndi mankhwala a lixisenatide. Chifukwa chake, mankhwala onsewa amatha kuyambitsa zovuta zina. M'munsimu muli zitsanzo za zotsatirazi.

Zotsatira zofala kwambiri

Mndandandandawu muli zitsanzo za zovuta zoyipa zomwe zimatha kuchitika ndi Soliqua 100/33, ndi Adlyxin, kapena ndi mankhwala onsewa (akatengedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • matenda opuma monga chimfine kapena chimfine
• Zitha kuchitika ndi Adlyxin:
  • kusanza
  • chizungulire
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Adlyxin:
  • nseru
  • kutsegula m'mimba
  • mutu
  • hypoglycemia (shuga wotsika magazi)

Zotsatira zoyipa

Mndandandawu muli zitsanzo za zovuta zoyipa zomwe zitha kuchitika ndi Soliqua 100/33, ndi Adlyxin, kapena ndi mankhwala onse awiri (akamwedwa payekhapayekha).

• Zitha kuchitika ndi Soliqua 100/33:
  • hypokalemia (potaziyamu otsika)
• Zitha kuchitika ndi Adlyxin:
  • zotsatira zoyipa zingapo zoyipa
• Zitha kuchitika ndi onse Soliqua 100/33 ndi Adlyxin:
  • kwambiri thupi lawo siligwirizana
  • hypoglycemia (shuga wotsika kwambiri wamagazi)
  • kapamba (kutupa kwa kapamba)
  • kuwonongeka kwa impso

Kuchita bwino

Kugwiritsa ntchito kwa Soliqua 100/33 kapena Adlyxin ngati mankhwala amodzi a mtundu wa 2 shuga sikunafanizidwe mwachindunji pakufufuza kwamankhwala.Komabe, kugwiritsa ntchito mankhwala aliwonse kuphatikiza ndi metformin (mankhwala akumwa ashuga) amafanizidwa mwachindunji.

Patulani maphunziro mukamagwiritsa ntchito nokha

M'maphunziro osiyana azachipatala, Soliqua 100/33 ndi Adlyxin onse anali othandiza okha pochepetsa shuga wamagazi mwa omwe ali ndi matenda amtundu wa 2.

• Pakafukufuku wamankhwala, Soliqua 100/33 yachepetsa hemoglobin A1c (HbA1c) ndi 1.1 peresenti ndikusala magazi m'magazi ndi 5.7 mg / dL patatha milungu 30.
• M'maphunziro ena azachipatala, Adlyxin adachepetsa HbA1c ndi 0,57 kufika pa 0.71 peresenti ndikusala magazi msinkhu ndi 4.48 mpaka 24.56 mg / dL pamasabata 24 achipatala.

Kuyerekeza mwachindunji mukamagwiritsa ntchito metformin

Kafukufuku wina adayesa kugwiritsa ntchito Soliqua 100/33 yokhala ndi metformin mwachindunji motsutsana ndi kugwiritsa ntchito Adlyxin yokhala ndi metformin mwa akulu omwe ali ndi matenda a shuga amtundu wa 2. Anthu omwe anali mu kafukufukuyu anali atathandizidwapo kale ndi metformin yokha, kapena metformin ndi mankhwala ena am'mimba ashuga.

Pambuyo pa masabata 30, Soliqua 100/33 yokhala ndi metformin inali yothandiza kwambiri kuposa Adlyxin wokhala ndi metformin. Soliqua 100/33 yokhala ndi metformin yachepetsa HbA1c ndi 1.6 peresenti ndikusala magazi m'magazi ndi 59.1 mg / dL. Adlyxin ndi metformin, mbali inayo, adachepetsa HbA1c ndi 0.9 peresenti ndikusala magazi m'magazi ndi 27.2 mg / dL.

Zindikirani: Ndikofunika kukumbukira kuti momwe mankhwalawa angachepetsere HbA1c kapena shuga m'magazi angadalire pazinthu zambiri, kuphatikizapo:

• shuga m'magazi anu mukamayamba mankhwalawa
• zakudya zanu ndi masewera olimbitsa thupi
• mankhwala ena ashuga omwe mumamwa
• mumatsata kwambiri mankhwala anu

Mtengo

Soliqua 100/33 ndi Adlyxin onse ndi mankhwala osokoneza bongo. Pakadali pano palibe mitundu yabwinobwino ya mankhwalawa. Mankhwala omwe ali ndi dzina nthawi zambiri amawononga ndalama zambiri kuposa ma generic.

Malinga ndi kuyerekezera kochokera ku GoodRx.com, Adlyxin nthawi zambiri amawononga ndalama zoposa Soliqua 100/33. Mtengo weniweni womwe mungalipire mankhwalawa umadalira mulingo wanu, mapulani anu a inshuwaransi, malo omwe muli, komanso mankhwala omwe mumagwiritsa ntchito.

Mu Meyi 2020, Food and Drug Administration (FDA) idalimbikitsa kuti ena opanga metformin awonjezere kutulutsa mapiritsi awo pamsika waku US. Izi ndichifukwa choti mulingo wosavomerezeka wa khansa yotenga khansa (wothandizira khansa) udapezeka m'mapiritsi ena a metformin. Ngati mukumwa mankhwalawa, itanani woyang'anira zaumoyo wanu. Adzakulangizani ngati mupitiliza kumwa mankhwala anu kapena ngati mukufuna mankhwala atsopano.

Soliqua 100/33 imagwiritsa ntchito

Food and Drug Administration (FDA) imavomereza mankhwala akuchipatala monga Soliqua 100/33 kuti athetse mavuto ena. Soliqua 100/33 ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito posintha zakudya ndi masewera olimbitsa thupi kuti athetse shuga m'magazi mwa achikulire omwe ali ndi matenda a shuga amtundu wa 2.

Pakufufuza kwamasabata 30 kwa anthu omwe adalandira mtundu wa basal insulin (monga insulin glargine), Soliqua 100/33 adapezeka kuti ndi othandiza. Inachepetsa hemoglobin A1c (HbA1c) ndi 1.1 peresenti ndikusala shuga m'magazi a 5.7 mg / dL.

Kafukufuku wamankhwala wamasabata 30 adayang'ana kwambiri kwa anthu omwe adachiritsidwa ndi metformin okha, kapena ndi metformin ndi mankhwala ena a shuga. Kwa anthu omwe anali phunziroli, Soliqua 100/33 ndi metformin adachepetsa HbA1c wawo ndi 1.6 peresenti ndikusala magazi msinkhu ndi 59.1 mg / dL.

Soliqua 100/33 amagwiritsanso ntchito mankhwala ena

Soliqua 100/33 itha kugwiritsidwa ntchito payokha kapena kuphatikiza ndi mankhwala ena opititsa patsogolo misinkhu ya shuga m'magazi mwa anthu omwe ali ndi matenda amtundu wa 2. Pochiza matenda ashuga, ndizodziwika kuti mankhwala opitilira umodzi amagwiritsidwa ntchito kuchepetsa milingo ya shuga ngati mankhwala amodzi okha sanasinthe kuchuluka kwa shuga m'magazi mokwanira.

Zitsanzo za mankhwala omwe angagwiritsidwe ntchito ndi Soliqua 100/33 ndi awa:

• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• glimepiride (Amaryl)
• glipizide (Glucotrol)
• glyburide (DiaBeta, Glynase)
• metformin (Glucophage, Glumetza, Riomet)
• pioglitazone (Actos)

Soliqua 100/33 ndi mowa

Pewani kumwa mowa kwambiri mukamamwa Soliqua 100/33. Mowa umatha kusintha shuga m'magazi ndikuwonjezera chiopsezo cha hypoglycemia (shuga wotsika magazi) ndi kapamba (kapamba wotupa).

Ngati mumamwa mowa, kambiranani ndi dokotala wanu za momwe mowa ungakhalire wabwino kwa inu.

Kuyanjana kwa Soliqua 100/33

Soliqua 100/33 imatha kulumikizana ndi mankhwala ena angapo. Itha kulumikizananso ndi zowonjezera zowonjezera komanso zakudya zina.

Kuyanjana kosiyanasiyana kumatha kubweretsa zovuta zosiyanasiyana. Mwachitsanzo, ena amatha kusokoneza momwe mankhwala amagwirira ntchito, pomwe ena amatha kuyambitsa zovuta zina.

Soliqua 100/33 ndi mankhwala ena

M'munsimu muli mndandanda wa mankhwala omwe amatha kuyanjana ndi Soliqua 100/33. Mndandandawu mulibe mankhwala onse omwe atha kuyanjana ndi Soliqua 100/33.

Musanatenge Soliqua 100/33, onetsetsani kuti mukuwuza adotolo ndi asayansi wanu zamankhwala onse, owonjezera pa counter, ndi mankhwala ena omwe mumamwa. Auzeni za mavitamini, zitsamba, ndi zowonjezera zilizonse zomwe mumagwiritsa ntchito. Kugawana izi kungakuthandizeni kupewa kuyanjana komwe kungachitike.

Ngati muli ndi mafunso okhudzana ndi mankhwala omwe angakukhudzeni, funsani dokotala kapena wamankhwala.

Mankhwala ena a shuga

Kutenga Soliqua 100/33 ndi mankhwala ena ashuga kumatha kubweretsa kutsika kwa shuga wambiri m'magazi ndikuwonjezera chiopsezo cha hypoglycemia (shuga wotsika magazi). Ngati mumamwa mankhwala aliwonse, mungafunike kuwunika kuchuluka kwa shuga m'magazi anu pafupipafupi. Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo za mankhwala ashuga ndi awa:

• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• Mpweya (DiaBeta, Glynase, Micronase)
• glimepiride (Amaryl)
• glipizide (Glucotrol)
• insulins yanthawi yakudya (Humalog, Novolog)
• metformin (Glucophage)
• mtundu (Starlix)
• repaglinide (Prandin)

Kuphatikiza apo, kugwiritsa ntchito Soliqua 100/33 yokhala ndi mankhwala ashuga omwe amatchedwa thiazolidinediones (TZDs) atha kubweretsa kusungidwa kwamadzimadzi. Ikhozanso kuwonjezera chiopsezo cha kulephera kwa mtima kapena kukulitsa zizindikilo za kulephera kwa mtima (onani chenjezo pansipa). Zitsanzo za mankhwalawa ndi monga:

• pioglitazone (Actos)
• rosiglitazone (Avandia)

Ngati mukutenga TZD, lankhulani ndi dokotala musanayambe Soliqua 100/33. Ngati dokotala akuvomereza kugwiritsa ntchito kwanu TZD pogwiritsa ntchito Soliqua 100/33, onetsetsani kuti mwayang'ana zizindikiritso za mtima. Mukayamba kulephera mtima, dokotala wanu akhoza kuchepetsa kuchuluka kwa TZD yanu kapena kuisiya.

Zizindikiro za kulephera kwa mtima zingaphatikizepo:

• kuvuta kupuma
• kutupa miyendo, akakolo, ndi mapazi
• kuthamanga kapena kusakhazikika kwamtima
• kupweteka pachifuwa

Mankhwala a kuthamanga kwa magazi

Kutenga Soliqua 100/33 ndi mankhwala ena othamanga magazi kumatha kubweretsa kutsika kwa shuga wambiri m'magazi ndikuwonjezera chiopsezo cha hypoglycemia (shuga wotsika magazi). Ngati mumamwa mankhwala aliwonse, mungafunike kuwunika kuchuluka kwa shuga m'magazi anu pafupipafupi. Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo zamankhwala am'magazi omwe amatha kuwonjezera chiopsezo cha hypoglycemia akatengedwa ndi Soliqua 100/33 ndi awa:

• angiotensin-converting enzyme (ACE) inhibitors, monga:
• benazepril (Lotensin)
• kapita
• enalapril (Vasotec)
• lisinopril (Zestril)
• angiotensin II receptor blockers (ARBs), monga:
• valsartan (Diovan)
• makandulo (Atacand)
• irbesartani (Avapro)
• losartan (Cozaar)
• Olmesartan (Benicar)

Mankhwala ena amtundu wa magazi amatha kubisa zizindikiro zakuchepa kwama shuga. Mankhwalawa amathanso kukulitsa kapena kuchepetsa momwe Soliqua 100/33 imagwirira ntchito pochepetsa shuga. Ngati mumamwa mankhwalawa ndi Soliqua 100/33, mungafunikire kuyang'anitsitsa kuchuluka kwa shuga wamagazi pafupipafupi. Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo zamankhwala am'magazi omwe amatha kubisa chizindikiro cha kuthamanga kwa magazi kapena kukhudza momwe Soliqua 100/33 imagwirira ntchito ndi monga:

• clonidine (Catapres)
• metoprolol (Lopressor, Toprol-XL)
• atenolol (Tenormin)

Mankhwala ena omwe amabisa zizindikiro za hypoglycemia

Mankhwala ena amatha kubisa zizindikilo za shuga wotsika kwambiri wamagazi. Ngati mumamwa mankhwalawa, mungafunike kufufuza kuchuluka kwa shuga m'magazi anu pafupipafupi. Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo za mankhwalawa ndi awa:

• albuterol (ProAir, Proventil, Ventolin)
• guanethidine
• kupatsanso

Mankhwala ena omwe amachepetsa shuga m'magazi

Kutenga Soliqua 100/33 ndi mankhwala ena kumatha kubweretsa shuga wambiri m'magazi ndikuwonjezera chiopsezo cha hypoglycemia (shuga wotsika magazi). Ngati mumamwa mankhwala aliwonse, mungafunike kuwunika kuchuluka kwa shuga m'magazi anu pafupipafupi. Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo za mankhwalawa ndi awa:

• disopyramide (Norpace)
• mankhwala ena a cholesterol, monga fenofibrate (Tricor, Triglide) ndi gemfibrozil (Lopid)
• mankhwala opatsirana pogonana, monga fluoxetine (Prozac, Sarafem) ndi selegiline (Emsam, Zelapar)
• octreotide (Sandostatin)
• sulfamethoxazole-trimethoprim (Bactrim, Septra)

Mankhwala ena omwe amachulukitsa shuga m'magazi anu

Mankhwala ena amatha kuwonjezera shuga m'magazi mwanu. Ngati mumamwa mankhwalawa, mungafunike kuwunika kuchuluka kwa shuga m'magazi anu pafupipafupi kuti mupewe hyperglycemia (shuga wambiri wamagazi). Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo za mankhwalawa ndi awa:

• albuterol (ProAir, Proventil, Ventolin)
• mankhwala enaake, monga atazanavir (Reyataz) ndi lopinavir / ritonavir (Kaletra)
• ma steroids ena, monga budesonide (Entocort EC, Pulmicort, Uceris), prednisone, ndi fluticasone (Flonase, Flovent)
• ma diuretics ena, monga chlorothiazide (Diuril) ndi hydrochlorothiazide (Microzide)
• antipsychotic, monga clozapine (Clozaril, Fazaclo) ndi olanzapine (Zyprexa)
• mahomoni ena, monga danazol (Danazol), levothyroxine (Levoxyl, Synthroid) ndi somatropin (Genotropin)
• glucagon (GlucaGen)
• niacin (Niaspan, Slo-Niacin, ena)
• njira zakulera zam'kamwa (mapiritsi oletsa kubereka)

Mankhwala omwe amachulukitsa kapena amachepetsa zotsatira za Soliqua 100/33

Mankhwala ena angakhudze momwe Soliqua 100/33 imagwirira ntchito m'thupi lanu. Ngati mumamwa mankhwalawa, mungafunike kufufuza kuchuluka kwa shuga m'magazi anu pafupipafupi. Komanso, dokotala wanu angafunike kusintha mlingo wanu wa Soliqua 100/33.

Zitsanzo za mankhwalawa ndi awa:

• albuterol (ProAir, Proventil, Ventolin)
• lifiyamu

Soliqua 100/33 ndi zitsamba ndi zowonjezera

Kutenga Soliqua 100/33 ndi zitsamba zina kapena zowonjezera kumatha kuwonjezera chiopsezo cha hypoglycemia (shuga wotsika magazi). Zitsanzo za izi ndi izi:

• alpha-lipoic acid
• banaba
• vwende wowawasa
• chromium
• masewera olimbitsa thupi
• prickly peyala nkhadze
• mabulosi oyera

Momwe Soliqua 100/33 imagwirira ntchito

Soliqua 100/33 imathandizira kukulitsa kuchuluka kwa shuga wamagazi mwa anthu omwe ali ndi matenda amtundu wa 2.

Momwe insulin imakhudzira shuga wamagazi

Nthawi zambiri, mukamadya chakudya, thupi lanu limatulutsa timadzi totchedwa insulin. Glucose (shuga) kuchokera pachakudya amapita m'magazi anu, ndipo insulini imathandizira kuyiyika m'maselo amthupi lanu. Kenako maselowo amatembenuza shugawo kukhala mphamvu.

Anthu omwe ali ndi matenda a shuga amtundu wa 2 nthawi zambiri samakhala ndi insulin. Izi zikutanthauza kuti thupi lawo silimayankha insulin momwe liyenera kukhalira. Popita nthawi, anthu omwe ali ndi matenda a shuga amtundu wa 2 amathanso kusiya kupanga insulin yokwanira.

Thupi lanu likapanda kuyankha insulini momwe liyenera kukhalira, kapena ngati silitulutsa insulin yokwanira, izi zimabweretsa mavuto. Maselo a thupi lanu sangapeze shuga wofunikira kuti agwire bwino ntchito.

Komanso, mutha kukhala ndi shuga wambiri m'magazi anu. Izi zimatchedwa hyperglycemia (shuga wambiri wamagazi). Kukhala ndi shuga wambiri m'magazi anu kumatha kuwononga thupi lanu ndi ziwalo zanu, kuphatikiza maso, mtima, misempha, ndi impso.

Zomwe Soliqua 100/33 amachita

Soliqua 100/33 ili ndi mankhwala awiri. Awa ndi insulini glargine, yomwe imakhala yotenga insulini yayitali, komanso lixisenatide, yomwe ndi glucagon ngati peptide 1 (GLP-1) receptor agonist.

Insulini glargine imagwira ntchito m'njira imodzi: imachepetsa shuga m'magazi anu posunthira shuga m'magazi anu kupita m'maselo anu.

Lixisenatide imagwira ntchito m'njira zitatu. Choyamba, zimawonjezera kuchuluka kwa insulin komwe thupi lanu limapanga. Kuwonjezeka kwa insulini kumathandizira kusunthira shuga wambiri m'magazi anu ndikulowetsa m'maselo anu. Chachiwiri, zimapangitsa kuti m'mimba mwanu musadye pang'onopang'ono mukatha kudya, kukupangitsani kuti mukhale okwanira nthawi yayitali. Ndipo chachitatu, imauza chiwindi chako kuti chimasule shuga wochepa m'magazi ako.

Zimatenga nthawi yayitali bwanji kuti zigwire ntchito?

Soliqua 100/33 imayamba kugwira ntchito mukangoibaya jekeseni. Komabe, zimafika pachimake pafupifupi maola 2.5 mpaka 3 pambuyo pa jakisoni aliyense.

Soliqua 100/33 ndi mimba

Zambiri zophunzirira ndizochepa kugwiritsa ntchito Soliqua 100/33 panthawi yapakati mwa anthu. Komabe, kafukufuku wazinyama akuwonetsa kuti pakhoza kukhala pachiwopsezo cha zolepheretsa kubadwa pogwiritsa ntchito lixisenatide panthawi yapakati. Lixisenatide ndi imodzi mwa mankhwala omwe amapezeka ku Soliqua 100/33. Chifukwa chake, Soliqua 100/33 iyenera kugwiritsidwa ntchito panthawi yapakati ngati phindu lomwe lingakhalepo likuposa zomwe zingachitike.

Ngati muli ndi pakati kapena mukukonzekera kutenga pakati, lankhulani ndi dokotala wanu za kuopsa ndi phindu logwiritsa ntchito Soliqua 100/33 panthawi yapakati.

Soliqua 100/33 ndi kuyamwitsa

Sizikudziwika ngati Soliqua 100/33 imadutsa mkaka wa m'mawere. Musanayamwitse, muyenera kukambirana ndi dokotala kuopsa ndi zabwino zakumwa mankhwalawa mukamayamwitsa.

Mafunso wamba pa Soliqua 100/33

Nawa mayankho pamafunso omwe amafunsidwa kawirikawiri za Soliqua 100/33.

Kodi Soliqua 100/33 imapangitsa kunenepa?

M'mayesero azachipatala, Soliqua 100/33 sanapezeke kuti amathandizira kunenepa. M'malo mwake, mu kafukufuku wina wamankhwala, anthu omwe adatenga Soliqua 100/33 kwamasabata 30 adataya pafupifupi mapaundi 1.5.

Ndizosangalatsa kudziwa kuti mankhwala omwe ali mu Soliqua 100/33 akuwoneka kuti ali ndi zovuta zosiyanasiyana pakulemera. Imodzi mwa mankhwalawa ndi insulini glargine, yomwe imakhala insulin yotenga nthawi yayitali. Nthawi zambiri, mankhwala okhala ndi insulin amalumikizidwa ndi kunenepa.

Komabe, mankhwala ena ku Soliqua 100/33 amatchedwa lixisenatide, yomwe imakhala ngati peptide 1 (GLP-1) yolandila agonist. Mankhwala m'kalasi la mankhwala a GLP-1 awonetsa kuchepa kwa thupi ngati gawo lina lamaphunziro osiyanasiyana azachipatala.

Ngati mukuda nkhawa ndi zomwe Soliqua 100/33 angakhale nazo pakulemera kwanu, lankhulani ndi dokotala wanu.

Kodi Soliqua 100/33 insulin?

Inde, Soliqua 100/33 ili ndi insulin. Soliqua 100/33 amapangidwa ndi mankhwala awiri, imodzi mwa mankhwalawa ndi insulin glargine, insulin yotenga nthawi yayitali.

Mankhwala achiwiri ndi lixisenatide, omwe ndi peputayidi 1 (GLP-1) yolandila agonist.

Kodi Soliqua 100/33 ikugwira ntchito yayitali?

Inde. Soliqua 100/33 ili ndi mankhwala awiri ogwira ntchito. Chimodzi mwazinthuzi ndi insulin glargine, yomwe imakhala insulin yotenga nthawi yayitali.

Kodi Soliqua 100/33 ingagwiritsidwe ntchito pochiza matenda amtundu woyamba 1?

Ayi, Soliqua 100/33 sayenera kugwiritsidwa ntchito pochiza matenda amtundu woyamba 1. Soliqua 100/33 sinaphunzirepo kapena kuvomerezedwa ndi Food and Drug Administration kuti athetse vutoli. Zimangovomerezedwa kuchiza matenda amtundu wa 2.

Machenjezo a Soliqua 100/33

Musanatenge Soliqua 100/33, lankhulani ndi dokotala wanu za mbiri yanu. Soliqua 100/33 mwina siyabwino kwa inu ngati mukudwala. Izi zikuphatikiza:

• Matenda a impso. Ngati muli ndi matenda a impso, kumwa Soliqua 100/33 kumatha kukulitsa vuto lanu. Ngati matenda anu akukula, mungafunike kusiya kumwa Soliqua 100/33. Musamamwe mankhwalawa ngati muli ndi matenda a impso.
• Kuchepetsa m'mimba. Lixisenatide, imodzi mwa mankhwala ku Soliqua 100/33, imachedwetsa minofu ya m'mimba mwanu. Ngati muli ndi gastroparesis, zomwe zikutanthauza kuti thupi lanu limagaya chakudya pang'onopang'ono, kutenga Soliqua 100/33 kumatha kukulitsa vuto lanu. Anthu omwe ali ndi gastroparesis ovuta sayenera kumwa mankhwalawa.
• Matenda a kapamba kapena ndulu, kapena vuto lakumwa mowa. Soliqua 100/33 itha kukulitsa chiopsezo chanu chofalikira. Mutha kukhala pachiwopsezo chachikulu chopatsirana ngati muli ndi mbiri ya kapamba, miyala ya ndulu, kapena uchidakwa. Ngati muli ndi mbiri yamavutowa, kambiranani ndi dokotala ngati Soliqua 100/33 ili yoyenera kwa inu.

Soliqua 100/33 bongo

Kumwa mankhwalawa mopitirira muyeso kungapangitse kuti mukhale ndi zovuta zina.

Zizindikiro zambiri za bongo

Zizindikiro za bongo zingaphatikizepo:

• hypoglycemia yoopsa (shuga wotsika kwambiri wamagazi), yomwe imatha kubweretsa kunjenjemera, kuda nkhawa, komanso kusokonezeka
• hypokalemia (potaziyamu wochepa), yomwe imatha kuyambitsa kufooka, kudzimbidwa, komanso kukokana kwa minofu
• mavuto am'mimba, omwe amatha kuyambitsa kutsekula m'mimba, nseru, ndi kusanza

Zomwe muyenera kuchita mukamagwiritsa ntchito bongo

Ngati mukuganiza kuti mwamwa kwambiri mankhwalawa, itanani dokotala wanu kapena funsani malangizo kuchokera ku American Association of Poison Control Center ku 800-222-1222 kapena kudzera pa chida chawo pa intaneti. Koma ngati matenda anu akukulira, itanani 911 kapena pitani kuchipatala chapafupi pomwepo.

Kutha kwa Soliqua 100/33 ndikusunga

Soliqua 100/33 ikagulitsidwa ku pharmacy, wamankhwala adzawonjezera tsiku lotha ntchito pazolemba zomwe zili pachidebecho. Tsikuli limakhala chaka chimodzi kuchokera tsiku lomwe mankhwalawa adaperekedwa.

Cholinga cha masiku otha ntchitowa ndikutsimikizira kuti mankhwalawa ndi othandiza panthawiyi. Maganizo apano a Food and Drug Administration (FDA) ndikupewa kugwiritsa ntchito mankhwala omwe atha ntchito.

Kutalika kwa nthawi yayitali kumadalira mankhwala, kuphatikiza momwe mankhwalawo amasungidwira. Sungani zolembera zanu za Soliqua 100/33 mufiriji, kutentha pakati pa 36 ° F mpaka 46 ° F (2 ° C ndi 8 ° C). Osamaundana zolembera zanu.

Mutagwiritsa ntchito cholembera chilichonse koyambirira, mutha kuyisunga kutentha (77 ° F / 25 ° C), koma onetsetsani kuti mumateteza ku kuwala. Taya cholembera chilichonse pakatha masiku 28 kuyambira pomwe adagwiritsa ntchito koyamba.

Ngati mwagwiritsa ntchito mankhwala omwe sanadutse tsiku lomaliza, lankhulani ndi wamankhwala wanu ngati mungakwanitse kuugwiritsabe ntchito.

Zambiri zamaluso za Soliqua 100/33

Zotsatirazi zimaperekedwa kwa azachipatala ndi ena othandizira azaumoyo.

Zisonyezero

Soliqua 100/33 ndivomerezedwa ndi FDA kuti igwiritsidwe ntchito ndi zakudya komanso kuchita masewera olimbitsa thupi kuti athetse vuto la glycemic mwa akulu omwe ali ndi matenda a shuga a mtundu wachiwiri.

Njira yogwirira ntchito

Soliqua 100/33 ndi kuphatikiza kwa insulin glargine (basal insulin analog) ndi lixisenatide (glucagon-ngati peptide 1 [GLP-1] receptor agonist).

Insulini glargine imachepetsa shuga wamagazi powonjezera kuchuluka kwa shuga wambiri komanso kuchepetsa kupanga shuga kuchokera pachiwindi. Lixisenatide imachepetsa magazi m'magazi powonjezera kutulutsa kwa insulin, kuchepa kwa kutulutsa kwa glucagon, ndikuchepetsa kutaya kwa m'mimba.

Pharmacokinetics ndi metabolism

Kuchuluka kwa insulin glargine-to-lixisenatide sikukhudza ma pharmacokinetics amtundu uliwonse.

Insulini glargine ilibe pachimake ndipo imapukusidwa pang'ono pang'ono pa carboxyl terminus ya B chain mu subcutaneous depot.

Nthawi yokwanira kuchuluka kwa lixisenatide ndi maola 2.5 mpaka 3. Lixisenatide ali ndi maperesenti 55 omanga mapuloteni ndipo amachotsedwa kudzera mkodzo komanso kuwonongeka kwa proteolytic. Kutanthauza theka la moyo ndi pafupifupi maola atatu.

Zotsutsana

Soliqua 100/33 imatsutsana ndi odwala:

• panthawi yamagulu okhudzana ndi hypoglycemic
• ndi mbiri yakale ya hypersensitivity ku insulin glargine kapena lixisenatide

Yosungirako

Zolembera za Soliqua 100/33 ziyenera kusungidwa mufiriji, kutentha pakati pa 36 ° F mpaka 46 ° F (2 ° C ndi 8 ° C), koma osazizira konse. Mutagwiritsa ntchito koyamba, zolembera zimatha kusungidwa kutentha kwa 77 ° F (25 ° C). Ayenera kutetezedwa ku kuwala. Taya cholembera pakatha masiku 28 kuchokera koyamba kugwiritsidwa ntchito.

Chodzikanira: MedicalNewsToday yachita zonse zotheka kuti zitsimikizire kuti zidziwitso zonse ndizolondola, zonse, komanso zaposachedwa. Komabe, nkhaniyi sikuyenera kugwiritsidwa ntchito m'malo mwa chidziwitso ndi ukadaulo wa akatswiri pazachipatala. Muyenera kufunsa adotolo kapena akatswiri azaumoyo musanamwe mankhwala aliwonse. Zambiri zamankhwala zomwe zili pano zitha kusintha ndipo sizingapangidwe kuti zigwiritse ntchito, mayendedwe, zodzitetezera, machenjezo, kulumikizana ndi mankhwala, kusokonezeka, kapena zovuta zina. Kusapezeka kwa machenjezo kapena zidziwitso za mankhwala omwe apatsidwa sikuwonetsa kuti kuphatikiza mankhwala kapena mankhwalawa ndiwotetezeka, ogwira ntchito, komanso oyenera kwa odwala onse kapena ntchito zina zilizonse.